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INPP5J Gene

protein-coding GIFtS: 51

GC22P014480

inositol polyphosphate-5-phosphatase J
(Previous names: phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PIB5PA)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
inositol polyphosphate-5-phosphatase J¹ ²		Inositol polyphosphate 5-phosphatase J² ³
PIB5PA² ³ ⁵		MGC129984²
PIPP² ³ ⁵		phosphatidylinositol 4,5-bisphosphate 5-phosphatase A²
phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A¹ ²		OTTHUMP00000199393²
INPP5¹ ²		EC 3.1.3.56³

External Ids:	HGNC: 8956¹	Entrez Gene: 27124²	Ensembl: ENSG00000185133⁷	UniProtKB: Q15735³

Export aliases for INPP5J gene to outside databases

Previous GC identifers: GC22P029848 GC22P031518

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PI5PA_HUMAN, Q15735

Function: Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also

converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol

1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of

inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By similarity)

Gene Wiki entry for INPP5J (PIB5PA)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for INPP5J
Other transcription factors

Search SABiosciences Chromatin IP Primers for INPP5J

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2 Ensembl cytogenetic band: 22q12.2 HGNC cytogenetic band: 22q12.2

INPP5J Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INPP5J gene location

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P014480: view genomic region (about GC identifiers)

Start:	14,480,700 bp from pter
End:	14,492,341 bp from pter
Size:	11,642 bases
Orientation:	plus strand

1 alternative location:

Chr22+ 31,518,717-31,530,682

RefSeq DNA sequence:

NC_000022.10 NT_011520.12

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PI5PA_HUMAN, Q15735 (See protein sequence)

Recommended Name: Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

Size: 1006 amino acids; 107197 Da

Subcellular location: Cytoplasm (By similarity). Note=Predominantly localized to membrane ruffles (By similarity)

Sequence caution: Sequence=AAD15618.1; Type=Erroneous gene model prediction;

Secondary accessions: B3KS54 Q32M61 Q6ZTH6 Q8N902 Q9UDT9

Alternative splicing: 3 isoforms: Q15735-1 Q15735-2 Q15735-3

Explore the universe of human proteins at neXtProt for INPP5J: NX_Q15735

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001002837.1

ENSEMBL proteins:

ENSP00000383150 ENSP00000401124 ENSP00000384540 ENSP00000392924 ENSP00000333262 ENSP00000384534

ENSP00000406570 ENSP00000385264 ENSP00000384596 ENSP00000385343

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates
	GenScript Custom Purified and Recombinant Proteins Services for INPP5J
	Novus Biologicals Protein for INPP5J
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001726	ruffle	IDA	12536145
GO:0005737	cytoplasm	IDA	12536145
GO:0005886	plasma membrane	IEA	--
GO:0030426	growth cone	IEA	--
GO:0043198	dendritic shaft	IEA	--

About this table

INPP5J for ontologies About GeneDecksing

Antibodies for INPP5J:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for INPP5J
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for INPP5J
	Novus Biologicals Antibodies for INPP5J
	Browse antibodies at Epitomics

Assays for INPP5J:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for INPP5J
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for INPP5J

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

INPP5J for domains About GeneDecksing

2 InterPro domains/families:

IPR005135 Endo/exonuclease/phosphatase

IPR000300 IPPc

Graphical View of Domain Structure for InterPro Entry Q15735

ProtoNet protein and cluster: Q15735

1 Blocks protein family: IPB000300 Inositol polyphosphate related phosphatase family

UniProtKB/Swiss-Prot: PI5PA_HUMAN, Q15735

Domain: The 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein

Similarity: Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type II family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: PI5PA_HUMAN, Q15735

Function: Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also

converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol

1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of

inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By similarity)

Catalytic activity: D-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate

Catalytic activity: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate

Enzyme Number (IUBMB): EC 3.1.3.56

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for INPP5J Sigma-Aldrich shRNA for INPP5J
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): INPP5J OriGene shRNA RFP (see all 3): INPP5J OriGene basic RS shRNA (see all 3): INPP5J OriGene siRNA (see all 2): INPP5J
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of INPP5J

miRNA:		Sigma-Aldrich microRNA Mimics for INPP5J Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of INPP5J
		1 SABiosciences Assays for microRNA that regulate INPP5J:
		hsa-miR-219-5p

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): INPP5J OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): INPP5J OriGene untagged cDNA clones in CMV expression vector: INPP5J OriGene 3'-UTR clone: INPP5J Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: INPP5J
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for INPP5J

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004437	inositol or phosphatidylinositol phosphatase activity	IEA	--
GO:0004445	inositol-polyphosphate 5-phosphatase activity	IEA	--
GO:0016787	hydrolase activity	IEA	--
GO:0017124	SH3 domain binding	IEA	--
GO:0034485	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	IEA	--

About this table

INPP5J for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

INPP5J for pathways About GeneDecksing

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for INPP5J

Inositol Phosphate Metabolism

3 Kegg Pathways (Kegg details for INPP5J):

	hsa00562 Inositol phosphate metabolism
	hsa01100 Metabolic pathways
	hsa04070 Phosphatidylinositol signaling system

SABiosciences Custom Pathway-Focused PCR Arrays for INPP5J

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for INPP5J

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for INPP5J

5/23 Interacting proteins for INPP5J (ENSP00000333262³) via UniProtKB, MINT, and/or STRING (see all 23)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PLCB1	ENSP00000338185³	STRING: ENSP00000338185
PLCB2	ENSP00000260402³	STRING: ENSP00000260402
PLCB3	ENSP00000279230³	STRING: ENSP00000279230
PLCB4	ENSP00000334105³	STRING: ENSP00000334105
PLCD3	ENSP00000313731³	STRING: ENSP00000313731

About this table

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0010977	negative regulation of neuron projection development	IEA	--
GO:0031115	negative regulation of microtubule polymerization	IEA	--
GO:0033137	negative regulation of peptidyl-serine phosphorylation	IEA	--

About this table

INPP5J for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

INPP5J for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for INPP5J
10 Novoseek chemical compound relationships for INPP5J gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inositol 1,3,4,5-tetrakisphosphate	90	8	9430698 (1), 9525932 (1), 7556092 (1), 8529643 (1) (see all 8)
phosphatidylinositol-3,4,5-trisphosphate	86.4	3	9430698 (1), 7556092 (1), 12556481 (1)
inositol	81.8	20	1321346 (2), 11691828 (1), 15093605 (1), 9038219 (1) (see all 14)
phosphoinositide	73.1	12	12018403 (2), 7556092 (1), 8968499 (1), 19272022 (1) (see all 9)
inositol 1,4,5 trisphosphate	69.8	7	9430698 (1), 9525932 (1), 7556092 (1), 8529643 (1) (see all 7)
phosphatidylinositol	69.2	6	9525932 (1), 19736566 (1), 12676785 (1), 8256286 (1) (see all 6)
phosphatidylinositol 3-phosphate	58.9	2	16880518 (2)
tyrosine	32	5	8805618 (1), 9838104 (1), 9009077 (1), 9232445 (1)
calcium	7.34	4	8529643 (1), 9973602 (1), 1718960 (1)
lipid	6.41	1	12018403 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for INPP5J Sigma-Aldrich shRNA for INPP5J
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): INPP5J OriGene shRNA RFP (see all 3): INPP5J OriGene basic RS shRNA (see all 3): INPP5J OriGene siRNA (see all 2): INPP5J
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of INPP5J

miRNA:		Sigma-Aldrich microRNA Mimics for INPP5J Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of INPP5J
		1 SABiosciences Assays for microRNA that regulate INPP5J:
		hsa-miR-219-5p

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): INPP5J OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): INPP5J OriGene untagged cDNA clones in CMV expression vector: INPP5J OriGene 3'-UTR Clone: INPP5J Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: INPP5J

Primers:		OriGene genome-wide validated SYBR primer pairs: INPP5J Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for INPP5J: PPH08329A

REFSEQ mRNAs for INPP5J gene:

NM_001002837.1

Additional cDNA sequence:

AK092859.1 AK095944.1 AK126610.1 AK293992.1 AK308921.1 AK309548.1 BC041652.1 BC109288.2

CR599279.1 CR604969.1 CR610046.1 CR611668.1 CR615040.1 CR615918.1 CR617561.1 CR617784.1

CR624482.1 CR625511.1 U45975.1

11 DOTS entries:

DT.311553 DT.100024052 DT.100777877 DT.100777879 DT.100753623 DT.100806091 DT.101982761 DT.120648431

DT.100687939 DT.100832177 DT.100778863

24/106 AceView cDNA sequences (see all 106):

BU507439 CR604969 CR611668 BC041652 CR615040 BP352955 AK126610 BM711841

CA868401 CB107367 CR617561 BF436472 CR610046 BM994866 BU684668 BX102670

CR615918 CR625511 AI540418 BU584792 CR599279 CR624482 CR617784 BX376752

Unigene Cluster for INPP5J:

Inositol polyphosphate-5-phosphatase J

Hs.517549 [show with all ESTs]

Unigene Representative Sequence: AK092859

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for INPP5J (see all 10)

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	·	2f	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·
SP1:															-										-										-
SP2:															-		-								-										-
SP3:															-		-						-		-										-
SP4:
SP5:															-		-		-		-				-

ExUns:	17b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for INPP5J
12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000400294 ENST00000461241(uc003ajw.2) ENST00000412985 ENST00000401755(uc003ajz.2)

ENST00000412277 ENST00000331075(uc010gwf.2 uc003ajt.3 uc003ajs.3 uc011alk.1 uc003aju.3 uc010gwg.2)

ENST00000404390 ENST00000420017 ENST00000402238(uc003ajy.2) ENST00000405300(uc003ajv.3)

ENST00000404453(uc003ajx.2) ENST00000463528

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

INPP5J expression in normal and diseased human tissues

¹ / ²

3 probe-sets matching INPP5J gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38960_at²	U95-A	1	1.00	1.00	1.00	1.00	--	--	--	--	--
213651_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
213651_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

INPP5J for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

INPP5J gene electronic northern expression

About these images

CGAP SAGE TAG: GAGACTTCAT

SOURCE GeneReport for Unigene cluster: Hs.517549

Primers:		OriGene genome-wide validated SYBR primer pairs: INPP5J Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for INPP5J: PPH08329A

SABiosciences Custom PCR Arrays for INPP5J

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for INPP5J gene from 3 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
mouse (Mus musculus)	Inpp5j⁵	11 (2.45 cM)	inositol polyphosphate 5-phosphatase J	--	BY629401
fruit fly (Drosophila melanogaster)	CG9784¹	--	CG9784	51.75(n) 37.85(a)	32629 NM_132907.1 NP_573135.1
African malaria mosquito (Anopheles gambiae)	AgaP_AGAP011644¹	--	AGAP011644-PA	51.64(n) 39.41(a)	1280991 XM_320865.2 XP_320865.2

About this table Species with no ortholog for INPP5J

ENSEMBL Gene Tree for INPP5J (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for INPP5J gene

INPPL1² INPP5B² OCRL² INPP5D² INPP5K²

INPP5J for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs1468411^1,2	C,F,O,A,H,	31526644(-)	`AATAAT/CGAATG`	1	--	int¹		16		NA NS EA WA	720
rs2240428^1,2	C	31518950(-)	`CTCTAC/TCGCTC`	1	--	ng5¹		4		NS EA	418
rs2240431^1,2	C,F,O,A,H,	31521850(-)	`CTCTGG/TGTGCC`	1	--	int¹ ese³		15		EA NS NA	2288
rs2240432^1,2	C,F,O,A,	31521404(-)	`GGCTGC/TGCCTG`	1	--	int¹ ese³		20		EA NA NS WA	3006
rs2413027^1,2	C,F,A,H,	31528932(+)	`TTGGTA/TTTTAT`	1	--	int¹		10		NS EA NA WA	684
rs3747152^1,2	C,F,	31520338(+)	`GGAAGG/AGAGAG`	1	--	int¹ trp³		15		EA NS NA WA	2450
rs4820942^1,2	C,F,	31519847(+)	`GCCGGA/TCATAA`	1	--	int¹		9		NS EA NA	912
rs5749216^1,2	--	31526933(+)	`aggctC/Gtgcag`	1	--	int¹		0	--	--	--	--
rs5753469^1,2	C,F,A,H,	31526811(+)	`CAAAAC/TGGGAa`	1	--	int¹		24		NS EA NA WA	1614
rs5997881^1,2	H	31521631(+)	`CCCCAG/AACCTT`	1	--	int¹ ese³		4		NS EA	420

About this table

HapMap Linkage Disequilibrium images for INPP5J (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for INPP5J: --

QIAGEN SeqTarget long-range PCR primers for resequencing INPP5J

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

INPP5J for disorders About GeneDecksing

OMIM: 606481

3 Novoseek disease relationships for INPP5J gene

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lowe syndrome	95	6	9430698 (1), 15353600 (1), 1321346 (1), 7762303 (1) (see all 5)
developmental disabilities	25	1	7762303 (1)
genetic disorder	11	1	9599410 (1)

About this table

Export disorders and mutations for INPP5J gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/79 PubMed articles for INPP5J gene, integrated from 7 sources (see all 79):
(articles sorted by number of sources associating them with INPP5J)

The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2, 3} Dunham I....O'Brien K.P. (1999)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification of a novel domain in two mammalian inositol- polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase SKIP localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. (PubMed id 12536145)^{1, 7} Gurung R.... Mitchell C.A. (2003)
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)² Cantin G.T....Yates J.R. III (2008)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles. (PubMed id 10593988)¹ Mochizuki Y. and Takenawa T. (1999)
A novel isoform of the smooth muscle cell differentiation marker smoothelin. (PubMed id 10023782)¹ Kraemer J.... Leonhardt H. (1999)
Toward a complete human genome sequence. (PubMed id 9847074)¹ Wilson R. (1998)
The inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation. (PubMed id 16280363)⁷ Ooms L.M....Mitchell C.A. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 27124	HGNC: 8956	AceView: PIB5PA	Ensembl:ENSG00000185133	euGenes: HUgn27124
ECgene: INPP5J	Kegg: 27124	H-InvDB: INPP5J

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Intellectual Property for INPP5J gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for INPP5J gene:
Search GeneIP for patents involving INPP5J

GeneCards and IP:
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