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ILK Gene

protein-coding   GIFtS: 70

GC11P006283
integrin-linked kinase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
integrin-linked kinase1 2     integrin-linked kinase-22
59 kDa serine/threonine-protein kinase2 3     integrin-linked protein kinase2
p59ILK2 3     DKFZp686F17652
ILK-12 3     ILK13
ILK-22 3     EC 2.7.11.13
P592 5     ILK23

External Ids:    HGNC: 60401   Entrez Gene: 36112   Ensembl: ENSG000001663337   UniProtKB: Q134183   

Export aliases for ILK gene to outside databases

Previous GC identifers: GC11P007367 GC11P007085 GC11P006584 GC11P006590 GC11P006560 GC11P006581


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ILK:
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions,
and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase
(ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase
with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal
receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants
encoding the same protein have been found for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: ILK_HUMAN, Q13418
Function: Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of
inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be
one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell
architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates
beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B

Gene Wiki entry for ILK (Integrin-linked kinase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ILK gene promoter:
         HNF-4alpha2   STAT3   NF-kappaB1   SRF   NF-kappaB   p300   GR-alpha   GATA-1   ATF-2   CREB   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ILK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ILK 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

ILK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ILK gene location

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P006283:  view genomic region     (about GC identifiers)

Start:
6,283,901 bp from pter
End:
6,291,033 bp from pter
Size:
7,133 bases
Orientation:
plus strand

1 alternative location:
Chr11+ 6,624,961-6,632,101     
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ILK_HUMAN, Q13418 (See protein sequence)
Recommended Name: Integrin-linked protein kinase  
Size: 452 amino acids; 51419 Da
Subunit: Interacts with cytoplasmic domain of beta 1 subunit of integrin. Could also interacts with beta 2, beta 3
and/or beta 5 subunit of integrin. Interacts (via ANK repeats) with LIMS1 and LIMS2. Interacts with parvins and
probably TGFB1I1
Subcellular location: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side
Sequence caution: Sequence=CAB94832.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Was originally
thought to be distinct gene (ILK2) (PubMed:10871859);
PDB structures from and Proteopedia :
2KBX (3D)    3F6Q (3D)    3IXE (3D)    3KMU (3D)    3KMW (3D)    
Secondary accessions: P57043 Q68DZ3

Explore the universe of human proteins at neXtProt for ILK: NX_Q13418 

Post-translational modifications:

  • Autophosphorylated on serine residues1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_001014794.1  NP_001014795.1  NP_004508.1  


    ENSEMBL proteins: 
    ENSP00000403487 ENSP00000379975 ENSP00000299421 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ILK
    OriGene Protein Over-expression Lysate (see all 2): ILK
    GenScript Custom Purified and Recombinant Proteins Services for ILK 
    Novus Biologicals Proteins for ILK
    Novus Biologicals Lysates for ILK
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for ILK

    5/12 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 12):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725 stress fiber IEA--
    GO:0005737 cytoplasm NAS--
    GO:0005829 cytosol EXP8538749
    GO:0005886 plasma membrane IEA--
    GO:0005911 cell-cell junction IEA--
    About this table

    ILK for ontologies           About GeneDecksing



    Antibodies for ILK: 
    Millipore Mono- and Polyclonal Antibodies for the study of ILK
    Sigma-Aldrich Antibody Arrays and Antibodies for ILK
    R&D Systems Antibodies for ILK
    Cell Signaling Technology (CST) Antibodies for ILK  (ILK1)
    OriGene Antibodies (see all 3): ILK
    GenScript Custom Superior Antibodies Services for ILK 
    Novus Biologicals Antibodies for ILK
    Epitomics antibodies for ILK

    Assays for ILK: 
    Millipore Kits and Assays for the Analysis of ILK
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ILK 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ILK 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ILK for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR016253 Integrin-linked_kinase
     IPR001245 Ser-Thr/Tyr-Pkinase
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q13418

    ProtoNet protein and cluster: Q13418

    1 Blocks protein family: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: ILK_HUMAN, Q13418
    Domain: A PH-like domain is involved in phosphatidylinositol phosphate binding
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family
    Similarity: Contains 5 ANK repeats
    Similarity: Contains 1 protein kinase domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: ILK_HUMAN, Q13418
    Function: Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of
    inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be
    one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell
    architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates
    beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Stimulated rapidly but transiently by both cell fibronectin interactions, as well as by insulin, in
    a PI3-K-dependent manner, likely via the binding of PtdIns(3,4,5)P3 with a PH-like domain of ILK
    Enzyme Number (IUBMB): EC 2.7.11.1 

    Inhib.
    RNA:
        
    Millipore RNAi Products for the Analysis of ILK Gene knock-down
    Sigma-Aldrich Nano Scale siRNA for ILK
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ILK
    Sigma-Aldrich shRNA Panels and shRNA for ILK
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): ILK
    OriGene shRNA RFP (see all 4): ILK
    OriGene basic RS shRNA (see all 4): ILK
    OriGene siRNA (see all 3): ILK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ILK 
    miRNA:Sigma-Aldrich microRNA Mimics for ILK
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ILK 
    1 SABiosciences Assays for microRNA that regulate ILK:
    hsa-miR-542-3p

    Gene
    Editing:
    Sigma-Aldrich CompoZr Knockout ZFN for ILK 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): ILK
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): ILK
    OriGene untagged cDNA clones in CMV expression vector (see all 5): ILK
    OriGene 3'-UTR clone (see all 3): ILK 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 3): ILK 
    Sino Biological Human cDNA Clone for ILK

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for ILK 

    Genatlas biochemistry entry for ILK:
    integrin-linked kinase,59kDa,widely expressed,potential regulator of integrin beta-1 mediated signal
    transduction,overlapping TAF2H by its 3'end (divergently oriented)

    5/10 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 10):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004672 protein kinase activity ----
    GO:0004674 protein serine/threonine kinase activity IDA9366252
    GO:0004871 signal transducer activity IEA--
    GO:0005178 integrin binding IEA--
    About this table

    ILK for ontologies           About GeneDecksing

    Animal Models: 15/16 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Ilk) (see all 16):

    behavior/neurologicalcardiovascular systemcellularcraniofacialdigestive/alimentary
    embryogenesisgrowth/sizelethality-prenatal/perinatallimbs/digits/tailno phenotypic analysis
    normalotherrenal/urinary systemrespiratory systemskeleton

    ILK for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    ILK for pathways           About GeneDecksing

    4 Millipore Pathways for ILK
        Cytoskeleton remodeling Integrin outside-in signaling
    Signal transduction PTEN pathway
    Cell adhesion PLAU signaling
    Cytoskeleton remodeling Reverse signaling by ephrin B

    5/7 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  ILK (see all 7)
        Integrin Signaling
    Wnt/β-catenin Signaling
    PTEN Signaling
    PI3K/AKT Signaling
    ILK Signaling

    2 Cell Signaling Technology (CST) Pathways for ILK
        Cytoskeletal Signaling
    Akt/PKB Signaling

    4 Kegg Pathways  (Kegg details for ILK):
        hsa03320 PPAR signaling pathway
    hsa04510 Focal adhesion
    hsa05100 Bacterial invasion of epithelial cells
    hsa05213 Endometrial cancer

        SABiosciences Pathway-Focused PCR Arrays including ILK (see all 3): PAHS-058A PAHS-090A  

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for ILK
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ILK

    5/610 Interacting proteins for ILK (Q134181, 2 ENSP000002994213) via UniProtKB, MINT, and/or STRING (see all 610)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARVBQ9HBI11, 2, ENSP000003539243EBI-747644,EBI-1047679 MINT-7945693 STRING: ENSP00000353924
    PARVAQ9NVD72, ENSP000003340083MINT-67103 MINT-7945693 STRING: ENSP00000334008
    LIMS1P480592, ENSP000003375983MINT-7945693 STRING: ENSP00000337598
    COPB2P356061, 2EBI-747644,EBI-1056534 MINT-7945693
    COPGQ9Y6781, 2EBI-747644,EBI-1049127 MINT-7945693
    About this table

    5/37 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 37):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558 regulation of cell growth IEA--
    GO:0001658 branching involved in ureteric bud morphogenesis IEA--
    GO:0001954 positive regulation of cell-matrix adhesion IEA--
    GO:0006468 protein phosphorylation IDA10871859
    GO:0006469 negative regulation of protein kinase activity IEA--
    About this table

    ILK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    ILK for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ILK
    10/26 Novoseek chemical compound relationships for ILK gene (see all 26)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 60.8 28 12778079 (2), 15735038 (2), 15867245 (2), 16648553 (2) (see all 23)
    phosphatidylinositol 58.4 16 16546979 (1), 17107957 (1), 11313365 (1), 16407822 (1) (see all 15)
    threonine 55.9 23 15722199 (2), 11694518 (1), 17656471 (1), 19262169 (1) (see all 22)
    phosphoinositide 51 13 12101188 (4), 17298394 (1), 19920184 (1), 12637511 (1) (see all 9)
    ly294002 50.4 6 15044083 (2), 17234779 (1), 14751515 (1), 16472257 (1)
    serine 43 23 15722199 (2), 11694518 (1), 17656471 (1), 19262169 (1) (see all 22)
    rapamycin 39 14 16014356 (1), 17588951 (1), 20232298 (1), 16397254 (1) (see all 8)
    chlorothalonil 35.6 3 2266108 (1)
    matrigel 33.9 3 12925691 (1), 16818815 (1)
    wortmannin 33 2 15044083 (1), 14751515 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Millipore RNAi Products for the Analysis of ILK Gene knock-down
    Sigma-Aldrich Nano Scale siRNA for ILK
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for ILK
    Sigma-Aldrich shRNA Panels and shRNA for ILK
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): ILK
    OriGene shRNA RFP (see all 4): ILK
    OriGene basic RS shRNA (see all 4): ILK
    OriGene siRNA (see all 3): ILK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ILK 
    miRNA: Sigma-Aldrich microRNA Mimics for ILK
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ILK 
    1 SABiosciences Assays for microRNA that regulate ILK:
    hsa-miR-542-3p
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): ILK
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): ILK
    OriGene untagged cDNA clones in CMV expression vector (see all 5): ILK
    OriGene 3'-UTR Clone (see all 3): ILK 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 3): ILK 
    Primers: OriGene genome-wide validated SYBR primer pairs: ILK
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ILK: PPH00737A

    REFSEQ mRNAs for ILK gene (3 alternative transcripts): 

    NM_001014794.1  NM_001014795.1  NM_004517.2  

    Additional cDNA sequence: 

    AK293474.1 AK296628.1 AK314843.1 BC001554.1 CR407673.1 CR598952.1 CR599632.1 CR601713.1 
    CR604127.1 CR608758.1 CR611887.1 CR615121.1 CR619697.1 CR622983.1 CR624967.1 CR625625.1 
    CR625972.1 CR749220.1 U40282.1 

    24/31 DOTS entries (see all 31):

    DT.92447057  DT.92447059  DT.452885  DT.100038213  DT.100886845  DT.95173144  DT.100886859  DT.97802133 
    DT.95272900  DT.100886848  DT.70101889  DT.95272905  DT.100886863  DT.449776  DT.100886855  DT.120709573 
    DT.120709433  DT.100886843  DT.100886846  DT.100886862  DT.100886860  DT.100886865  DT.100886868  DT.100886870 

    24/522 AceView cDNA sequences (see all 522):

    CD368094 BU615476 BM765458 BF525448 CR749220 BU628446 BX419993 CK430065 
    D82565 CR625625 BQ721237 BG682011 BF724323 BM997788 CR611887 CR604127 
    AI807533 CR624967 CN482245 CR601713 BQ931548 CA976008 CR615121 AI752153 

    highest scoring ESTs for ILK:

    U40282 AA035185 AA035186 AA084545 AA088224 AA135000 AA148200 AA157581 AA205999 AA281103 

    Unigene Cluster for ILK:

    Integrin-linked kinase
    Hs.706355  [show with all ESTs]
    Unigene Representative Sequence: CR749220


    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for ILK (see all 16)

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^
    SP1:                                -     -           -                             -                 -                                                         
    SP2:        -     -                 -     -           -                             -                 -                                                         
    SP3:        -                             -           -                             -                 -                                                         
    SP4:        -     -                 -     -           -                                               -                                                         
    SP5:        -                       -     -           -                             -                 -                                                         

    ExUns: 14a · 14b ^ 15
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  

    About this scheme

    ECgene alternative splicing isoforms for ILK
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000420936 ENST00000396751(uc001meh.2) ENST00000299421(uc001mee.2 uc001mef.2 uc010rap.1 uc010raq.1 uc001meg.2 uc001mei.2)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ILK expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching ILK gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    35365_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 U40282 1.00 1.00 1.00 1
    201234_at2, 3 U133-A 2 0.91 0.95 -- -- NM_004517 0.60 1.00 0.82 1
    201234_at2 U133Plus2 2 0.91 0.95 -- -- -- -- -- -- --
    About this table

    ILK for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ILK gene expression
    ILK gene electronic northern expression
    ILK gene sage expression
    About these images

    CGAP SAGE TAG: GGAGGGATCA

    SOURCE GeneReport for Unigene cluster: Hs.706355

    Expression variation in blood from EXPOLDB for ILK

    UniProtKB/Swiss-Prot: ILK_HUMAN, Q13418
    Tissue specificity: Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in
    placenta, lung and liver

    Primers: OriGene genome-wide validated SYBR primer pairs: ILK
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ILK: PPH00737A
        SABiosciences Expression via Pathway-Focused PCR Arrays including ILK (see all 3): PAHS-058A PAHS-090A  


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for ILK gene from 5/14 species (see all 14)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ILK1   -- integrin-linked kinase 93.66(n)
    99.78(a)
    476836  XM_534040.2  XP_534040.1 
    chimpanzee
    (Pan troglodytes)
    ILK1   -- integrin-linked kinase 99.58(n)
    100(a)
    748941  XM_001164277.1  XP_001164277.1 
    cow
    (Bos taurus)
    ILK1   -- integrin-linked kinase 94.03(n)
    99.34(a)
    540207  NM_001034693.1  NP_001029865.1 
    rat
    (Rattus norvegicus)
    Ilk1   -- integrin linked kinase 91.37(n)
    99.56(a)
    170922  NM_133409.2  NP_596900.1 
    mouse
    (Mus musculus)
    Ilk1 , 5 7 (55.97 cM)5
    integrin linked kinase1, 5 91.52(n)1
    99.12(a)1
    162021  NM_010562.11  NP_034692.11 
     AA5115155  AK0023445  (see all 27)
    About this table        Species with no ortholog for ILK

    ENSEMBL Gene Tree for ILK (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ILK gene
    TNNI3K2  KSR12  ZAK2  MAP3K122  MAP3K132  KSR22  

    ILK for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/51 NCBI SNPs in ILK are shown (see all 51)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs10433881,2
    C,F,6629665(+) GAACAC/TGGGAA 4 H ref1 syn1 ese313Minor allele frequency- T:0.33EA MN NA NS 2394
    rs10433901,2
    C,F,A,6630833(+) ATGCCG/ATATGG 4 /P syn1 ref19Minor allele frequency- A:0.36EA MN NA WA 1976
    rs18762981,2
    --6627767(+) CAGTTC/GGCCAG 2 -- int10--------
    rs18762991,2
    --6627768(+) AGTTCC/GCCAGT 2 -- int10--------
    rs20480921,2
    C,F,O,A,H,6629530(+) TGTGTG/ACTCTT 2 -- int116Minor allele frequency- A:0.48EA NS NA WA 2268
    rs22436251,2
    C,A,6627989(+) TGGCAG/CGCAGC 2 -- int17Minor allele frequency- C:0.14EA NA WA 308
    rs22554051,2
    C,6628053(+) GCCCTG/AGCGCC 2 -- int14Minor allele frequency- A:0.23NA WA 78
    rs22555381,2
    C,F,A,H,6629042(+) ATATGG/ATGAAG 2 -- int114Minor allele frequency- A:0.15NS EA NA WA 1010
    rs22921951,2
    C,F,A,H,6631016(+) ATGGCC/TTTCCT 4 A ref1 syn111Minor allele frequency- T:0.25EA NA NS WA 2004
    rs25551751,2
    C,F,A,H,6627531(-) TTTGAT/ATTTGC 2 -- int119Minor allele frequency- A:0.49EA NS NA WA 2538
    About this table

    HapMap Linkage Disequilibrium images for ILK (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ILK: --

    QIAGEN SeqTarget long-range PCR primers for resequencing ILK 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ILK for disorders           About GeneDecksing

    OMIM: 602366

    10/43 Novoseek disease relationships for ILK gene (see all 43)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    renal fibrosis 49.7 4 12925691 (2), 17498677 (2)
    carcinoma non-small cell lung 34.4 1 19176380 (1)
    tumors 32.8 94 17224516 (5), 19923885 (5), 12596061 (4), 15631637 (3) (see all 39)
    cancer 30.9 55 19895269 (3), 17143519 (3), 18505933 (3), 19409087 (2) (see all 27)
    ovarian cancer 29.9 20 14517840 (4), 17187779 (3), 12642872 (2), 19334037 (2) (see all 8)
    metastasis 29.4 18 12596061 (3), 16836071 (3), 15300800 (2), 15631637 (1) (see all 9)
    familial adenomatous polyposis 28.9 2 16799642 (1), 12771992 (1)
    thyroid carcinoma anaplastic 28.4 6 16093430 (5)
    prostate carcinoma 27.8 4 14990992 (1), 9681506 (1), 10716737 (1)
    prostate cancer 25.4 12 15704679 (4), 15870868 (1), 15782140 (1), 10716737 (1) (see all 6)
    About this table

    Human Gene Mutation Database (HGMD): ILK
    Human Genome Epidemiology (HuGE) Navigator: ILK (1 document)

    Export disorders and mutations for ILK gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/289 PubMed articles for ILK gene, integrated from 7 sources (see all 289):
    (articles sorted by number of sources associating them with ILK)
    1. Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. (PubMed id 8538749)1, 2, 3 Hannigan G.E.... Dedhar S. (1996)
    2. Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation. (PubMed id 10871859)1, 2, 7 Janji B.... Kieffer N. (2000)
    3. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. (PubMed id 9736715)1, 2, 7 Delcommenne M.... Dedhar S. (1998)
    4. The structural basis of integrin-linked kinase-PINCH interactions. (PubMed id 19074270)1, 2, 7 Chiswell B.P.... Calderwood D.A. (2008)
    5. Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration. (PubMed id 12167643)1, 2, 7 Zhang Y.... Wu C. (2002)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Cell-substrate interactions and signaling through ILK. (PubMed id 10712922)1, 2 Dedhar S. (2000)
    8. Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions. (PubMed id 11304546)1, 7 Nikolopoulos S.N. and Turner C.E. (2001)
    9. Expression of integrin-linked kinase in the murine lens is consistent with its role in epithelial-mesenchymal transition of lens epithelial cells in vitro. (PubMed id 17563721)1, 7 Weaver M.S....Sage E.H. (2007)
    10. Increased expression of integrin-linked kinase is correlated with melanoma progression and poor patient survival. (PubMed id 14555513)1, 7 Dai D.L....Li G. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3611 HGNC: 6040 AceView: ILK Ensembl:ENSG00000166333 euGenes: HUgn3611
    ECgene: ILK Kegg: 3611 H-InvDB: ILK

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for ILK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for ILK gene:
    Search GeneIP for patents involving ILK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
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