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ISL2 Gene

protein-coding   GIFtS: 48

GC15P053386
ISL LIM homeobox 2
(Previous names: ISL2 transcription factor, LIM/homeodomain, (islet-2) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
ISL LIM homeobox 21 2
FLJ101601 2
ISL2 transcription factor, LIM/homeodomain, (islet-2)1 2
insulin gene enhancer protein ISL-22
islet-22
Islet-23

External Ids:    HGNC: 185241   Entrez Gene: 648432   Ensembl: ENSG000001595567   UniProtKB: Q96A473   

Export aliases for ISL2 gene to outside databases

Previous GC identifers: GC15P072517 GC15P069719 GC15P074205 GC15P074344 GC15P074416 GC15P076629


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ISL2_HUMAN, Q96A47
Function: Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord
and select distinct axon pathways (By similarity)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ISL2 gene promoter:
         GATA-1   Sox9   ATF-2   POU3F2 (N-Oct-5a)   POU3F2   POU3F2 (N-Oct-5b)   c-Jun   Egr-2   Pbx1a   Arnt   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for ISL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ISL2 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23   Ensembl cytogenetic band:  15q24.3   HGNC cytogenetic band: 15q24.3

ISL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ISL2 gene location

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P053386:  view genomic region     (about GC identifiers)

Start:
53,386,124 bp from pter
End:
53,391,793 bp from pter
Size:
5,670 bases
Orientation:
plus strand

1 alternative location:
Chr15+ 76,629,065-76,634,817     
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: ISL2_HUMAN, Q96A47 (See protein sequence)
Recommended Name: Insulin gene enhancer protein ISL-2  
Size: 359 amino acids; 39768 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: B3KM37

Explore the universe of human proteins at neXtProt for ISL2: NX_Q96A47 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_665804.1  

    ENSEMBL proteins: 
    ENSP00000290759 


    Human Recombinant Proteins 
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    Novus Biologicals Proteins for ISL2
    Novus Biologicals Lysate for ISL2
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    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IEA--
    About this table

    ISL2 for ontologies           About GeneDecksing



    Antibodies for ISL2: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals Antibodies for ISL2
    Browse antibodies at Epitomics

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    Browse Kits and Assays available from Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ISL2 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ISL2 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ISL2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR001781 Znf_LIM
     IPR001356 Homeobox
     IPR017970 Homeobox_CS
     IPR009057 Homeodomain-like
     IPR012287 Homeodomain-rel

    Graphical View of Domain Structure for InterPro Entry Q96A47

    ProtoNet protein and cluster: Q96A47

    1 Blocks protein family: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: ISL2_HUMAN, Q96A47
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 2 LIM zinc-binding domains


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: ISL2_HUMAN, Q96A47
    Function: Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord
    and select distinct axon pathways (By similarity)

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for ISL2
    Sigma-Aldrich shRNA for ISL2
    OriGene 29mer shRNA kits in GFP-retroviral vector: ISL2
    OriGene shRNA RFP: ISL2
    OriGene basic RS shRNA: ISL2
    OriGene siRNA: ISL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ISL2 
    miRNA:Sigma-Aldrich microRNA Mimics for ISL2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ISL2 
    1 SABiosciences Assays for microRNA that regulate ISL2:
    hsa-miR-375

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ISL2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ISL2
    OriGene untagged cDNA clones in CMV expression vector: ISL2
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: ISL2 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for ISL2 

    5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700 sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515 protein binding IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0030528 transcription regulator activity IEA--
    GO:0043565 sequence-specific DNA binding IEA--
    About this table

    ISL2 for ontologies           About GeneDecksing

    Animal Models: 6 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Isl2):

    growth/sizelethality-prenatal/perinatalnervous systemno phenotypic analysisnormal
    respiratory system

    ISL2 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Pathway-Focused PCR Array including ISL2: PAHS-083A 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ISL2

    5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0007275 multicellular organismal development IEA--
    GO:0021524 visceral motor neuron differentiation IEA--
    GO:0031290 retinal ganglion cell axon guidance IEA--
    GO:0045665 negative regulation of neuron differentiation IEA--
    About this table

    ISL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ISL2


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for ISL2
    Sigma-Aldrich shRNA for ISL2
    OriGene 29mer shRNA kits in GFP-retroviral vector: ISL2
    OriGene shRNA RFP: ISL2
    OriGene basic RS shRNA: ISL2
    OriGene siRNA: ISL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ISL2 
    miRNA: Sigma-Aldrich microRNA Mimics for ISL2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ISL2 
    1 SABiosciences Assays for microRNA that regulate ISL2:
    hsa-miR-375
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: ISL2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: ISL2
    OriGene untagged cDNA clones in CMV expression vector: ISL2
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: ISL2 
    Primers: OriGene genome-wide validated SYBR primer pairs: ISL2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ISL2: PPH23356A

    REFSEQ mRNAs for ISL2 gene: 

    NM_145805.1  

    Additional cDNA sequence: 

    AK001022.1 BC011967.1 BC012136.1 CR610026.1 

    2 DOTS entries:

    DT.305214  DT.75175862 

    24 AceView cDNA sequences:

    BC012136 CR610026 NM_145805 AA459822 BC011967 BQ881714 AK001022 BU845300 
    BE778146 BX327471 BE783453 BU849219 AU118412 BU553385 AI936027 BM827241 
    AA459702 AA776817 AL559453 AL559452 BG472783 BX280469 BU553899 AU144983 

    highest scoring ESTs for ISL2:

    AA776817 AA459702 AA459822 AI936027 AK001022 BC011967 BC012136 AL559452 AU118412 AU144983 

    Unigene Cluster for ISL2:

    ISL LIM homeobox 2
    Hs.444677  [show with all ESTs]
    Unigene Representative Sequence: BC012136


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000290759(uc002bbw.1)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    ISL2 expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching ISL2 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    44384_at2, 3 U95-B 1 0.94 1.00 1.00 1.00 AA776817 1.00 1.00 1.00 1
    232352_at2, 3 U133-B 1 0.91 1.00 -- -- AK001022 0.80 1.00 0.91 1
    232352_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table

    ISL2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    ISL2 gene expression
    ISL2 gene electronic northern expression
    ISL2 gene sage expression
    About these images

    CGAP SAGE TAG: ATTGCTGGGA

    SOURCE GeneReport for Unigene cluster: Hs.444677
    Primers: OriGene genome-wide validated SYBR primer pairs: ISL2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for ISL2: PPH23356A
        SABiosciences Expression via Pathway-Focused PCR Array including ISL2: PAHS-083A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for ISL2 gene from 5/7 species (see all 7)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    ISL21   -- ISL LIM homeobox 2 99.81(n)
    100(a)
    738258  XM_001147206.1  XP_001147206.1 
    cow
    (Bos taurus)
    ISL21   -- ISL LIM homeobox 2 95.2(n)
    98.24(a)
    786913  XM_001254462.1  XP_001254463.1 
    rat
    (Rattus norvegicus)
    Isl21   -- ISL LIM homeobox 2 92.57(n)
    96.66(a)
    57233  NM_020471.1  NP_065204.1 
    mouse
    (Mus musculus)
    Isl21 , 5 9 (30.13 cM)5
    insulin related protein 2 (islet 2)1, 5 92.94(n)1
    97.49(a)1
    1043601  NM_027397.21  NP_081673.11 
     AK0139645  BC1208805  (see all 8)
    zebrafish
    (Danio rerio)
    isl22   -- islet2 81.06(n) 30157  D38453.1 
    About this table        Species with no ortholog for ISL2

    ENSEMBL Gene Tree for ISL2 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for ISL2 gene
    ISL12  LMO22  LMO32  LMO12  

    ISL2 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/73 NCBI SNPs in ISL2 are shown (see all 73)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 15 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs8742231,2
    C,A,76631571(+) ATCCGC/TAGACC 1 -- int19Minor allele frequency- T:0.20NA EA WA 222
    rs8742241,2
    C,F,A,76631797(+) CAAGCG/CGGTAT 1 -- int113Minor allele frequency- C:0.14NS EA NA WA 1058
    rs18103481,2
    C,F,A,76632487(-) TTTAAC/TTGTTC 1 -- int115Minor allele frequency- T:0.17NS EA NA WA 914
    rs20033441,2
    C,F,A,76632301(-) GTCGCA/GGGACC 1 -- int16Minor allele frequency- G:0.40NA EA WA 216
    rs22038211,2
    C,76629168(-) GTCGCA/GCGCCC 1 -- ut51 ese30--------
    rs38665431,2
    C,F,76629609(-) GAAAAA/CCCGAA 1 -- int112Minor allele frequency- C:0.29NS EA NA WA 818
    rs44899701,2
    C,76631027(+) TGTGTG/ATTCTC 1 -- int16Minor allele frequency- A:0.11NA EA WA 98
    rs46368791,2
    C,F,A,76630303(+) GACTAC/TGTCAG 2 Y ref1 syn1 ese310Minor allele frequency- T:0.32NS EA NA WA 628
    rs48864901,2
    C,F,H,76628440(+) AATCTG/AAAGTT 1 -- ng5113Minor allele frequency- A:0.19NS EA NA WA 642
    rs58138321,2
    --76629601(+) GTTTG-/CCTTTC 1 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for ISL2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ISL2: --

    QIAGEN SeqTarget long-range PCR primers for resequencing ISL2 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ISL2 for disorders           About GeneDecksing

    OMIM: 609481


    Export disorders and mutations for ISL2 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    9 PubMed articles for ISL2 gene integrated from 7 sources:
    (articles sorted by number of sources associating them with ISL2)
    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1, 2 Beausoleil S.A....Gygi S.P. (2004)
    4. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    5. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    6. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    7. Cloning and expression of a novel human gene, Isl-2, encoded a LIM-homeodomain protein. (PubMed id 17091338)1 Li Y....Liu M. (2007)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors. (PubMed id 9452425)1 Jurata L.W....Gill G.N. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64843 HGNC: 18524 AceView: ISL2 Ensembl:ENSG00000159556 euGenes: HUgn64843
    ECgene: ISL2 H-InvDB: ISL2

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for ISL2 gene:
    Search GeneIP for patents involving ISL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ISL2
     SeqTarget long-range PCR primers for resequencing ISL2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ISL2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ISL2
     GenScript Custom Purified and Recombinant Proteins Services for ISL2 GenScript cDNA clones with any tag delivered in your preferred vector for ISL2
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     Regulatory tfbs in ISL2 promoter
     Search Chromatin IP Primers for ISL2
     RT2 qPCR Primer Assay for ISL2
     Search GNC Networks for ISL2
     Assays for microRNAs that regulate ISL2
     SABiosciences PCR Arrays including ISL2
     Search Tocris compounds for ISL2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for ISL2
     Proteins for ISL2
     Lysates for ISL2
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for ISL2
           

    GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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