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IMPDH2 Gene

protein-coding   GIFtS: 64

GC03M049061
IMP (inosine 5'-monophosphate) dehydrogenase 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
IMP (inosine 5'-monophosphate) dehydrogenase 21 2     OTTHUMP000002105562
IMPD22 3 5     inosine 5' phosphate dehydrogenase 22
IMPD 22 3     IMP oxireductase 22
IMPDH-II2 3     IMP (inosine monophosphate) dehydrogenase 22
IMPDH 22 3     IMP dehydrogenase 23
inosine-5'-monophosphate dehydrogenase 22     EC 1.1.1.2053
inosine monophosphate dehydrogenase type II2     

External Ids:    HGNC: 60531   Entrez Gene: 36152   Ensembl: ENSG000001780357   UniProtKB: P122683   

Export aliases for IMPDH2 gene to outside databases

Previous GC identifers: GC03U990046 GC03M048208 GC03M048916 GC03M049020 GC03M049036


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IMPDH2:
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in
maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein
catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then
converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role
in malignant transformation. (provided by RefSeq)

UniProtKB/Swiss-Prot: IMDH2_HUMAN, P12268
Function: Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the
regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some
tumors


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IMPDH2 gene promoter:
         POU3F2   MEF-2A   c-Myb   RORalpha2   USF1   MyoD   C/EBPalpha   E47   IRF-7A   SREBP-1c   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for IMPDH2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for IMPDH2 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.2   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.2

IMPDH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IMPDH2 gene location

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M049061:  view genomic region     (about GC identifiers)

Start:
49,061,758 bp from pter
End:
49,066,875 bp from pter
Size:
5,118 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: IMDH2_HUMAN, P12268 (See protein sequence)
Recommended Name: Inosine-5'-monophosphate dehydrogenase 2  
Size: 514 amino acids; 55805 Da
Cofactor: Potassium
Subunit: Homotetramer
PDB structures from and Proteopedia :
1B3O (3D)    1NF7 (3D)    1NFB (3D)    
Secondary accessions: Q6LEF3

Explore the universe of human proteins at neXtProt for IMPDH2: NX_P12268 

Post-translational modifications:

  • The N-terminus is blocked1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_000875.2  

    ENSEMBL proteins: 
    ENSP00000393525 ENSP00000321584 ENSP00000403502 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for IMPDH2
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: IMPDH2
    OriGene Protein Over-expression Lysate: IMPDH2
    GenScript Custom Purified and Recombinant Proteins Services for IMPDH2 
    Novus Biologicals Protein for IMPDH2
    Novus Biologicals Lysates for IMPDH2
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829 cytosol EXP7903306
    About this table

    IMPDH2 for ontologies           About GeneDecksing



    Antibodies for IMPDH2: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for IMPDH2
    Browse R&D Systems for Antibodies
    OriGene Antibodies: IMPDH2
    GenScript Custom Superior Antibodies Services for IMPDH2 
    Novus Biologicals Antibodies for IMPDH2
    Epitomics antibodies for IMPDH2

    Assays for IMPDH2: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IMPDH2 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for IMPDH2 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    IMPDH2 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR018529 IMP_DH-rel
     IPR013785 Aldolase_TIM
     IPR000644 Cysta_beta_synth_core
     IPR005990 IMP_DH
     IPR001093 IMP_DH_GMPRt

    Graphical View of Domain Structure for InterPro Entry P12268

    ProtoNet protein and cluster: P12268

    2 Blocks protein families:
    IPB000644 CBS domain
    IPB001093 IMP dehydrogenase/GMP reductase


    UniProtKB/Swiss-Prot: IMDH2_HUMAN, P12268
    Similarity: Belongs to the IMPDH/GMPR family
    Similarity: Contains 2 CBS domains


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: IMDH2_HUMAN, P12268
    Function: Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the
    regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some
    tumors
    Catalytic activity: Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH
    Enzyme Number (IUBMB): EC 1.1.1.205 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for IMPDH2
    Sigma-Aldrich shRNA Panels and shRNA for IMPDH2
    OriGene 29mer shRNA kits in GFP-retroviral vector: IMPDH2
    OriGene shRNA RFP: IMPDH2
    OriGene basic RS shRNA: IMPDH2
    OriGene siRNA: IMPDH2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IMPDH2 
    miRNA:Sigma-Aldrich microRNA Mimics for IMPDH2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IMPDH2 
    Search SABiosciences for Assays for microRNAs that regulate IMPDH2

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: IMPDH2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: IMPDH2
    OriGene untagged cDNA clones in CMV expression vector: IMPDH2
    OriGene 3'-UTR clone: IMPDH2 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: IMPDH2 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for IMPDH2 

    Genatlas biochemistry entry for IMPDH2:
    inosine 5'-monophosphate dehydrogenase,type II,paralog to IMPDH1

    5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824 catalytic activity ----
    GO:0003938 IMP dehydrogenase activity IEA--
    GO:0005515 protein binding IPI17353931
    GO:0016491 oxidoreductase activity IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    IMPDH2 for ontologies           About GeneDecksing

    Animal Models: 3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Impdh2):

    hematopoietic systemimmune systemlethality-prenatal/perinatal

    IMPDH2 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    IMPDH2 for pathways           About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  IMPDH2
        Purine Metabolism

    3 Kegg Pathways  (Kegg details for IMPDH2):
        hsa00230 Purine metabolism
    hsa00983 Drug metabolism - other enzymes
    hsa01100 Metabolic pathways

    UniProtKB/Swiss-Prot: IMDH2_HUMAN, P12268
    Pathway: Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1

        SABiosciences Custom Pathway-Focused PCR Arrays for IMPDH2 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for IMPDH2
        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IMPDH2

    5/32 Interacting proteins for IMPDH2 (ENSP000003215843 P122681, 2) via UniProtKB, MINT, and/or STRING (see all 32)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCAR3O758151EBI-353389,EBI-702336
    IKBKEQ141641EBI-353389,EBI-307369
    VHLP403371EBI-353389,EBI-301246
    PIAS4Q8N2W92MINT-3980557
    UBQLN4Q9NRR52MINT-2860079
    About this table

    5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006144 purine base metabolic process TAS--
    GO:0006164 purine nucleotide biosynthetic process IEA--
    GO:0006177 GMP biosynthetic process IEA--
    GO:0009168 purine ribonucleoside monophosphate biosynthetic process EXP1574589
    GO:0046651 lymphocyte proliferation IEA--
    About this table

    IMPDH2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    IMPDH2 for compounds           About GeneDecksing

    Sigma-Aldrich Small Molecules for IMPDH2:
    Small Molecule - Inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IMPDH2
    7 Novoseek chemical compound relationships for IMPDH2 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inosine monophosphate 95.6 52 17496727 (3), 7707313 (3), 16647299 (2), 18976158 (2) (see all 28)
    xanthosine-5'-monophosphate 87.4 2 7906542 (1)
    mycophenolic acid 84.8 17 19299544 (2), 19770842 (2), 15614187 (1), 7600680 (1) (see all 9)
    purine 59.9 4 17496727 (1), 16647299 (1), 15621150 (1)
    mycophenolate mofetil 57.1 5 12193749 (1), 15252268 (1), 15621150 (1), 17805303 (1)
    methotrexate 21.3 6 16609701 (3), 15614187 (1), 15670151 (1)
    hydrogen 0 1 9434751 (1)
    About this table

    1 PharmGKB drug compound relationship for IMPDH2 gene
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    mycophenolate mofetilPD  FA  15621150
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for IMPDH2
    Sigma-Aldrich shRNA Panels and shRNA for IMPDH2
    OriGene 29mer shRNA kits in GFP-retroviral vector: IMPDH2
    OriGene shRNA RFP: IMPDH2
    OriGene basic RS shRNA: IMPDH2
    OriGene siRNA: IMPDH2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of IMPDH2 
    miRNA: Sigma-Aldrich microRNA Mimics for IMPDH2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of IMPDH2 
    Search SABiosciences for Assays for microRNAs that regulate IMPDH2
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: IMPDH2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: IMPDH2
    OriGene untagged cDNA clones in CMV expression vector: IMPDH2
    OriGene 3'-UTR Clone: IMPDH2 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: IMPDH2 
    Primers: OriGene genome-wide validated SYBR primer pairs: IMPDH2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for IMPDH2: PPH02275A

    REFSEQ mRNAs for IMPDH2 gene: 

    NM_000884.2  

    Additional cDNA sequence: 

    AF075074.1 AK293397.1 AY545560.1 BC006124.1 BC009236.2 BC012840.1 BC015567.2 J04208.1 

    24/37 DOTS entries (see all 37):

    DT.100671256  DT.449997  DT.100045605  DT.100769128  DT.100671233  DT.100045602  DT.95250877  DT.100671235 
    DT.95250897  DT.100671239  DT.102838814  DT.100671243  DT.427613  DT.424101  DT.95250899  DT.120910354 
    DT.92469759  DT.100866768  DT.121643111  DT.92469756  DT.100671245  DT.100858086  DT.120910317  DT.120910380 

    24/1197 AceView cDNA sequences (see all 1197):

    BG754164 BQ064687 BU554064 AL514250 BU858002 AL538175 BI824466 BQ068178 
    BM452548 BE278807 BU854899 BQ072251 BU182760 BE409362 BM852385 AI273893 
    BM710686 BI489905 BQ063190 BU931006 AL547478 BU185986 BM810086 AL557569 

    highest scoring ESTs for IMPDH2:

    AA315303 AL535072 AL551909 AL557145 AL557223 AW403955 AW732937 BC009236 BC012840 BC015567 

    Unigene Cluster for IMPDH2:

    IMP (inosine 5'-monophosphate) dehydrogenase 2
    Hs.654400  [show with all ESTs]
    Unigene Representative Sequence: AK293397


    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for IMPDH2 (see all 10)

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^
    SP1:                          -                                                                                               -                                 
    SP2:                          -                                   -                                                                                             
    SP3:                          -                                                                                                                                 
    SP4:                                                                                                                                                            
    SP5:                          -     -     -                                                                                                                     

    ExUns: 15
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      

    About this scheme

    ECgene alternative splicing isoforms for IMPDH2
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429182 ENST00000496837 ENST00000491610 ENST00000326739(uc003cvt.2)
    ENST00000463903 ENST00000462980 ENST00000481274 ENST00000442157 ENST00000466147
    ENST00000484872 ENST00000485500(uc010hkp.1) ENST00000472328

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    IMPDH2 expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching IMPDH2 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    36624_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 L33842 0.20 1.00 0.72 1
    201892_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000884 0.40 0.67 0.55 1
    201892_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    IMPDH2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    IMPDH2 gene expression
    IMPDH2 gene electronic northern expression
    IMPDH2 gene sage expression
    About these images

    CGAP SAGE TAG: ATGTACTCTG

    SOURCE GeneReport for Unigene cluster: Hs.654400

    Expression variation in blood from EXPOLDB for IMPDH2

    UniProtKB/Swiss-Prot: IMDH2_HUMAN, P12268
    Tissue specificity: IMP type I is the main species in normal leukocytes and type II predominates over type I in the
    tumor

    Primers: OriGene genome-wide validated SYBR primer pairs: IMPDH2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for IMPDH2: PPH02275A
        SABiosciences Custom PCR Arrays for IMPDH2 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for IMPDH2 gene from 5/18 species (see all 18)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    IMPDH21   -- IMP (inosine monophosphate) dehydrogenase 2 92.15(n)
    99.42(a)
    476630  XM_857805.1  XP_862898.1 
    chimpanzee
    (Pan troglodytes)
    IMPDH21   -- IMP (inosine monophosphate) dehydrogenase 2 99.94(n)
    100(a)
    460362  XM_516452.2  XP_516452.2 
    cow
    (Bos taurus)
    IMPDH21   -- IMP (inosine monophosphate) dehydrogenase 2 91.31(n)
    98.05(a)
    511969  NM_001034416.1  NP_001029588.1 
    rat
    (Rattus norvegicus)
    Impdh21   -- IMP (inosine monophosphate) dehydrogenase 2 89.49(n)
    98.44(a)
    301005  NM_199099.1  NP_954530.1 
    mouse
    (Mus musculus)
    Impdh21 , 5 9 (59.50 cM)5
    inosine 5'-phosphate dehydrogenase 21, 5 90.08(n)1
    98.83(a)1
    239181  NM_011830.31  NP_035960.21 
     AK1435055  AK1463625  (see all 23)
    About this table        Species with no ortholog for IMPDH2

    ENSEMBL Gene Tree for IMPDH2 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for IMPDH2 gene
    GMPR2  IMPDH12  GMPR22  

    IMPDH2 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/63 NCBI SNPs in IMPDH2 are shown (see all 63)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 3 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs10498181,2
    C49061819(-) CTTTTC/TTGAAA 2 F ref1 syn10--------
    rs11341221,2
    --49061732(+) CCCACC/ATGTCT 1 -- ng311Minor allele frequency- A:0.00MN 184
    rs38911871,2
    --49061659(-) CTCAGC/GGCCCG 1 -- ng310--------
    rs38911881,2
    --49061658(-) TCAGCC/GCCCGA 1 -- ng310--------
    rs39299731,2
    C49064750(-) GGGTGT/GTTTGG 1 -- int14Minor allele frequency- G:0.00NS EA 418
    rs39299741,2
    --49062888(-) GAGGTA/CCGCAC 1 -- int10--------
    rs39299751,2
    --49062887(-) AGGTAA/CGCACA 1 -- int10--------
    rs58488601,2
    --49061950(+) GCCAC-/CTTCCACC 2 G EG fra1 ref10--------
    rs115575401,2
    C49062371(-) TCTCGA/GTGCCA 2 D G ref1 mis1 ese30--------
    rs115575411,2
    C49065735(-) GGCTTC/TATCCA 2 F ref1 syn10--------
    About this table

    HapMap Linkage Disequilibrium images for IMPDH2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IMPDH2: --

    QIAGEN SeqTarget long-range PCR primers for resequencing IMPDH2 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    IMPDH2 for disorders           About GeneDecksing

    OMIM: 146691

    3 Novoseek disease relationships for IMPDH2 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 8.66 7 20233875 (1), 19108589 (1), 18976158 (1), 19583440 (1)
    leukemia 0 1 11370715 (1)
    tumors 0 6 18976158 (1), 19597826 (1)
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    1 PharmGKB disease relationship for IMPDH2 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    liver transplantationPD  FA  15621150
    About this table

    Human Gene Mutation Database (HGMD): IMPDH2
    Human Genome Epidemiology (HuGE) Navigator: IMPDH2 (11 documents)

    Export disorders and mutations for IMPDH2 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
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    10/85 PubMed articles for IMPDH2 gene, integrated from 7 sources (see all 85):
    (articles sorted by number of sources associating them with IMPDH2)
    1. An exploratory study on pharmacogenetics of inosine-monophosphate dehydrogenase II in peripheral mononuclear cells from liver-transplant recipients. (PubMed id 15621150)1, 5, 7 Vannozzi F....Del Tacca M. (2004)
    2. Two distinct cDNAs for human IMP dehydrogenase. (PubMed id 1969416)1, 2, 3 Natsumeda Y.... Suzuki K. (1990)
    3. Chromosomal localization and structure of the human type II IMP dehydrogenase gene. (PubMed id 8098009)1, 2, 7 Glesne D.A.... Huberman E. (1993)
    4. Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design. (PubMed id 10097070)1, 2, 7 Colby T.D....Goldstein B.M. (1999)
    5. Assignment1 of inosine '-monophosphate dehydrogenase type 2 (IMPDH2) to human chromosome band 3p21.2 by in situ hybridization. (PubMed id 9858805)1, 3, 7 Kost-Alimova M.V....Zelenin A.V. (1998)
    6. Characterization of the human inosine-5'-monophosphate dehydrogenase type II gene. (PubMed id 7896827)1, 2, 7 Zimmermann A.G.... Mitchell B.S. (1995)
    7. Cloning and sequence of the human type II IMP dehydrogenase gene. (PubMed id 7999076)1, 2, 7 Glesne D.A. and Huberman E. (1994)
    8. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding. (PubMed id 7763314)1, 2 Hager P.W.... Mitchell B.S. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3615 HGNC: 6053 AceView: IMPDH2 Ensembl:ENSG00000178035 euGenes: HUgn3615
    ECgene: IMPDH2 Kegg: 3615 H-InvDB: IMPDH2

    (According to HUGE)
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    ATLAS Chromosomes in Cancer entry for IMPDH2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for IMPDH2 gene:
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