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JUB Gene

protein-coding   GIFtS: 51

GC14M003557
jub, ajuba homolog (Xenopus laevis)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for JUB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
jub, ajuba homolog (Xenopus laevis)1 2
MGC155631 2
Ajuba2
protein ajuba2

External Ids:    HGNC: 202501   Entrez Gene: 849622   Ensembl: ENSG000001294747   UniProtKB: Q96IF13   

Export aliases for JUB gene to outside databases

Previous GC identifers: GC14M020813 GC14M017228 GC14M021431 GC14M021430 GC14M022510 GC14M023440


Summaries
for JUB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: JUB_HUMAN, Q96IF1
Function: Components of cellular adhesives complexes. Contribute to cell fate determination and regulate cell
proliferation and differentiation. Involved in the regulation of actin cytoskeleton dynamics and cell migration.
Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors
to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays a
important role in regulation of the kinase activity of AURKA/Aurora-A for mitotic commitment. Is also a component of
the IL-1 signaling pathway modulating IL-1-induced NF-kappa-B activation by influencing the assembly and activity of
the PRKCZ/SQSTM1/TRAF6 multiprotein signaling complex. Can functions as adapter molecules in the formation of large
multiprotein complexes that form on DNA and that influence transcription

Gene Wiki entry for JUB

Genomic Views
for JUB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the JUB gene promoter:
         NF-kappaB1   Egr-1   GATA-1   NF-1   LUN-1   c-Myb   POU2F1   MRF-2   Arnt   AhR   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for JUB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for JUB 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

JUB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JUB gene location

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M003557:  view genomic region     (about GC identifiers)

Start:
 3,557,642 bp from pter
End:
 3,569,085 bp from pter
Size:
 11,444 bases
Orientation:
 minus strand

1 alternative location:
Chr14- 23,440,383-23,451,851     
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  

Proteins
for JUB gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: JUB_HUMAN, Q96IF1 (See protein sequence)
Recommended Name: Protein ajuba  
Size: 538 amino acids; 56934 Da
Subunit: Interacts with AURKA/Aurora-A during mitosis and both proteins are phosphorylated as they form a complex.
Interacts with CTNNA1/alpha-catenin and with F-actin. Interacts with LATS2 during mitosis and this complex regulates
organization of the spindle apparatus through recruitment of gamma-tubulin to the centrosome. Interacts with GRB2 and
PIP5K1A (By similarity). Forms a complex with SQSTM1, PRKCZ and TRAF6. Interacts with SLC1A2 (By similarity)
Subcellular location: Cytoplasm, cytoskeleton. Cell membrane. Cell junction. Nucleus. Cytoplasm, cytoskeleton,
centrosome. Note=Shuttles between the cytoplasm and the nucleus. Localizes on centrosomes during G2-M phase.
Preferentially co-localizes with cadherin-adhesive complexes at sites of cell-cell contacts
Miscellaneous: 'Ajuba' means 'curiosity' in Urdu, an Indian dialect

Explore the universe of human proteins at neXtProt for JUB: NX_Q96IF1 

Post-translational modifications:

  • Phosphorylated by LATS2 during mitosis. Phosphorylated by AURKA1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_116265.1  NP_932352.1  


    ENSEMBL proteins: 
    ENSP00000354491 ENSP00000262713 ENSP00000380543 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: JUB
    OriGene Protein Over-expression Lysate (see all 2): JUB
    GenScript Custom Purified and Recombinant Proteins Services for JUB 
    Novus Biologicals Protein for JUB
    Novus Biologicals Lysates for JUB
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/8 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    GO:0005815 microtubule organizing center IEA--
    GO:0005856 cytoskeleton IEA--
    GO:0005886 plasma membrane IEA--
    About this table

    JUB for ontologies           About GeneDecksing



    Antibodies for JUB: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for JUB
    R&D Systems Antibodies for JUB (Ajuba)
    Cell Signaling Technology (CST) Antibodies for JUB  (Ajuba)
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for JUB 
    Novus Biologicals Antibodies for JUB
    Browse antibodies at Epitomics

    Assays for JUB: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for JUB 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for JUB 

    Protein Domains/
    Families
    for JUB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    JUB for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q96IF1

    ProtoNet protein and cluster: Q96IF1

    1 Blocks protein family: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: JUB_HUMAN, Q96IF1
    Domain: LIM region interacts with CTNNA1. The preLIM region binds directly actin filaments
    Domain: LIM-2 and LIM-3 domains mediate the interaction with the N-terminal region of AURKA. The association between
    LATS2 and JUB required the second LIM domain of JUB
    Similarity: Belongs to the zyxin/ajuba family
    Similarity: Contains 3 LIM zinc-binding domains


    Gene Function
    for JUB gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: JUB_HUMAN, Q96IF1
    Function: Components of cellular adhesives complexes. Contribute to cell fate determination and regulate cell
    proliferation and differentiation. Involved in the regulation of actin cytoskeleton dynamics and cell migration.
    Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors
    to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays a
    important role in regulation of the kinase activity of AURKA/Aurora-A for mitotic commitment. Is also a component of
    the IL-1 signaling pathway modulating IL-1-induced NF-kappa-B activation by influencing the assembly and activity of
    the PRKCZ/SQSTM1/TRAF6 multiprotein signaling complex. Can functions as adapter molecules in the formation of large
    multiprotein complexes that form on DNA and that influence transcription

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for JUB
    Sigma-Aldrich shRNA for JUB
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): JUB
    OriGene shRNA RFP (see all 2): JUB
    OriGene basic RS shRNA (see all 2): JUB
    OriGene siRNA (see all 2): JUB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of JUB 
    miRNA:Sigma-Aldrich microRNA Mimics for JUB
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of JUB 
    6 SABiosciences Assays for microRNAs that regulate JUB:
    hsa-miR-103 hsa-miR-182 hsa-miR-1184 hsa-miR-137 hsa-miR-1205 hsa-miR-512-3p

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): JUB
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): JUB
    OriGene untagged cDNA clones in CMV expression vector (see all 2): JUB
    OriGene 3'-UTR clone (see all 2): JUB 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): JUB 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for JUB 

    3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    JUB for ontologies           About GeneDecksing

    Animal Models: 1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Jub):

    cellular

    JUB for phenotypes           About GeneDecksing


    Pathways & Interactions
    for JUB gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for JUB 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for JUB

    5/8 Interacting proteins for JUB (ENSP000002627133 Q96IF12) via UniProtKB, MINT, and/or STRING (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LATS2Q9NRM72MINT-1772128 MINT-1778030 MINT-1772055 MINT-1790017 MINT-1771993 MINT-1772097
    SFNP319472MINT-3975697 MINT-3976673
    GFI1BQ5VTD92MINT-2877712
    AURKAENSP000003215913STRING: ENSP00000321591
    CDH1ENSP000002687943STRING: ENSP00000268794
    About this table

    5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049 cell cycle IEA--
    GO:0007155 cell adhesion IEA--
    GO:0030032 lamellipodium assembly IEA--
    GO:0030334 regulation of cell migration IEA--
    GO:0035313 wound healing, spreading of epidermal cells IEA--
    About this table

    JUB for ontologies           About GeneDecksing



    Drugs & Compounds
    for JUB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for JUB


    Transcripts
    for JUB gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for JUB
    Sigma-Aldrich shRNA for JUB
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): JUB
    OriGene shRNA RFP (see all 2): JUB
    OriGene basic RS shRNA (see all 2): JUB
    OriGene siRNA (see all 2): JUB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of JUB 
    miRNA: Sigma-Aldrich microRNA Mimics for JUB
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of JUB 
    6 SABiosciences Assays for microRNAs that regulate JUB:
    hsa-miR-103 hsa-miR-182 hsa-miR-1184 hsa-miR-137 hsa-miR-1205 hsa-miR-512-3p
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): JUB
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): JUB
    OriGene untagged cDNA clones in CMV expression vector (see all 2): JUB
    OriGene 3'-UTR Clone (see all 2): JUB 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): JUB 
    Primers: OriGene genome-wide validated SYBR primer pairs: JUB
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for JUB: PPH20409A

    REFSEQ mRNAs for JUB gene (2 alternative transcripts): 

    NM_032876.4  NM_198086.1  

    Additional cDNA sequence: 

    AK025567.1 AK096128.1 AY169959.1 BC007580.1 BC016733.1 BC034968.2 

    10 DOTS entries:

    DT.100775739  DT.455766  DT.120777830  DT.92426492  DT.102836338  DT.100775734  DT.100737442  DT.40129291 
    DT.120777678  DT.100775735 

    24/146 AceView cDNA sequences (see all 146):

    AY169959 CN482905 CB135297 BQ958701 BU163376 BC007580 BQ232031 BU149830 
    NM_198086 BQ439546 BM680549 D12422 BM718100 NM_032876 BM479543 CA442366 
    AI918246 BI260853 BU543883 CB105530 CB106040 AW169067 BX109281 CB143855 

    highest scoring ESTs for JUB:

    BM046574 BM800674 BG490419 CB150160 CK903938 AA152464 AI289311 BC034968 BG117516 BG753539 

    Unigene Cluster for JUB:

    Jub, ajuba homolog (Xenopus laevis)
    Hs.655832  [show with all ESTs]
    Unigene Representative Sequence: NM_032876


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361265 ENST00000262713(uc001why.2 uc001whz.2) ENST00000397388


    Expression
    for JUB gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    JUB expression in normal and diseased human tissues

    1  / 2  / 3

    7 probe-sets matching JUB gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    45845_at2, 3 U95-B 1 0.81 1.00 0.94 0.66 AA628404 0.40 0.67 0.55 1
    54506_at2, 3 U95-B 1 0.81 1.00 0.95 1.34 AI289311 0.60 0.75 0.68 1
    225806_at2, 3 U133-B 1 1.00 1.00 -- -- AI289311 0.60 0.75 0.68 1
    225807_at2, 3 U133-B 1 0.82 1.00 -- -- AK025567 0.40 0.67 0.55 1
    1553764_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    225806_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    225807_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    About this table

    JUB for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    JUB gene expression
    JUB gene electronic northern expression
    JUB gene sage expression
    About these images

    CGAP SAGE TAG: CTTTGGATAT

    SOURCE GeneReport for Unigene cluster: Hs.655832
    Primers: OriGene genome-wide validated SYBR primer pairs: JUB
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for JUB: PPH20409A
        SABiosciences Custom PCR Arrays for JUB 


    Orthologs
    for JUB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for JUB gene from 5 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 JUB1   -- jub, ajuba homolog (Xenopus laevis) 92.07(n)
    96.84(a)    		 480244  XM_537368.2  XP_537368.2 
    cow
    (Bos taurus)    		 JUB1   -- jub, ajuba homolog (Xenopus laevis) 91.64(n)
    95.91(a)    		 519937  XM_598167.3  XP_598167.3 
    rat
    (Rattus norvegicus)    		 Jub1   -- jub, ajuba homolog (Xenopus laevis) 88.17(n)
    93.12(a)    		 85265  NM_053503.1  NP_445955.1 
    mouse
    (Mus musculus)    		 Jub1 , 5 14 (27.84 cM)5
    		 ajuba1, 5 88.39(n)1
    93.67(a)1    		 164751  NM_010590.31  NP_034720.21 
     AK1916595  BC0110355  (see all 8)
    zebrafish
    (Danio rerio)    		 wu:fj66b051   -- wu:fj66b05 56.34(n)
    53.85(a)    		 572549  XM_696274.3  XP_701366.2 
    About this table        Species with no ortholog for JUB

    ENSEMBL Gene Tree for JUB (if available)

    Paralogs
    for JUB gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for JUB gene
    TRIP62  FBLIM12  LPP2  LOC1002886952  LIMS3-LOC4408952  WTIP2  LIMS12  ZYX2  
    LIMS22  LIMD12  

    JUB for paralogs           About GeneDecksing



    Genomic Variants
    for JUB gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/111 NCBI SNPs in JUB are shown (see all 111)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 14 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs19231,2
    		C,F,O,A,23441179(+) TAATAA/GCTCAG 2 -- ut31 ese325Minor allele frequency- N:0.00MN NS EA NA WA 1756
    rs9417201,2
    		C,A,H,23443882(+) CGGATG/ATTAGG 2 -- int17Minor allele frequency- A:0.00NA WA 14
    rs9417211,2
    		C,F,A,H,23443962(+) ACTTCT/CGGCAG 2 -- int114Minor allele frequency- C:0.39NS EA NA WA 690
    rs9417221,2
    		C,F,A,23448138(+) ACGAGC/ATGTTC 2 -- int1 ng515Minor allele frequency- A:0.04NA EA MN WA 486
    rs9417231,2
    		C23448531(+) CGGGCC/TTGCCC 1 -- int14Minor allele frequency- T:0.00NS EA 414
    rs9417241,2
    		C,F,23448868(+) CAAGAT/CTGCCA 1 -- int18Minor allele frequency- C:0.31NA EA WA 222
    rs10486521,2
    		--23441395(-) ATACTA/GGTCAG 2 -- ut31 ese31Minor allele frequency- G:0.00MN 184
    rs10486541,2
    		--23441379(-) TTGAAA/GCTAGT 2 -- ut311Minor allele frequency- G:0.00MN 184
    rs10486551,2
    		--23441376(-) AAACTA/GGTTCA 2 -- ut311Minor allele frequency- G:0.00MN 184
    rs11346071,2
    		--23452474(-) ATTGCA/GGTTTA 1 -- ng510--------
    About this table

    HapMap Linkage Disequilibrium images for JUB (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for JUB: --

    QIAGEN SeqTarget long-range PCR primers for resequencing JUB 

    Disorders & Mutations
    for JUB gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    JUB for disorders           About GeneDecksing

    OMIM: 609066


    Export disorders and mutations for JUB gene to outside databases

    Medical News
    for JUB gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for JUB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/26 PubMed articles for JUB gene, integrated from 7 sources (see all 26):
    (articles sorted by number of sources associating them with JUB)
    1. LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis. (PubMed id 16413547)1, 2 Abe Y.... Yamamoto T. (2006)
    2. The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex. (PubMed id 15870274)1, 2 Feng Y. and Longmore G.D. (2005)
    3. The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin. (PubMed id 12417594)1, 2 Marie H.... Braga V.M. (2003)
    4. Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. (PubMed id 13678582)1, 2 Hirota T.... Saya H. (2003)
    5. Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner. (PubMed id 10330178)1, 3 Goyal R.K....Longmore G.D. (1999)
    6. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1 Olson J.E....Couch F.J. (2010)
    7. LIM protein Ajuba functions as a nuclear receptor cor epressor and negatively regulates retinoic acid signaling. (PubMed id 20133701)1 Hou Z....Rauscher F.J. (2010)
    8. Ajuba: a new microtubule-associated protein that interacts with BUBR1 and Aurora B at kinetochores in metaphase. (PubMed id 18710370)1 Ferrand A....Birnbaum D. (2009)
    9. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
    10. Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3beta-mediated phosphorylation of beta-catenin. (PubMed id 17621269)1 Haraguchi K....Yamamoto T. (2008)

    External Searches for JUB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing JUB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84962 HGNC: 20250 AceView: JUB Ensembl:ENSG00000129474 euGenes: HUgn84962
    ECgene: JUB H-InvDB: JUB

    Other Databases showing JUB gene

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    Specialized Databases showing JUB gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    Intellectual Property
    for JUB gene

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    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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