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ISL2 Gene

protein-coding GIFtS: 48

GC15P053386

ISL LIM homeobox 2
(Previous names: ISL2 transcription factor, LIM/homeodomain, (islet-2) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
ISL LIM homeobox 2¹ ²
FLJ10160¹ ²
ISL2 transcription factor, LIM/homeodomain, (islet-2)¹ ²
insulin gene enhancer protein ISL-2²
islet-2²
Islet-2³

External Ids:	HGNC: 18524¹	Entrez Gene: 64843²	Ensembl: ENSG00000159556⁷	UniProtKB: Q96A47³

Export aliases for ISL2 gene to outside databases

Previous GC identifers: GC15P072517 GC15P069719 GC15P074205 GC15P074344 GC15P074416 GC15P076629

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ISL2_HUMAN, Q96A47

Function: Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord

and select distinct axon pathways (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ISL2 gene promoter:
         GATA-1   Sox9   ATF-2   POU3F2 (N-Oct-5a)   POU3F2   POU3F2 (N-Oct-5b)   c-Jun   Egr-2   Pbx1a   Arnt
         Other transcription factors

Search SABiosciences Chromatin IP Primers for ISL2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ISL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23 Ensembl cytogenetic band: 15q24.3 HGNC cytogenetic band: 15q24.3

ISL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ISL2 gene location

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P053386: view genomic region (about GC identifiers)

Start:	53,386,124 bp from pter
End:	53,391,793 bp from pter
Size:	5,670 bases
Orientation:	plus strand

1 alternative location:

Chr15+ 76,629,065-76,634,817

RefSeq DNA sequence:

NC_000015.9 NT_010194.17

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ISL2_HUMAN, Q96A47 (See protein sequence)

Recommended Name: Insulin gene enhancer protein ISL-2

Size: 359 amino acids; 39768 Da

Subcellular location: Nucleus (By similarity)

Secondary accessions: B3KM37

Explore the universe of human proteins at neXtProt for ISL2: NX_Q96A47

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_665804.1

ENSEMBL proteins:

ENSP00000290759

Human Recombinant Proteins

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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates
	GenScript Custom Purified and Recombinant Proteins Services for ISL2
	Novus Biologicals Proteins for ISL2
	Novus Biologicals Lysate for ISL2
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--

About this table

ISL2 for ontologies About GeneDecksing

Antibodies for ISL2:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ISL2
	R&D Systems Antibodies for ISL2 (Islet-2)
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	Novus Biologicals Antibodies for ISL2
	Browse antibodies at Epitomics

Assays for ISL2:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ISL2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ISL2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ISL2 for domains About GeneDecksing

5 InterPro domains/families:

IPR001781 Znf_LIM

IPR001356 Homeobox

IPR017970 Homeobox_CS

IPR009057 Homeodomain-like

IPR012287 Homeodomain-rel

Graphical View of Domain Structure for InterPro Entry Q96A47

ProtoNet protein and cluster: Q96A47

1 Blocks protein family: IPB001781 Zn-binding protein

UniProtKB/Swiss-Prot: ISL2_HUMAN, Q96A47

Similarity: Contains 1 homeobox DNA-binding domain

Similarity: Contains 2 LIM zinc-binding domains

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: ISL2_HUMAN, Q96A47

Function: Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord

and select distinct axon pathways (By similarity)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for ISL2 Sigma-Aldrich shRNA for ISL2
		OriGene 29mer shRNA kits in GFP-retroviral vector: ISL2 OriGene shRNA RFP: ISL2 OriGene basic RS shRNA: ISL2 OriGene siRNA: ISL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ISL2

miRNA:		Sigma-Aldrich microRNA Mimics for ISL2 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ISL2
		1 SABiosciences Assays for microRNA that regulate ISL2:
		hsa-miR-375

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: ISL2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ISL2 OriGene untagged cDNA clones in CMV expression vector: ISL2 Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: ISL2
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for ISL2

5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0005515	protein binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0030528	transcription regulator activity	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

About this table

ISL2 for ontologies About GeneDecksing

Animal Models: 6 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Isl2):

growth/size	lethality-prenatal/perinatal	nervous system	no phenotypic analysis	normal
respiratory system

ISL2 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Pathway-Focused PCR Array including ISL2: PAHS-083A

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ISL2

5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007275	multicellular organismal development	IEA	--
GO:0021524	visceral motor neuron differentiation	IEA	--
GO:0031290	retinal ganglion cell axon guidance	IEA	--
GO:0045665	negative regulation of neuron differentiation	IEA	--

About this table

ISL2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ISL2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for ISL2 Sigma-Aldrich shRNA for ISL2
		OriGene 29mer shRNA kits in GFP-retroviral vector: ISL2 OriGene shRNA RFP: ISL2 OriGene basic RS shRNA: ISL2 OriGene siRNA: ISL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ISL2

miRNA:		Sigma-Aldrich microRNA Mimics for ISL2 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ISL2
		1 SABiosciences Assays for microRNA that regulate ISL2:
		hsa-miR-375

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: ISL2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ISL2 OriGene untagged cDNA clones in CMV expression vector: ISL2 Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: ISL2

Primers:		OriGene genome-wide validated SYBR primer pairs: ISL2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ISL2: PPH23356A

REFSEQ mRNAs for ISL2 gene:

NM_145805.1

Additional cDNA sequence:

AK001022.1 BC011967.1 BC012136.1 CR610026.1

2 DOTS entries:

DT.305214 DT.75175862

24 AceView cDNA sequences:

BC012136 CR610026 NM_145805 AA459822 BC011967 BQ881714 AK001022 BU845300

BE778146 BX327471 BE783453 BU849219 AU118412 BU553385 AI936027 BM827241

AA459702 AA776817 AL559453 AL559452 BG472783 BX280469 BU553899 AU144983

highest scoring ESTs for ISL2:

AA776817 AA459702 AA459822 AI936027 AK001022 BC011967 BC012136 AL559452 AU118412 AU144983

Unigene Cluster for ISL2:

ISL LIM homeobox 2

Hs.444677 [show with all ESTs]

Unigene Representative Sequence: BC012136

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000290759(uc002bbw.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ISL2 expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching ISL2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
44384_at²^{, 3}	U95-B	1	0.94	1.00	1.00	1.00	AA776817	1.00	1.00	1.00	1
232352_at²^{, 3}	U133-B	1	0.91	1.00	--	--	AK001022	0.80	1.00	0.91	1
232352_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

About this table

ISL2 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

ISL2 gene electronic northern expression

About these images

CGAP SAGE TAG: ATTGCTGGGA

SOURCE GeneReport for Unigene cluster: Hs.444677

Primers:		OriGene genome-wide validated SYBR primer pairs: ISL2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ISL2: PPH23356A

SABiosciences Expression via Pathway-Focused PCR Array including ISL2: PAHS-083A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ISL2 gene from 5/7 species (see all 7)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ISL2¹	--	ISL LIM homeobox 2	99.81(n) 100(a)	738258 XM_001147206.1 XP_001147206.1
cow (Bos taurus)	ISL2¹	--	ISL LIM homeobox 2	95.2(n) 98.24(a)	786913 XM_001254462.1 XP_001254463.1
rat (Rattus norvegicus)	Isl2¹	--	ISL LIM homeobox 2	92.57(n) 96.66(a)	57233 NM_020471.1 NP_065204.1
mouse (Mus musculus)	Isl2^{1 , 5}	9 (30.13 cM)⁵	insulin related protein 2 (islet 2)^{1, 5}	92.94(n)¹ 97.49(a)¹	104360¹ NM_027397.2¹ NP_081673.1¹ AK013964⁵ BC120880⁵ (see all 8)
zebrafish (Danio rerio)	isl2²	--	islet2	81.06(n)	30157 D38453.1

About this table Species with no ortholog for ISL2

ENSEMBL Gene Tree for ISL2 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ISL2 gene

ISL1² LMO2² LMO3² LMO1²

ISL2 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs874223^1,2	C,A,	76631571(+)	`ATCCGC/TAGACC`	1	--	int¹		9		NA EA WA	222
rs874224^1,2	C,F,A,	76631797(+)	`CAAGCG/CGGTAT`	1	--	int¹		13		NS EA NA WA	1058
rs1810348^1,2	C,F,A,	76632487(-)	`TTTAAC/TTGTTC`	1	--	int¹		15		NS EA NA WA	914
rs2003344^1,2	C,F,A,	76632301(-)	`GTCGCA/GGGACC`	1	--	int¹		6		NA EA WA	216
rs2203821^1,2	C,	76629168(-)	`GTCGCA/GCGCCC`	1	--	ut5¹ ese³		0	--	--	--	--
rs3866543^1,2	C,F,	76629609(-)	`GAAAAA/CCCGAA`	1	--	int¹		12		NS EA NA WA	818
rs4489970^1,2	C,	76631027(+)	`TGTGTG/ATTCTC`	1	--	int¹		6		NA EA WA	98
rs4636879^1,2	C,F,A,	76630303(+)	`GACTAC/TGTCAG`	2	Y	ref¹ syn¹ ese³		10		NS EA NA WA	628
rs4886490^1,2	C,F,H,	76628440(+)	`AATCTG/AAAGTT`	1	--	ng5¹		13		NS EA NA WA	642
rs5813832^1,2	--	76629601(+)	`GTTTG-/CCTTTC`	1	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for ISL2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ISL2: --

QIAGEN SeqTarget long-range PCR primers for resequencing ISL2

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ISL2 for disorders About GeneDecksing

OMIM: 609481

Export disorders and mutations for ISL2 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

9 PubMed articles for ISL2 gene integrated from 7 sources:
(articles sorted by number of sources associating them with ISL2)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{1, 2} Beausoleil S.A....Gygi S.P. (2004)
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)² Gauci S....Mohammed S. (2009)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
Cloning and expression of a novel human gene, Isl-2, encoded a LIM-homeodomain protein. (PubMed id 17091338)¹ Li Y....Liu M. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors. (PubMed id 9452425)¹ Jurata L.W....Gill G.N. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 64843	HGNC: 18524	AceView: ISL2	Ensembl:ENSG00000159556	euGenes: HUgn64843
ECgene: ISL2	H-InvDB: ISL2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for ISL2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for ISL2 gene:
Search GeneIP for patents involving ISL2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
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	Predesigned and custom siRNAs for ISL2		Antibodies for ISL2
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	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

	Antibodies for ISL2 (Islet-2)		Cell Culture Products
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	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ISL2
	SeqTarget long-range PCR primers for resequencing ISL2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ISL2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ISL2

	GenScript Custom Purified and Recombinant Proteins Services for ISL2		GenScript cDNA clones with any tag delivered in your preferred vector for ISL2
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ELISAs and CLIAs for ISL2

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ISL2 Gene

protein-coding GIFtS: 48

Aliases &
Descriptions
for ISL2 gene

Summaries
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for ISL2 gene

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ISL2 Gene

protein-coding GIFtS: 48

Aliases & Descriptionsfor ISL2 gene

Summariesfor ISL2 gene

Genomic Viewsfor ISL2 gene

Proteinsfor ISL2 gene

Protein Domains/Familiesfor ISL2 gene

Gene Functionfor ISL2 gene

Pathways & Interactionsfor ISL2 gene

Drugs & Compoundsfor ISL2 gene

Transcriptsfor ISL2 gene

Expression for ISL2 gene

Orthologsfor ISL2 gene

Paralogsfor ISL2 gene

Genomic Variantsfor ISL2 gene

Disorders & Mutationsfor ISL2 gene

Medical Newsfor ISL2 gene

Publicationsfor ISL2 gene

External Searches for ISL2 gene

Genome Databases showing ISL2 gene

Other Databases showing ISL2 gene

Specialized Databases showing ISL2 gene

Intellectual Propertyfor ISL2 gene

Productsfor ISL2 gene

View Random Gene

Aliases &
Descriptions
for ISL2 gene

Summaries
for ISL2 gene

Genomic Views
for ISL2 gene

Proteins
for ISL2 gene

Protein Domains/
Families
for ISL2 gene

Gene Function
for ISL2 gene

Pathways & Interactions
for ISL2 gene

Drugs & Compounds
for ISL2 gene

Transcripts
for ISL2 gene

Expression
for ISL2 gene

Orthologs
for ISL2 gene

Paralogs
for ISL2 gene

Genomic Variants
for ISL2 gene

Disorders & Mutations
for ISL2 gene

Medical News
for ISL2 gene

Publications
for ISL2 gene

Intellectual Property
for ISL2 gene

Products
for ISL2 gene