Aliases &
Descriptions
for KCTD13 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| potassium channel tetramerisation domain containing 131 2 | | BTB/POZ domain-containing protein KCTD132 3 | | POLDIP11 2 3 5 | | TNFAIP1-like protein2 3 | | PDIP11 2 3 | | FKSG861 5 | | Polymerase delta-interacting protein 12 3 | | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 12 | | hBACURD12 3 | | BACURD13 |
Export aliases for KCTD13 gene to outside databasesPrevious GC identifers: GC16M029955 GC16M029948 GC16M029826 GC16M029917 |
Summaries
for KCTD13 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: BACD1_HUMAN, Q8WZ19Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved inregulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination ofRHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration
Gene Wiki entry for KCTD13 |
Genomic Views
for KCTD13 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCTD13 gene promoter:
PPAR-gamma2 PPAR-gamma1 RFX1 GCNF-2 GCNF-1 SRY MEF-2A Egr-2 Egr-3 Elk-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KCTD13
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for KCTD13  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2KCTD13 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M027578: view genomic region
(about GC identifiers)
Start:
|
27,578,579 bp from pter |
End:
|
27,598,466 bp from pter |
Size:
|
19,888 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr16- 29,917,657-29,937,549 |
RefSeq DNA sequence:- NC_000016.9 NT_010393.16
|
Proteins
for KCTD13 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: BACD1_HUMAN, Q8WZ19 (See
protein sequence)Recommended Name: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 Size: 329 amino acids; 36357 Da
Subunit: Component of the BCR(BACURD1) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD13/BACURD1 and RBX1.Interacts with RHOA; with a preferrence for RhoA-GDP. Interacts with POLD2 and PCNA
Subcellular location: Nucleus
Secondary accessions: A8K0R5 Q96P93 Q96SA1Explore the universe of human proteins at neXtProt for KCTD13: NX_Q8WZ19
REFSEQ proteins: NP_849194.1
ENSEMBL proteins: ENSP00000311202
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
KCTD13 for ontologies About GeneDecksing
Antibodies for KCTD13:
Assays for KCTD13: |
Protein
Domains/
Families
for KCTD13 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KCTD13 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WZ19ProtoNet protein and cluster: Q8WZ19 UniProtKB/Swiss-Prot: BACD1_HUMAN, Q8WZ19Similarity: Belongs to the BACURD familySimilarity: Contains 1 BTB (POZ) domain |
Gene Function
for KCTD13 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: BACD1_HUMAN, Q8WZ19Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved inregulation of cytoskeleton structure. The BCR(BACURD1) E3 ubiquitin ligase complex mediates the ubiquitination ofRHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migrationInduction: By TNF and IL6/interleukin-6
5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
KCTD13 for ontologies About GeneDecksing
|
Pathways & Interactions
for KCTD13 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: BACD1_HUMAN, Q8WZ19Pathway: Protein modification; protein ubiquitination SABiosciences Custom Pathway-Focused PCR Arrays for KCTD13
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KCTD13
5/6 Interacting proteins for KCTD13 (Q8WZ192) via UniProtKB, MINT, and/or STRING (see all 6) About this table
5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7): About this table
KCTD13 for ontologies About GeneDecksing
|
Drugs & Compounds
for KCTD13 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for KCTD13
|
Transcripts
for KCTD13 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for KCTD13 gene: NM_178863.2 Additional cDNA sequence: AF289573.1 AF401315.2 AK097407.1 AK289630.1 AY027918.1 BC036228.1 CR625548.1 11 DOTS entries: DT.310512 DT.97761909 DT.100763899 DT.86852582 DT.86852581 DT.91910291 DT.40311171 DT.436190 DT.91757828 DT.95372783 DT.120697946 24/125 AceView cDNA sequences (see all 125): BU074656 AI651765 AI650907 AW029203 AA062930 BQ668650 CR625548 N59321 AF289573 BC036228 BU072010 NM_178863 CB995205 AA960968 AI633916 BX108207 CD366018 BI715111 CK004733 AA323542 AK097407 CD107040 AI659467 BG166274
 highest scoring ESTs for KCTD13:AA577366 AI929455 AA974004 AF289573 AF401315 AI633916 AI650907 AI816461 AI911202 AK097407 Unigene Cluster for KCTD13: Potassium channel tetramerisation domain containing 13 Hs.534590 [show with all ESTs]Unigene Representative Sequence: AK097407
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for KCTD13
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 |
|---|
|
| SP1: | | | | | | | | | - | | | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for KCTD13
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000308768(uc010vee.1 uc002duv.2)
|
Expression
for KCTD13 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| KCTD13 expression in normal and diseased human tissues
1 / 2 / 3 8 probe-sets matching KCTD13 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 72312_s_at2, 3
|
U95-D |
1 |
1.00 |
1.00 |
0.72 |
0.78 |
AA577366 |
1.00 |
1.00 |
1.00 |
1 |
| 45653_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
0.82 |
1.17 |
AW026481 |
0.80 |
1.00 |
0.91 |
1 |
| 86393_at2, 3
|
U95-E |
1 |
1.00 |
1.00 |
0.88 |
0.77 |
AI929455 |
1.00 |
1.00 |
1.00 |
1 |
| 43409_at2, 3
|
U95-B |
1 |
0.88 |
1.00 |
0.82 |
1.30 |
AI911202 |
0.80 |
1.00 |
0.91 |
1 |
| 45653_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AW026481 |
0.80 |
1.00 |
0.91 |
1 |
| 221889_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AW026481 |
0.80 |
1.00 |
0.91 |
1 |
| 45653_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 221889_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
KCTD13 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CCAAAGTGTG
SOURCE GeneReport for Unigene cluster: Hs.534590
UniProtKB/Swiss-Prot: BACD1_HUMAN, Q8WZ19Tissue specificity: Expressed in a wide variety of tissues
SABiosciences Custom PCR Arrays for KCTD13
|
Orthologs
for KCTD13 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KCTD13 gene from 5/6 species (see all 6)
About this table Species with no ortholog for KCTD13
ENSEMBL Gene Tree for KCTD13 (if available) |
Paralogs
for KCTD13 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for KCTD13 gene
- TNFAIP12 KCTD102
KCTD13 for paralogs About GeneDecksing
|
Genomic Variants
for KCTD13 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KCTD13
1 CNV: 35383 | | QIAGEN SeqTarget long-range PCR primers for resequencing KCTD13 |
|
Disorders & Mutations
for KCTD13 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KCTD13 for disorders About GeneDecksing
OMIM: 608947
Export disorders and mutations for KCTD13 gene to outside databases
|
Medical News
for KCTD13 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for KCTD13 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/13 PubMed articles for KCTD13 gene, integrated from 7 sources (see all 13):
(articles sorted by number of sources associating them with KCTD13)- A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen. (PubMed id 11593007)1, 2, 3, 7 He H.... So A.G. (2001)
- Cullin mediates degradation of RhoA through evolution arily conserved BTB adaptors to control actin cytoskeleton structure and cell m ovement. (PubMed id 19782033)1, 2 Chen Y....Shao F. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
- Cloning of two rat PDIP1 related genes and their interactions with proliferating cell nuclear antigen. (PubMed id 15726626)1, 7 Zhou J....Zhang J. (2005)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the DNA-binding domain of peroxisome proliferator-activated receptor gamma. (PubMed id 16239304)1 Tomaru T.... Mori M. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
|
External Searches for KCTD13 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KCTD13 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KCTD13 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCTD13 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for KCTD13 gene:
Search GeneIP for patents involving KCTD13
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KCTD13 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for KCTD13 |
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