Aliases &
Descriptions
for KCNJ11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| potassium inwardly-rectifying channel, subfamily J, member 111 2 | | Kir6.21 | | BIR1 2 5 | | inwardly rectifying potassium channel KIR6.22 | | Potassium channel, inwardly rectifying subfamily J member 112 3 | | ATP-sensitive inward rectifier potassium channel 112 | | Inward rectifier K(+) channel Kir6.22 3 | | potassium channel inwardly rectifing subfamily J member 112 | | IKATP2 3 | | beta-cell inward rectifier subunit2 | | TNDM32 5 | | KIR6.22 | | HHF22 5 | | MGC1332302 | | PHHI2 5 | | |
Export aliases for KCNJ11 gene to outside databasesPrevious GC identifers: GC11M018547 GC11M018350 GC11M017446 GC11M017372 GC11M017371 GC11M017363 |
Summaries
for KCNJ11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KCNJ11:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologicresponses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassiumchannel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of acell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this geneare a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disordercharacterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominantnon-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), andpermanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode differentprotein isoforms have been described for this gene. (provided by RefSeq)
UniProtKB/Swiss-Prot: IRK11_HUMAN, Q14654Function: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greatertendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by theconcentration of extracellular potassium; as external potassium is raised, the voltage range of the channel openingshifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current byinternal magnesium. Can be blocked by extracellular barium (By similarity)
 summary
for KCNJ11: The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong
inward-rectifier channels (KIR2.x), the G-protein-activated inward-rectifier channels (KIR3.x) and the
ATP-sensitive channels (KIR6.x, which combine with sulphonylurea receptors (SUR)). Structurally, the
pore-forming subunit of KIR channels is the alpha-subunit. It contains a single pore domain between two
membrane spanning regions. Four alpha-subunits combine to form a tetramer, with the pore domain of each
subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within
subfamilies, e.g. KIR3.2 with KIR3.3.
Gene Wiki entry for KCNJ11 (Kir6.2) |
Genomic Views
for KCNJ11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCNJ11 gene promoter:
NF-kappaB1 HNF-4alpha2 COUP-TF1 NF-kappaB GR-alpha MEF-2A Oct-B1 oct-B2 oct-B3 POU2F1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KCNJ11
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for KCNJ11  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.1 Ensembl cytogenetic band: 11p15.1 HGNC cytogenetic band: 11p15.1KCNJ11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M017090: view genomic region
(about GC identifiers)
Start:
|
17,090,617 bp from pter |
End:
|
17,094,700 bp from pter |
Size:
|
4,084 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr11- 17,406,798-17,410,206 |
RefSeq DNA sequence:- NC_000011.9 NT_009237.18
|
Proteins
for KCNJ11 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: IRK11_HUMAN, Q14654 (See
protein sequence)Recommended Name: ATP-sensitive inward rectifier potassium channel 11 Size: 390 amino acids; 43541 Da
Subunit: Interacts with ABCC8/SUR
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q2M1H7 Q58EX3Explore the universe of human proteins at neXtProt for KCNJ11: NX_Q14654
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_000516.3 NP_001159762.1
ENSEMBL proteins: ENSP00000345708
Human Recombinant Proteins
5/8 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 8): About this table
KCNJ11 for ontologies About GeneDecksing
Antibodies for KCNJ11:
Assays for KCNJ11: |
Protein
Domains/
Families
for KCNJ11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KCNJ11 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q14654ProtoNet protein and cluster: Q14654 2 Blocks protein families: IPB001838 Inward rectifier K+ channel superfamily signature IPB003279 Kir6.2 inward rectifier K+ channel signature
UniProtKB/Swiss-Prot: IRK11_HUMAN, Q14654Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily |
Gene Function
for KCNJ11 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: IRK11_HUMAN, Q14654Function: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greatertendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by theconcentration of extracellular potassium; as external potassium is raised, the voltage range of the channel openingshifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current byinternal magnesium. Can be blocked by extracellular barium (By similarity)
Genatlas biochemistry entry for KCNJ11:potassium non voltage-gated channel,weakly inwardly rectifying,member 11,component with SUR1 of an ATP dependentpotassium channel,expressed in pancreatic islet,beta cell5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
KCNJ11 for ontologies About GeneDecksing
Animal Models: 5 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Kcnj11):
KCNJ11 for phenotypes About GeneDecksing
|
Pathways & Interactions
for KCNJ11 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
KCNJ11 for pathways About GeneDecksing
3  Millipore Pathways for KCNJ11
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for KCNJ11
1  Kegg Pathway (Kegg details for KCNJ11):
SABiosciences Pathway-Focused PCR Array including KCNJ11: PAHS-036A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for KCNJ11
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNJ11
5/9 Interacting proteins for KCNJ11 (ENSP000003457083) via UniProtKB, MINT, and/or STRING (see all 9)About this table
5/12 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 12): About this table
KCNJ11 for ontologies About GeneDecksing
|
Drugs & Compounds
for KCNJ11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
KCNJ11 for compounds About GeneDecksing
Compounds for KCNJ11 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| Repaglinide | KATP channel blocker | [135062-02-1] | | Diazoxide | Blocks desensitization of AMPA receptors | [364-98-7] | | Y-27152 | Prodrug of KATP channel opener Y-26763; orally active in vivo | [127408-30-4] | | ZM 226600 | KATP channel opener | [147695-92-9] | | PNU 37883 hydrochloride | Vascular KATP channel blocker | [57568-80-6] |
About this table
10/26  Novoseek chemical compound relationships for KCNJ11 gene (see all 26)
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| katp |
95.3 |
230 |
9326676 (4), 15380676 (4), 14739809 (3), 10049691 (3) (see all 99) |
| sulfonylurea |
95.3 |
145 |
17213273 (4), 17047922 (4), 18548275 (3), 8607800 (3) (see all 99) |
| potassium |
84 |
151 |
8607800 (3), 10559219 (2), 9356020 (1), 9867219 (1) (see all 99) |
| mgadp |
82.1 |
11 |
11585851 (2), 10833411 (1), 9756869 (1), 18008114 (1) (see all 6) |
| diazoxide |
81.9 |
3 |
20164212 (1), 9756869 (1), 18596924 (1) |
| glibenclamide |
76.7 |
18 |
9458745 (2), 12145099 (2), 17659066 (2), 15678092 (2) (see all 11) |
| tolbutamide |
74.7 |
3 |
15562009 (1), 9032110 (1), 8897013 (1) |
| atp |
65.8 |
96 |
10545134 (4), 11585851 (4), 10049691 (3), 9763630 (3) (see all 53) |
| repaglinide |
65.7 |
9 |
15678092 (4), 18664331 (1), 11440368 (1) |
| glucose |
56.8 |
41 |
11145575 (5), 15579791 (3), 12351459 (2), 9032110 (2) (see all 21) |
About this table
2 PharmGKB drug compound relationships for KCNJ11 geneAbout this table
|
Transcripts
for KCNJ11 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for KCNJ11 gene (2 alternative transcripts): NM_000525.3 NM_001166290.1 Additional cDNA sequence: AK301550.1 AK314943.1 BC040617.1 BC064497.1 BC112358.1 3 DOTS entries: DT.91981566 DT.100749583 DT.95194885 24 AceView cDNA sequences: NM_000525 AA679741 BX281091 AI377272 BM546966 BM676395 CA778121 CB112941 BU738791 BQ711583 BQ917358 BM713280 BC064497 CA777857 BC040617 BE019467 BE294700 BM480315 BG394461 BE253084 AI792302 F21303 BF842095 AI313045
 highest scoring ESTs for KCNJ11:AI792302 BC064497 BE019467 BE159475 BE253084 BE294700 BF842095 BG394461 BM480315 BX281091 Unigene Cluster for KCNJ11: Potassium inwardly-rectifying channel, subfamily J, member 11 Hs.248141 [show with all ESTs]Unigene Representative Sequence: NM_000525
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for KCNJ11
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
|---|
|
| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for KCNJ11
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000339994(uc001mna.2 uc001mnb.3)
|
Expression
for KCNJ11 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| KCNJ11 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching KCNJ11 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 67681_at2, 3
|
U95-D |
1 |
0.75 |
1.00 |
1.00 |
1.00 |
AI377272 |
0.60 |
1.00 |
0.82 |
1 |
| 231740_at2, 3
|
U133-B |
1 |
0.91 |
1.00 |
-- |
-- |
NM_000525 |
0.60 |
1.00 |
0.82 |
1 |
| 231740_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
KCNJ11 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CTGAGGAAAC
SOURCE GeneReport for Unigene cluster: Hs.248141
SABiosciences Expression via Pathway-Focused PCR Array including KCNJ11: PAHS-036A
|
Orthologs
for KCNJ11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KCNJ11 gene from 5/7 species (see all 7)
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
dog
(Canis familiaris) |
KCNJ111 |
-- |
potassium inwardly-rectifying channel, subfamily J, more |
91.54(n)
96.92(a) |
485401 XM_542519.2 XP_542519.1 |
chimpanzee
(Pan troglodytes) |
KCNJ111 |
-- |
potassium inwardly-rectifying channel, subfamily J, more |
98.97(n)
98.97(a) |
466450 XM_521849.2 XP_521849.2 |
cow
(Bos taurus) |
KCNJ111 |
-- |
potassium inwardly-rectifying channel, subfamily J, more |
91.49(n)
95.1(a) |
532060 XM_610569.3 XP_610569.3 |
rat
(Rattus norvegicus) |
Kcnj111 |
-- |
potassium inwardly rectifying channel, subfamily J, more |
88.55(n)
96.15(a) |
83535 NM_031358.3 NP_112648.2 |
mouse
(Mus musculus) |
Kcnj111 , 5 |
7 (29.66 cM)5
|
potassium inwardly rectifying channel, subfamily J, more1, 5 |
89.4(n)1
95.9(a)1 |
165141 NM_010602.21 NP_034732.11
AF0373135 AI8427225 (see all 13) |
About this table Species with no ortholog for KCNJ11
ENSEMBL Gene Tree for KCNJ11 (if available) |
Paralogs
for KCNJ11 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for KCNJ11 gene
- KCNJ102 KCNJ162 KCNJ12 KCNJ82 KCNJ152 KCNJ132
KCNJ11 for paralogs About GeneDecksing
|
Genomic Variants
for KCNJ11 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 11 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for KCNJ11 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for KCNJ11
7 CNVs: 48756 2165 48754 48755 48757 48753 48752 | | QIAGEN SeqTarget long-range PCR primers for resequencing KCNJ11 |
|
Disorders & Mutations
for KCNJ11 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KCNJ11 for disorders About GeneDecksing
OMIM: 600937 disorders: 601820 606176 125853 610582 UniProtKB/Swiss-Prot: IRK11_HUMAN, Q14654
Defects in KCNJ11 are the cause of familial hyperinsulinemic hypoglycemia type 2 (HHF2) [MIM:601820]; alsoknown as persistent hyperinsulinemic hypoglycemia of infancy (PPHI) or congenital hyperinsulinism. HHF is the mostcommon cause of persistent hypoglycemia in infancy and is due to defective negative feedback regulation of insulinsecretion by low glucose levels. It causes nesidioblastosis, a diffuse abnormality of the pancreas in which there isextensive, often disorganized formation of new islets. Unless early and aggressive intervention is undertaken, braindamage from recurrent episodes of hypoglycemia may occur Defects in KCNJ11 are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:606176]. PNDM is a rare formof diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized byinsulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetesrequires lifelong therapy Defects in KCNJ11 are the cause of transient neonatal diabetes mellitus type 3 (TNDM3) [MIM:610582]. Neonataldiabetes mellitus, defined as insulin-requiring hyperglycemia within the first month of life, is a rare entity. Inabout half of the neonates, diabetes is transient and resolves at a median age of 3 months, whereas the rest have apermanent form of diabetes. In a significant number of patients with transient neonatal diabetes mellitus, diabetestype 2 appears later in life. The onset and severity of TNDM3 is variable with childhood-onset diabetes, gestationaldiabetes or adult-onset diabetes described Defects in KCNJ11 may contribute to non-insulin-dependent diabetes mellitus (NIDDM), also known as diabetesmellitus type 2
10/20 Novoseek disease relationships for KCNJ11 gene (see all 20)
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| neonatal diabetes mellitus |
94.1 |
31 |
17491708 (2), 19169493 (2), 17659066 (2), 20220270 (2) (see all 18) |
| hyperinsulinism |
93.8 |
46 |
15579781 (2), 18767144 (2), 17451083 (2), 16332676 (2) (see all 25) |
| hypoglycemia |
80.7 |
17 |
16142506 (2), 10615958 (1), 19214942 (1), 10334322 (1) (see all 11) |
| developmental delay |
68.2 |
9 |
16670688 (2), 17047922 (2), 16375017 (1), 17890419 (1) (see all 7) |
| hyperammonemia |
53.8 |
1 |
17003566 (1) |
| insulinoma |
53.6 |
3 |
10928959 (1), 8549751 (1) |
| niddm |
48.4 |
28 |
9032110 (3), 9032109 (3), 8549873 (2), 11318841 (2) (see all 14) |
| diabetes mellitus |
39.9 |
8 |
17890419 (1), 11424233 (1), 18767144 (1), 8607800 (1) (see all 6) |
| hyperinsulinemia |
34.3 |
1 |
16416420 (1) |
| epilepsy |
30.8 |
7 |
16670688 (2), 16375017 (1), 16339180 (1), 17635943 (1) (see all 6) |
About this table
GeneTests: KCNJ11
Familial Hyperinsulinism
Human Gene Mutation Database (HGMD): KCNJ11
Genetic Association Database (GAD): KCNJ11
Human Genome Epidemiology (HuGE) Navigator: KCNJ11 (122 documents)
Export disorders and mutations for KCNJ11 gene to outside databases
|
Medical News
for KCNJ11 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for KCNJ11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/458 PubMed articles for KCNJ11 gene, integrated from 7 sources (see all 458):
(articles sorted by number of sources associating them with KCNJ11)- Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor. (PubMed id 7502040)1, 2, 3, 5, 7 Inagaki N.... Bryan J. (1995)
- Sequence variations in the human Kir6.2 gene, a subunit of the beta- cell ATP-sensitive K-channel: no association with NIDDM in white Caucasian subjects or evidence of abnormal function when expressed in vitro. (PubMed id 8897013)1, 2, 4, 7 Sakura H.... Ashcroft F.M. (1996)
- Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. (PubMed id 15115830)1, 2, 4, 7 Gloyn A.L....Hattersley A.T. (2004)
- A novel KCNJ11 mutation associated with congenital hyperinsulinism reduces the intrinsic open probability of beta-cell ATP-sensitive potassium channels. (PubMed id 16332676)1, 2, 7 Lin Y.-W.... Shyng S.-L. (2006)
- The C42R mutation in the Kir6.2 (KCNJ11) gene as a cause of transient neonatal diabetes, childhood diabetes, or later-onset, apparently type 2 diabetes mellitus. (PubMed id 15784703)1, 2, 7 Yorifuji T.... Nakahata T. (2005)
- Mutation of the pancreatic islet inward rectifier Kir6.2 also leads to familial persistent hyperinsulinemic hypoglycemia of infancy. (PubMed id 8923010)1, 2, 7 Thomas P.... Lightner E. (1996)
- Prevalence of permanent neonatal diabetes in Slovakia and successful replacement of insulin with sulfonylurea therapy in KCNJ11 and ABCC8 mutation carriers. (PubMed id 17213273)1, 2, 7 Stanik J.... Klimes I. (2007)
- Mutations at the same residue (R50) of Kir6.2 (KCNJ11) that cause neonatal diabetes produce different functional effects. (PubMed id 16731833)1, 2, 7 Shimomura K....Ashcroft F.M. (2006)
- KCNJ11 activating mutations in Italian patients with permanent neonatal diabetes. (PubMed id 15580558)1, 2, 7 Massa O.... Barbetti F. (2005)
- Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study. (PubMed id 15579791)1, 4, 7 Laukkanen O....Laakso M. (2004)
|
External Searches for KCNJ11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KCNJ11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing KCNJ11 gene
(According to HUGE)
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Specialized Databases showing KCNJ11 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/KCNJ11 |
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| Patent Information for KCNJ11 gene:
Search GeneIP for patents involving KCNJ11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for KCNJ11 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
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