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JTB Gene

protein-coding   GIFtS: 49

GC01M125309
jumping translocation breakpoint
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
jumping translocation breakpoint1 2     HJTB2
hJT1 2     protein JTB2
Jumping translocation breakpoint protein2 3     HSPC2222
Prostate androgen-regulated protein2 3     PAR protein3
PAR2 5     

External Ids:    HGNC: 62011   Entrez Gene: 108992   Ensembl: ENSG000001435437   UniProtKB: O760953   

Export aliases for JTB gene to outside databases

Previous GC identifers: GC01M151763 GC01M149677 GC01M150722 GC01M151163 GC01M150759 GC01M152213 GC01M153946


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for JTB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the JTB gene promoter:
         CREB   p53   deltaCREB   NF-kappaB   NF-kappaB1   FOXF2   CUTL1   YY1   POU2F1   GATA-3   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for JTB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for JTB 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

JTB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JTB gene location

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M125309:  view genomic region     (about GC identifiers)

Start:
125,309,107 bp from pter
End:
125,312,813 bp from pter
Size:
3,707 bases
Orientation:
minus strand

1 alternative location:
Chr1- 153,946,745-153,950,164     
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: JTB_HUMAN, O76095 (See protein sequence)
Recommended Name: Protein JTB precursor  
Size: 146 amino acids; 16358 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
PDB structures from and Proteopedia :
2KJX (3D)    
Secondary accessions: O95442

Explore the universe of human proteins at neXtProt for JTB: NX_O76095 

REFSEQ proteins: NP_006685.1  

ENSEMBL proteins: 
ENSP00000271843 ENSP00000349069 ENSP00000357578 ENSP00000395250 ENSP00000413206 


Human Recombinant Proteins 
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Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate: JTB
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Novus Biologicals Lysates for JTB
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4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005624 membrane fraction TAS10321732
GO:0005887 integral to plasma membrane TAS10321732
GO:0016020 membrane IEA--
GO:0016021 integral to membrane ----
About this table

JTB for ontologies           About GeneDecksing



Antibodies for JTB: 
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Browse antibodies at Epitomics

Assays for JTB: 
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Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for JTB 
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for JTB 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

JTB for domains           About GeneDecksing

1 InterPro domain/family:
 IPR008657 JTB

Graphical View of Domain Structure for InterPro Entry O76095

ProtoNet protein and cluster: O76095

1 Blocks protein family: IPB008657 Jumping translocation breakpoint

UniProtKB/Swiss-Prot: JTB_HUMAN, O76095
Similarity: Belongs to the JTB family


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for JTB
Sigma-Aldrich shRNA for JTB
OriGene 29mer shRNA kits in GFP-retroviral vector: JTB
OriGene shRNA RFP: JTB
OriGene basic RS shRNA: JTB
OriGene siRNA: JTB
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of JTB 
miRNA:Sigma-Aldrich microRNA Mimics for JTB
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of JTB 
1 SABiosciences Assays for microRNA that regulate JTB:
hsa-miR-539

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: JTB
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: JTB
OriGene untagged cDNA clones in CMV expression vector (see all 2): JTB
OriGene 3'-UTR clone: JTB 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for JTB 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for JTB 

Genatlas biochemistry entry for JTB:
jumping translocation breakpoint,fused with the telomeric repeats case of jumping translocation

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for JTB 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for JTB

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for JTB


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for JTB
Sigma-Aldrich shRNA for JTB
OriGene 29mer shRNA kits in GFP-retroviral vector: JTB
OriGene shRNA RFP: JTB
OriGene basic RS shRNA: JTB
OriGene siRNA: JTB
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of JTB 
miRNA: Sigma-Aldrich microRNA Mimics for JTB
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of JTB 
1 SABiosciences Assays for microRNA that regulate JTB:
hsa-miR-539
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: JTB
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: JTB
OriGene untagged cDNA clones in CMV expression vector (see all 2): JTB
OriGene 3'-UTR Clone: JTB 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for JTB 
Primers: OriGene genome-wide validated SYBR primer pairs: JTB
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for JTB: PPH01009A

REFSEQ mRNAs for JTB gene: 

NM_006694.3  

Additional cDNA sequence: 

AB016488.1 AF115850.2 AF131797.1 AF151056.1 AK312106.1 BC000499.1 BC000996.2 BC001363.1 
BC001667.1 BC004239.1 BC019277.1 BT007285.1 CR456985.1 CR595312.1 CR599832.1 CR603308.1 
CR608719.1 CR613105.1 CR618181.1 CR620505.1 CR625103.1 

24/26 DOTS entries (see all 26):

DT.421099  DT.75130019  DT.75133749  DT.100817421  DT.100817416  DT.97844584  DT.95277027  DT.121436598 
DT.92453787  DT.95277035  DT.121436576  DT.121436568  DT.100039009  DT.95277024  DT.100817411  DT.100817420 
DT.92453774  DT.95155142  DT.95104852  DT.97844583  DT.121436377  DT.92453775  DT.95277026  DT.95277029 

24/930 AceView cDNA sequences (see all 930):

BE790802 BE880512 CF126823 BQ652220 AI024017 AI860163 CR625103 BQ063321 
BC073168 BX398284 AI081515 BE561212 AW015199 CK822494 BQ955026 BE271726 
CB128367 AI633718 BE905641 BQ934342 AF115850 BE906475 BI850384 AF131797 

highest scoring ESTs for JTB:

AA147827 AA186580 AA278716 AA312833 AA313810 AA324649 AA384595 AA403075 AA424759 AA478159 

Unigene Cluster for JTB:

Jumping translocation breakpoint
Hs.6396  [show with all ESTs]
Unigene Representative Sequence: BQ062593


GeneLoc Exon Structure

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000271843(uc001fds.2) ENST00000356648 ENST00000368589 ENST00000428469
ENST00000461365 ENST00000471173 ENST00000433648

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

JTB expression in normal and diseased human tissues

1  / 2  / 3

10 probe-sets matching JTB gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
41833_at2, 3 U95-A 1 1.00 1.00 0.65 1.13 AB016492 0.20 1.00 0.72 1
59797_f_at2, 3 U95-C 1 1.00 1.00 0.71 1.15 AW025321 0.80 0.70 0.75 1
41834_g_at2, 3 U95-A 1 1.00 1.00 0.76 0.97 AB016492 0.20 1.00 0.72 1
59798_r_at2, 3 U95-C 1 0.62 1.00 0.62 0.75 AW025321 0.80 0.70 0.75 1
200048_s_at2, 3 U133-B 1 1.00 1.00 -- -- NM_006694 0.60 0.83 0.73 1
210927_x_at2, 3 U133-A 1 1.00 1.00 -- -- BC004239 0.80 0.88 0.84 1
210434_x_at2, 3 U133-A 1 1.00 1.00 -- -- AF151056 0.80 0.88 0.84 1
200048_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
210927_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
210434_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table

JTB for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
JTB gene expression
JTB gene electronic northern expression
JTB gene sage expression
About these images

CGAP SAGE TAG: CAGCTCATCT

SOURCE GeneReport for Unigene cluster: Hs.6396

Expression variation in blood from EXPOLDB for JTB

UniProtKB/Swiss-Prot: JTB_HUMAN, O76095
Tissue specificity: Expressed in all normal human tissues studied but overexpressed in most of their malignant
counterparts

Primers: OriGene genome-wide validated SYBR primer pairs: JTB
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for JTB: PPH01009A
    SABiosciences Custom PCR Arrays for JTB 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for JTB gene from 5/6 species (see all 6)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
JTB1   -- jumping translocation breakpoint 86.53(n)
87.67(a)
612300  XM_850043.1  XP_855136.1 
chimpanzee
(Pan troglodytes)
JTB1   -- jumping translocation breakpoint 99.54(n)
100(a)
457342  XM_001149478.1  XP_001149478.1 
cow
(Bos taurus)
JTB1   -- jumping translocation breakpoint 89.95(n)
89.73(a)
513970  XM_591741.3  XP_591741.1 
rat
(Rattus norvegicus)
Jtb1   -- jumping translocation breakpoint 84.02(n)
86.99(a)
29439  NM_019213.2  NP_062086.1 
mouse
(Mus musculus)
Jtb1 , 5 3 (39.21 cM)5
jumping translocation breakpoint1, 5 82.88(n)1
85.62(a)1
239221  NM_206924.21  NP_996807.11 
 AB0164905  AK0044695  (see all 12)
About this table        Species with no ortholog for JTB

ENSEMBL Gene Tree for JTB (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
  --

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/28 NCBI SNPs in JTB are shown (see all 28)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs15477661,2
153952205(+) TATTAA/CACATA 1 -- ng51 tfbs30--------
rs15477671,2
153952220(+) AATTAC/TATATA 1 -- ng510--------
rs31829461,2
--153950090(-) ACCGGG/CCCCCG 1 -- ut51 ese31Minor allele frequency- C:0.00MN 184
rs75279631,2
C153948221(+) CCCCAG/AACCAG 1 -- int14Minor allele frequency- A:0.00NS EA 416
rs112647631,2
C,A,H153948705(+) gaggcC/Tgaggc 1 -- int11Minor allele frequency- T:0.50NA 2
rs115432741,2
--153949829(-) ACCTCC/TGGGAG 1 -- ut51 ese30--------
rs115432751,2
C153949941(-) CGCCTA/CCCTAG 1 -- ut51 ese30--------
rs115432761,2
--153949227(-) ATGCTG/TGGCTG 3 V L C fra1 ref10--------
rs115810391,2
C,H153948590(+) GTCTAG/AGAGTG 1 -- int15Minor allele frequency- A:0.00NS EA NA 420
rs125641991,2
C,F,H,153948540(+) GTGGTG/AGTTGC 1 -- int110Minor allele frequency- A:0.17NS EA NA WA 808
About this table

HapMap Linkage Disequilibrium images for JTB (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for JTB: --

QIAGEN SeqTarget long-range PCR primers for resequencing JTB 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

JTB for disorders           About GeneDecksing

OMIM: 604671


Export disorders and mutations for JTB gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

10/13 PubMed articles for JTB gene, integrated from 7 sources (see all 13):
(articles sorted by number of sources associating them with JTB)
  1. JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation. (PubMed id 10321732)1, 2, 3 Hatakeyama S.... Ishikawa F. (1999)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells. (PubMed id 10762645)1, 2 Platica O.... Platica M. (2000)
  4. Interacting with HBsAg compromises resistance of jump ing translocation breakpoint protein to ultraviolet radiation-induced apoptosis in 293FT cells. (PubMed id 19487072)1 Pan J.S....Ren J.L. (2009)
  5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
  6. Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression. (PubMed id 12586295)1 Wong N....Johnson P.J. (2003)
  7. Physical and functional interaction between DNA ligase IIIalpha and poly(ADP-Ribose) polymerase 1 in DNA single-strand break repair. (PubMed id 12897160)1 Leppard J.B....Tomkinson A.E. (2003)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  9. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1 Zhang Q.-H.... Chen Z. (2000)
  10. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 10899 HGNC: 6201 AceView: RAB13andJTB Ensembl:ENSG00000143543 euGenes: HUgn10899
ECgene: JTB H-InvDB: JTB

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
ATLAS Chromosomes in Cancer entry for JTB Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for JTB gene:
Search GeneIP for patents involving JTB

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of JTB
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 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for JTB
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of JTB
 GenScript Custom Purified and Recombinant Proteins Services for JTB GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for JTB
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 Regulatory tfbs in JTB promoter
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 ELISAs and CLIAs for JTB
       

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

JTB gene at Home site.
hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4