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KLHL12 Gene

protein-coding   GIFtS: 48

GC01M174025
kelch-like 12 (Drosophila)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
kelch-like 12 (Drosophila)1 2     kelch-like protein 122
C3IP11 2 3     DKIR2
CUL3-interacting protein 12 3     kelch-like protein C3IP12
FLJ271522     

External Ids:    HGNC: 193601   Entrez Gene: 593492   Ensembl: ENSG000001171537   UniProtKB: Q53G593   

Export aliases for KLHL12 gene to outside databases

Previous GC identifers: GC01M200149 GC01M199591 GC01M201126 GC01M202860


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59
Function: Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively
regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3

Gene Wiki entry for KLHL12

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLHL12 gene promoter:
         MEF-2A   RP58   FOXC1   GATA-1   ITF-2   Tal-1beta   E47   Tal-1   deltaCREB   CREB   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for KLHL12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for KLHL12 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

KLHL12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL12 gene location

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M174025:  view genomic region     (about GC identifiers)

Start:
174,025,817 bp from pter
End:
174,061,990 bp from pter
Size:
36,174 bases
Orientation:
minus strand

1 alternative location:
Chr1- 202,860,228-202,897,764     
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59 (See protein sequence)
Recommended Name: Kelch-like protein 12  
Size: 568 amino acids; 63277 Da
Subunit: Component of an ubiquitin-protein E3 ligase complex which includes at least CUL3 and KLHL12. This complex
interacts with DVL3 upon activation of the Wnt signaling pathway by WNT3A
PDB structures from and Proteopedia :
2VPJ (3D)    
Secondary accessions: Q9HBX5

Explore the universe of human proteins at neXtProt for KLHL12: NX_Q53G59 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_067646.1  

    ENSEMBL proteins: 
    ENSP00000356230 ENSP00000356228 ENSP00000356227 ENSP00000356229 ENSP00000416886 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
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    OriGene Protein Over-expression Lysate: KLHL12
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    Novus Biologicals Protein for KLHL12
    Novus Biologicals Lysates for KLHL12
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    Browse ProSpec Recombinant Proteins


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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for KLHL12 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    KLHL12 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR017096 Kelch-like_gigaxonin
     IPR000210 BTB/POZ-like
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR015916 Gal_Oxidase_b-propeller

    Graphical View of Domain Structure for InterPro Entry Q53G59

    ProtoNet protein and cluster: Q53G59

    3 Blocks protein families:
    IPB000210 BTB/POZ domain
    IPB006651 Kelch repeat signature
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59
    Domain: The BTB domain is required for interaction with CUL3
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59
    Function: Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively
    regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for KLHL12
    Sigma-Aldrich shRNA for KLHL12
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    OriGene basic RS shRNA: KLHL12
    OriGene siRNA: KLHL12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KLHL12 
    miRNA:Sigma-Aldrich microRNA Mimics for KLHL12
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KLHL12 
    3 SABiosciences Assays for microRNAs that regulate KLHL12:
    hsa-miR-875-3p hsa-miR-1825 hsa-miR-1299

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: KLHL12
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: KLHL12
    OriGene untagged cDNA clones in CMV expression vector: KLHL12
    OriGene 3'-UTR clone: KLHL12 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: KLHL12 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for KLHL12 

    1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI16189514
    About this table

    KLHL12 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for KLHL12 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLHL12

    5/17 Interacting proteins for KLHL12 (Q53G591, 2) via UniProtKB, MINT, and/or STRING (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542531, 2EBI-740929,EBI-930964 MINT-2875559 MINT-2855203
    PEF1Q9UBV81EBI-740929,EBI-724639
    BAG6P463792MINT-66953
    CPSF6Q166302MINT-67222
    ENSG00000229524P463792
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016055 Wnt receptor signaling pathway IEA--
    About this table

    KLHL12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLHL12


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for KLHL12
    Sigma-Aldrich shRNA for KLHL12
    OriGene 29mer shRNA kits in GFP-retroviral vector: KLHL12
    OriGene shRNA RFP: KLHL12
    OriGene basic RS shRNA: KLHL12
    OriGene siRNA: KLHL12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KLHL12 
    miRNA: Sigma-Aldrich microRNA Mimics for KLHL12
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KLHL12 
    3 SABiosciences Assays for microRNAs that regulate KLHL12:
    hsa-miR-875-3p hsa-miR-1825 hsa-miR-1299
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: KLHL12
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: KLHL12
    OriGene untagged cDNA clones in CMV expression vector: KLHL12
    OriGene 3'-UTR Clone: KLHL12 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: KLHL12 
    Primers: OriGene genome-wide validated SYBR primer pairs: KLHL12
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for KLHL12: PPH07221A

    REFSEQ mRNAs for KLHL12 gene: 

    NM_021633.2  

    Additional cDNA sequence: 

    AF190900.1 AF306687.1 AF306689.1 AK024412.1 AK027656.1 AK130662.1 AK223072.1 AK301791.1 
    BC003183.1 BC004175.2 

    9 DOTS entries:

    DT.116274  DT.100784180  DT.100025398  DT.100784179  DT.97846638  DT.100784178  DT.85105660  DT.120668416 
    DT.95206014 

    24/246 AceView cDNA sequences (see all 246):

    BM764489 BQ422794 AI125849 AA227427 AF306689 AI333665 AI468687 AI283713 
    AA514940 AI123409 BM826174 AI436238 BM742703 AA442554 CK819843 AI276997 
    N24733 BM670604 BQ422098 AW293125 CK819844 BM713730 BM998417 AW467990 

    highest scoring ESTs for KLHL12:

    AA314329 AA323430 AW732578 BE615762 BE784433 BF204009 BG773551 BI463251 BI464637 BM019569 

    Unigene Cluster for KLHL12:

    Kelch-like 12 (Drosophila)
    Hs.706793  [show with all ESTs]
    Unigene Representative Sequence: NM_021633


    GeneLoc Exon Structure

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367261(uc001gyn.1 uc001gyo.1 uc009xah.1) ENST00000367259(uc001gym.1)
    ENST00000367258 ENST00000367260 ENST00000435533(uc010pqc.1)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    KLHL12 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching KLHL12 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    65869_at2, 3 U95-C 1 0.94 1.00 1.00 1.00 U69560 0.80 0.88 0.84 1
    225068_at2, 3 U133-B 1 0.91 1.00 -- -- AK024412 0.60 1.00 0.82 1
    219931_s_at2, 3 U133-A 2 0.91 0.77 -- -- NM_021633 0.60 1.00 0.82 1
    225068_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    219931_s_at2 U133Plus2 2 0.91 0.77 -- -- -- -- -- -- --
    About this table

    KLHL12 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    KLHL12 gene expression
    KLHL12 gene electronic northern expression
    KLHL12 gene sage expression
    About these images

    CGAP SAGE TAG: GAGTGAAATT

    SOURCE GeneReport for Unigene cluster: Hs.706793

    UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59
    Tissue specificity: Highly expressed in testis and at lower levels in the submandibular salivary gland

    Primers: OriGene genome-wide validated SYBR primer pairs: KLHL12
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for KLHL12: PPH07221A
        SABiosciences Custom PCR Arrays for KLHL12 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for KLHL12 gene from 5/9 species (see all 9)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    KLHL121   -- kelch-like 12 (Drosophila) 93.43(n)
    99.82(a)
    479996  XM_537119.2  XP_537119.2 
    chimpanzee
    (Pan troglodytes)
    KLHL121   -- kelch-like 12 (Drosophila) 99.47(n)
    100(a)
    457634  XM_514106.2  XP_514106.2 
    cow
    (Bos taurus)
    KLHL121   -- kelch-like 12 (Drosophila) 88.15(n)
    97.91(a)
    768068  NM_001077125.1  NP_001070593.1 
    rat
    (Rattus norvegicus)
    Klhl121   -- kelch-like 12 (Drosophila) 91.43(n)
    99.47(a)
    266772  NM_153730.1  NP_714952.1 
    mouse
    (Mus musculus)
    Klhl121 , 5 1 (58.23 cM)5
    kelch-like 12 (Drosophila)1, 5 91(n)1
    99.26(a)1
    2407561  NM_153128.21  NP_694768.11 
     AI5959535  AK0341705  (see all 9)
    About this table        Species with no ortholog for KLHL12

    ENSEMBL Gene Tree for KLHL12 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for KLHL12 gene
    KLHL72  KEAP12  IPP2  KLHL102  IVNS1ABP2  KLHL82  

    KLHL12 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/394 NCBI SNPs in KLHL12 are shown (see all 394)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs9607071,2
    C,F,A,H,202888223(+) aaaaaA/Tttttg 1 -- int15Minor allele frequency- T:0.40NA EA WA 216
    rs10429901,2
    C,F,A,H,202861566(-) CACTAT/CGTGCA 1 -- ut31 ese37Minor allele frequency- C:0.40MN NS NA 314
    rs14184431,2
    C,F,O,H,202892975(-) CTATCG/ATCTTA 1 -- int115Minor allele frequency- A:0.17EA NA NS WA 644
    rs15393571,2
    C,F,O,A,202878454(-) CTAGTA/TTGTTA 1 -- int120Minor allele frequency- N:0.01NS EA NA WA 1210
    rs19778371,2
    C202897396(-) agacgG/Aagtct 1 -- ng511Minor allele frequency- A:0.50WA 2
    rs19778381,2
    C202897266(-) gccacC/Tacgcc 1 -- ng511Minor allele frequency- T:0.50WA 2
    rs22757341,2
    C,F,A,H,202887295(-) AGGTAC/TGGATT 1 -- int112Minor allele frequency- T:0.35NS EA NA WA 638
    rs22757391,2
    C,F202862345(-) GAATCC/TAGACT 1 -- int15Minor allele frequency- T:0.03EA NS 1916
    rs23637651,2
    --202861559(+) CACCCG/TGTGCA 1 -- ut31 ese30--------
    rs23637661,2
    C202861682(+) ACACAA/CACACC 2 V syn1 ref10--------
    About this table

    HapMap Linkage Disequilibrium images for KLHL12 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KLHL12: --

    QIAGEN SeqTarget long-range PCR primers for resequencing KLHL12 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KLHL12 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: KLHL12 (1 document)

    Export disorders and mutations for KLHL12 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/14 PubMed articles for KLHL12 gene, integrated from 7 sources (see all 14):
    (articles sorted by number of sources associating them with KLHL12)
    1. The KLHL12-cullin-3 ubiquitin ligase negatively regulates the Wnt- beta-catenin pathway by targeting Dishevelled for degradation. (PubMed id 16547521)1, 2 Angers S.... Moon R.T. (2006)
    2. Identification of specific autoantigens in Sjoegren's syndrome by SEREX. (PubMed id 16108817)1, 2 Uchida K.... Kozaki K. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    6. Follow-up of a major linkage peak on chromosome 1 rev eals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1 Ehret G.B....Chakravarti A. (2009)
    7. Automated phosphoproteome analysis for cultured cancer cells by two- dimensional nanoLC-MS using a calcined titania/C18 biphasic column. (PubMed id 18187866)2 Imami K.... Ishihama Y. (2008)
    8. BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase. (PubMed id 18303015)1 Rondou P....Van Craenenbroeck K. (2008)
    9. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 59349 HGNC: 19360 AceView: KLHL12 Ensembl:ENSG00000117153 euGenes: HUgn59349
    ECgene: KLHL12 H-InvDB: KLHL12

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for KLHL12 gene:
    Search GeneIP for patents involving KLHL12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
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     Predesigned and custom siRNAs for KLHL12 Antibodies for KLHL12
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     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KLHL12
     SeqTarget long-range PCR primers for resequencing KLHL12
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for KLHL12
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KLHL12
     GenScript Custom Purified and Recombinant Proteins Services for KLHL12 GenScript cDNA clones with any tag delivered in your preferred vector for KLHL12
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     Regulatory tfbs in KLHL12 promoter
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     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for KLHL12
           

    GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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