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INS-IGF2 Gene

protein-coding   GIFtS: 14

GC11M001940

symbol from the EntrezGene Database
NOT approved by the HUGO Gene Nomenclature Committee (HGNC).
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Aliases &
Descriptions
for INS-IGF2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
insulin- insulin-like growth factor 2 read-through2
INSIGF2
OTTHUMP000002001162
insulin- insulin-like growth factor 2 read-through product2
INS-IGF2 readthrough transcript2

External Ids:    Entrez Gene: 7239612   

Export aliases for INS-IGF2 gene to outside databases

Previous GC identifers: GC11U900700 GC11M002124 GC11M002116 GC11M002119 GC11M002120


Summaries
for INS-IGF2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for INS-IGF2:
This locus includes two alternatively spliced read-through transcript variants which align to the INS gene in the 5'
region and to the IGF2 gene in the 3' region. One transcript is predicted to encode a protein which shares the
N-terminus with the INS protein but has a distinct and longer C-terminus, whereas the other transcript is a candidate
for nonsense-mediated decay (NMD). The transcripts are imprinted and are paternally expressed in the limb and eye.
(provided by RefSeq)


Genomic Views
for INS-IGF2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for INS-IGF2
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for INS-IGF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   

INS-IGF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
INS-IGF2 gene location

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M001940:  view genomic region     (about GC identifiers)

Start:
 1,940,872 bp from pter
End:
 1,972,702 bp from pter
Size:
 31,831 bases
Orientation:
 minus strand

Proteins
for INS-IGF2 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
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REFSEQ proteins: NP_001035835.1  
Human Recombinant Proteins 
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Protein Domains/
Families
for INS-IGF2 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
   --

Gene Function
for INS-IGF2 gene

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section
Inhib.
RNA:    		Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for INS-IGF2
Sigma-Aldrich shRNA for INS-IGF2
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): INS-IGF2
OriGene shRNA RFP (see all 3): INS-IGF2
OriGene basic RS shRNA (see all 3): INS-IGF2
OriGene siRNA (see all 3): INS-IGF2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of INS-IGF2 
miRNA:Sigma-Aldrich microRNA Mimics for INS-IGF2
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of INS-IGF2 
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Gene
Editing:		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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OriGene GFP tagged cDNA clones in CMV expression vector: INS-IGF2
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: INS-IGF2
OriGene untagged cDNA clones in CMV expression vector: INS-IGF2
Browse 3'-UTR reporter clones for miRNA target validation 
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Cell
Lines:  		GenScript Custom overexpressing Cell Line Services for INS-IGF2 


Pathways & Interactions
for INS-IGF2 gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for INS-IGF2 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for INS-IGF2

Drugs & Compounds
for INS-IGF2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for INS-IGF2


Transcripts
for INS-IGF2 gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section
Inhib.
RNA:     		Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for INS-IGF2
Sigma-Aldrich shRNA for INS-IGF2
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): INS-IGF2
OriGene shRNA RFP (see all 3): INS-IGF2
OriGene basic RS shRNA (see all 3): INS-IGF2
OriGene siRNA (see all 3): INS-IGF2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of INS-IGF2 
miRNA: Sigma-Aldrich microRNA Mimics for INS-IGF2
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of INS-IGF2 
Search SABiosciences for Assays for microRNAs that regulate INS-IGF2
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: INS-IGF2
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: INS-IGF2
OriGene untagged cDNA clones in CMV expression vector: INS-IGF2
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for INS-IGF2 
Primers: OriGene genome-wide validated SYBR primer pairs: INS-IGF2
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for INS-IGF2: PPH66009A

REFSEQ mRNAs for INS-IGF2 gene: 

NM_001042376.2  

highest scoring ESTs for INS-IGF2:

HG3543-HT3739 AA595780 


GeneLoc Exon Structure


Expression
for INS-IGF2 gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

INS-IGF2 expression in normal and diseased human tissues

1  / 3 Data from Genenote  (Publications) and GNF BioGPS
    About these images

INS-IGF2 gene expression
INS-IGF2 gene electronic northern expression
INS-IGF2 gene sage expression
About these images

CGAP SAGE TAG: --
Primers: OriGene genome-wide validated SYBR primer pairs: INS-IGF2
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for INS-IGF2: PPH66009A
    SABiosciences Custom PCR Arrays for INS-IGF2 


Orthologs
for INS-IGF2 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
   --

Paralogs
for INS-IGF2 gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
  --

Genomic Variants
for INS-IGF2 gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/75 NCBI SNPs in INS-IGF2 are shown (see all 75)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 11 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
----------
rs20009931,2
C,F,A,2178616(-) CCACCG/AGGCTG 1 -- int121Minor allele frequency- A:0.24EU CA EA WA CSA NS MN NA 1592
rs38427571,2
C,F2180225(-) GACCAG/CGGCCA 1 -- int18Minor allele frequency- C:0.02EU CA EA WA CSA NS 846
rs38427581,2
F2180195(-) TAGCCC/TACCCC 1 -- int16Minor allele frequency- T:0.00EU CA EA WA CSA NS 756
rs38427591,2
C,F,2179869(-) CACCCA/TGGGCT 1 -- int17Minor allele frequency- T:0.28EU CA EA WA CSA NS NA 828
rs38427601,2
C,F2179856(-) CTGGGCTGGG/- 
        GATGG 		1 -- int16Minor allele frequency- -:0.30EU CA EA WA CSA NS 756
rs38427621,2
C,F,2179313(-) ACCGTG/ATGTTG 1 -- int18Minor allele frequency- A:0.07EU CA EA WA CSA NS 840
rs38427631,2
C,F,2179204(-) GGGGGC/ATGAGG 1 -- int118Minor allele frequency- A:0.27EU CA EA WA CSA NS NA 2480
rs38427641,2
C,F,2179190(-) GTCTTT/CTGAGG 1 -- int18Minor allele frequency- C:0.12EU CA EA WA CSA NS 808
rs38427651,2
C,F2179118(-) AAGGCC/TGCCCA 1 -- int16Minor allele frequency- T:0.01EU CA EA WA CSA NS 756
rs38427661,2
F2179065(-) CCTGGG/ACCAGA 1 -- int16Minor allele frequency- A:0.01EU CA EA WA CSA NS 756
About this table

HapMap Linkage Disequilibrium images for INS-IGF2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for INS-IGF2: --

Search QIAGEN SeqTarget long-range PCR primers for resequencing for INS-IGF2 

Disorders & Mutations
for INS-IGF2 gene

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
INS-IGF2 for disorders           About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: INS-IGF2 (3 documents)

Export disorders and mutations for INS-IGF2 gene to outside databases

Medical News
for INS-IGF2 gene

(Possibly Related Articles in Doctor's Guide)
About This Section

Publications
for INS-IGF2 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

10/18 PubMed articles for INS-IGF2 gene, integrated from 7 sources (see all 18):
(articles sorted by number of sources associating them with INS-IGF2)
  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
  2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
  3. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
  4. Association between small for gestational age and paternally inherited 5' insulin haplotypes. (PubMed id 17700581)1 Adkins R.M....Somes G. (2008)
  5. A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. (PubMed id 17632545)1 Hakonarson H....Polychronakos C. (2007)
  6. Association between paternally inherited haplotypes upstream of the insulin gene and umbilical cord IGF-II levels. (PubMed id 17667841)1 Adkins R.M....Morrison J.C. (2007)
  7. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. (PubMed id 17554260)1 Todd J.A.... Clayton D.G. (2007)
  8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  9. Imprinting of IGF2 P0 transcript and novel alternatively spliced INS- IGF2 isoforms show differences between mouse and human. (PubMed id 16531418)1 Monk D.... Moore G.E. (2006)
  10. Evidence for a Type 1 diabetes-specific mechanism for the insulin gene-associated IDDM2 locus rather than a general influence on aut oimmunity. (PubMed id 15008838)1 Tait K.F....Gough S.C. (2004)

External Searches for INS-IGF2 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing INS-IGF2 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 723961 euGenes: HUgn723961

Other Databases showing INS-IGF2 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing INS-IGF2 gene

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
   --

Intellectual Property
for INS-IGF2 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for INS-IGF2 gene:
Search GeneIP for patents involving INS-IGF2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for INS-IGF2 gene

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

 Millipore Custom Antibody & Bulk Services
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