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KIAA0408 Gene

protein-coding   GIFtS: 37

GC06M127803
KIAA0408
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
KIAA04081 2
hypothetical protein LOC97292
FLJ439952
OTTHUMP000000171742
RP3-403A15.22

External Ids:    HGNC: 216361   Entrez Gene: 97292   Ensembl: ENSG000001893677   UniProtKB: Q6ZU523   

Export aliases for KIAA0408 gene to outside databases

Previous GC identifers: GC06M127421 GC06M127608 GC06M127742 GC06M127745


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIAA0408 gene promoter:
         NRSF form 2   NRSF form 1   CUTL1   SRF   POU2F1   FOXJ2 (long isoform)   RP58   Arnt   C/EBPalpha   AhR   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for KIAA0408

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for KIAA0408 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.33   Ensembl cytogenetic band:  6q22.33   HGNC cytogenetic band: 6q22.33

KIAA0408 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIAA0408 gene location

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M127803:  view genomic region     (about GC identifiers)

Start:
127,759,551 bp from pter
End:
127,840,078 bp from pter
Size:
80,528 bases
Orientation:
minus strand

1 alternative location:
Chr6- 125,336,237-125,357,220     

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: K0408_HUMAN, Q6ZU52 (See protein sequence)
Recommended Name: Uncharacterized protein KIAA0408  
Size: 694 amino acids; 79163 Da
Sequence caution: Sequence=BAA23704.2; Type=Erroneous initiation;
Secondary accessions: B3KRE5 O43158 Q5TF20 Q7L2M2
Alternative splicing: 2 isoforms:  Q6ZU52-1   Q6ZU52-2   

Explore the universe of human proteins at neXtProt for KIAA0408: NX_Q6ZU52 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_055517.3  

    ENSEMBL proteins: 
    ENSP00000357264 ENSP00000009606 ENSP00000385515 


    Human Recombinant Proteins 
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    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q6ZU52


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for KIAA0408
    Sigma-Aldrich shRNA for KIAA0408
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): KIAA0408
    OriGene shRNA RFP (see all 2): KIAA0408
    OriGene basic RS shRNA (see all 2): KIAA0408
    OriGene siRNA: KIAA0408
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KIAA0408 
    miRNA:Sigma-Aldrich microRNA Mimics for KIAA0408
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KIAA0408 
    8/13 SABiosciences Assays for microRNAs that regulate KIAA0408 (see all 13):
    hsa-miR-505 hsa-miR-607 hsa-miR-548d-3p hsa-miR-300 hsa-miR-381 hsa-miR-1278 hsa-miR-501-3p hsa-miR-1305

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: KIAA0408
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: KIAA0408
    OriGene untagged cDNA clones in CMV expression vector (see all 2): KIAA0408
    OriGene 3'-UTR clone: KIAA0408 
    Browse MicroRNA Expression Plasmids 
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    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for KIAA0408 

    1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI--
    About this table

    KIAA0408 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for KIAA0408 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIAA0408

    5/20 Interacting proteins for KIAA0408 (Q6ZU521, 2) via UniProtKB, MINT, and/or STRING (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR3C1P041501EBI-739493,EBI-493507
    ABI3Q9P2A42MINT-66748
    AP2B1P630102MINT-66266
    BEGAINQ9BUH82MINT-66776
    CCDC85BQ158342MINT-67342
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KIAA0408


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for KIAA0408
    Sigma-Aldrich shRNA for KIAA0408
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): KIAA0408
    OriGene shRNA RFP (see all 2): KIAA0408
    OriGene basic RS shRNA (see all 2): KIAA0408
    OriGene siRNA: KIAA0408
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KIAA0408 
    miRNA: Sigma-Aldrich microRNA Mimics for KIAA0408
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KIAA0408 
    8/13 SABiosciences Assays for microRNAs that regulate KIAA0408 (see all 13):
    hsa-miR-505 hsa-miR-607 hsa-miR-548d-3p hsa-miR-300 hsa-miR-381 hsa-miR-1278 hsa-miR-501-3p hsa-miR-1305
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: KIAA0408
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: KIAA0408
    OriGene untagged cDNA clones in CMV expression vector (see all 2): KIAA0408
    OriGene 3'-UTR Clone: KIAA0408 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for KIAA0408 
    Primers: OriGene genome-wide validated SYBR primer pairs: KIAA0408
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for KIAA0408: PPH17210A

    REFSEQ mRNAs for KIAA0408 gene: 

    NM_014702.4  

    24/78 AceView cDNA sequences (see all 78):

    AI249493 BC018396 CR591062 AI018230 AX746974 BM671495 AI911498 AI674081 
    AL118748 AK096490 BI517371 AK091424 AI694978 AK125983 AL712906 BE552225 
    BE796893 CB156548 AB007868 AK127114 BM807573 BQ028165 BI766291 AW003608 

    highest scoring ESTs for KIAA0408:

    AK091416 AK091424 AK096490 AK125983 BG717349 BI463537 BI822141 AA010527 AA010528 AA167627 


    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0408 (see all 11)

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12 ^ 13a · 13b · 13c · 13d ^
    SP1:                                                                                            -     -     -                       -                           
    SP2:                                                                                            -     -     -                       -                           
    SP3:              -                                                                                                                                             
    SP4:                                                                                            -     -     -     -                                             
    SP5:                                                                                                        -                       -                           

    ExUns: 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    

    About this scheme

    ECgene alternative splicing isoforms for KIAA0408
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368281(uc003qba.2 uc003qbb.2) ENST00000481848 ENST00000465254
    ENST00000473298 ENST00000474293 ENST00000487331 ENST00000472335 ENST00000483725
    ENST00000464495 ENST00000465909 ENST00000467753 ENST00000009606(uc011ebs.1 uc003qbc.2 uc003qbd.2)
    ENST00000405702

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    KIAA0408 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching KIAA0408 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    37499_at2, 3 U95-A 2 0.94 0.77 0.91 0.59 AB007868 0.60 1.00 0.82 1
    52544_at2 U95-C 2 0.38 0.64 0.93 1.67 -- -- -- -- --
    44332_at2 U95-B 2 0.38 0.50 0.95 0.91 -- -- -- -- --
    205496_at2, 3 U133-A 2 0.82 0.67 -- -- NM_014702 0.60 1.00 0.82 1
    205496_at2 U133Plus2 2 0.82 0.67 -- -- -- -- -- -- --
    About this table

    KIAA0408 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    KIAA0408 gene expression
    KIAA0408 gene electronic northern expression
    KIAA0408 gene sage expression
    About these images

    CGAP SAGE TAG: --

    Expression variation in blood from EXPOLDB for KIAA0408

    Primers: OriGene genome-wide validated SYBR primer pairs: KIAA0408
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for KIAA0408: PPH17210A
        SABiosciences Custom PCR Arrays for KIAA0408 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for KIAA0408 gene from 3 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LOC4762891   -- hypothetical LOC476289 83.76(n)
    75.86(a)
    476289  XM_533494.2  XP_533494.2 
    mouse
    (Mus musculus)
    6330407J23Rik5 10 (16.52 cM) RIKEN cDNA 6330407J23 gene   -- CD355864 
    chicken
    (Gallus gallus)
    LOC4217141   -- hypothetical LOC421714 59.85(n)
    44.71(a)
    421714  XM_419751.2  XP_419751.2 
    About this table        Species with no ortholog for KIAA0408

    ENSEMBL Gene Tree for KIAA0408 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
      --

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section
    QIAGEN SeqTarget long-range PCR primers for resequencing KIAA0408 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    6 PubMed articles for KIAA0408 gene integrated from 7 sources:
    (articles sorted by number of sources associating them with KIAA0408)
    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K....Ohara O. (1997)
    5. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9729 HGNC: 21636 AceView: KIAA0408 Ensembl:ENSG00000189367 euGenes: HUgn9729
    ECgene: KIAA0408 H-InvDB: KIAA0408

    (According to HUGE)
    About This Section
    HUGE: KIAA0408

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for KIAA0408 gene:
    Search GeneIP for patents involving KIAA0408

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

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     Regulatory tfbs in KIAA0408 promoter
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     Browse ELISAs and CLIAs at Uscn
           

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