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KCNH3 Gene

protein-coding   GIFtS: 52

GC12P046963
potassium voltage-gated channel, subfamily H (eag-related), member 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
potassium voltage-gated channel, subfamily H (eag-related), member 31 2     ELK channel 22 3
BEC11 2 3 5     ELK22 3
Kv12.21 2     KIAA12822 3
Ether-a-go-go-like potassium channel 22 3     elk21
Voltage-gated potassium channel subunit Kv12.22 3     potassium voltage-gated channel subfamily H member 32
Brain-specific eag-like channel 12 3     ether-a-go-go K(+) channel family member2

External Ids:    HGNC: 62521   Entrez Gene: 234162   Ensembl: ENSG000001355197   UniProtKB: Q9ULD83   

Export aliases for KCNH3 gene to outside databases

Previous GC identifers: GC12P050150 GC12P049989 GC12P049649 GC12P048219 GC12P049933


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8
Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast
inactivation. Channel properties may be modulated by cAMP and subunit assembly

summary for KCNH3:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNH3 gene promoter:
         PPAR-gamma2   PPAR-gamma1   LUN-1   POU2F1   NF-kappaB   NF-kappaB1   RelA   RREB-1   LCR-F1   p300   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for KCNH3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for KCNH3 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13

KCNH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNH3 gene location

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P046963:  view genomic region     (about GC identifiers)

Start:
46,963,792 bp from pter
End:
46,982,929 bp from pter
Size:
19,138 bases
Orientation:
plus strand

1 alternative location:
Chr12+ 49,932,940-49,952,059     
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily H member 3  
Size: 1083 amino acids; 117129 Da
Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha
subunits that can associate with modulating beta subunits
Subcellular location: Membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAA86596.1; Type=Erroneous initiation;
Secondary accessions: Q9UQ06

Explore the universe of human proteins at neXtProt for KCNH3: NX_Q9ULD8 

REFSEQ proteins: NP_036416.1  

ENSEMBL proteins: 
ENSP00000257981 


Human Recombinant Proteins 
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Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
Browse OriGene Protein Over-expression Lysates
GenScript Custom Purified and Recombinant Proteins Services for KCNH3 
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0016020 membrane IEA--
GO:0016021 integral to membrane NAS10455180
About this table

KCNH3 for ontologies           About GeneDecksing



Antibodies for KCNH3: 
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Assays for KCNH3: 
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Uscn ELISAs and CLIAs for KCNH3 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KCNH3 for domains           About GeneDecksing

5/10 InterPro domains/families (see all 10):
 IPR003950 K_chnl_volt-dep_ELK
 IPR018490 cNMP-bd-like
 IPR005821 Ion_trans
 IPR000595 cNMP-bd_dom
 IPR001610 PAC

Graphical View of Domain Structure for InterPro Entry Q9ULD8

ProtoNet protein and cluster: Q9ULD8

5/6 Blocks protein families (see all 6):
IPB000014 PAS domain
IPB000595 Cyclic nucleotide-binding domain
IPB001610 PAC motif
IPB003938 EAG/ELK/ERG potassium channel family signature
IPB003950 ELK potassium channel family signature


UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8
Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
acids at every third position
Similarity: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily
Similarity: Contains 1 cyclic nucleotide-binding domain
Similarity: Contains 1 PAC (PAS-associated C-terminal) domain
Similarity: Contains 1 PAS (PER-ARNT-SIM) domain


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8
Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast
inactivation. Channel properties may be modulated by cAMP and subunit assembly

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for KCNH3
Sigma-Aldrich shRNA Panels and shRNA for KCNH3
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): KCNH3
OriGene shRNA RFP (see all 2): KCNH3
OriGene basic RS shRNA (see all 2): KCNH3
OriGene siRNA (see all 2): KCNH3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KCNH3 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KCNH3 
1 SABiosciences Assays for microRNA that regulate KCNH3:
hsa-miR-324-3p

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: KCNH3
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: KCNH3
OriGene untagged cDNA clones in CMV expression vector: KCNH3
OriGene 3'-UTR clone: KCNH3 
Browse MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: KCNH3 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for KCNH3 

Genatlas biochemistry entry for KCNH3:
potassium voltage-gated channel,subfamily H (eag-related),member 3,ether-a-go-go K+ channel family member,exclusively
expressed in the brain,mainly in the cerebral cortex,amygdala,hippocampus and striatum

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000155 two-component sensor activity IEA--
GO:0004871 signal transducer activity ----
GO:0005216 ion channel activity ----
GO:0005244 voltage-gated ion channel activity IEA--
GO:0005249 voltage-gated potassium channel activity TAS10455180
About this table

KCNH3 for ontologies           About GeneDecksing

Animal Models: 2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Kcnh3):

behavior/neurologicalnervous system

KCNH3 for phenotypes           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for KCNH3 

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNH3

1 Interacting protein for KCNH3 (Q9ULD82) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
--P045782MINT-7968695 MINT-7968714 MINT-7968675
About this table

5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6):

GO IDQualified GO termEvidencePubMed IDs
GO:0000160 two-component signal transduction system (phosphorelay) ----
GO:0006355 regulation of transcription, DNA-dependent IEA--
GO:0006811 ion transport IEA--
GO:0006813 potassium ion transport TAS10455180
GO:0007165 signal transduction ----
About this table

KCNH3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Compounds for KCNH3 available from Tocris Bioscience
CompoundAction CAS number
AM 92016 hydrochlorideKV channel blocker[178894-81-0]
KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
SG 209K+ channel opener; vasodilator[83440-03-3]
4-AminopyridineNon-selective KV channel blocker[504-24-5]
About this table




(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for KCNH3
Sigma-Aldrich shRNA Panels and shRNA for KCNH3
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): KCNH3
OriGene shRNA RFP (see all 2): KCNH3
OriGene basic RS shRNA (see all 2): KCNH3
OriGene siRNA (see all 2): KCNH3
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KCNH3 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KCNH3 
1 SABiosciences Assays for microRNA that regulate KCNH3:
hsa-miR-324-3p
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: KCNH3
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: KCNH3
OriGene untagged cDNA clones in CMV expression vector: KCNH3
OriGene 3'-UTR Clone: KCNH3 
Browse OriGene MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: KCNH3 
Primers: OriGene genome-wide validated SYBR primer pairs: KCNH3
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for KCNH3: PPH01661A

REFSEQ mRNAs for KCNH3 gene: 

NM_012284.1  

Additional cDNA sequence: 

AB022696.1 AB033108.1 BC033141.1 BC144254.1 BC150602.1 

1 DOTS entry:

DT.403685 

24/39 AceView cDNA sequences (see all 39):

BX095172 NM_012284 AI272282 AW248878 BC033141 AB033108 BM452074 AB022696 
CA433932 CD106245 BU187340 AI627894 AW251056 AW082228 U69184 M79045 
BV185837 AI017220 AI124750 AL134774 BG060031 AW249035 AW248597 BE646495 

highest scoring ESTs for KCNH3:

AB022696 AB033108 AI124750 AI627894 AI873733 AW248597 AW248878 AW249035 AW251056 AW518396 

Unigene Cluster for KCNH3:

Potassium voltage-gated channel, subfamily H (eag-related), member 3
Hs.64064  [show with all ESTs]
Unigene Representative Sequence: NM_012284


GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for KCNH3

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1:                                            -                                                               
SP2:                                                                                                            
SP3:                                                                                                            

About this scheme

ECgene alternative splicing isoforms for KCNH3
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000257981(uc001ruh.1 uc010smj.1)

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

KCNH3 expression in normal and diseased human tissues

1  / 2  / 3

3 probe-sets matching KCNH3 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
53681_at2, 3 U95-C 1 0.62 1.00 1.00 1.00 R38427 0.60 1.00 0.82 1
223726_at2, 3 U133-B 1 1.00 1.00 -- -- AB022696 0.80 1.00 0.91 1
223726_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table

KCNH3 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
KCNH3 gene expression
KCNH3 gene electronic northern expression
KCNH3 gene sage expression
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.64064

UniProtKB/Swiss-Prot: KCNH3_HUMAN, Q9ULD8
Tissue specificity: Detected only in brain, in particular in the telencephalon. Detected in the cerebral cortex,
occipital pole, frontal and temporal lobe, putamen, amygdala, hippocampus and caudate nucleus

Primers: OriGene genome-wide validated SYBR primer pairs: KCNH3
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for KCNH3: PPH01661A
    SABiosciences Custom PCR Arrays for KCNH3 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KCNH3 gene from 5/7 species (see all 7)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
KCNH31   -- potassium voltage-gated channel, subfamily H (eag-related), more 89.57(n)
92.69(a)
486556  XM_543682.2  XP_543682.2 
chimpanzee
(Pan troglodytes)
KCNH31   -- potassium voltage-gated channel, subfamily H (eag-related), more 99.63(n)
99.72(a)
451880  XM_509046.2  XP_509046.2 
cow
(Bos taurus)
KCNH31   -- potassium voltage-gated channel, subfamily H (eag-related), more 92.3(n)
95.9(a)
514409  XM_592255.3  XP_592255.3 
rat
(Rattus norvegicus)
Kcnh31   -- potassium voltage-gated channel, subfamily H (eag-related), more 89.32(n)
95.94(a)
27150  NM_017108.1  NP_058804.1 
mouse
(Mus musculus)
Kcnh31 , 5 15 (56.08 cM)5
potassium voltage-gated channel, subfamily H (eag-related), more1, 5 89.72(n)1
95.84(a)1
165121  NM_010601.21  NP_034731.21 
 AF1091435  AK1350935  (see all 10)
About this table        Species with no ortholog for KCNH3

ENSEMBL Gene Tree for KCNH3 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for KCNH3 gene
KCNH52  KCNH62  KCNH22  KCNH72  KCNH42  KCNH82  KCNH12  

KCNH3 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/133 NCBI SNPs in KCNH3 are shown (see all 133)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 12 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs9337381,2
C,F,A,H,49943122(-) AGGCCT/CGAAGG 1 -- int16Minor allele frequency- C:0.21MN NA WA 442
rs11438721,2
C,F,49939821(-) TGTCTC/TAGCCC 1 -- int15Minor allele frequency- T:0.02NS EA WA 462
rs11500561,2
C,A,H,49931867(-) TGCCCG/TGGGGC 1 -- ng513Minor allele frequency- T:0.10NA WA 10
rs11500571,2
C,F,O,A,49937813(-) AGCGCT/CGCGAT 2 /A ref1 syn1 ese312Minor allele frequency- C:0.19MN NS EA NA WA 968
rs11500581,2
C,A,49937912(-) CGGGCC/TGGCCC 1 -- int10--------
rs17972151,2
--49939360(-) tgtctC/Ttacta 1 -- int10--------
rs17975591,2
--49933631(-) GCCTCG/CCCTTA 1 -- int11Minor allele frequency- C:0.00MN 184
rs19023291,2
C,F,A,49939836(+) ATCCCT/CAGGTC 1 -- int17Minor allele frequency- C:0.11NS EA NA WA 482
rs19023301,2
C,F,O,A,49939953(+) CTTCAG/ACTCCC 1 -- int19Minor allele frequency- A:0.13NS EA NA WA 616
rs22414181,2
C,A,49951232(-) CACGGG/ACCCTC 2 /G syn1 ref1 ese31Minor allele frequency- A:0.50WA 2
About this table

HapMap Linkage Disequilibrium images for KCNH3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for KCNH3: --

QIAGEN SeqTarget long-range PCR primers for resequencing KCNH3 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KCNH3 for disorders           About GeneDecksing

OMIM: 604527


Export disorders and mutations for KCNH3 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

8 PubMed articles for KCNH3 gene integrated from 7 sources:
(articles sorted by number of sources associating them with KCNH3)
  1. New ether-a-go-go K+ channel family members localized in human telencephalon. (PubMed id 10455180)1, 2, 3, 7 Miyake A.... Furuichi K. (1999)
  2. International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)
  3. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (1999)
  4. Interaction of human immunodeficiency virus gp120 wit h the voltage-gated potassium channel BEC1. (PubMed id 20638388)1 Herrmann M....Mueller-Lantzsch N. (2010 Aug 20)
  5. Disruption of the ether-a-go-go K+ channel gene BEC1/ KCNH3 enhances cognitive function. (PubMed id 19923296)1 Miyake A....Katou M. (2009)
  6. Distribution and functional properties of human KCNH8 (Elk1) potassium channels. (PubMed id 12890647)1 Zou A.... Wickenden A.D. (2003)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  8. Functional up-regulation of HERG K+ channels in neoplastic hematopoietic cells. (PubMed id 11893742)7 Smith G.A....Schlichter L.C. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 23416 HGNC: 6252 AceView: KCNH3 Ensembl:ENSG00000135519 euGenes: HUgn23416
ECgene: KCNH3 H-InvDB: KCNH3

(According to HUGE)
About This Section
HUGE: KIAA1282

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for KCNH3 gene:
Search GeneIP for patents involving KCNH3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KCNH3
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 Regulatory tfbs in KCNH3 promoter
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 ELISAs and CLIAs for KCNH3
       

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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