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INPP5J Gene

protein-coding   GIFtS: 51

GC22P014480
inositol polyphosphate-5-phosphatase J
(Previous names: phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PIB5PA)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
inositol polyphosphate-5-phosphatase J1 2     Inositol polyphosphate 5-phosphatase J2 3
PIB5PA2 3 5     MGC1299842
PIPP2 3 5     phosphatidylinositol 4,5-bisphosphate 5-phosphatase A2
phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A1 2     OTTHUMP000001993932
INPP51 2     EC 3.1.3.563

External Ids:    HGNC: 89561   Entrez Gene: 271242   Ensembl: ENSG000001851337   UniProtKB: Q157353   

Export aliases for INPP5J gene to outside databases

Previous GC identifers: GC22P029848 GC22P031518


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PI5PA_HUMAN, Q15735
Function: Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also
converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol
1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of
inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By similarity)

Gene Wiki entry for INPP5J (PIB5PA)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for INPP5J
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for INPP5J

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12.2

INPP5J Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INPP5J gene location

GeneLoc gene densities for chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P014480:  view genomic region     (about GC identifiers)

Start:
14,480,700 bp from pter
End:
14,492,341 bp from pter
Size:
11,642 bases
Orientation:
plus strand

1 alternative location:
Chr22+ 31,518,717-31,530,682     
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PI5PA_HUMAN, Q15735 (See protein sequence)
Recommended Name: Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A  
Size: 1006 amino acids; 107197 Da
Subcellular location: Cytoplasm (By similarity). Note=Predominantly localized to membrane ruffles (By similarity)
Sequence caution: Sequence=AAD15618.1; Type=Erroneous gene model prediction;
Secondary accessions: B3KS54 Q32M61 Q6ZTH6 Q8N902 Q9UDT9
Alternative splicing: 3 isoforms:  Q15735-1   Q15735-2   Q15735-3   

Explore the universe of human proteins at neXtProt for INPP5J: NX_Q15735 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001002837.1  

    ENSEMBL proteins: 
    ENSP00000383150 ENSP00000401124 ENSP00000384540 ENSP00000392924 ENSP00000333262 ENSP00000384534 
    ENSP00000406570 ENSP00000385264 ENSP00000384596 ENSP00000385343 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for INPP5J 
    Novus Biologicals Protein for INPP5J
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726 ruffle IDA12536145
    GO:0005737 cytoplasm IDA12536145
    GO:0005886 plasma membrane IEA--
    GO:0030426 growth cone IEA--
    GO:0043198 dendritic shaft IEA--
    About this table

    INPP5J for ontologies           About GeneDecksing



    Antibodies for INPP5J: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for INPP5J
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for INPP5J 
    Novus Biologicals Antibodies for INPP5J
    Browse antibodies at Epitomics

    Assays for INPP5J: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for INPP5J 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for INPP5J 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    INPP5J for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR005135 Endo/exonuclease/phosphatase
     IPR000300 IPPc

    Graphical View of Domain Structure for InterPro Entry Q15735

    ProtoNet protein and cluster: Q15735

    1 Blocks protein family: IPB000300 Inositol polyphosphate related phosphatase family

    UniProtKB/Swiss-Prot: PI5PA_HUMAN, Q15735
    Domain: The 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein
    Similarity: Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type II family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: PI5PA_HUMAN, Q15735
    Function: Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also
    converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol
    1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of
    inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By similarity)
    Catalytic activity: D-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate
    Catalytic activity: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate
    Enzyme Number (IUBMB): EC 3.1.3.56 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for INPP5J
    Sigma-Aldrich shRNA for INPP5J
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): INPP5J
    OriGene shRNA RFP (see all 3): INPP5J
    OriGene basic RS shRNA (see all 3): INPP5J
    OriGene siRNA (see all 2): INPP5J
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of INPP5J 
    miRNA:Sigma-Aldrich microRNA Mimics for INPP5J
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of INPP5J 
    1 SABiosciences Assays for microRNA that regulate INPP5J:
    hsa-miR-219-5p

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): INPP5J
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): INPP5J
    OriGene untagged cDNA clones in CMV expression vector: INPP5J
    OriGene 3'-UTR clone: INPP5J 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: INPP5J 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for INPP5J 

    5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004437 inositol or phosphatidylinositol phosphatase activity IEA--
    GO:0004445 inositol-polyphosphate 5-phosphatase activity IEA--
    GO:0016787 hydrolase activity IEA--
    GO:0017124 SH3 domain binding IEA--
    GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IEA--
    About this table

    INPP5J for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    INPP5J for pathways           About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  INPP5J
        Inositol Phosphate Metabolism

    3 Kegg Pathways  (Kegg details for INPP5J):
        hsa00562 Inositol phosphate metabolism
    hsa01100 Metabolic pathways
    hsa04070 Phosphatidylinositol signaling system

        SABiosciences Custom Pathway-Focused PCR Arrays for INPP5J 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for INPP5J
        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INPP5J

    5/23 Interacting proteins for INPP5J (ENSP000003332623) via UniProtKB, MINT, and/or STRING (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLCB1ENSP000003381853STRING: ENSP00000338185
    PLCB2ENSP000002604023STRING: ENSP00000260402
    PLCB3ENSP000002792303STRING: ENSP00000279230
    PLCB4ENSP000003341053STRING: ENSP00000334105
    PLCD3ENSP000003137313STRING: ENSP00000313731
    About this table

    3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010977 negative regulation of neuron projection development IEA--
    GO:0031115 negative regulation of microtubule polymerization IEA--
    GO:0033137 negative regulation of peptidyl-serine phosphorylation IEA--
    About this table

    INPP5J for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    INPP5J for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for INPP5J
    10 Novoseek chemical compound relationships for INPP5J gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 1,3,4,5-tetrakisphosphate 90 8 9430698 (1), 9525932 (1), 7556092 (1), 8529643 (1) (see all 8)
    phosphatidylinositol-3,4,5-trisphosphate 86.4 3 9430698 (1), 7556092 (1), 12556481 (1)
    inositol 81.8 20 1321346 (2), 11691828 (1), 15093605 (1), 9038219 (1) (see all 14)
    phosphoinositide 73.1 12 12018403 (2), 7556092 (1), 8968499 (1), 19272022 (1) (see all 9)
    inositol 1,4,5 trisphosphate 69.8 7 9430698 (1), 9525932 (1), 7556092 (1), 8529643 (1) (see all 7)
    phosphatidylinositol 69.2 6 9525932 (1), 19736566 (1), 12676785 (1), 8256286 (1) (see all 6)
    phosphatidylinositol 3-phosphate 58.9 2 16880518 (2)
    tyrosine 32 5 8805618 (1), 9838104 (1), 9009077 (1), 9232445 (1)
    calcium 7.34 4 8529643 (1), 9973602 (1), 1718960 (1)
    lipid 6.41 1 12018403 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for INPP5J
    Sigma-Aldrich shRNA for INPP5J
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): INPP5J
    OriGene shRNA RFP (see all 3): INPP5J
    OriGene basic RS shRNA (see all 3): INPP5J
    OriGene siRNA (see all 2): INPP5J
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of INPP5J 
    miRNA: Sigma-Aldrich microRNA Mimics for INPP5J
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of INPP5J 
    1 SABiosciences Assays for microRNA that regulate INPP5J:
    hsa-miR-219-5p
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): INPP5J
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): INPP5J
    OriGene untagged cDNA clones in CMV expression vector: INPP5J
    OriGene 3'-UTR Clone: INPP5J 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: INPP5J 
    Primers: OriGene genome-wide validated SYBR primer pairs: INPP5J
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for INPP5J: PPH08329A

    REFSEQ mRNAs for INPP5J gene: 

    NM_001002837.1  

    Additional cDNA sequence: 

    AK092859.1 AK095944.1 AK126610.1 AK293992.1 AK308921.1 AK309548.1 BC041652.1 BC109288.2 
    CR599279.1 CR604969.1 CR610046.1 CR611668.1 CR615040.1 CR615918.1 CR617561.1 CR617784.1 
    CR624482.1 CR625511.1 U45975.1 

    11 DOTS entries:

    DT.311553  DT.100024052  DT.100777877  DT.100777879  DT.100753623  DT.100806091  DT.101982761  DT.120648431 
    DT.100687939  DT.100832177  DT.100778863 

    24/106 AceView cDNA sequences (see all 106):

    BU507439 CR604969 CR611668 BC041652 CR615040 BP352955 AK126610 BM711841 
    CA868401 CB107367 CR617561 BF436472 CR610046 BM994866 BU684668 BX102670 
    CR615918 CR625511 AI540418 BU584792 CR599279 CR624482 CR617784 BX376752 

    Unigene Cluster for INPP5J:

    Inositol polyphosphate-5-phosphatase J
    Hs.517549  [show with all ESTs]
    Unigene Representative Sequence: AK092859


    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for INPP5J (see all 10)

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a ·
    SP1:                                            -                             -                             -                                                   
    SP2:                                            -     -                       -                             -                                                   
    SP3:                                            -     -                 -     -                             -                                                   
    SP4:                                                                                                                                                            
    SP5:                                            -     -     -     -           -                                                                                 

    ExUns: 17b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      

    About this scheme

    ECgene alternative splicing isoforms for INPP5J
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400294 ENST00000461241(uc003ajw.2) ENST00000412985 ENST00000401755(uc003ajz.2)
    ENST00000412277 ENST00000331075(uc010gwf.2 uc003ajt.3 uc003ajs.3 uc011alk.1 uc003aju.3 uc010gwg.2)
    ENST00000404390 ENST00000420017 ENST00000402238(uc003ajy.2) ENST00000405300(uc003ajv.3)
    ENST00000404453(uc003ajx.2) ENST00000463528

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    INPP5J expression in normal and diseased human tissues

    1  / 2

    3 probe-sets matching INPP5J gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    38960_at2 U95-A 1 1.00 1.00 1.00 1.00 -- -- -- -- --
    213651_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --
    213651_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    INPP5J for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    INPP5J gene expression
    INPP5J gene electronic northern expression
    INPP5J gene sage expression
    About these images

    CGAP SAGE TAG: GAGACTTCAT

    SOURCE GeneReport for Unigene cluster: Hs.517549
    Primers: OriGene genome-wide validated SYBR primer pairs: INPP5J
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for INPP5J: PPH08329A
        SABiosciences Custom PCR Arrays for INPP5J 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for INPP5J gene from 3 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    mouse
    (Mus musculus)
    Inpp5j5 11 (2.45 cM) inositol polyphosphate 5-phosphatase J   -- BY629401 
    fruit fly
    (Drosophila melanogaster)
    CG97841   -- CG9784 51.75(n)
    37.85(a)
    32629  NM_132907.1  NP_573135.1 
    African malaria mosquito
    (Anopheles gambiae)
    AgaP_AGAP0116441   -- AGAP011644-PA 51.64(n)
    39.41(a)
    1280991  XM_320865.2  XP_320865.2 
    About this table        Species with no ortholog for INPP5J

    ENSEMBL Gene Tree for INPP5J (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for INPP5J gene
    INPPL12  INPP5B2  OCRL2  INPP5D2  INPP5K2  

    INPP5J for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/85 NCBI SNPs in INPP5J are shown (see all 85)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 22 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs14684111,2
    C,F,O,A,H,31526644(-) AATAAT/CGAATG 1 -- int116Minor allele frequency- C:0.34NA NS EA WA 720
    rs22404281,2
    C31518950(-) CTCTAC/TCGCTC 1 -- ng514Minor allele frequency- T:0.00NS EA 418
    rs22404311,2
    C,F,O,A,H,31521850(-) CTCTGG/TGTGCC 1 -- int1 ese315Minor allele frequency- T:0.37EA NS NA 2288
    rs22404321,2
    C,F,O,A,31521404(-) GGCTGC/TGCCTG 1 -- int1 ese320Minor allele frequency- T:0.48EA NA NS WA 3006
    rs24130271,2
    C,F,A,H,31528932(+) TTGGTA/TTTTAT 1 -- int110Minor allele frequency- T:0.21NS EA NA WA 684
    rs37471521,2
    C,F,31520338(+) GGAAGG/AGAGAG 1 -- int1 trp315Minor allele frequency- A:0.47EA NS NA WA 2450
    rs48209421,2
    C,F,31519847(+) GCCGGA/TCATAA 1 -- int19Minor allele frequency- T:0.19NS EA NA 912
    rs57492161,2
    --31526933(+) aggctC/Gtgcag 1 -- int10--------
    rs57534691,2
    C,F,A,H,31526811(+) CAAAAC/TGGGAa 1 -- int124Minor allele frequency- N:0.00NS EA NA WA 1614
    rs59978811,2
    H31521631(+) CCCCAG/AACCTT 1 -- int1 ese34Minor allele frequency- A:0.00NS EA 420
    About this table

    HapMap Linkage Disequilibrium images for INPP5J (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for INPP5J: --

    QIAGEN SeqTarget long-range PCR primers for resequencing INPP5J 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    INPP5J for disorders           About GeneDecksing

    OMIM: 606481

    3 Novoseek disease relationships for INPP5J gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lowe syndrome 95 6 9430698 (1), 15353600 (1), 1321346 (1), 7762303 (1) (see all 5)
    developmental disabilities 25 1 7762303 (1)
    genetic disorder 11 1 9599410 (1)
    About this table


    Export disorders and mutations for INPP5J gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
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    10/79 PubMed articles for INPP5J gene, integrated from 7 sources (see all 79):
    (articles sorted by number of sources associating them with INPP5J)
    1. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I....O'Brien K.P. (1999)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification of a novel domain in two mammalian inositol- polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase SKIP localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. (PubMed id 12536145)1, 7 Gurung R.... Mitchell C.A. (2003)
    5. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles. (PubMed id 10593988)1 Mochizuki Y. and Takenawa T. (1999)
    8. A novel isoform of the smooth muscle cell differentiation marker smoothelin. (PubMed id 10023782)1 Kraemer J.... Leonhardt H. (1999)
    9. Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)
    10. The inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation. (PubMed id 16280363)7 Ooms L.M....Mitchell C.A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27124 HGNC: 8956 AceView: PIB5PA Ensembl:ENSG00000185133 euGenes: HUgn27124
    ECgene: INPP5J Kegg: 27124 H-InvDB: INPP5J

    (According to HUGE)
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      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for INPP5J gene:
    Search GeneIP for patents involving INPP5J

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