Aliases &
Descriptions
for KCNJ16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| potassium inwardly-rectifying channel, subfamily J, member 161 2 | | Kir5.11 | | BIR91 2 | | inward rectifier K+ channel KIR5.12 | | Inward rectifier K(+) channel Kir5.12 3 | | inward rectifier potassium channel 162 | | Potassium channel, inwardly rectifying subfamily J member 162 3 | | MGC337172 | | KIR5.12 5 | | |
Export aliases for KCNJ16 gene to outside databasesPrevious GC identifers: GC17P067826 GC17P071031 GC17P068535 GC17P068668 GC17P065583 GC17P068071 |
Summaries
for KCNJ16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KCNJ16:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologicresponses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassiumchannel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of acell, can form heterodimers with two other inward-rectifier type potassium channels. It may be involved in theregulation of fluid and pH balance. Three transcript variants encoding the same protein have been found for this gene.(provided by RefSeq)
UniProtKB/Swiss-Prot: IRK16_HUMAN, Q9NPI9Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow intothe cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium;as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inwardrectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in theregulation of fluid and pH balance
 summary
for KCNJ16: The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong
inward-rectifier channels (KIR2.x), the G-protein-activated inward-rectifier channels (KIR3.x) and the
ATP-sensitive channels (KIR6.x, which combine with sulphonylurea receptors (SUR)). Structurally, the
pore-forming subunit of KIR channels is the alpha-subunit. It contains a single pore domain between two
membrane spanning regions. Four alpha-subunits combine to form a tetramer, with the pore domain of each
subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within
subfamilies, e.g. KIR3.2 with KIR3.3.
Gene Wiki entry for KCNJ16 |
Genomic Views
for KCNJ16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCNJ16 gene promoter:
MEF-2A Arnt ATF-2 Max1 PPAR-gamma2 PPAR-gamma1 HNF-1A TGIF XBP-1 HNF-4alpha2
Other transcription factors
Search SABiosciences Chromatin IP Primers for KCNJ16
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q24.3 Ensembl cytogenetic band: 17q24.3 HGNC cytogenetic band: 17q24.3KCNJ16 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P063457: view genomic region
(about GC identifiers)
Start:
|
63,457,621 bp from pter |
End:
|
63,518,274 bp from pter |
Size:
|
60,654 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr17+ 68,071,426-68,131,744 |
RefSeq DNA sequence:- NC_000017.10 NT_010783.15
|
Proteins
for KCNJ16 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: IRK16_HUMAN, Q9NPI9 (See
protein sequence)Recommended Name: Inward rectifier potassium channel 16 Size: 418 amino acids; 47949 Da
Subunit: Seems to form heterodimer with Kir4.1/KCNJ10 or Kir2.1/KCNJ2
Subcellular location: Membrane; Multi-pass membrane proteinExplore the universe of human proteins at neXtProt for KCNJ16: NX_Q9NPI9
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (3 alternative transcripts):
NP_061128.1 NP_733937.1 NP_733938.1
ENSEMBL proteins: ENSP00000283936 ENSP00000376439 ENSP00000376438
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
KCNJ16 for ontologies About GeneDecksing
Antibodies for KCNJ16:
Assays for KCNJ16: |
Protein
Domains/
Families
for KCNJ16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KCNJ16 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9NPI9ProtoNet protein and cluster: Q9NPI9 2 Blocks protein families: IPB001838 Inward rectifier K+ channel superfamily signature IPB008061 Kir5 inward rectifier K+ channel signature
UniProtKB/Swiss-Prot: IRK16_HUMAN, Q9NPI9Similarity: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ16 subfamily |
Gene Function
for KCNJ16 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: IRK16_HUMAN, Q9NPI9Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow intothe cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium;as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inwardrectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in theregulation of fluid and pH balance
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005242 | inward rectifier potassium channel activity |
NAS | 11060447 | | GO:0005244 | voltage-gated ion channel activity |
IEA | -- |
About this table
KCNJ16 for ontologies About GeneDecksing
Animal Models: 1 MGI phenotypic allele  for Kcnj16 (no phenotypes)
KCNJ16 for phenotypes About GeneDecksing
|
Pathways & Interactions
for KCNJ16 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
KCNJ16 for pathways About GeneDecksing
1  Millipore Pathway for KCNJ16
1  Kegg Pathway (Kegg details for KCNJ16):
SABiosciences Custom Pathway-Focused PCR Arrays for KCNJ16
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCNJ16
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
KCNJ16 for ontologies About GeneDecksing
|
Drugs & Compounds
for KCNJ16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for KCNJ16 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| Tertiapin-Q | Potent, selective blocker of inward-rectifier K+ channels | [252198-49-5] |
About this table
|
Transcripts
for KCNJ16 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for KCNJ16 gene (3 alternative transcripts): NM_018658.1 NM_170741.1 NM_170742.1 Additional cDNA sequence: AF153815.1 AF153816.1 AF153817.1 AF179353.1 AK225944.1 AK290799.1 BC033038.2 8 DOTS entries: DT.314490 DT.100747413 DT.95370381 DT.121011065 DT.121011080 DT.121011067 DT.75181134 DT.91858856 24/107 AceView cDNA sequences (see all 107): AF153816 AI925563 NM_170742 AF153817 AI051637 BF197355 AI151022 AF179353 AI419663 AA748747 AI672450 BE167251 AI253080 NM_018658 BF194884 AF153815 N90543 AI949950 AW271344 BU784888 AI092303 AW611744 AI217331 AI650798
 highest scoring ESTs for KCNJ16:AA846603 AI636030 AA700514 AA724359 AA725284 AA725475 AA757330 AA845511 AA846348 AA846606 Unigene Cluster for KCNJ16: Potassium inwardly-rectifying channel, subfamily J, member 16 Hs.463985 [show with all ESTs]Unigene Representative Sequence: NM_170742
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for KCNJ16 (see all 8)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e | · | 9f |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | - | | - | | | | - | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | | | - | | | | - | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for KCNJ16
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000283936(uc002jin.2) ENST00000392671(uc002jio.2 uc002jiq.2)
ENST00000392670(uc002jip.2)
|
Expression
for KCNJ16 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| KCNJ16 expression in normal and diseased human tissues
1 / 2 / 3 7 probe-sets matching KCNJ16 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 51579_at2, 3
|
U95-C |
1 |
0.94 |
1.00 |
0.78 |
1.12 |
AA846603 |
1.00 |
1.00 |
1.00 |
1 |
| 88538_at2, 3
|
U95-D |
1 |
0.94 |
1.00 |
0.78 |
0.63 |
AI636030 |
1.00 |
1.00 |
1.00 |
1 |
| 53005_at2, 3
|
U95-B |
1 |
0.69 |
1.00 |
0.92 |
1.33 |
AI953634 |
0.60 |
1.00 |
0.82 |
1 |
| 222901_s_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AF153815 |
0.80 |
1.00 |
0.91 |
1 |
| 219564_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_018658 |
0.60 |
1.00 |
0.82 |
1 |
| 222901_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 219564_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
KCNJ16 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: ACAATAAACA
SOURCE GeneReport for Unigene cluster: Hs.463985
UniProtKB/Swiss-Prot: IRK16_HUMAN, Q9NPI9Tissue specificity: Highly expressed in kidney, pancreas and thyroid gland
SABiosciences Custom PCR Arrays for KCNJ16
|
Orthologs
for KCNJ16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KCNJ16 gene from 5/9 species (see all 9)
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
dog
(Canis familiaris) |
KCNJ161 |
-- |
potassium inwardly-rectifying channel, subfamily J, more |
89(n)
95.93(a) |
611045 XM_848671.1 XP_853764.1 |
chimpanzee
(Pan troglodytes) |
KCNJ161 |
-- |
potassium inwardly-rectifying channel, subfamily J, more |
99.12(n)
99.52(a) |
468311 XM_523700.2 XP_523700.2 |
cow
(Bos taurus) |
KCNJ161 |
-- |
potassium inwardly-rectifying channel, subfamily J, more |
77.11(n)
89.71(a) |
613890 NM_001076294.1 NP_001069762.1 |
rat
(Rattus norvegicus) |
Kcnj161 |
-- |
potassium inwardly-rectifying channel, subfamily J, more |
83.41(n)
92.58(a) |
29719 NM_053314.2 NP_445766.2 |
mouse
(Mus musculus) |
Kcnj161 , 5 |
11 (75.01 cM)5
|
potassium inwardly-rectifying channel, subfamily J, more1, 5 |
84.45(n)1
92.34(a)1 |
165171 NM_010604.31 NP_034734.31
AB0161975 AI0352935 (see all 18) |
About this table Species with no ortholog for KCNJ16
ENSEMBL Gene Tree for KCNJ16 (if available) |
Paralogs
for KCNJ16 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for KCNJ16 gene
- KCNJ102 KCNJ12 KCNJ82 KCNJ152 KCNJ132 KCNJ112
KCNJ16 for paralogs About GeneDecksing
|
Genomic Variants
for KCNJ16 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 17 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for KCNJ16 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for KCNJ16
2 CNVs: 0211 35485 | | QIAGEN SeqTarget long-range PCR primers for resequencing KCNJ16 |
|
Disorders & Mutations
for KCNJ16 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KCNJ16 for disorders About GeneDecksing
OMIM: 605722
Human Genome Epidemiology (HuGE) Navigator: KCNJ16 (2 documents)
Export disorders and mutations for KCNJ16 gene to outside databases
|
Medical News
for KCNJ16 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for KCNJ16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/15 PubMed articles for KCNJ16 gene, integrated from 7 sources (see all 15):
(articles sorted by number of sources associating them with KCNJ16)- Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits. (PubMed id 11240146)1, 2, 3, 7 Derst C.... Karschin A. (2001)
- The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas. (PubMed id 11060447)1, 2, 7 Liu Y.... Swanson R. (2000)
- International Union of Pharmacology. LIV. Nomenclatur e and molecular relationships of inwardly rectifying potassium channels. (PubMed id 16382105)1, 3 Kubo Y....Vandenberg C.A. (2005)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
- Highly conserved non-coding elements on either side of SOX9 associated with Pierre Robin sequence. (PubMed id 19234473)1 Benko S....Lyonnet S. (2009)
- Rare independent mutations in renal salt handling genes contribute to blood pressure variation. (PubMed id 18391953)1 Ji W....Lifton R.P. (2008)
- Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels. (PubMed id 12923169)1 Casamassima M....Tucker S.J. (2003)
- Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels. (PubMed id 12456399)1 Konstas A.A....Tucker S.J. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for KCNJ16 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KCNJ16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KCNJ16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCNJ16 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for KCNJ16 gene:
Search GeneIP for patents involving KCNJ16
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KCNJ16 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
|
|
