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KCNH5 Gene

protein-coding   GIFtS: 56

GC14M043339
potassium voltage-gated channel, subfamily H (eag-related), member 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
potassium voltage-gated channel, subfamily H (eag-related), member 51 2     EAG22 3
H-EAG21 2     eag21
Kv10.21 2     potassium voltage-gated channel subfamily H member 52
Voltage-gated potassium channel subunit Kv10.22 3     voltage-gated potassium channel EAG22
Ether-a-go-go potassium channel 22 3     ether-a-go-go-related potassium channel 22
hEAG22 3     potassium channel HEAG22

External Ids:    HGNC: 62541   Entrez Gene: 271332   Ensembl: ENSG000001400157   UniProtKB: Q8NCM23   

Export aliases for KCNH5 gene to outside databases

Previous GC identifers: GC14M060501 GC14M056967 GC14M061163 GC14M062243 GC14M063173


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNH5:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both
functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart
rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell
volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming
(alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. This gene is not expressed in
differentiating myoblasts. Alternative splicing results in three transcript variants encoding distinct isoforms.
(provided by RefSeq)

UniProtKB/Swiss-Prot: KCNH5_HUMAN, Q8NCM2
Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward
rectifying current. Channel properties may be modulated by cAMP and subunit assembly

summary for KCNH5:
Voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the
Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The pore-forming alpha-subunits
contain a single pore-forming region and combine to form tetramers. Heteromeric channels can be formed
within subfamilies e.g. KV1.1 with KV1.2 and KCNQ2 with KCNQ3.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNH5 gene promoter:
         Oct-B1   POU2F2C   POU2F2B   POU2F2 (Oct-2.1)   POU2F2   POU2F1   oct-B3   oct-B2   E4BP4   RREB-1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for KCNH5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for KCNH5 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.1   Ensembl cytogenetic band:  14q23.2   HGNC cytogenetic band: 14q23.1

KCNH5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNH5 gene location

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M043339:  view genomic region     (about GC identifiers)

Start:
43,339,418 bp from pter
End:
43,735,432 bp from pter
Size:
396,015 bases
Orientation:
minus strand

1 alternative location:
Chr14- 63,173,946-63,568,584     
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: KCNH5_HUMAN, Q8NCM2 (See protein sequence)
Recommended Name: Potassium voltage-gated channel subfamily H member 5  
Size: 988 amino acids; 111907 Da
Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha
subunits that can associate with modulating beta subunits. Heteromultimer with KCNH1/EAG (Probable)
Subcellular location: Membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAC11016.1; Type=Erroneous termination; Positions=436; Note=Translated as Gly;
Alternative splicing: 3 isoforms:  Q8NCM2-1   Q8NCM2-2   Q8NCM2-3   (Experimental confirmation may be lacking for some isoforms)

Explore the universe of human proteins at neXtProt for KCNH5: NX_Q8NCM2 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_647479.2  NP_758963.1  NP_758964.1  


    ENSEMBL proteins: 
    ENSP00000378415 ENSP00000321427 ENSP00000389568 ENSP00000395439 ENSP00000394833 ENSP00000378419 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for KCNH5 
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020 membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    KCNH5 for ontologies           About GeneDecksing



    Antibodies for KCNH5: 
    Millipore Mono- and Polyclonal Antibodies for the study of KCNH5
    Sigma-Aldrich Antibodies for KCNH5
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for KCNH5 
    Novus Biologicals Antibody for KCNH5
    Browse antibodies at Epitomics

    Assays for KCNH5: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KCNH5 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for KCNH5 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    KCNH5 for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR003949 K_chnl_volt-dep_EAG
     IPR018490 cNMP-bd-like
     IPR005821 Ion_trans
     IPR000595 cNMP-bd_dom
     IPR001610 PAC

    Graphical View of Domain Structure for InterPro Entry Q8NCM2

    ProtoNet protein and cluster: Q8NCM2

    5/7 Blocks protein families (see all 7):
    IPB000014 PAS domain
    IPB000595 Cyclic nucleotide-binding domain
    IPB001610 PAC motif
    IPB003938 EAG/ELK/ERG potassium channel family signature
    IPB003949 EAG potassium channel signature


    UniProtKB/Swiss-Prot: KCNH5_HUMAN, Q8NCM2
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position
    Similarity: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.2/KCNH5 sub-subfamily
    Similarity: Contains 1 cyclic nucleotide-binding domain
    Similarity: Contains 1 PAC (PAS-associated C-terminal) domain
    Similarity: Contains 1 PAS (PER-ARNT-SIM) domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: KCNH5_HUMAN, Q8NCM2
    Function: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward
    rectifying current. Channel properties may be modulated by cAMP and subunit assembly

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for KCNH5
    Sigma-Aldrich shRNA Panels and shRNA for KCNH5
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): KCNH5
    OriGene shRNA RFP (see all 3): KCNH5
    OriGene basic RS shRNA (see all 3): KCNH5
    OriGene siRNA (see all 3): KCNH5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KCNH5 
    miRNA:Sigma-Aldrich microRNA Mimics for KCNH5
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KCNH5 
    Search SABiosciences for Assays for microRNAs that regulate KCNH5

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): KCNH5
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): KCNH5
    OriGene untagged cDNA clones in CMV expression vector (see all 5): KCNH5
    OriGene 3'-UTR clone (see all 3): KCNH5 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 3): KCNH5 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for KCNH5 

    Genatlas biochemistry entry for KCNH5:
    potassium voltage-gated channel, subfamily H (eag-related), member 5

    5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000155 two-component sensor activity IEA--
    GO:0004871 signal transducer activity ----
    GO:0005216 ion channel activity ----
    GO:0005244 voltage-gated ion channel activity IEA--
    GO:0005249 voltage-gated potassium channel activity IEA--
    About this table

    KCNH5 for ontologies           About GeneDecksing

    Animal Models: 3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Kcnh5):

    behavior/neurologicalhearing/vestibular/earno phenotypic analysis

    KCNH5 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    KCNH5 for pathways           About GeneDecksing

    1 Millipore Pathway for KCNH5
        Potassium transporters- outward current

        SABiosciences Custom Pathway-Focused PCR Arrays for KCNH5 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNH5

    5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000160 two-component signal transduction system (phosphorelay) ----
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0006811 ion transport IEA--
    GO:0006813 potassium ion transport IEA--
    GO:0007165 signal transduction ----
    About this table

    KCNH5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    KCNH5 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNH5 available from Tocris Bioscience
    CompoundAction CAS number
    AM 92016 hydrochlorideKV channel blocker[178894-81-0]
    KN-93CaM kinase II inhibitor. Also K+ channel blocker (KV)[139298-40-1]
    SG 209K+ channel opener; vasodilator[83440-03-3]
    4-AminopyridineNon-selective KV channel blocker[504-24-5]
    About this table


    1 Novoseek chemical compound relationship for KCNH5 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 32.1 1 11943152 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for KCNH5
    Sigma-Aldrich shRNA Panels and shRNA for KCNH5
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): KCNH5
    OriGene shRNA RFP (see all 3): KCNH5
    OriGene basic RS shRNA (see all 3): KCNH5
    OriGene siRNA (see all 3): KCNH5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KCNH5 
    miRNA: Sigma-Aldrich microRNA Mimics for KCNH5
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KCNH5 
    Search SABiosciences for Assays for microRNAs that regulate KCNH5
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): KCNH5
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): KCNH5
    OriGene untagged cDNA clones in CMV expression vector (see all 5): KCNH5
    OriGene 3'-UTR Clone (see all 3): KCNH5 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 3): KCNH5 
    Primers: OriGene genome-wide validated SYBR primer pairs: KCNH5
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for KCNH5: PPH08723A

    REFSEQ mRNAs for KCNH5 gene (3 alternative transcripts): 

    NM_139318.3  NM_172375.1  NM_172376.1  

    Additional cDNA sequence: 

    AF418206.1 AF472412.1 AF493798.1 BC043409.2 BC073979.1 

    4 DOTS entries:

    DT.100018940  DT.100018941  DT.97819289  DT.100741448 

    19 AceView cDNA sequences:

    AF493798 NM_172376 AF472412 F01716 AW628656 NM_172375 NM_139318 Z38438 
    AF418206 F05455 BC073979 U69185 BX281706 F05456 AK074484 BC043409 
    CD636893 CD636891 BQ439615 

    highest scoring ESTs for KCNH5:

    AF418206 AF472412 AF493798 BC043409 BQ439615 BX281706 U69185 AK074484 AW628656 BC073979 

    Unigene Cluster for KCNH5:

    Potassium voltage-gated channel, subfamily H (eag-related), member 5
    Hs.27043  [show with all ESTs]
    Unigene Representative Sequence: BC073979


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KCNH5

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:              -     -                                         -                                       
    SP2:                                                              -                       -               
    SP3:                                                              -                 -     -               
    SP4:              -     -                                                                                 

    About this scheme

    ECgene alternative splicing isoforms for KCNH5
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394964 ENST00000322893(uc001xfx.2 uc001xfy.2) ENST00000453406(uc001xga.2)
    ENST00000420622 ENST00000453834 ENST00000394968(uc001xfz.1)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    KCNH5 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching KCNH5 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    47008_at2, 3 U95-B 1 0.94 1.00 1.00 1.00 U69185 0.80 1.00 0.91 1
    242502_at2, 3 U133-B 1 0.91 1.00 -- -- AW628656 0.60 1.00 0.82 1
    1555074_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    1555304_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    242502_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table

    KCNH5 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    KCNH5 gene expression
    KCNH5 gene electronic northern expression
    KCNH5 gene sage expression
    About these images

    CGAP SAGE TAG: TCAGGATATT

    SOURCE GeneReport for Unigene cluster: Hs.27043

    UniProtKB/Swiss-Prot: KCNH5_HUMAN, Q8NCM2
    Tissue specificity: Detected in brain, skeletal muscle, heart, placenta, lung and liver, and at low levels in kidney

    Primers: OriGene genome-wide validated SYBR primer pairs: KCNH5
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for KCNH5: PPH08723A
        SABiosciences Custom PCR Arrays for KCNH5 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for KCNH5 gene from 5/11 species (see all 11)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    KCNH51   -- potassium voltage-gated channel, subfamily H (eag-related), more 93.86(n)
    99.09(a)
    490724  XM_547846.2  XP_547846.2 
    chimpanzee
    (Pan troglodytes)
    KCNH51   -- potassium voltage-gated channel, subfamily H (eag-related), more 99.59(n)
    99.8(a)
    467476  XM_522873.2  XP_522873.2 
    cow
    (Bos taurus)
    KCNH51   -- potassium voltage-gated channel, subfamily H (eag-related), more 93.72(n)
    99.09(a)
    537813  XM_864922.2  XP_870015.1 
    rat
    (Rattus norvegicus)
    Kcnh51   -- potassium voltage-gated channel, subfamily H (eag-related), more 91.4(n)
    98.28(a)
    171146  NM_133610.1  NP_598294.1 
    mouse
    (Mus musculus)
    Kcnh51 , 5 12 (32.62 cM)5
    potassium voltage-gated channel, subfamily H (eag-related), more1, 5 91.33(n)1
    97.98(a)1
    2382711  NM_172805.21  NP_766393.11 
     AF3095655  AK0324385  (see all 6)
    About this table        Species with no ortholog for KCNH5

    ENSEMBL Gene Tree for KCNH5 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for KCNH5 gene
    KCNH62  KCNH22  KCNH72  KCNH42  KCNH32  KCNH82  KCNH12  

    KCNH5 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/3705 NCBI SNPs in KCNH5 are shown (see all 3705)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 14 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs1714561,2
    --63283731(-) aagttC/Taataa 3 -- int10--------
    rs1714571,2
    C,F,A,63305545(-) TTACTC/TTTTCC 3 -- int112Minor allele frequency- T:0.44NS EA NA WA 632
    rs1714581,2
    H63289687(+) ATACCG/AAAATA 3 -- int14Minor allele frequency- A:0.00NS EA 418
    rs1714591,2
    C,F,H,63289179(+) tatacC/Gaacac 3 -- int116Minor allele frequency- G:0.28NS EA NA WA 1018
    rs1733761,2
    --63281458(-) agtggG/Tgtgaa 3 -- int10--------
    rs1816841,2
    C,H,63253094(-) TGAAGC/GCATGG 3 -- int110Minor allele frequency- G:0.00NS EA NA WA 432
    rs1836091,2
    --63281479(-) ttgtcG/Tcccag 3 -- int10--------
    rs1836101,2
    C63281334(-) tagtaG/Tagata 3 -- int11Minor allele frequency- A:0.50NA 2
    rs1848401,2
    --63281125(-) CTGTTA/TTTTAG 3 -- int10--------
    rs1896291,2
    --63256192(-) atagtA/Cctact 3 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for KCNH5 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for KCNH5
         3 CNVs: 76655 76654 101968
         1 Indel: 71910

    QIAGEN SeqTarget long-range PCR primers for resequencing KCNH5 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KCNH5 for disorders           About GeneDecksing

    OMIM: 605716

    Human Genome Epidemiology (HuGE) Navigator: KCNH5 (3 documents)

    Export disorders and mutations for KCNH5 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/19 PubMed articles for KCNH5 gene, integrated from 7 sources (see all 19):
    (articles sorted by number of sources associating them with KCNH5)
    1. Functional distinction of human EAG1 and EAG2 potassium channels. (PubMed id 11943152)1, 2, 7 Schoenherr R.... Heinemann S.H. (2002)
    2. Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells. (PubMed id 18655026)1, 2 Tan F....Peng X. (2008)
    3. International Union of Pharmacology. LIII. Nomenclatu re and molecular relationships of voltage-gated potassium channels. (PubMed id 16382104)1, 3 Gutman G.A....Wang X. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Molecular identification and characterisation of the human eag2 potassium channel. (PubMed id 12135768)1, 2 Ju M. and Wray D. (2002)
    7. Cloning of a human ether-a-go-go potassium channel expressed in myoblasts at the onset of fusion. (PubMed id 9738473)1, 3 Occhiodoro T.... Fischer-Lougheed J. (1998)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analy sis among pharmacogenomics, mouse expression, and genetic case-control associat ion approaches. (PubMed id 19850283)1 Ikeda M....Iwata N. (2010)
    10. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1 Flachsbart F....Nebel A. (2010 Dec 10)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27133 HGNC: 6254 AceView: KCNH5 Ensembl:ENSG00000140015 euGenes: HUgn27133
    ECgene: KCNH5 H-InvDB: KCNH5

    (According to HUGE)
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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