Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS

Search by expression pattern Search by expression pattern



KCNN3 Gene

protein-coding   GIFtS: 59

GC01M126042
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
potassium intermediate/small conductance calcium-activated channel, subfamily
N, member 31 2
     SKCa 32 3
KCa2.31 2 3     small conductance calcium-activated potassium channel protein 32
SKCA31 2 5     OTTHUMP000000353712
SK32 3 5     K33
hSK31 2     SKCa33

External Ids:    HGNC: 62921   Entrez Gene: 37822   Ensembl: ENSG000001436037   UniProtKB: Q9UGI63   

Export aliases for KCNN3 gene to outside databases

Previous GC identifers: GC01M152495 GC01M150410 GC01M151455 GC01M151896 GC01M151492 GC01M152946 GC01M154680


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KCNN3:
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several
seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is
kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this
gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing
to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a
voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene contains two CAG
repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an
increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the
case. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding two
different isoforms have been found for this gene. One of the variants lacks the CAG repeat regions. (provided by
RefSeq)

UniProtKB/Swiss-Prot: KCNN3_HUMAN, Q9UGI6
Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by
membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of
synaptic afterhyperpolarization. The channel is blocked by apamin

summary for KCNN3:
Ca2+-activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+
ions across biological membranes. They are broadly classified into three subtypes, SK, IK and BK channels,
based on their conductance (small, intermediate and big conductance respectively). The small conductance KCa
channels (KCa2.1, 2.2 and 2.3, also known as SK1, SK2 and SK3 respectively) and the intermediate conductance
KCa channel (KCa3.1, also known as SK4) are voltage-insensitive and are activated by Ca2+-calmodulin. Both
play important roles in many processes involving Ca2+-dependent signalling in both electrically excitable
and non-excitable cells.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KCNN3 gene promoter:
         Sp1   Pax-6   ISGF-3   IRF-1   C/EBPbeta   GATA-1   POU2F2   POU2F2B   POU2F2C   POU2F2 (Oct-2.1)   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for KCNN3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

KCNN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KCNN3 gene location

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M126042:  view genomic region     (about GC identifiers)

Start:
126,042,867 bp from pter
End:
126,048,987 bp from pter
Size:
6,121 bases
Orientation:
minus strand

1 alternative location:
Chr1- 154,679,902-154,842,756     
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: KCNN3_HUMAN, Q9UGI6 (See protein sequence)
Recommended Name: Small conductance calcium-activated potassium channel protein 3  
Size: 736 amino acids; 82026 Da
Subunit: Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit
which regulates the channel activity through calcium-binding (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: B1ANX0 O43517 Q8WXG7
Alternative splicing: 2 isoforms:  Q9UGI6-1   Q9UGI6-2   

Explore the universe of human proteins at neXtProt for KCNN3: NX_Q9UGI6 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_002240.3  NP_740752.1  


    ENSEMBL proteins: 
    ENSP00000354764 ENSP00000271915 ENSP00000351295 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 2): KCNN3
    GenScript Custom Purified and Recombinant Proteins Services for KCNN3 
    Novus Biologicals Proteins for KCNN3
    Novus Biologicals Lysate for KCNN3
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    KCNN3 for ontologies           About GeneDecksing



    Antibodies for KCNN3: 
    Millipore Mono- and Polyclonal Antibodies for the study of KCNN3
    Sigma-Aldrich Antibodies for KCNN3
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for KCNN3 
    Novus Biologicals Antibodies for KCNN3
    Browse antibodies at Epitomics

    Assays for KCNN3: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KCNN3 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for KCNN3 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    KCNN3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR004178 CaM-bd_dom
     IPR015449 K_chnl_Ca-activ_SK
     IPR011996 K_chnl_Ca-activ_SK_con
     IPR003931 K_chnl_Ca-activ_SK_sub
     IPR013099 Ion_trans_2

    Graphical View of Domain Structure for InterPro Entry Q9UGI6

    ProtoNet protein and cluster: Q9UGI6

    3 Blocks protein families:
    IPB004178 Calmodulin binding domain
    IPB011996 SK channel region
    IPB013099 Ion transport 2


    UniProtKB/Swiss-Prot: KCNN3_HUMAN, Q9UGI6
    Similarity: Belongs to the potassium channel KCNN family. KCa2.3/KCNN3 subfamily


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: KCNN3_HUMAN, Q9UGI6
    Function: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by
    membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of
    synaptic afterhyperpolarization. The channel is blocked by apamin

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for KCNN3
    Sigma-Aldrich shRNA Panels and shRNA for KCNN3
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): KCNN3
    OriGene shRNA RFP (see all 2): KCNN3
    OriGene basic RS shRNA (see all 2): KCNN3
    OriGene siRNA (see all 2): KCNN3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KCNN3 
    miRNA:Sigma-Aldrich microRNA Mimics for KCNN3
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KCNN3 
    2 SABiosciences Assays for microRNAs that regulate KCNN3:
    hsa-miR-182 hsa-miR-1184

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): KCNN3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): KCNN3
    OriGene untagged cDNA clones in CMV expression vector (see all 3): KCNN3
    OriGene 3'-UTR clone (see all 2): KCNN3 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: KCNN3 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for KCNN3 

    Genatlas biochemistry entry for KCNN3:
    potassium intermediate/small conductance calcium-activated channel,subfamily N,member 3

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216 ion channel activity IEA--
    GO:0005516 calmodulin binding IEA--
    GO:0015269 calcium-activated potassium channel activity ----
    GO:0016286 small conductance calcium-activated potassium channel activity IEA--
    About this table

    KCNN3 for ontologies           About GeneDecksing

    Animal Models: 4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Kcnn3):

    life span-post-weaning/agingnervous systemreproductive systemrespiratory system

    KCNN3 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    KCNN3 for pathways           About GeneDecksing

    2 Millipore Pathways for KCNN3
        Synaptic transmission- ion currents
    Potassium transporters- outward current

    2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  KCNN3
        Neuropathic Pain Signaling In Dorsal Horn Neurons
    Cellular Effects of Sildenafil (Viagra)

        SABiosciences Pathway-Focused PCR Array including KCNN3: PAHS-036A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for KCNN3
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCNN3

    2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811 ion transport IEA--
    GO:0006813 potassium ion transport IEA--
    About this table

    KCNN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    KCNN3 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KCNN3 available from Tocris Bioscience
    CompoundAction CAS number
    UCL 1684Highly potent blocker of SKCa[199934-16-2]
    SG 209K+ channel opener; vasodilator[83440-03-3]
    Apamin K+ channel blocker (small conductance, Ca2+-dependent) [24345-16-2]
    4-AminopyridineNon-selective KV channel blocker[504-24-5]
    About this table


    9 Novoseek chemical compound relationships for KCNN3 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    scyllatoxin 86.9 2 14978258 (1)
    1-ethyl-2-benzimidazolinone 83.7 2 14978258 (1)
    apamin 80.2 6 11245600 (2), 12382077 (1), 17101631 (1), 14978258 (1)
    potassium 66.5 19 10395218 (2), 19472917 (2), 11501944 (1), 12850554 (1) (see all 16)
    d-tubocurarine 49.5 2 14978258 (1)
    glutamine 42.9 5 9866821 (1), 10395218 (1), 11121173 (1), 16162291 (1) (see all 5)
    tetraethylammonium 32.2 3 14978258 (1)
    calcium 4.96 7 11245600 (2), 19472917 (2), 15068253 (1), 16162291 (1) (see all 5)
    h2o2 0 1 16173951 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for KCNN3
    Sigma-Aldrich shRNA Panels and shRNA for KCNN3
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): KCNN3
    OriGene shRNA RFP (see all 2): KCNN3
    OriGene basic RS shRNA (see all 2): KCNN3
    OriGene siRNA (see all 2): KCNN3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KCNN3 
    miRNA: Sigma-Aldrich microRNA Mimics for KCNN3
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KCNN3 
    2 SABiosciences Assays for microRNAs that regulate KCNN3:
    hsa-miR-182 hsa-miR-1184
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): KCNN3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): KCNN3
    OriGene untagged cDNA clones in CMV expression vector (see all 3): KCNN3
    OriGene 3'-UTR Clone (see all 2): KCNN3 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: KCNN3 
    Primers: OriGene genome-wide validated SYBR primer pairs: KCNN3
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for KCNN3: PPH01666A

    REFSEQ mRNAs for KCNN3 gene (2 alternative transcripts): 

    NM_002249.4  NM_170782.1  

    Additional cDNA sequence: 

    AF031815.1 AF438203.1 AJ251016.1 AK310077.1 AY049734.1 AY138900.1 AY258142.1 BC042147.1 
    BX649146.1 CR595038.1 

    5 DOTS entries:

    DT.410710  DT.410709  DT.100642243  DT.100698840  DT.100746102 

    24/69 AceView cDNA sequences (see all 69):

    NM_002249 AA808321 N47474 CB067998 NM_170782 AI611826 CR595038 AI769660 
    BG231908 AA767647 AA741463 AA419456 BC042147 AY138900 AA491238 AW575885 
    AU118918 BE513322 AI813448 AW074697 AI201553 AY258142 AA285078 AL560989 

    highest scoring ESTs for KCNN3:

    AF031815 AI813448 AJ251016 AW411311 AY049734 AY258142 BE297121 BG829011 BI113946 BI114086 

    Unigene Cluster for KCNN3:

    Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
    Hs.490765  [show with all ESTs]
    Unigene Representative Sequence: BX649146


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KCNN3

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b
    SP1:                                                                                          
    SP2:        -     -                                                                           
    SP3:              -                                                                           
    SP4:                                                                    -     -               

    About this scheme

    ECgene alternative splicing isoforms for KCNN3
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361147(uc001ffo.2) ENST00000271915(uc001ffp.2 uc009wox.1)
    ENST00000358505

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    KCNN3 expression in normal and diseased human tissues

    1  / 2  / 3

    6 probe-sets matching KCNN3 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    37051_at2, 3 U95-A 1 0.94 1.00 0.96 0.44 AF031815 1.00 1.00 1.00 1
    83110_at2, 3 U95-E 1 0.50 1.00 0.00 1.64 AI813448 0.80 1.00 0.91 1
    205903_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002249 0.60 1.00 0.82 1
    205902_at2, 3 U133-A 1 0.82 1.00 -- -- AJ251016 0.80 1.00 0.91 1
    205903_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    205902_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    About this table

    KCNN3 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    KCNN3 gene expression
    KCNN3 gene electronic northern expression
    KCNN3 gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.490765

    Expression variation in blood from EXPOLDB for KCNN3

    Primers: OriGene genome-wide validated SYBR primer pairs: KCNN3
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for KCNN3: PPH01666A
        SABiosciences Expression via Pathway-Focused PCR Array including KCNN3: PAHS-036A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for KCNN3 gene from 5/9 species (see all 9)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    KCNN31   -- potassium intermediate/small conductance calcium-activated more 91.38(n)
    95.48(a)
    490441  XM_547563.2  XP_547563.2 
    cow
    (Bos taurus)
    KCNN31   -- potassium intermediate/small conductance calcium-activated more 94.96(n)
    98.06(a)
    534180  XM_868686.2  XP_873779.1 
    rat
    (Rattus norvegicus)
    Kcnn31   -- potassium intermediate/small conductance calcium-activated more 92.1(n)
    96.97(a)
    54263  NM_019315.2  NP_062188.2 
    mouse
    (Mus musculus)
    Kcnn31 , 5 3 (39.16 cM)5
    potassium intermediate/small conductance calcium-activated more1, 5 91.6(n)1
    96.14(a)1
    1404931  NM_080466.11  NP_536714.11 
     AF3572415  AK1377385  (see all 10)
    zebrafish
    (Danio rerio)
    LOC5701381   -- similar to potassium channel TSK3 69.77(n)
    74.59(a)
    570138  XM_001921759.1  XP_001921794.1 
    About this table        Species with no ortholog for KCNN3

    ENSEMBL Gene Tree for KCNN3 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for KCNN3 gene
    KCNN42  KCNN22  KCNN12  

    KCNN3 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    UniProtKB/Swiss-Prot: KCNN3_HUMAN, Q9UGI6
    Polymorphism: The second poly-Gln region of KCNN3 is highly polymorphic and the number of Gln varies from 12 to 28 in
    the population


    10/1823 NCBI SNPs in KCNN3 are shown (see all 1823)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs8681081,2
    C,F,A,H,154720289(+) ACTGCC/GGCATC 2 -- int121Minor allele frequency- G:0.21NS EA NA WA 1612
    rs8700311,2
    C,F,O,A,154724003(+) CTTCTG/AATGGC 2 -- int17Minor allele frequency- A:0.15NS EA NA 580
    rs8703271,2
    C,F,A,H,154795277(-) AGGGTC/ACTTCT 2 -- int19Minor allele frequency- A:0.35NA EA WA 224
    rs8703281,2
    C,F,A,H,154795292(+) GTCCCT/GCCTGC 2 -- int12Minor allele frequency- G:0.31NA EA 160
    rs8833191,2
    C,F,A,H,154758422(+) AATAGC/TCCCAT 2 -- int120Minor allele frequency- N:0.01NS EA NA WA 1284
    rs8833201,2
    H154758800(-) TTTCTA/GTCTTG 2 -- int14Minor allele frequency- G:0.00NS EA 406
    rs8839051,2
    C,F,A,H,154815366(-) agtggT/Caaagt 2 -- int120Minor allele frequency- C:0.41NA EA NS 1386
    rs8846641,2
    C,F,O,A,H,154703725(+) TCCTCA/GTGACA 2 -- int121Minor allele frequency- N:0.00NS EA NA WA 948
    rs9062741,2
    C,F,O,A,154779122(-) TCATGA/CTCTCA 2 -- int119Minor allele frequency- N:0.00NA EA NS WA 1510
    rs9062751,2
    C,F,A,H,154724127(+) CACCAC/TGGAAG 2 -- int112Minor allele frequency- T:0.04EA NS NA WA 388
    About this table

    HapMap Linkage Disequilibrium images for KCNN3 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for KCNN3
         1 CNV: 23272

    QIAGEN SeqTarget long-range PCR primers for resequencing KCNN3 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KCNN3 for disorders           About GeneDecksing

    OMIM: 602983

    5 Novoseek disease relationships for KCNN3 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hirschsprung disease 58.5 2 12778407 (1), 12457234 (1)
    schizophrenia 54.8 32 10395218 (4), 10196711 (4), 16086287 (3), 12898569 (3) (see all 13)
    myotonic dystrophy 50.6 3 12875918 (2), 19472917 (1)
    bipolar disorder 48.2 9 12898569 (3), 11121173 (2), 11311923 (1), 11526470 (1) (see all 6)
    anorexia nervosa 28.8 1 15389773 (1)
    About this table

    Human Gene Mutation Database (HGMD): KCNN3
    Genetic Association Database (GAD): KCNN3
    Human Genome Epidemiology (HuGE) Navigator: KCNN3 (20 documents)

    Export disorders and mutations for KCNN3 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/86 PubMed articles for KCNN3 gene, integrated from 7 sources (see all 86):
    (articles sorted by number of sources associating them with KCNN3)
    1. Isolation of a novel potassium channel gene hSKCa3 containing a polymorphic CAG repeat: a candidate for schizophrenia and bipolar disorder? (PubMed id 9491810)1, 2, 3 Chandy K.G.... Gargus J.J. (1998)
    2. [Transmission disequilibrium analysis of 1137-1140 Del GTGA frameshift mutation within the KCNN3 gene and schizophrenia based on family trios] (PubMed id 16086287)1, 4, 7 Hong X.H....Wu C.R. (2005)
    3. CAG repeat polymorphism within the KCNN3 gene is a significant contributor to susceptibility to anorexia nervosa: a case-control study of female patients and several ethnic groups in the Israeli Jewish population. (PubMed id 15389773)1, 4, 7 Koronyo-Hamaoui M....Weizman A. (2004)
    4. Schizophrenia and polymorphic CAG repeats array of calcium-activated potassium channel (KCNN3) gene in Serbian population. (PubMed id 16393881)1, 4, 7 Ivkovic M....Romac S. (2006)
    5. CAG-repeat length in exon 1 of KCNN3 does not influence risk for schizophrenia or bipolar disorder: a meta-analysis of association studies. (PubMed id 12898569)1, 4, 7 Glatt S.J....Tsuang M.T. (2003)
    6. Association study of CAG repeats in the KCNN3 gene in Israeli patients with major psychosis. (PubMed id 12960745)1, 4, 7 Ritsner M....Navon R. (2003)
    7. Association and linkage studies between bipolar affective disorder and the polymorphic CAG/CTG repeat loci ERDA1, SEF2-1B, MAB21L and KCNN3. (PubMed id 11526470)1, 4, 7 Meira-Lima I.V....Vallada H. (2001)
    8. Association analysis of CAG repeats at the KCNN3 locus in Indian patients with bipolar disorder and schizophrenia. (PubMed id 11121173)1, 4, 7 Saleem Q....Jain S. (2000)
    9. Association analysis of a highly polymorphic CAG Repeat in the human potassium channel gene KCNN3 and migraine susceptibility. (PubMed id 16162291)1, 4, 7 Curtain R....Griffiths L. (2005)
    10. CAG repeat polymorphisms in KCNN3 (HSKCa3) and PPP2R2B show no association or linkage to schizophrenia. (PubMed id 12497613)1, 4, 7 Laurent C....Mallet J. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3782 HGNC: 6292 AceView: KCNN3 Ensembl:ENSG00000143603 euGenes: HUgn3782
    ECgene: KCNN3 H-InvDB: KCNN3

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for KCNN3 gene:
    Search GeneIP for patents involving KCNN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for KCNN3 Antibodies for KCNN3
     Super-pooled esiRNAs for KCNN3 Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for KCNN3 microRNA Mimics for KCNN3
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KCNN3
     SeqTarget long-range PCR primers for resequencing KCNN3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KCNN3
     GenScript Custom Purified and Recombinant Proteins Services for KCNN3 GenScript cDNA clones with any tag delivered in your preferred vector for KCNN3
     GenScript Custom Assay Services for KCNN3 GenScript Custom Superior Antibodies Services for KCNN3
     GenScript Custom overexpressing Cell Line Services for KCNN3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KCNN3 promoter
     Search Chromatin IP Primers for KCNN3
     RT2 qPCR Primer Assay for KCNN3
     GNC Network for KCNN3
     Assays for microRNAs that regulate KCNN3
     SABiosciences PCR Arrays including KCNN3
     Tocris compounds for KCNN3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for KCNN3
     Proteins for KCNN3
     Lysates for KCNN3
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for KCNN3
           

    GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    KCNN3 gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4