Aliases &
Descriptions
for KCTD18 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| potassium channel tetramerisation domain containing 181 2 | | 6530404F10Rik1 2 | | FLJ378181 2 | | FLJ313221 2 | | BTB/POZ domain-containing protein KCTD182 |
Export aliases for KCTD18 gene to outside databasesPrevious GC identifers: GC02M201180 GC02M201061 GC02M201353 |
Summaries
for KCTD18 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KCTD18 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KCTD18 gene promoter:
FOXO1a STAT3 FOXO4 CUTL1 c-Myb Nkx6-1 AP-4 Pbx1a STAT5A HOXA9B
Other transcription factors
Search SABiosciences Chromatin IP Primers for KCTD18
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q33.1 Ensembl cytogenetic band: 2q33.1 HGNC cytogenetic band: 2q33.1KCTD18 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M193206: view genomic region
(about GC identifiers)
Start:
|
193,206,069 bp from pter |
End:
|
193,227,176 bp from pter |
Size:
|
21,108 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr2- 201,353,675-201,384,507 |
RefSeq DNA sequence:- NC_000002.11 NT_005403.17
|
Proteins
for KCTD18 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: KCD18_HUMAN, Q6PI47 (See
protein sequence)Recommended Name: BTB/POZ domain-containing protein KCTD18 Size: 426 amino acids; 46739 Da
Secondary accessions: Q53T21 Q6NW26 Q6PCD8 Q8N9B7 Q96N73Alternative splicing: 3 isoforms: Q6PI47-1 Q6PI47-2 Q6PI47-3 Explore the universe of human proteins at neXtProt for KCTD18: NX_Q6PI47
REFSEQ proteins: NP_689600.2
ENSEMBL proteins: ENSP00000352941 ENSP00000386751 ENSP00000414011 ENSP00000409538
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008076 | voltage-gated potassium channel complex |
IEA | -- | | GO:0016020 | membrane |
IEA | -- |
About this table
KCTD18 for ontologies About GeneDecksing
Antibodies for KCTD18:
Assays for KCTD18: |
Protein
Domains/
Families
for KCTD18 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KCTD18 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6PI47ProtoNet protein and cluster: Q6PI47 1 Blocks protein family: IPB000210 BTB/POZ domain
UniProtKB/Swiss-Prot: KCD18_HUMAN, Q6PI47Similarity: Contains 1 BTB (POZ) domain |
Gene Function
for KCTD18 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005249 | voltage-gated potassium channel activity |
IEA | -- | | GO:0005515 | protein binding |
IEA | -- |
About this table
KCTD18 for ontologies About GeneDecksing
|
Pathways & Interactions
for KCTD18 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for KCTD18
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KCTD18
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006813 | potassium ion transport |
IEA | -- |
About this table
KCTD18 for ontologies About GeneDecksing
|
Drugs & Compounds
for KCTD18 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for KCTD18
|
Transcripts
for KCTD18 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for KCTD18 gene: NM_152387.2 Additional cDNA sequence: AK055884.1 AK095137.1 AK290867.1 BC045189.1 BC059366.1 BC067755.1 CR596892.1 6 DOTS entries: DT.436165 DT.100745205 DT.411929 DT.92418378 DT.95159293 DT.40307370 24/68 AceView cDNA sequences (see all 68): BU618216 AA424064 CR596892 AW070292 AA708329 AI281421 AW339549 CA396085 AI566925 NM_152387 BM992087 AA730044 N23090 BQ224321 AA765603 BC067755 AI355934 AA814384 CF264997 AA767454 AK095137 BI550019 AI341862 BG426699
 highest scoring ESTs for KCTD18:AA767454 AK055884 BC045189 BC059366 BC067755 BG706240 BG719689 BI550019 BI561257 BI598043 Unigene Cluster for KCTD18: Potassium channel tetramerisation domain containing 18 Hs.605775 [show with all ESTs]Unigene Representative Sequence: BC045189
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for KCTD18
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for KCTD18
6 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000359878(uc002uvs.2) ENST00000409157(uc002uvt.2) ENST00000468413
ENST00000478816(uc002uvu.1) ENST00000447556 ENST00000458583
|
Expression
for KCTD18 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| KCTD18 expression in normal and diseased human tissues
1 / 2 / 3 4 probe-sets matching KCTD18 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 62129_at2, 3
|
U95-C |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
AA767454 |
0.80 |
1.00 |
0.91 |
1 |
| 226493_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AI627249 |
0.40 |
1.00 |
0.76 |
1 |
| 226493_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1553136_at2
|
U133Plus2 |
1 |
0.46 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
KCTD18 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: ACTATTCAGT
SOURCE GeneReport for Unigene cluster: Hs.605775
SABiosciences Custom PCR Arrays for KCTD18
|
Orthologs
for KCTD18 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KCTD18 gene from 5/7 species (see all 7)
About this table Species with no ortholog for KCTD18
ENSEMBL Gene Tree for KCTD18 (if available) |
Paralogs
for KCTD18 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for KCTD18 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 2 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for KCTD18 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KCTD18
1 CNV: 90215 | | QIAGEN SeqTarget long-range PCR primers for resequencing KCTD18 |
|
Disorders & Mutations
for KCTD18 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for KCTD18 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for KCTD18 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
4 PubMed articles for KCTD18 gene integrated from 7 sources:
(articles sorted by number of sources associating them with KCTD18)- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for KCTD18 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KCTD18 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KCTD18 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KCTD18 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for KCTD18 gene:
Search GeneIP for patents involving KCTD18
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KCTD18 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for KCTD18 |
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