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KIF19 Gene

protein-coding   GIFtS: 41

GC17P072321
kinesin family member 19
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
kinesin family member 191 2
KIF19A1 2
FLJ373001 2
kinesin-like protein KIF192

External Ids:    HGNC: 267351   Entrez Gene: 1246022   Ensembl: ENSG000001961697   UniProtKB: Q2TAC63   

Export aliases for KIF19 gene to outside databases

Previous GC identifer: GC17P069834


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KIF19 gene promoter:
         CUTL1   STAT5A   Max1   c-Myc   Pax-2   GR-alpha   GR-beta   deltaCREB   CREB   NF-kappaB1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for KIF19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for KIF19 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25

KIF19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KIF19 gene location

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P072321:  view genomic region     (about GC identifiers)

Start:
72,321,951 bp from pter
End:
72,371,096 bp from pter
Size:
49,146 bases
Orientation:
plus strand

1 alternative location:
Chr17+ 67,732,034-67,761,658     
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: KIF19_HUMAN, Q2TAC6 (See protein sequence)
Recommended Name: Kinesin-like protein KIF19  
Size: 998 amino acids; 111332 Da
Secondary accessions: A6NLG2 B7ZKR1 Q52M87 Q8N1X8 Q8TAB6
Alternative splicing: 3 isoforms:  Q2TAC6-1   Q2TAC6-2   Q2TAC6-3   

Explore the universe of human proteins at neXtProt for KIF19: NX_Q2TAC6 

REFSEQ proteins: NP_694941.2  

ENSEMBL proteins: 
ENSP00000374566 ENSP00000414666 ENSP00000374567 ENSP00000353021 ENSP00000335158 


Human Recombinant Proteins 
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3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005874 microtubule IEA--
GO:0005886 plasma membrane ----
GO:0016021 integral to membrane ----
About this table

KIF19 for ontologies           About GeneDecksing



Antibodies for KIF19: 
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Browse antibodies at Epitomics

Assays for KIF19: 
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Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KIF19 for domains           About GeneDecksing

2 InterPro domains/families:
 IPR001752 Kinesin_motor_dom
 IPR019821 Kinesin_motor_CS

Graphical View of Domain Structure for InterPro Entry Q2TAC6

ProtoNet protein and cluster: Q2TAC6

UniProtKB/Swiss-Prot: KIF19_HUMAN, Q2TAC6
Similarity: Belongs to the kinesin-like protein family
Similarity: Contains 1 kinesin-motor domain


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for KIF19
Sigma-Aldrich shRNA for KIF19
OriGene 29mer shRNA kits in GFP-retroviral vector: KIF19
OriGene shRNA RFP: KIF19
OriGene basic RS shRNA: KIF19
OriGene siRNA: KIF19
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KIF19 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KIF19 
Search SABiosciences for Assays for microRNAs that regulate KIF19

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: KIF19
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: KIF19
OriGene untagged cDNA clones in CMV expression vector (see all 2): KIF19
OriGene 3'-UTR clone: KIF19 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for KIF19 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for KIF19 

5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

GO IDQualified GO termEvidencePubMed IDs
GO:0000166 nucleotide binding IEA--
GO:0003777 microtubule motor activity IEA--
GO:0004872 receptor activity ----
GO:0004930 G-protein coupled receptor activity ----
GO:0005524 ATP binding IEA--
About this table

KIF19 for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for KIF19 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIF19

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007018 microtubule-based movement IEA--
GO:0007186 G-protein coupled receptor protein signaling pathway ----
About this table

KIF19 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KIF19


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for KIF19
Sigma-Aldrich shRNA for KIF19
OriGene 29mer shRNA kits in GFP-retroviral vector: KIF19
OriGene shRNA RFP: KIF19
OriGene basic RS shRNA: KIF19
OriGene siRNA: KIF19
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KIF19 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KIF19 
Search SABiosciences for Assays for microRNAs that regulate KIF19
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: KIF19
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: KIF19
OriGene untagged cDNA clones in CMV expression vector (see all 2): KIF19
OriGene 3'-UTR Clone: KIF19 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for KIF19 
Primers: OriGene genome-wide validated SYBR primer pairs: KIF19
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for KIF19: PPH18207A

REFSEQ mRNAs for KIF19 gene: 

NM_153209.3  

Additional cDNA sequence: 

AK094619.1 BC067749.1 BC093631.1 BC104852.1 BC110989.1 BC143327.1 

6 DOTS entries:

DT.65287915  DT.100016524  DT.99932766  DT.102820343  DT.91791104  DT.40214064 

15 AceView cDNA sequences:

BG713907 CB134958 CD672631 CD517210 CD518240 BC067749 NM_153209 BC026362 
BI833383 AK094619 BU150146 AX746676 BI772188 AK090911 BI544532 

highest scoring ESTs for KIF19:

AK094619 BC026362 BC093631 BG713907 BI772188 BI833383 BU150146 CD517210 NM_153209 AI560769 

Unigene Cluster for KIF19:

Kinesin family member 19
Hs.372773  [show with all ESTs]
Unigene Representative Sequence: NM_153209


GeneLoc Exon Structure

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000389916(uc002jkl.2 uc002jkm.3) ENST00000440684 ENST00000389917(uc002jkj.2)
ENST00000359939(uc002jkk.2) ENST00000335666(uc010wqx.1 uc010wqy.1)


(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

KIF19 expression in normal and diseased human tissues

1  / 2  / 3

4 probe-sets matching KIF19 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
74496_at2, 3 U95-D 1 0.44 1.00 0.83 1.00 AW014742 0.20 1.00 0.72 1
73434_at2, 3 U95-D 1 0.38 1.00 0.73 1.28 AI560769 0.40 1.00 0.76 1
87629_at*2 U95-E 6 0.31 0.17 0.30 0.73 -- -- -- -- --
1553314_a_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
About this table

KIF19 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
KIF19 gene expression
KIF19 gene electronic northern expression
KIF19 gene sage expression
About these images

CGAP SAGE TAG: GCCAGGACGG

SOURCE GeneReport for Unigene cluster: Hs.372773
Primers: OriGene genome-wide validated SYBR primer pairs: KIF19
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for KIF19: PPH18207A
    SABiosciences Custom PCR Arrays for KIF19 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KIF19 gene from 5/9 species (see all 9)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
KIF191   -- kinesin family member 19 89.82(n)
90.22(a)
483285  XM_540404.2  XP_540404.2 
cow
(Bos taurus)
KIF191   -- kinesin family member 19 83.88(n)
79.43(a)
538109  XM_618303.3  XP_618303.3 
rat
(Rattus norvegicus)
Kif19a1   -- kinesin family member 19A 86.3(n)
89.64(a)
303659  XM_221082.4  XP_221082.4 
mouse
(Mus musculus)
Kif19a1 , 5 11 (80.44 cM)5
kinesin family member 19A1, 5 86.69(n)1
89.77(a)1
2869421  XM_988580.21  XP_993674.11 
 AB0540265  AK1555445  (see all 8)
zebrafish
(Danio rerio)
zgc:1630091   -- zgc:163009 65.04(n)
64.62(a)
565913  XM_001920940.1  XP_001920975.1 
About this table        Species with no ortholog for KIF19

ENSEMBL Gene Tree for KIF19 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for KIF19 gene
GPR1392  

KIF19 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/388 NCBI SNPs in KIF19 are shown (see all 388)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 17 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs7473211,2
C,F,A,H,72340057(+) GGGAAC/TGGGGA 1 -- int117Minor allele frequency- T:0.24NA PA NS EA WA 896
rs8725071,2
C,F,72350014(+) TAATCA/TCTGTA 1 -- int117Minor allele frequency- T:0.09MN NS EA NA WA 1504
rs8777911,2
C,F,A,H,72331938(+) GGGGGG/TGCTGT 1 -- int18Minor allele frequency- T:0.36MN NA EA WA 406
rs10101611,2
C,F,A,72337651(-) GAGCAG/AAGCAC 1 -- int16Minor allele frequency- A:0.25NS EA NA 580
rs10107731,2
C,F,72335328(+) GCCCCA/GCCCCA 1 -- int14Minor allele frequency- G:0.44MN NA 169
rs10107741,2
C,F,72335483(+) tccccG/AtCTGA 1 -- int18Minor allele frequency- A:0.47NA EA WA 328
rs11097551,2
C,F,H,72333903(-) TGCTGA/GGCAAG 1 -- int113Minor allele frequency- G:0.31NA EA WA 414
rs11097561,2
C,F,H,72333847(-) GACCCT/CCAAGG 1 -- int112Minor allele frequency- C:0.37NS EA NA WA 522
rs11115961,2
C,F,A,72332849(+) ccacaG/Actctg 1 -- int116Minor allele frequency- A:0.27NS EA NA WA 914
rs13179561,2
C,F,72327554(+) CCTGGG/AGCAGC 1 -- int114Minor allele frequency- A:0.01NS EA NA WA 2428
About this table

HapMap Linkage Disequilibrium images for KIF19 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for KIF19
     8 CNVs: 34522 53066 5336 67262 7171 8852 39209 5029

QIAGEN SeqTarget long-range PCR primers for resequencing KIF19 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KIF19 for disorders           About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: KIF19 (1 document)

Export disorders and mutations for KIF19 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

7 PubMed articles for KIF19 gene integrated from 7 sources:
(articles sorted by number of sources associating them with KIF19)
  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (2006)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  4. All kinesin superfamily protein, KIF, genes in mouse and human. (PubMed id 11416179)1, 3 Miki H....Hirokawa N. (2001)
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
  6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 124602 HGNC: 26735 AceView: FLJ37300 Ensembl:ENSG00000196169 euGenes: HUgn124602
ECgene: KIF19 H-InvDB: KIF19

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for KIF19 gene:
Search GeneIP for patents involving KIF19

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KIF19
 SeqTarget long-range PCR primers for resequencing KIF19
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for KIF19
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KIF19
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