Aliases &
Descriptions
for JAG2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| jagged 21 2 | | SER22 | | protein jagged-22 | | HJ22 | | hJ23 | | Jagged23 |
Export aliases for JAG2 gene to outside databasesPrevious GC identifers: GC14M102987 GC14M099599 GC14M103579 GC14M104679 GC14M105607 |
Summaries
for JAG2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for JAG2:
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development.Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. Theprotein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcriptvariants encoding different isoforms have been found for this gene. (provided by RefSeq)
UniProtKB/Swiss-Prot: JAG2_HUMAN, Q9Y219Function: Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (Bysimilarity)
Gene Wiki entry for JAG2 |
Genomic Views
for JAG2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the JAG2 gene promoter:
PPAR-gamma2 PPAR-gamma1 MEF-2A HNF-4alpha2 Arnt AhR Oct-B1 POU2F2B POU2F2 (Oct-2.1) oct-B3
Other transcription factors
Search SABiosciences Chromatin IP Primers for JAG2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for JAG2  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32 Ensembl cytogenetic band: 14q32.33 HGNC cytogenetic band: 14q32JAG2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M085799: view genomic region
(about GC identifiers)
Start:
|
85,799,455 bp from pter |
End:
|
85,815,481 bp from pter |
Size:
|
16,027 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr14- 105,607,319-105,635,161 |
RefSeq DNA sequence:- NC_000014.8 NT_026437.12
|
Proteins
for JAG2 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: JAG2_HUMAN, Q9Y219 (See
protein sequence)Recommended Name: Protein jagged-2 precursor Size: 1238 amino acids; 133367 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q9UE17 Q9UE99 Q9UNK8 Q9Y6P9 Q9Y6Q0Alternative splicing: 2 isoforms: Q9Y219-1 Q9Y219-2 Explore the universe of human proteins at neXtProt for JAG2: NX_Q9Y219
REFSEQ proteins (2 alternative transcripts):
NP_002217.3 NP_660142.1
ENSEMBL proteins: ENSP00000328566 ENSP00000328169
Human Recombinant Proteins
5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6): About this table
JAG2 for ontologies About GeneDecksing
Antibodies for JAG2:
Assays for JAG2: |
Protein
Domains/
Families
for JAG2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
JAG2 for domains About GeneDecksing
5/12 InterPro domains/families (see all 12):Graphical View of Domain Structure for InterPro Entry Q9Y219ProtoNet protein and cluster: Q9Y219 5 Blocks protein families: IPB000152 Aspartic acid and asparagine hydroxylation site IPB001007 von Willebrand factor IPB001774 Delta/Serrate/lag-2 (DSL) protein IPB001881 EGF-like calcium-binding IPB011651 Notch ligand
UniProtKB/Swiss-Prot: JAG2_HUMAN, Q9Y219Similarity: Contains 1 DSL domainSimilarity: Contains 16 EGF-like domainsSimilarity: Contains 1 VWFC domain |
Gene Function
for JAG2 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: JAG2_HUMAN, Q9Y219Function: Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (Bysimilarity)
Genatlas biochemistry entry for JAG2:NOTCH1 ligand,homolog to rat jagged 2 and Drosophila serrate,Dres30,mouse homolog,expressed in high levels in embryoniclimb buds,first branchial arch,developing cochlea and the organ of Corti,central and peripheral nervoussystem,retina,tooth buds,thymus,submandilas gland,stomach5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
JAG2 for ontologies About GeneDecksing
Animal Models: 15/16 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Jag2) (see all 16):
JAG2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for JAG2 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
JAG2 for pathways About GeneDecksing
1  Millipore Pathway for JAG2
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for JAG2
1  Kegg Pathway (Kegg details for JAG2):
SABiosciences Pathway-Focused PCR Arrays including JAG2 (see all 3): PAHS-041A PAHS-054A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for JAG2
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for JAG2
5/12 Interacting proteins for JAG2 (ENSP000003281693 Q9Y2191, 2) via UniProtKB, MINT, and/or STRING (see all 12)About this table
5/23 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 23): About this table
JAG2 for ontologies About GeneDecksing
|
Drugs & Compounds
for JAG2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for JAG2
|
Transcripts
for JAG2 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for JAG2 gene (2 alternative transcripts): NM_002226.3 NM_145159.1 Additional cDNA sequence: AF003521.1 AF020201.1 AF029778.1 AF029779.1 BC032053.1 CR618490.1 Y14330.1 5 DOTS entries: DT.444013 DT.100747349 DT.97833334 DT.120762392 DT.92057622 9 AceView cDNA sequences: NM_002226 CR618490 NM_145159 AF029778 AF003521 BC032053 AF020201 Y14330 AF029779
 highest scoring ESTs for JAG2:AF003521 AF020201 AF029778 AF029779 BC032053 Y14330 AA587904 AA854701 AA887741 AI124725 Unigene Cluster for JAG2: Jagged 2 Hs.433445 [show with all ESTs]Unigene Representative Sequence: NM_002226
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for JAG2 (see all 8)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for JAG2
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000347004(uc010axf.2 uc001yqh.2) ENST00000331782(uc001yqf.2 uc001yqg.2)
|
Expression
for JAG2 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| JAG2 expression in normal and diseased human tissues
1 / 2 / 3 6 probe-sets matching JAG2 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 80131_at2, 3
|
U95-D |
1 |
0.94 |
1.00 |
0.98 |
0.72 |
AA775404 |
0.20 |
1.00 |
0.72 |
1 |
| 32137_at2, 3
|
U133-A |
1 |
0.75 |
1.00 |
0.94 |
1.29 |
Y14330 |
0.80 |
1.00 |
0.91 |
1 |
| 209784_s_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
AF029778 |
0.80 |
1.00 |
0.91 |
1 |
| 32137_at2, 3
|
U133-A |
1 |
0.75 |
1.00 |
-- |
-- |
Y14330 |
0.80 |
1.00 |
0.91 |
1 |
| 209784_s_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 32137_at2
|
U133Plus2 |
1 |
0.75 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
JAG2 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GCTGTTGGTG
SOURCE GeneReport for Unigene cluster: Hs.433445
Expression variation in blood from EXPOLDB for JAG2 UniProtKB/Swiss-Prot: JAG2_HUMAN, Q9Y219Tissue specificity: Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very lowexpression in brain, lung, liver and kidney
SABiosciences Expression via Pathway-Focused PCR Arrays including JAG2 (see all 3): PAHS-041A PAHS-054A
|
Orthologs
for JAG2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for JAG2 gene from 5/8 species (see all 8)
About this table Species with no ortholog for JAG2
ENSEMBL Gene Tree for JAG2 (if available) |
Paralogs
for JAG2 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for JAG2 gene
- SLIT22 DLK22 DLK12 JAG12 SLIT32 SLIT12
JAG2 for paralogs About GeneDecksing
|
Genomic Variants
for JAG2 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 14 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for JAG2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for JAG2
8 CNVs: 10453 3950 53303 66720 29968 29967 29966 30666
3 Indels: 102034 11082 60164 | | QIAGEN SeqTarget long-range PCR primers for resequencing JAG2 |
|
Disorders & Mutations
for JAG2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
JAG2 for disorders About GeneDecksing
OMIM: 602570
2  Novoseek disease relationships for JAG2 gene
About this table
Human Gene Mutation Database (HGMD): JAG2
Genetic Association Database (GAD): JAG2
Human Genome Epidemiology (HuGE) Navigator: JAG2 (9 documents)
Export disorders and mutations for JAG2 gene to outside databases
|
Medical News
for JAG2 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for JAG2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/46 PubMed articles for JAG2 gene, integrated from 7 sources (see all 46):
(articles sorted by number of sources associating them with JAG2)- Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene. (PubMed id 10662552)1, 2, 3, 7 Deng Y....Li L. (2000)
- Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. (PubMed id 9315665)1, 2, 3, 7 Luo B.... Sklar J. (1997)
- Medical Sequencing of Candidate Genes for Nonsyndromic Cleft Lip and Palate. (PubMed id 16327884)1, 4 Vieira A.R.... Murray J.C. (2005)
- Human ligands of the Notch receptor. (PubMed id 10079256)1, 2 Gray G.E.... Artavanis-Tsakonas S. (1999)
- JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions. (PubMed id 9486542)1, 2 Valsecchi C.... Rugarli E.I. (1997)
- Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines. (PubMed id 15292061)1, 7 Houde C....Coignet L.J. (2004)
- Tumor necrosis factor-alpha and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation. (PubMed id 18439488)1, 7 Fernandez L....Carlesso N. (2008)
- Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors. (PubMed id 11006133)1, 7 Shimizu K....Hirai H. (2000)
- Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2. (PubMed id 10958687)1, 7 Shimizu K....Hirai H. (2000)
- Detection of Notch signaling molecules in cemento-oss ifying fibroma of the jaws. (PubMed id 20040020)1, 7 Zhang T.H....Zheng G.S. (2010)
|
External Searches for JAG2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing JAG2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing JAG2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing JAG2 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for JAG2 gene:
Search GeneIP for patents involving JAG2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for JAG2 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
 | Antibodies & Assays for JAG2 (Jagged2) |
| | | | Search Tocris compounds for JAG2 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for JAG2 |
| |
|
|
