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Aliases & Descriptionsfor JTB gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions jumping translocation breakpoint1 2 HJTB2 hJT1 2 protein JTB2 Jumping translocation breakpoint protein2 3 HSPC2222 Prostate androgen-regulated protein2 3 PAR protein3 PAR2 5
Export aliases for JTB gene to outside databases Previous GC identifers: GC01M151763 GC01M149677 GC01M150722 GC01M151163 GC01M150759 GC01M152213 GC01M153946
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Summariesfor JTB gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Gene Wiki entry for JTB
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Genomic Viewsfor JTB gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the JTB gene promoter: CREB p53 deltaCREB NF-kappaB NF-kappaB1 FOXF2 CUTL1 YY1 POU2F1 GATA-3 Other transcription factors Search SABiosciences Chromatin IP Primers for JTB Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for JTB
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21 JTB Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M125309: view genomic region
(about GC identifiers )
Start:
125,309,107 bp from pter
End:
125,312,813 bp from pter
Size:
3,707 bases
Orientation:
minus strand
1 alternative location : Chr 1- 153,946,745-153,950,164
RefSeq DNA sequence: NC_000001.10 NT_004487.19
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Proteinsfor JTB gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: JTB_HUMAN, O76095 (See
protein sequence )Recommended Name: Protein JTB precursor Size : 146 amino acids; 16358 Da
Subcellular location : Membrane; Single-pass type I membrane protein (Potential)
PDB structures from and Proteopedia : 2KJX (3D)
 
Secondary accessions : O95442Explore the universe of human proteins at neXtProt for JTB: NX_O76095
REFSEQ proteins: NP_006685.1 ENSEMBL proteins: ENSP00000271843 ENSP00000349069 ENSP00000357578 ENSP00000395250 ENSP00000413206 Human Recombinant Proteins 4 Gene Ontology (GO) cellular component terms (GO ID links to tree view) :
About this table
JTB for ontologies About GeneDecksing Antibodies for JTB: Assays for JTB:
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Protein
Domains/ Familiesfor JTB gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
JTB for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry O76095 ProtoNet protein and cluster: O76095
1 Blocks protein family : IPB008657 Jumping translocation breakpoint UniProtKB/Swiss-Prot: JTB_HUMAN, O76095 Similarity : Belongs to the JTB family
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Gene Functionfor JTB gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section Genatlas biochemistry entry for JTB :jumping translocation breakpoint,fused with the telomeric repeats case of jumping translocation
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Pathways & Interactionsfor JTB gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section SABiosciences Custom Pathway-Focused PCR Arrays for JTB Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for JTB
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Drugs & Compoundsfor JTB gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for JTB
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Transcriptsfor JTB gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for JTB gene: NM_006694.3
Additional cDNA sequence: AB016488.1 AF115850.2 AF131797.1 AF151056.1 AK312106.1 BC000499.1 BC000996.2 BC001363.1 BC001667.1 BC004239.1 BC019277.1 BT007285.1 CR456985.1 CR595312.1 CR599832.1 CR603308.1 CR608719.1 CR613105.1 CR618181.1 CR620505.1 CR625103.1
24/26 DOTS entries (see all 26 ): DT.421099 DT.75130019 DT.75133749 DT.100817421 DT.100817416 DT.97844584 DT.95277027 DT.121436598
DT.92453787 DT.95277035 DT.121436576 DT.121436568 DT.100039009 DT.95277024 DT.100817411 DT.100817420 DT.92453774 DT.95155142 DT.95104852 DT.97844583 DT.121436377 DT.92453775 DT.95277026 DT.95277029 24/930 AceView cDNA sequences (see all 930 ):
BE790802 BE880512 CF126823 BQ652220 AI024017 AI860163 CR625103 BQ063321 BC073168 BX398284 AI081515 BE561212 AW015199 CK822494 BQ955026 BE271726 CB128367 AI633718 BE905641 BQ934342 AF115850 BE906475 BI850384 AF131797
highest scoring ESTs for JTB :AA147827 AA186580 AA278716 AA312833 AA313810 AA324649 AA384595 AA403075 AA424759 AA478159 Unigene Cluster for JTB:
Jumping translocation breakpoint Hs.6396 [show with all ESTs ] Unigene Representative Sequence: BQ062593 GeneLoc Exon Structure 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000271843 (uc001fds.2 ) ENST00000356648 ENST00000368589 ENST00000428469 ENST00000461365 ENST00000471173 ENST00000433648
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Expression for JTB gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section JTB expression in normal and diseased human tissues 1 / 2 / 3
10 probe-sets matching JTB gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
41833_at2 , 3
U95-A
1
1.00
1.00
0.65
1.13
AB016492
0.20
1.00
0.72
1
59797_f_at2 , 3
U95-C
1
1.00
1.00
0.71
1.15
AW025321
0.80
0.70
0.75
1
41834_g_at2 , 3
U95-A
1
1.00
1.00
0.76
0.97
AB016492
0.20
1.00
0.72
1
59798_r_at2 , 3
U95-C
1
0.62
1.00
0.62
0.75
AW025321
0.80
0.70
0.75
1
200048_s_at2 , 3
U133-B
1
1.00
1.00
--
--
NM_006694
0.60
0.83
0.73
1
210927_x_at2 , 3
U133-A
1
1.00
1.00
--
--
BC004239
0.80
0.88
0.84
1
210434_x_at2 , 3
U133-A
1
1.00
1.00
--
--
AF151056
0.80
0.88
0.84
1
200048_s_at2
U133Plus2
1
1.00
1.00
--
--
--
--
--
--
--
210927_x_at2
U133Plus2
1
1.00
1.00
--
--
--
--
--
--
--
210434_x_at2
U133Plus2
1
1.00
1.00
--
--
--
--
--
--
--
About this table
JTB for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CAGCTCATCT SOURCE GeneReport for Unigene cluster: Hs.6396 Expression variation in blood from EXPOLDB for JTB
UniProtKB/Swiss-Prot: JTB_HUMAN, O76095 Tissue specificity : Expressed in all normal human tissues studied but overexpressed in most of their malignantcounterparts
SABiosciences Custom PCR Arrays for JTB
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Orthologsfor JTB gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for JTB gene from 5/6 species (see all 6 )
About this table Species with no ortholog for JTB ENSEMBL Gene Tree for JTB (if available)
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Paralogsfor JTB gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section --
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Genomic Variantsfor JTB gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 1 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for JTB (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for JTB: --
QIAGEN SeqTarget long-range PCR primers for resequencing JTB
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Disorders & Mutationsfor JTB gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
JTB for disorders About GeneDecksing
OMIM: 604671 Export disorders and mutations for JTB gene to outside databases
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Medical Newsfor JTB gene (Possibly Related Articles in
Doctor's Guide )
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Publicationsfor JTB gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10/13 PubMed articles for JTB gene, integrated from 7 sources (see all 13 ): (articles sorted by number of sources associating them with JTB) JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation. (PubMed id 10321732) 1 , 2 , 3 Hatakeyama S.... Ishikawa F. (1999) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells. (PubMed id 10762645) 1 , 2 Platica O.... Platica M. (2000) Interacting with HBsAg compromises resistance of jump ing translocation breakpoint protein to ultraviolet radiation-induced apoptosis in 293FT cells. (PubMed id 19487072) 1 Pan J.S....Ren J.L. (2009) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008) Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression. (PubMed id 12586295) 1 Wong N....Johnson P.J. (2003) Physical and functional interaction between DNA ligase IIIalpha and poly(ADP-Ribose) polymerase 1 in DNA single-strand break repair. (PubMed id 12897160) 1 Leppard J.B....Tomkinson A.E. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152) 1 Zhang Q.-H.... Chen Z. (2000) Large-scale concatenation cDNA sequencing. (PubMed id 9110174) 1 Yu W.... Gibbs R.A. (1997)
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External Searches for JTB gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing JTB gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing JTB gene
(According to HUGE )
About This Section --
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Specialized Databases showing JTB gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for JTB gene: Search GeneIP for patents involving JTB GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor JTB gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for JTB
ELISAs and CLIAs for JTB
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