Aliases &
Descriptions
for KIR2DS1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail,11 2 | | KIR2DL1-KIR2DS12 | | CD158H1 2 3 | | CD158a2 | | MHC class I NK cell receptor Eb6 ActI2 3 | | p50.12 | | CD158 antigen-like family member H2 3 | | killer-cell immunoglobulin-like receptor2 | | EB6ActII1 | | killer cell immunoglobulin-like receptor 2DS12 | | EB6ActI1 | | CD158h antigen3 |
Export aliases for KIR2DS1 gene to outside databasesPrevious GC identifers: GC19U990053 GC19P9D0115 GC19P9F0116 GC00P9Q0116 GC19P9H0008 GC19P059932 GC19P9I0115 GC19P9I0024 GC19P9I0101 |
Summaries
for KIR2DS1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KIR2DS1:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells andsubsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies amonghaplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4,KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and bywhether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduceinhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins withthe short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase bindingprotein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules;thus, KIR proteins are thought to play an important role in regulation of the immune response. (provided by RefSeq)
UniProtKB/Swiss-Prot: KI2S1_HUMAN, Q14954Function: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells
|
Genomic Views
for KIR2DS1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
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|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for KIR2DS1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KIR2DS1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.4 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.4KIR2DS1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P055281: view genomic region
(about GC identifiers)
Start:
|
55,281,263 bp from pter |
End:
|
55,295,498 bp from pter |
Size:
|
14,236 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr19+,NT_113949 115,099-129,113 |
|
Proteins
for KIR2DS1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
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|
UniProtKB/Swiss-Prot: KI2S1_HUMAN, Q14954 (See
protein sequence)Recommended Name: Killer cell immunoglobulin-like receptor 2DS1 precursor Size: 304 amino acids; 33646 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein
Secondary accessions: O43471Explore the universe of human proteins at neXtProt for KIR2DS1: NX_Q14954
REFSEQ proteins: NP_055327.1
ENSEMBL proteins: ENSP00000336769 ENSP00000291633
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
KIR2DS1 for ontologies About GeneDecksing
Antibodies for KIR2DS1:
Assays for KIR2DS1: |
Protein
Domains/
Families
for KIR2DS1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KIR2DS1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14954ProtoNet protein and cluster: Q14954 1 Blocks protein family: IPB003599 Immunoglobulin subtype
UniProtKB/Swiss-Prot: KI2S1_HUMAN, Q14954Similarity: Belongs to the immunoglobulin superfamilySimilarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains |
Gene Function
for KIR2DS1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: KI2S1_HUMAN, Q14954Function: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells
Genatlas biochemistry entry for KIR2DS1:natural killer cell immunoglobulin-like activating receptor for HLA-C antigens,2DS13 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
KIR2DS1 for ontologies About GeneDecksing
|
Pathways & Interactions
for KIR2DS1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
KIR2DS1 for pathways About GeneDecksing
1  Millipore Pathway for KIR2DS1
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for KIR2DS1
2  Kegg Pathways (Kegg details for KIR2DS1):  | hsa04612 Antigen processing and presentation | | hsa04650 Natural killer cell mediated cytotoxicity |
SABiosciences Custom Pathway-Focused PCR Arrays for KIR2DS1
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for KIR2DS1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KIR2DS1
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002769 | natural killer cell inhibitory signaling pathway |
-- | -- | | GO:0006955 | immune response |
NAS | 8627176 | | GO:0050776 | regulation of immune response |
TAS | -- |
About this table
KIR2DS1 for ontologies About GeneDecksing
|
Drugs & Compounds
for KIR2DS1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for KIR2DS1
|
Transcripts
for KIR2DS1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
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|
REFSEQ mRNAs for KIR2DS1 gene: NM_014512.1 24/93 AceView cDNA sequences (see all 93): AY366242 AF208054 AY223515 AY052497 AY052498 AF285434 AF034773 AF002981 X99480 NM_014219 BV203728 BV199098 BM917014 BV204361 BM918119 AF002979 BC041611 BX952500 X99481 L76668 AF002256 BV199144 U24079 Y13054
 highest scoring ESTs for KIR2DS1:AJ620616
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000336077(uc010erz.1 uc002qhb.1) ENST00000291633
|
Expression
for KIR2DS1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| KIR2DS1 expression in normal and diseased human tissues
1 / 2 / 3 2 probe-sets matching KIR2DS1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 208198_x_at2, 3
|
U133-A |
16 |
0.91 |
0.29 |
-- |
-- |
NM_014512 |
0.20 |
0.03 |
0.14 |
2 |
| 208198_x_at2
|
U133Plus2 |
16 |
0.91 |
0.29 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SABiosciences Custom PCR Arrays for KIR2DS1
|
Orthologs
for KIR2DS1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
| ENSEMBL Gene Tree for KIR2DS1 (if available) |
Paralogs
for KIR2DS1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for KIR2DS1 gene
- KIR2DL1 KIR2DS2 KIR2DS5 KIR2DS41 2 KIR2DL3 KIR2DL42 KIR2DS32 KIR3DX12
- IGSF12 KIR3DL32 KIR3DL12 OSCAR2 A1BG2 KIR2DL22 KIR3DL22 ENSG000002177922
- TARM12
KIR2DS1 for paralogs About GeneDecksing
|
Genomic Variants
for KIR2DS1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
| |
Disorders & Mutations
for KIR2DS1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KIR2DS1 for disorders About GeneDecksing
OMIM: 604952
1  Novoseek disease relationship for KIR2DS1 gene
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| psoriasis |
33.9 |
5 |
16829306 (3), 15310528 (2) |
About this table
Locus Specific Mutation Databases (LSDB): KIR2DS1
Genetic Association Database (GAD): KIR2DS1
Human Genome Epidemiology (HuGE) Navigator: KIR2DS1 (81 documents)
Export disorders and mutations for KIR2DS1 gene to outside databases
|
Medical News
for KIR2DS1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for KIR2DS1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/106 PubMed articles for KIR2DS1 gene, integrated from 7 sources (see all 106):
(articles sorted by number of sources associating them with KIR2DS1)- The human leukocyte antigen (HLA)-C-specific 'activatory' or 'inhibitory' natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions. (PubMed id 8627176)1, 2, 3 Biassoni R.... Moretta L. (1996)
- Gene for the activating natural killer cell receptor, KIR2DS1, is associated with susceptibility to psoriasis vulgaris. (PubMed id 15310528)1, 4, 7 L/uszczek W....Kusnierczyk P. (2004)
- Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population. (PubMed id 15896204)1, 4 Jiang K....Yan L.X. (2005)
- Distinct HLA-C/KIR genotype profile associates with guttate psoriasis. (PubMed id 16185272)1, 4 Holm S.J....Sanchez F.O. (2005)
- Activating killer cell immunoglobulin-like receptor gene KIR2DS1 is associated with psoriatic arthritis. (PubMed id 16112031)1, 4 Williams F....Middleton D. (2005)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Genetic polymorphisms of killer cell immunoglobulin-like receptors are associated with susceptibility to psoriasis vulgaris. (PubMed id 15140215)1, 4 Suzuki Y....Muto M. (2004)
- Human diversity in killer cell inhibitory receptor genes. (PubMed id 9430221)1, 2 Uhrberg M.... Parham P. (1997)
- A role for KIR gene variants other than KIR2DS1 in conferring susceptibility to psoriasis. (PubMed id 16829306)1, 7 Pl/oski R....Malejczyk J. (2006)
- Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respirato ry papillomatosis. (PubMed id 19861144)1, 7 Bonagura V.R....Rajalingam R. (2010)
|
External Searches for KIR2DS1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing KIR2DS1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KIR2DS1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KIR2DS1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for KIR2DS1 gene:
Search GeneIP for patents involving KIR2DS1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KIR2DS1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
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