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JUN Gene

protein-coding GIFtS: 68

GC01M057356

jun proto-oncogene
(Previous names: v-jun avian sarcoma virus 17 oncogene homolog, v-jun sarcoma virus 17 oncogene homolog (avian), jun oncogene )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
jun proto-oncogene¹ ²		AP1² ³
V-jun avian sarcoma virus 17 oncogene homolog¹ ² ³		p39² ³
jun oncogene¹ ²		v-jun sarcoma virus 17 oncogene homolog (avian)¹
AP-1¹ ²		Jun activation domain binding protein²
c-Jun¹ ²		transcription factor AP-1²
Proto-oncogene c-Jun² ³		enhancer-binding protein AP1²
Activator protein 1² ³		v-jun sarcoma virus 17 oncogene homolog²

External Ids:	HGNC: 6204¹	Entrez Gene: 3725²	Ensembl: ENSG00000177606⁷	UniProtKB: P05412³

Export aliases for JUN gene to outside databases

Previous GC identifers: GC01M059163 GC01M058161 GC01M058604 GC01M058616 GC01M058958

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for JUN:

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to

the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This

gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in

human malignancies. (provided by RefSeq)

UniProtKB/Swiss-Prot: JUN_HUMAN, P05412

Function: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'

Gene Wiki entry for JUN (C-jun)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the JUN gene promoter:
         NF-kappaB1   NF-kappaB   PPAR-gamma2   PPAR-gamma1   GCNF-1   GCNF-2   MEF-2A   deltaCREB   CREB   GATA-3
         Other transcription factors

Search SABiosciences Chromatin IP Primers for JUN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for JUN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32-p31 Ensembl cytogenetic band: 1p32.1 HGNC cytogenetic band: 1p32-p31

JUN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JUN gene location

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M057356: view genomic region (about GC identifiers)

Start:	57,356,787 bp from pter
End:	57,360,109 bp from pter
Size:	3,323 bases
Orientation:	minus strand

1 alternative location:

Chr1- 59,246,465-59,249,785

RefSeq DNA sequence:

NC_000001.10 NT_032977.9

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: JUN_HUMAN, P05412 (See protein sequence)

Recommended Name: Transcription factor AP-1

Size: 331 amino acids; 35676 Da

Subunit: Heterodimer with either FOS or BATF3 or ATF7. The ATF7/JUN heterodimer is essential for ATF7 transactivation

activity. Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target DNA (By similarity).

Interacts with HIVEP3 and MYBBP1A (By similarity). Interacts with SMAD3/SMAD4 heterodimers. Interacts with SP1, SPIB

and TCF20. Interacts with COPS5; the interaction leads indirectly to its phosphorylation

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1A02 (3D)

1FOS (3D)

1JNM (3D)

1JUN (3D)

1S9K (3D)

1T2K (3D)

Secondary accessions: Q96G93

Explore the universe of human proteins at neXtProt for JUN: NX_P05412

Post-translational modifications:

Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002219.1

ENSEMBL proteins:

ENSP00000360266

Human Recombinant Proteins

	Millipore Purified and/or Recombinant JUN Protein
	Sigma-Aldrich Proteins for JUN
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for JUN
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: JUN
	GenScript Purified and Recombinant Proteins for JUN
	Novus Biologicals Proteins for JUN
	Novus Biologicals Lysates for JUN
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for JUN

5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000228	nuclear chromosome	TAS	10918580
GO:0000790	nuclear chromatin	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005667	transcription factor complex	IEA	--

About this table

JUN for ontologies About GeneDecksing

Antibodies for JUN:

	Millipore Mono- and Polyclonal Antibodies for the study of JUN
	Sigma-Aldrich Antibody Arrays and Antibodies for JUN
	R&D Systems Antibodies for JUN (c-Jun)
	Cell Signaling Technology (CST) Antibodies for JUN (JUN, c-Jun)
	OriGene Antibodies (see all 15): JUN
	GenScript Superior Antibodies for JUN
	Novus Biologicals Antibodies for JUN
	Epitomics antibodies for JUN

Assays for JUN:

	Millipore Kits and Assays for the Analysis of JUN
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for JUN
	Cell Signaling Technology (CST) Sandwich ELISA Kits for JUN (JUN, c-Jun)
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for JUN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

JUN for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR004827 TF_bZIP

IPR008917 Euk_TF_DNA-bd

IPR011616 bZIP_1

IPR002112 Leuzip_Jun

IPR005643 JNK

Graphical View of Domain Structure for InterPro Entry P05412

ProtoNet protein and cluster: P05412

3 Blocks protein families:

IPB002112 Jun transcription factor signature

IPB005643 Jun-like transcription factor

IPB011616 bZIP transcription factor

UniProtKB/Swiss-Prot: JUN_HUMAN, P05412

Similarity: Belongs to the bZIP family. Jun subfamily

Similarity: Contains 1 bZIP domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: JUN_HUMAN, P05412

Function: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'

Inhib. RNA:		Millipore RNAi Products for the Analysis of JUN Gene knock-down
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for JUN Sigma-Aldrich shRNA Panels and shRNA for JUN
		OriGene 29mer shRNA kits in GFP-retroviral vector: JUN OriGene shRNA RFP: JUN OriGene basic RS shRNA: JUN OriGene siRNA: JUN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of JUN

miRNA:		Sigma-Aldrich microRNA Mimics for JUN Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of JUN
		8/9 SABiosciences Assays for microRNAs that regulate JUN (see all 9):
		hsa-miR-200c hsa-miR-520d-5p hsa-miR-501-5p hsa-miR-429 hsa-miR-522 hsa-miR-524-5p hsa-miR-139-5p hsa-miR-580

Gene
Editing:

Sigma-Aldrich CompoZr Knockout ZFN for JUN

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: JUN OriGene Myc/DDK tagged cDNA clones in CMV expression vector: JUN OriGene untagged cDNA clones in CMV expression vector: JUN OriGene 3'-UTR clone: JUN Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: JUN
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for JUN

Genatlas biochemistry entry for JUN:

avian sarcoma virus 17 (v-jun) oncogene homolog,ligand induced,immediate (primary ) early response gene interacting

with MYC to regulate AP1 genes

5/16 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 16):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	TAS	2825349
GO:0003690	double-stranded DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IDA	9732876
GO:0003702	RNA polymerase II transcription factor activity	IEA	--
GO:0003705	sequence-specific enhancer binding RNA polymerase II transcription factor activity	IDA	2833704

About this table

JUN for ontologies About GeneDecksing

Animal Models: 15/19 MGI mutant phenotypes (inferred from 10 alleles) (MGI details for Jun) (see all 19):

behavior/neurological	cardiovascular system	cellular	embryogenesis	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal
lethality-prenatal/perinatal	life span-post-weaning/aging	liver/biliary system	nervous system	no phenotypic analysis

JUN for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

JUN for pathways About GeneDecksing

5/51 Millipore Pathways for JUN (see all 51)

	Development Activation of ERK by Alpha-1 adrenergic receptors
	Immune response CD16 signaling in NK cells
	Immune response MIF-mediated glucocorticoid regulation
	Immune response MIF in innate immunity response
	Immune response IL-1 signaling pathway

5/82 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for JUN (see all 82)

	MIF Regulation of Innate Immunity
	Cholecystokinin/Gastrin-mediated Signaling
	IL-2 Signaling
	HGF Signaling
	IL-12 Signaling and Production in Macrophages

3 Cell Signaling Technology (CST) Pathways for JUN

	SAPK/JNK Signaling Cascades
	T Cell Receptor Signaling
	B Cell Receptor Signaling

5/15 Kegg Pathways (Kegg details for JUN) (see all 15):

	hsa04010 MAPK signaling pathway
	hsa04012 ErbB signaling pathway
	hsa04310 Wnt signaling pathway
	hsa04510 Focal adhesion
	hsa04620 Toll-like receptor signaling pathway

SABiosciences Pathway-Focused PCR Arrays including JUN (see all 20): PAHS-005A PAHS-014A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for JUN

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for JUN

5/23 Interacting proteins for JUN (P05412^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 23)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FOS	P01100¹^,²	EBI-852823,EBI-852851 MINT-8077940 MINT-8077771 MINT-8077923 MINT-68804 MINT-8077906 MINT-8077789 MINT-8077872 MINT-8077889 MINT-8077856 MINT-8077649 MINT-8077677 MINT-8077831 MINT-8077811
ATF2	P15336¹^,²	EBI-852823,EBI-1170906 MINT-6699748 MINT-6628041
MAPK8	P45983¹^,²	EBI-852823,EBI-286483 MINT-7148314
BAT2	P48634¹	EBI-852823,EBI-347545
BBS7	Q8IWZ6¹	EBI-852823,EBI-1806001

About this table

5/41 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 41):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0001836	release of cytochrome c from mitochondria	IEA	--
GO:0002756	MyD88-independent toll-like receptor signaling pathway	TAS	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006366	transcription from RNA polymerase II promoter	--	--

About this table

JUN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

JUN for compounds About GeneDecksing

Sigma-Aldrich Small Molecules for JUN:

Small Molecule - Inhibitor

Enzo Life Sciences drugs & compounds for JUN

Browse Tocris compounds for JUN
10/126 Novoseek chemical compound relationships for JUN gene (see all 126)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sp 600125	87.7	146	15034932 (2), 20490773 (2), 19405983 (2), 18487435 (2) (see all 99)
12-o-tetradecanoylphorbol 13-acetate	80.8	449	2105946 (9), 1939341 (6), 11592962 (4), 9364213 (4) (see all 99)
curcumin	75.7	201	16157375 (6), 15514944 (4), 9439980 (4), 15358181 (4) (see all 99)
pd 98,059	75	87	19567187 (3), 18953964 (2), 17424890 (2), 15627897 (2) (see all 64)
sb 203580	73	44	17424890 (2), 11367542 (2), 12093796 (1), 17257889 (1) (see all 37)
phorbol	72.2	79	1901643 (3), 9037208 (2), 2122980 (2), 1496019 (2) (see all 49)
n acetylcysteine	67.6	114	9043100 (4), 16298762 (3), 7835407 (2), 8662787 (2) (see all 57)
retinoic acid	66.9	405	7489817 (7), 8637715 (7), 16052510 (7), 10329043 (7) (see all 99)
leucine	66.7	213	15087451 (5), 1901988 (4), 1739975 (4), 8112339 (4) (see all 99)
tyrosine	65	213	18073204 (6), 7524489 (4), 9442088 (4), 12388765 (3) (see all 99)

About this table

2 PharmGKB drug compound relationships for JUN gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
mercaptopurine	PD FA GN	12704389
methotrexate	PD FA GN	12704389

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Millipore RNAi Products for the Analysis of JUN Gene knock-down
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for JUN Sigma-Aldrich shRNA Panels and shRNA for JUN
		OriGene 29mer shRNA kits in GFP-retroviral vector: JUN OriGene shRNA RFP: JUN OriGene basic RS shRNA: JUN OriGene siRNA: JUN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of JUN

miRNA:		Sigma-Aldrich microRNA Mimics for JUN Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of JUN
		8/9 SABiosciences Assays for microRNAs that regulate JUN (see all 9):
		hsa-miR-200c hsa-miR-520d-5p hsa-miR-501-5p hsa-miR-429 hsa-miR-522 hsa-miR-524-5p hsa-miR-139-5p hsa-miR-580

Clones:		Sigma-Aldrich FLAG tag genes for JUN
		OriGene GFP tagged cDNA clones in CMV expression vector: JUN OriGene Myc/DDK tagged cDNA clones in CMV expression vector: JUN OriGene untagged cDNA clones in CMV expression vector: JUN OriGene 3'-UTR Clone: JUN Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: JUN

Primers:		OriGene genome-wide validated SYBR primer pairs: JUN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for JUN: PPH00095A

REFSEQ mRNAs for JUN gene:

NM_002228.3

Additional cDNA sequence:

AK307137.1 BC002646.2 BC006175.1 BC009874.2 BC068522.1 BT019759.1 CR541724.1 CR541752.1

22 DOTS entries:

DT.97762702 DT.100044313 DT.121359986 DT.121359920 DT.450792 DT.100675414 DT.100863059 DT.100675418

DT.100851939 DT.121359919 DT.121359948 DT.92473418 DT.95264854 DT.95107720 DT.121359935 DT.92473595

DT.95132043 DT.100675423 DT.100804761 DT.121359950 DT.91897383 DT.91843574

24/886 AceView cDNA sequences (see all 886):

BQ269083 BG165177 AA465045 BQ632325 BQ632684 AA854737 AA343833 BQ447614

CA774844 BQ268811 BM741108 BM758217 AA455273 AW389465 AI096582 AA043401

AI340023 AA782834 AI205975 BX334278 AA595884 BM827162 BM747230 BM758935

highest scoring ESTs for JUN:

AW005304 AA027941 AA040560 AA159143 AA179925 AA281805 AA351935 AA362757 AA423803 AA436799

Unigene Cluster for JUN:

Jun proto-oncogene

Hs.696684 [show with all ESTs]

Unigene Representative Sequence: NM_002228

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000371222(uc001cze.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

JUN expression in normal and diseased human tissues

¹ / ² / ³

9 probe-sets matching JUN gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
89913_s_at²^{, 3}	U95-D	1	0.75	1.00	0.95	1.10	AW005304	1.00	1.00	1.00	1
32583_at*²^{, 3}	U95-A	1	--	--	0.96	1.03	J04111	0.20	1.00	0.72	1
1895_at*²^{, 3}	U95-A	1	--	--	0.94	0.87	J04111	0.20	1.00	0.72	1
201465_s_at²^{, 3}	U133-A	1	0.82	1.00	--	--	BC002646	0.80	1.00	0.91	1
201466_s_at²^{, 3}	U133-A	1	0.36	1.00	--	--	NM_002228	0.60	1.00	0.82	1
201464_x_at²^{, 3}	U133-A	1	0.27	1.00	--	--	BG491844	0.40	1.00	0.76	1
201465_s_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--
201466_s_at²	U133Plus2	1	0.36	1.00	--	--	--	--	--	--	--
201464_x_at²	U133Plus2	1	0.27	1.00	--	--	--	--	--	--	--

About this table

JUN for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

About these images

CGAP SAGE TAG: CCTTTGTAAG

SOURCE GeneReport for Unigene cluster: Hs.696684

Expression variation in blood from EXPOLDB for JUN

Primers:		OriGene genome-wide validated SYBR primer pairs: JUN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for JUN: PPH00095A

SABiosciences Expression via Pathway-Focused PCR Arrays including JUN (see all 20): PAHS-005A PAHS-014A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for JUN gene from 5/9 species (see all 9)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	JUN¹	--	jun oncogene	93.15(n) 95.64(a)	609429 XM_860621.1 XP_865714.1
chimpanzee (Pan troglodytes)	JUN¹	--	jun oncogene	99.8(n) 100(a)	456893 XM_513442.2 XP_513442.2
cow (Bos taurus)	JUN¹	--	jun oncogene	94.76(n) 98.19(a)	280831 XM_001249361.1 XP_001249362.1
rat (Rattus norvegicus)	Jun¹	--	Jun oncogene	91.14(n) 96.68(a)	24516 NM_021835.3 NP_068607.1
mouse (Mus musculus)	Jun^{1 , 5}	4 (43.34 cM)⁵	Jun oncogene^{1, 5}	91.74(n)¹ 97.28(a)¹	16476¹ NM_010591.1¹ NP_034721.1¹ AK132019⁵ AK133722⁵ (see all 20)

About this table Species with no ortholog for JUN

ENSEMBL Gene Tree for JUN (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for JUN gene

JUND² JUNB²

JUN for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs2654^1,2	H	59247247(-)	`CCTGCC/TTTCGT`	1	--	ut3¹		5	MN NS EA	602
rs2655^1,2	--	59247203(-)	`TTGATG/TAAAGC`	1	--	ut3¹ ese³		1	MN	184
rs9989^1,2	--	59247853(-)	`GTCCAC/TGGCCA`	2	T M	ref¹ mis¹ ese³		1	MN	184
rs11688^1,2	C,F,A,H,	59247993(-)	`TCCCAG/AGAGCG`	2	/Q	syn¹ ref¹ ese³		13	MN NS EA NA	930
rs12816^1,2	F	59246658(+)	`GGTCAC/AAGCAC`	1	--	ut3¹		1	MN	184
rs1323287^1,2	C,F,H,	59245987(+)	`GTAGGC/TAGAAT`	1	--	ng3¹		18	NS EA NA WA	1142
rs1323288^1,2	C,F,A,H,	59246115(+)	`AGACTT/GATTCT`	1	--	ng3¹		16	NS NA EA WA	954
rs1407816^1,2	C,H,	59249347(+)	`AAGTTC/GGCTCC`	1	--	ut5¹		18	EA NA MN NS WA	854
rs1923942^1,2	C,F	59246626(+)	`CCTATT/GGTAAA`	1	--	ut3¹ ese³		7	NS	632
rs2760499^1,2	C,F,H,	59248813(+)	`GGGCTC/GTGGCA`	1	--	ut5¹ ese³		9	NS NA WA	228

About this table

HapMap Linkage Disequilibrium images for JUN (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for JUN
1 CNV: 63848

QIAGEN SeqTarget long-range PCR primers for resequencing JUN

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
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JUN for disorders About GeneDecksing

OMIM: 165160

10/95 Novoseek disease relationships for JUN gene (see all 95)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	69.3	732	7766308 (6), 10037172 (6), 10502734 (5), 19205384 (4) (see all 99)
necrosis	67.7	217	9357820 (4), 7935377 (2), 12770614 (2), 1520341 (2) (see all 99)
leukemia t-cell	62.1	15	11145887 (2), 12937177 (1), 8241024 (1), 7732661 (1) (see all 12)
inflammation	58.9	110	16753225 (4), 19064304 (2), 18793328 (2), 12391249 (2) (see all 91)
cancer	56.4	176	19653276 (4), 18008069 (3), 15884858 (2), 16135795 (2) (see all 99)
myeloid leukemia	53.6	40	2122980 (3), 1310062 (2), 1737349 (2), 2174893 (2) (see all 24)
neoplastic transformation	53.4	26	9652737 (2), 1801783 (2), 9092536 (2), 7766308 (1) (see all 18)
breast cancer	46.6	225	8597534 (7), 17407600 (6), 16027729 (5), 17672916 (4) (see all 96)
promyelocytic leukemia	45.4	9	11216470 (1), 15161980 (1), 15701643 (1), 20015448 (1) (see all 8)
colon cancer	40	27	17510524 (3), 15139522 (2), 12503187 (2), 19782465 (2) (see all 19)

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1 PharmGKB disease relationship for JUN gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	PD FA GN	12704389

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Human Genome Epidemiology (HuGE) Navigator: JUN (124 documents)
Tumor Gene Database (TGDB): JUN

Export disorders and mutations for JUN gene to outside databases

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
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10/4287 PubMed articles for JUN gene, integrated from 7 sources (see all 4287):
(articles sorted by number of sources associating them with JUN)

Structure and chromosomal localization of the functional intronless human JUN protooncogene. (PubMed id 3194415)^{1, 2, 3} Hattori K.... Karin M. (1988)
Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions. (PubMed id 12087103)^{1, 2, 7} Bower K.E....McGuire K.L. (2002)
High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer. (PubMed id 8662824)^{1, 2, 7} Junius F.K.... King G.F. (1996)
c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif. (PubMed id 8464713)^{1, 2, 7} Bannister A.J.... Jackson S.P. (1993)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{1, 2} Beausoleil S.A....Gygi S.P. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1. (PubMed id 10196196)^{1, 2} Rao S.... Simon M.C. (1999)
A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. (PubMed id 8837781)^{1, 2} Claret F.-X.... Karin M. (1996)
Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene. (PubMed id 8663478)^{1, 2} Kirstein M.... Saus J. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3725	HGNC: 6204	AceView: JUN	Ensembl:ENSG00000177606	euGenes: HUgn3725
ECgene: JUN	Kegg: 3725	H-InvDB: JUN

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for JUN	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/jun/

Intellectual Property for JUN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for JUN gene:
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GeneCards and IP:
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JUN Gene

protein-coding GIFtS: 68

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