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KCNH3 Gene

protein-coding GIFtS: 52

GC12P046963

potassium voltage-gated channel, subfamily H (eag-related), member 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
potassium voltage-gated channel, subfamily H (eag-related), member 3¹ ²		ELK channel 2² ³
BEC1¹ ² ³ ⁵		ELK2² ³
Kv12.2¹ ²		KIAA1282² ³
Ether-a-go-go-like potassium channel 2² ³		elk2¹
Voltage-gated potassium channel subunit Kv12.2² ³		potassium voltage-gated channel subfamily H member 3²
Brain-specific eag-like channel 1² ³		ether-a-go-go K(+) channel family member²

External Ids:	HGNC: 6252¹	Entrez Gene: 23416²	Ensembl: ENSG00000135519⁷	UniProtKB: Q9ULD8³

Export aliases for KCNH3 gene to outside databases

Previous GC identifers: GC12P050150 GC12P049989 GC12P049649 GC12P048219 GC12P049933

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8

Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast

inactivation. Channel properties may be modulated by cAMP and subunit assembly

summary for KCNH3:

Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the

Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits

contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed

within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KCNH3 gene promoter:
         PPAR-gamma2   PPAR-gamma1   LUN-1   POU2F1   NF-kappaB   NF-kappaB1   RelA   RREB-1   LCR-F1   p300
         Other transcription factors

Search SABiosciences Chromatin IP Primers for KCNH3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for KCNH3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13 Ensembl cytogenetic band: 12q13.12 HGNC cytogenetic band: 12q13

KCNH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNH3 gene location

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P046963: view genomic region (about GC identifiers)

Start:	46,963,792 bp from pter
End:	46,982,929 bp from pter
Size:	19,138 bases
Orientation:	plus strand

1 alternative location:

Chr12+ 49,932,940-49,952,059

RefSeq DNA sequence:

NC_000012.11 NT_029419.12

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8 (See protein sequence)

Recommended Name: Potassium voltage-gated channel subfamily H member 3

Size: 1083 amino acids; 117129 Da

Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha

subunits that can associate with modulating beta subunits

Subcellular location: Membrane; Multi-pass membrane protein

Sequence caution: Sequence=BAA86596.1; Type=Erroneous initiation;

Secondary accessions: Q9UQ06

Explore the universe of human proteins at neXtProt for KCNH3: NX_Q9ULD8

REFSEQ proteins: NP_036416.1

ENSEMBL proteins:

ENSP00000257981

Human Recombinant Proteins

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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	NAS	10455180

About this table

KCNH3 for ontologies About GeneDecksing

Antibodies for KCNH3:

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Assays for KCNH3:

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	Uscn ELISAs and CLIAs for KCNH3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KCNH3 for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR003950 K_chnl_volt-dep_ELK

IPR018490 cNMP-bd-like

IPR005821 Ion_trans

IPR000595 cNMP-bd_dom

IPR001610 PAC

Graphical View of Domain Structure for InterPro Entry Q9ULD8

ProtoNet protein and cluster: Q9ULD8

5/6 Blocks protein families (see all 6):

IPB000014 PAS domain

IPB000595 Cyclic nucleotide-binding domain

IPB001610 PAC motif

IPB003938 EAG/ELK/ERG potassium channel family signature

IPB003950 ELK potassium channel family signature

UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino

acids at every third position

Similarity: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily

Similarity: Contains 1 cyclic nucleotide-binding domain

Similarity: Contains 1 PAC (PAS-associated C-terminal) domain

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8

Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast

inactivation. Channel properties may be modulated by cAMP and subunit assembly

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for KCNH3 Sigma-Aldrich shRNA Panels and shRNA for KCNH3
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): KCNH3 OriGene shRNA RFP (see all 2): KCNH3 OriGene basic RS shRNA (see all 2): KCNH3 OriGene siRNA (see all 2): KCNH3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KCNH3

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KCNH3
		1 SABiosciences Assays for microRNA that regulate KCNH3:
		hsa-miR-324-3p

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: KCNH3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: KCNH3 OriGene untagged cDNA clones in CMV expression vector: KCNH3 OriGene 3'-UTR clone: KCNH3 Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: KCNH3
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Cell
Lines:

GenScript Custom overexpressing Cell Line Services for KCNH3

Genatlas biochemistry entry for KCNH3:

potassium voltage-gated channel,subfamily H (eag-related),member 3,ether-a-go-go K+ channel family member,exclusively

expressed in the brain,mainly in the cerebral cortex,amygdala,hippocampus and striatum

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000155	two-component sensor activity	IEA	--
GO:0004871	signal transducer activity	--	--
GO:0005216	ion channel activity	--	--
GO:0005244	voltage-gated ion channel activity	IEA	--
GO:0005249	voltage-gated potassium channel activity	TAS	10455180

About this table

KCNH3 for ontologies About GeneDecksing

Animal Models: 2 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Kcnh3):

behavior/neurological

nervous system

KCNH3 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for KCNH3

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KCNH3

1 Interacting protein for KCNH3 (Q9ULD8²) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
--	P04578²	MINT-7968695 MINT-7968714 MINT-7968675

About this table

5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000160	two-component signal transduction system (phosphorelay)	--	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006811	ion transport	IEA	--
GO:0006813	potassium ion transport	TAS	10455180
GO:0007165	signal transduction	--	--

About this table

KCNH3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Compounds for KCNH3 available from Tocris Bioscience

Compound	Action	CAS number
AM 92016 hydrochloride	KV channel blocker	[178894-81-0]
KN-93	CaM kinase II inhibitor. Also K+ channel blocker (KV)	[139298-40-1]
SG 209	K+ channel opener; vasodilator	[83440-03-3]
4-Aminopyridine	Non-selective KV channel blocker	[504-24-5]

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for KCNH3 Sigma-Aldrich shRNA Panels and shRNA for KCNH3
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): KCNH3 OriGene shRNA RFP (see all 2): KCNH3 OriGene basic RS shRNA (see all 2): KCNH3 OriGene siRNA (see all 2): KCNH3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KCNH3

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KCNH3
		1 SABiosciences Assays for microRNA that regulate KCNH3:
		hsa-miR-324-3p

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: KCNH3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: KCNH3 OriGene untagged cDNA clones in CMV expression vector: KCNH3 OriGene 3'-UTR Clone: KCNH3 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: KCNH3

Primers:		OriGene genome-wide validated SYBR primer pairs: KCNH3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for KCNH3: PPH01661A

REFSEQ mRNAs for KCNH3 gene:

NM_012284.1

Additional cDNA sequence:

AB022696.1 AB033108.1 BC033141.1 BC144254.1 BC150602.1

1 DOTS entry:

DT.403685

24/39 AceView cDNA sequences (see all 39):

BX095172 NM_012284 AI272282 AW248878 BC033141 AB033108 BM452074 AB022696

CA433932 CD106245 BU187340 AI627894 AW251056 AW082228 U69184 M79045

BV185837 AI017220 AI124750 AL134774 BG060031 AW249035 AW248597 BE646495

highest scoring ESTs for KCNH3:

AB022696 AB033108 AI124750 AI627894 AI873733 AW248597 AW248878 AW249035 AW251056 AW518396

Unigene Cluster for KCNH3:

Potassium voltage-gated channel, subfamily H (eag-related), member 3

Hs.64064 [show with all ESTs]

Unigene Representative Sequence: NM_012284

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for KCNH3

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17
SP1:															-
SP2:
SP3:

About this scheme

ECgene alternative splicing isoforms for KCNH3
1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000257981(uc001ruh.1 uc010smj.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

KCNH3 expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching KCNH3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
53681_at²^{, 3}	U95-C	1	0.62	1.00	1.00	1.00	R38427	0.60	1.00	0.82	1
223726_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AB022696	0.80	1.00	0.91	1
223726_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

KCNH3 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

KCNH3 gene electronic northern expression

About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.64064

UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8

Tissue specificity: Detected only in brain, in particular in the telencephalon. Detected in the cerebral cortex,

occipital pole, frontal and temporal lobe, putamen, amygdala, hippocampus and caudate nucleus

Primers:		OriGene genome-wide validated SYBR primer pairs: KCNH3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for KCNH3: PPH01661A

SABiosciences Custom PCR Arrays for KCNH3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KCNH3 gene from 5/7 species (see all 7)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KCNH3¹	--	potassium voltage-gated channel, subfamily H (eag-related), more	89.57(n) 92.69(a)	486556 XM_543682.2 XP_543682.2
chimpanzee (Pan troglodytes)	KCNH3¹	--	potassium voltage-gated channel, subfamily H (eag-related), more	99.63(n) 99.72(a)	451880 XM_509046.2 XP_509046.2
cow (Bos taurus)	KCNH3¹	--	potassium voltage-gated channel, subfamily H (eag-related), more	92.3(n) 95.9(a)	514409 XM_592255.3 XP_592255.3
rat (Rattus norvegicus)	Kcnh3¹	--	potassium voltage-gated channel, subfamily H (eag-related), more	89.32(n) 95.94(a)	27150 NM_017108.1 NP_058804.1
mouse (Mus musculus)	Kcnh3^{1 , 5}	15 (56.08 cM)⁵	potassium voltage-gated channel, subfamily H (eag-related), more^{1, 5}	89.72(n)¹ 95.84(a)¹	16512¹ NM_010601.2¹ NP_034731.2¹ AF109143⁵ AK135093⁵ (see all 10)

About this table Species with no ortholog for KCNH3

ENSEMBL Gene Tree for KCNH3 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KCNH3 gene

KCNH5² KCNH6² KCNH2² KCNH7² KCNH4² KCNH8² KCNH1²

KCNH3 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs933738^1,2	C,F,A,H,	49943122(-)	`AGGCCT/CGAAGG`	1	--	int¹		6		MN NA WA	442
rs1143872^1,2	C,F,	49939821(-)	`TGTCTC/TAGCCC`	1	--	int¹		5		NS EA WA	462
rs1150056^1,2	C,A,H,	49931867(-)	`TGCCCG/TGGGGC`	1	--	ng5¹		3		NA WA	10
rs1150057^1,2	C,F,O,A,	49937813(-)	`AGCGCT/CGCGAT`	2	/A	ref¹ syn¹ ese³		12		MN NS EA NA WA	968
rs1150058^1,2	C,A,	49937912(-)	`CGGGCC/TGGCCC`	1	--	int¹		0	--	--	--	--
rs1797215^1,2	--	49939360(-)	`tgtctC/Ttacta`	1	--	int¹		0	--	--	--	--
rs1797559^1,2	--	49933631(-)	`GCCTCG/CCCTTA`	1	--	int¹		1		MN	184
rs1902329^1,2	C,F,A,	49939836(+)	`ATCCCT/CAGGTC`	1	--	int¹		7		NS EA NA WA	482
rs1902330^1,2	C,F,O,A,	49939953(+)	`CTTCAG/ACTCCC`	1	--	int¹		9		NS EA NA WA	616
rs2241418^1,2	C,A,	49951232(-)	`CACGGG/ACCCTC`	2	/G	syn¹ ref¹ ese³		1		WA	2

About this table

HapMap Linkage Disequilibrium images for KCNH3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KCNH3: --

QIAGEN SeqTarget long-range PCR primers for resequencing KCNH3

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KCNH3 for disorders About GeneDecksing

OMIM: 604527

Export disorders and mutations for KCNH3 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

8 PubMed articles for KCNH3 gene integrated from 7 sources:
(articles sorted by number of sources associating them with KCNH3)

New ether-a-go-go K+ channel family members localized in human telencephalon. (PubMed id 10455180)^{1, 2, 3, 7} Miyake A.... Furuichi K. (1999)
International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)^{1, 3} Gutman G.A....Wang X. (2005)
Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)^{1, 2} Nagase T.... Ohara O. (1999)
Interaction of human immunodeficiency virus gp120 wit h the voltage-gated potassium channel BEC1. (PubMed id 20638388)¹ Herrmann M....Mueller-Lantzsch N. (2010 Aug 20)
Disruption of the ether-a-go-go K+ channel gene BEC1/ KCNH3 enhances cognitive function. (PubMed id 19923296)¹ Miyake A....Katou M. (2009)
Distribution and functional properties of human KCNH8 (Elk1) potassium channels. (PubMed id 12890647)¹ Zou A.... Wickenden A.D. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Functional up-regulation of HERG K+ channels in neoplastic hematopoietic cells. (PubMed id 11893742)⁷ Smith G.A....Schlichter L.C. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23416	HGNC: 6252	AceView: KCNH3	Ensembl:ENSG00000135519	euGenes: HUgn23416
ECgene: KCNH3	H-InvDB: KCNH3

(According to HUGE)
About This Section

HUGE: KIAA1282

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for KCNH3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for KCNH3 gene:
Search GeneIP for patents involving KCNH3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KCNH3		Antibodies for KCNH3
	Super-pooled esiRNAs for KCNH3		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KCNH3		Browse microRNA Mimics at Sigma-Aldrich
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
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	Antibodies		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
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	siRNA
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	Fluorogenic Cell Assay Kits
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	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KCNH3
	SeqTarget long-range PCR primers for resequencing KCNH3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for KCNH3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KCNH3

	GenScript Custom Purified and Recombinant Proteins Services for KCNH3		GenScript cDNA clones with any tag delivered in your preferred vector for KCNH3
	GenScript Custom Assay Services for KCNH3		GenScript Custom Superior Antibodies Services for KCNH3
	GenScript Custom overexpressing Cell Line Services for KCNH3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in KCNH3 promoter
	Search Chromatin IP Primers for KCNH3
	RT² qPCR Primer Assay for KCNH3
	GNC Network for KCNH3
	Assays for microRNAs that regulate KCNH3
	SABiosciences Custom PCR Arrays for KCNH3

Tocris compounds for KCNH3

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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for KCNH3

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for KCNH3

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

KCNH3 gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

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KCNH3 Gene

protein-coding GIFtS: 52

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KCNH3 Gene

protein-coding GIFtS: 52

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