Aliases &
Descriptions
for KCNJ14 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| potassium inwardly-rectifying channel, subfamily J, member 141 2 | | Kir2.41 | | IRK41 2 3 | | inwardly rectifying potassium channel KIR2.42 | | Inward rectifier K(+) channel Kir2.42 3 | | ATP-sensitive inward rectifier potassium channel 142 | | Potassium channel, inwardly rectifying subfamily J member 142 3 | | KIR2.42 | | IRK-42 3 | | MGC461112 |
Export aliases for KCNJ14 gene to outside databasesPrevious GC identifers: GC19P049603 GC19P049318 GC19P053634 GC19P053650 GC19P048958 |
Summaries
for KCNJ14 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KCNJ14:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologicresponses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassiumchannel, and probably has a role in controlling the excitability of motor neurons. Two transcript variants encodingthe same protein have been found for this gene. (provided by RefSeq)
UniProtKB/Swiss-Prot: IRK14_HUMAN, Q9UNX9Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow intothe cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium;as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inwardrectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise tolow-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity)
 summary
for KCNJ14: The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong
inward-rectifier channels (KIR2.x), the G-protein-activated inward-rectifier channels (KIR3.x) and the
ATP-sensitive channels (KIR6.x, which combine with sulphonylurea receptors (SUR)). Structurally, the
pore-forming subunit of KIR channels is the alpha-subunit. It contains a single pore domain between two
membrane spanning regions. Four alpha-subunits combine to form a tetramer, with the pore domain of each
subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within
subfamilies, e.g. KIR3.2 with KIR3.3.
Gene Wiki entry for KCNJ14 |
Genomic Views
for KCNJ14 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCNJ14 gene promoter:
GR-alpha GR-beta RFX1 MIF-1 AhR YY1 C/EBPalpha c-Jun ATF-2 c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for KCNJ14
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for KCNJ14  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13KCNJ14 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P045338: view genomic region
(about GC identifiers)
Start:
|
45,338,959 bp from pter |
End:
|
45,349,560 bp from pter |
Size:
|
10,602 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr19+ 48,958,766-48,969,367 |
RefSeq DNA sequence:- NC_000019.9 NT_011109.16
|
Proteins
for KCNJ14 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: IRK14_HUMAN, Q9UNX9 (See
protein sequence)Recommended Name: ATP-sensitive inward rectifier potassium channel 14 Size: 436 amino acids; 47846 Da
Subcellular location: Membrane; Multi-pass membrane proteinExplore the universe of human proteins at neXtProt for KCNJ14: NX_Q9UNX9
REFSEQ proteins (2 alternative transcripts):
NP_037480.1 NP_733838.1
ENSEMBL proteins: ENSP00000341479 ENSP00000375756
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
KCNJ14 for ontologies About GeneDecksing
Antibodies for KCNJ14:
Assays for KCNJ14: |
Protein
Domains/
Families
for KCNJ14 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KCNJ14 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UNX9ProtoNet protein and cluster: Q9UNX9 1 Blocks protein family: IPB001838 Inward rectifier K+ channel superfamily signature
UniProtKB/Swiss-Prot: IRK14_HUMAN, Q9UNX9Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ14 subfamily |
Gene Function
for KCNJ14 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: IRK14_HUMAN, Q9UNX9Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow intothe cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium;as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inwardrectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise tolow-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity)
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005242 | inward rectifier potassium channel activity |
IEA | -- | | GO:0005244 | voltage-gated ion channel activity |
IEA | -- |
About this table
KCNJ14 for ontologies About GeneDecksing
|
Pathways & Interactions
for KCNJ14 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
KCNJ14 for pathways About GeneDecksing
1  Millipore Pathway for KCNJ14
SABiosciences Custom Pathway-Focused PCR Arrays for KCNJ14
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNJ14
5/40 Interacting proteins for KCNJ14 (ENSP000003414793) via UniProtKB, MINT, and/or STRING (see all 40)About this table
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006811 | ion transport |
IEA | -- | | GO:0006813 | potassium ion transport |
IEA | -- |
About this table
KCNJ14 for ontologies About GeneDecksing
|
Drugs & Compounds
for KCNJ14 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for KCNJ14 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| Tertiapin-Q | Potent, selective blocker of inward-rectifier K+ channels | [252198-49-5] |
About this table
|
Transcripts
for KCNJ14 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for KCNJ14 gene (2 alternative transcripts): NM_013348.2 NM_170720.1 Additional cDNA sequence: BC042033.1 7 DOTS entries: DT.100019103 DT.426097 DT.91651388 DT.121429597 DT.308230 DT.97803483 DT.100845723 24/265 AceView cDNA sequences (see all 265): CR610853 BM834291 BM695721 AW300643 CB142128 CR598477 NM_017457 BU158112 BQ928509 AI082799 CR623405 CR607678 BM467438 CR593517 BM684176 BU196477 BC002440 NM_013348 AI589442 CR591768 BU849942 CR600368 BM553464 BF725832
 highest scoring ESTs for KCNJ14:AA504857 AA504908 AA641102 AA908950 AF081466 AI082799 AI208672 BC035918 BM710116 BM713631 Unigene Clusters for KCNJ14: Potassium inwardly-rectifying channel, subfamily J, member 14 Hs.590945 [show with all ESTs], Hs.644912 [show with all ESTs]Unigene Representative Sequences: NM_170720, BM553927
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000342291(uc002pje.1) ENST00000391884(uc002pjf.1)
|
Expression
for KCNJ14 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| KCNJ14 expression in normal and diseased human tissues
1 / 2 / 3 2 probe-sets matching KCNJ14 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 220776_at2, 3
|
U133-A |
1 |
0.46 |
1.00 |
-- |
-- |
NM_013348 |
0.60 |
1.00 |
0.82 |
1 |
| 220776_at2
|
U133Plus2 |
1 |
0.46 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AAGAGGAGTC GACATACTGG
SOURCE GeneReport for Unigene clusters: Hs.590945 Hs.644912
UniProtKB/Swiss-Prot: IRK14_HUMAN, Q9UNX9Tissue specificity: Expressed preferentially in retina
SABiosciences Custom PCR Arrays for KCNJ14
|
Orthologs
for KCNJ14 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KCNJ14 gene from 5/8 species (see all 8)
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
dog
(Canis familiaris) |
KCNJ141 |
-- |
potassium inwardly-rectifying channel, subfamily J, more |
92.59(n)
95.6(a) |
612053 XM_849781.1 XP_854874.1 |
chimpanzee
(Pan troglodytes) |
KCNJ141 |
-- |
potassium inwardly-rectifying channel, subfamily J, more |
99.62(n)
99.77(a) |
468940 XM_524325.2 XP_524325.1 |
cow
(Bos taurus) |
KCNJ141 |
-- |
potassium inwardly-rectifying channel, subfamily J, more |
91.17(n)
94.7(a) |
540740 XM_612893.3 XP_612893.1 |
rat
(Rattus norvegicus) |
Kcnj141 |
-- |
potassium inwardly-rectifying channel, subfamily J, more |
87.71(n)
94.47(a) |
276720 NM_170718.1 NP_733836.1 |
mouse
(Mus musculus) |
Kcnj141 , 5 |
7 (29.53 cM)5
|
potassium inwardly-rectifying channel, subfamily J, more1, 5 |
88.25(n)1
94.7(a)1 |
2114801 NM_145963.21 NP_666075.11
AK0307115 AK0447255 (see all 11) |
About this table Species with no ortholog for KCNJ14
ENSEMBL Gene Tree for KCNJ14 (if available) |
Paralogs
for KCNJ14 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for KCNJ14 gene
- KCNJ42 KCNJ92 KCNJ22 KCNJ122 KCNJ32 KCNJ52 KCNJ62
KCNJ14 for paralogs About GeneDecksing
|
Genomic Variants
for KCNJ14 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 19 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for KCNJ14 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KCNJ14
1 CNV: 32261 | | QIAGEN SeqTarget long-range PCR primers for resequencing KCNJ14 |
|
Disorders & Mutations
for KCNJ14 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KCNJ14 for disorders About GeneDecksing
OMIM: 603953
Human Genome Epidemiology (HuGE) Navigator: KCNJ14 (1 document)
Export disorders and mutations for KCNJ14 gene to outside databases
|
Medical News
for KCNJ14 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for KCNJ14 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/13 PubMed articles for KCNJ14 gene, integrated from 7 sources (see all 13):
(articles sorted by number of sources associating them with KCNJ14)- Cloning, structure and assignment to chromosome 19q13 of the human Kir2.4 inwardly rectifying potassium channel gene (KCNJ14). (PubMed id 10723734)1, 2, 3, 7 Toepert C.... Karschin A. (2000)
- International Union of Pharmacology. LIV. Nomenclatur e and molecular relationships of inwardly rectifying potassium channels. (PubMed id 16382105)1, 3 Kubo Y....Vandenberg C.A. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cloning and functional expression of human retinal Kir2.4, a pH- sensitive inwardly rectifying K+ channel. (PubMed id 10942728)1, 2 Hughes B.A.... Swaroop A. (2000)
- Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei. (PubMed id 9592090)1, 3 Topert C....Karschin A. (1998)
- Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2. (PubMed id 15958527)1, 7 Fang Y....Levitan I. (2005)
- L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1 Yokoyama K....Hosoya T. (2010)
- Rare independent mutations in renal salt handling genes contribute to blood pressure variation. (PubMed id 18391953)1 Ji W....Lifton R.P. (2008)
- Functional expression of inward rectifier potassium channels in cultured human pulmonary smooth muscle cells: evidence for a major role of Kir2.4 subunits. (PubMed id 17347781)1 Tennant B.P....Clapp L.H. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for KCNJ14 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KCNJ14 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KCNJ14 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCNJ14 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for KCNJ14 gene:
Search GeneIP for patents involving KCNJ14
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KCNJ14 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
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