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KLHL12 Gene

protein-coding GIFtS: 48

GC01M174025

kelch-like 12 (Drosophila)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
kelch-like 12 (Drosophila)¹ ²		kelch-like protein 12²
C3IP1¹ ² ³		DKIR²
CUL3-interacting protein 1² ³		kelch-like protein C3IP1²
FLJ27152²

External Ids:	HGNC: 19360¹	Entrez Gene: 59349²	Ensembl: ENSG00000117153⁷	UniProtKB: Q53G59³

Export aliases for KLHL12 gene to outside databases

Previous GC identifers: GC01M200149 GC01M199591 GC01M201126 GC01M202860

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59

Function: Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively

regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3

Gene Wiki entry for KLHL12

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KLHL12 gene promoter:
         MEF-2A   RP58   FOXC1   GATA-1   ITF-2   Tal-1beta   E47   Tal-1   deltaCREB   CREB
         Other transcription factors

Search SABiosciences Chromatin IP Primers for KLHL12

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for KLHL12

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1

KLHL12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL12 gene location

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M174025: view genomic region (about GC identifiers)

Start:	174,025,817 bp from pter
End:	174,061,990 bp from pter
Size:	36,174 bases
Orientation:	minus strand

1 alternative location:

Chr1- 202,860,228-202,897,764

RefSeq DNA sequence:

NC_000001.10 NT_004487.19

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59 (See protein sequence)

Recommended Name: Kelch-like protein 12

Size: 568 amino acids; 63277 Da

Subunit: Component of an ubiquitin-protein E3 ligase complex which includes at least CUL3 and KLHL12. This complex

interacts with DVL3 upon activation of the Wnt signaling pathway by WNT3A

PDB structures from and Proteopedia :

2VPJ (3D)

Secondary accessions: Q9HBX5

Explore the universe of human proteins at neXtProt for KLHL12: NX_Q53G59

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_067646.1

ENSEMBL proteins:

ENSP00000356230 ENSP00000356228 ENSP00000356227 ENSP00000356229 ENSP00000416886

Human Recombinant Proteins

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	Uscn ELISAs and CLIAs for KLHL12

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KLHL12 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR017096 Kelch-like_gigaxonin

IPR000210 BTB/POZ-like

IPR006652 Kelch_1

IPR011333 BTB/POZ_fold

IPR015916 Gal_Oxidase_b-propeller

Graphical View of Domain Structure for InterPro Entry Q53G59

ProtoNet protein and cluster: Q53G59

3 Blocks protein families:

IPB000210 BTB/POZ domain

IPB006651 Kelch repeat signature

IPB011705 BTB/Kelch-associated

UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59

Domain: The BTB domain is required for interaction with CUL3

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 6 Kelch repeats

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59

Function: Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively

regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for KLHL12 Sigma-Aldrich shRNA for KLHL12
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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KLHL12

miRNA:		Sigma-Aldrich microRNA Mimics for KLHL12 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KLHL12
		3 SABiosciences Assays for microRNAs that regulate KLHL12:
		hsa-miR-875-3p hsa-miR-1825 hsa-miR-1299

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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		OriGene GFP tagged cDNA clones in CMV expression vector: KLHL12 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: KLHL12 OriGene untagged cDNA clones in CMV expression vector: KLHL12 OriGene 3'-UTR clone: KLHL12 Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: KLHL12
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for KLHL12

1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16189514

About this table

KLHL12 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for KLHL12

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KLHL12

5/17 Interacting proteins for KLHL12 (Q53G59^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATXN1	P54253¹^,²	EBI-740929,EBI-930964 MINT-2875559 MINT-2855203
PEF1	Q9UBV8¹	EBI-740929,EBI-724639
BAG6	P46379²	MINT-66953
CPSF6	Q16630²	MINT-67222
ENSG00000229524	P46379²

About this table

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016055	Wnt receptor signaling pathway	IEA	--

About this table

KLHL12 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KLHL12

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for KLHL12 Sigma-Aldrich shRNA for KLHL12
		OriGene 29mer shRNA kits in GFP-retroviral vector: KLHL12 OriGene shRNA RFP: KLHL12 OriGene basic RS shRNA: KLHL12 OriGene siRNA: KLHL12
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KLHL12

miRNA:		Sigma-Aldrich microRNA Mimics for KLHL12 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KLHL12
		3 SABiosciences Assays for microRNAs that regulate KLHL12:
		hsa-miR-875-3p hsa-miR-1825 hsa-miR-1299

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: KLHL12 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: KLHL12 OriGene untagged cDNA clones in CMV expression vector: KLHL12 OriGene 3'-UTR Clone: KLHL12 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: KLHL12

Primers:		OriGene genome-wide validated SYBR primer pairs: KLHL12 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for KLHL12: PPH07221A

REFSEQ mRNAs for KLHL12 gene:

NM_021633.2

Additional cDNA sequence:

AF190900.1 AF306687.1 AF306689.1 AK024412.1 AK027656.1 AK130662.1 AK223072.1 AK301791.1

BC003183.1 BC004175.2

9 DOTS entries:

DT.116274 DT.100784180 DT.100025398 DT.100784179 DT.97846638 DT.100784178 DT.85105660 DT.120668416

DT.95206014

24/246 AceView cDNA sequences (see all 246):

BM764489 BQ422794 AI125849 AA227427 AF306689 AI333665 AI468687 AI283713

AA514940 AI123409 BM826174 AI436238 BM742703 AA442554 CK819843 AI276997

N24733 BM670604 BQ422098 AW293125 CK819844 BM713730 BM998417 AW467990

highest scoring ESTs for KLHL12:

AA314329 AA323430 AW732578 BE615762 BE784433 BF204009 BG773551 BI463251 BI464637 BM019569

Unigene Cluster for KLHL12:

Kelch-like 12 (Drosophila)

Hs.706793 [show with all ESTs]

Unigene Representative Sequence: NM_021633

GeneLoc Exon Structure

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367261(uc001gyn.1 uc001gyo.1 uc009xah.1) ENST00000367259(uc001gym.1)

ENST00000367258 ENST00000367260 ENST00000435533(uc010pqc.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

KLHL12 expression in normal and diseased human tissues

¹ / ² / ³

5 probe-sets matching KLHL12 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
65869_at²^{, 3}	U95-C	1	0.94	1.00	1.00	1.00	U69560	0.80	0.88	0.84	1
225068_at²^{, 3}	U133-B	1	0.91	1.00	--	--	AK024412	0.60	1.00	0.82	1
219931_s_at²^{, 3}	U133-A	2	0.91	0.77	--	--	NM_021633	0.60	1.00	0.82	1
225068_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--
219931_s_at²	U133Plus2	2	0.91	0.77	--	--	--	--	--	--	--

About this table

KLHL12 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

KLHL12 gene electronic northern expression

About these images

CGAP SAGE TAG: GAGTGAAATT

SOURCE GeneReport for Unigene cluster: Hs.706793

UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59

Tissue specificity: Highly expressed in testis and at lower levels in the submandibular salivary gland

Primers:		OriGene genome-wide validated SYBR primer pairs: KLHL12 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for KLHL12: PPH07221A

SABiosciences Custom PCR Arrays for KLHL12

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KLHL12 gene from 5/9 species (see all 9)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KLHL12¹	--	kelch-like 12 (Drosophila)	93.43(n) 99.82(a)	479996 XM_537119.2 XP_537119.2
chimpanzee (Pan troglodytes)	KLHL12¹	--	kelch-like 12 (Drosophila)	99.47(n) 100(a)	457634 XM_514106.2 XP_514106.2
cow (Bos taurus)	KLHL12¹	--	kelch-like 12 (Drosophila)	88.15(n) 97.91(a)	768068 NM_001077125.1 NP_001070593.1
rat (Rattus norvegicus)	Klhl12¹	--	kelch-like 12 (Drosophila)	91.43(n) 99.47(a)	266772 NM_153730.1 NP_714952.1
mouse (Mus musculus)	Klhl12^{1 , 5}	1 (58.23 cM)⁵	kelch-like 12 (Drosophila)^{1, 5}	91(n)¹ 99.26(a)¹	240756¹ NM_153128.2¹ NP_694768.1¹ AI595953⁵ AK034170⁵ (see all 9)

About this table Species with no ortholog for KLHL12

ENSEMBL Gene Tree for KLHL12 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KLHL12 gene

KLHL7² KEAP1² IPP² KLHL10² IVNS1ABP² KLHL8²

KLHL12 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs960707^1,2	C,F,A,H,	202888223(+)	`aaaaaA/Tttttg`	1	--	int¹		5		NA EA WA	216
rs1042990^1,2	C,F,A,H,	202861566(-)	`CACTAT/CGTGCA`	1	--	ut3¹ ese³		7		MN NS NA	314
rs1418443^1,2	C,F,O,H,	202892975(-)	`CTATCG/ATCTTA`	1	--	int¹		15		EA NA NS WA	644
rs1539357^1,2	C,F,O,A,	202878454(-)	`CTAGTA/TTGTTA`	1	--	int¹		20		NS EA NA WA	1210
rs1977837^1,2	C	202897396(-)	`agacgG/Aagtct`	1	--	ng5¹		1		WA	2
rs1977838^1,2	C	202897266(-)	`gccacC/Tacgcc`	1	--	ng5¹		1		WA	2
rs2275734^1,2	C,F,A,H,	202887295(-)	`AGGTAC/TGGATT`	1	--	int¹		12		NS EA NA WA	638
rs2275739^1,2	C,F	202862345(-)	`GAATCC/TAGACT`	1	--	int¹		5		EA NS	1916
rs2363765^1,2	--	202861559(+)	`CACCCG/TGTGCA`	1	--	ut3¹ ese³		0	--	--	--	--
rs2363766^1,2	C	202861682(+)	`ACACAA/CACACC`	2	V	syn¹ ref¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for KLHL12 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KLHL12: --

QIAGEN SeqTarget long-range PCR primers for resequencing KLHL12

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KLHL12 for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: KLHL12 (1 document)

Export disorders and mutations for KLHL12 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/14 PubMed articles for KLHL12 gene, integrated from 7 sources (see all 14):
(articles sorted by number of sources associating them with KLHL12)

The KLHL12-cullin-3 ubiquitin ligase negatively regulates the Wnt- beta-catenin pathway by targeting Dishevelled for degradation. (PubMed id 16547521)^{1, 2} Angers S.... Moon R.T. (2006)
Identification of specific autoantigens in Sjoegren's syndrome by SEREX. (PubMed id 16108817)^{1, 2} Uchida K.... Kozaki K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Follow-up of a major linkage peak on chromosome 1 rev eals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)¹ Ehret G.B....Chakravarti A. (2009)
Automated phosphoproteome analysis for cultured cancer cells by two- dimensional nanoLC-MS using a calcined titania/C18 biphasic column. (PubMed id 18187866)² Imami K.... Ishihama Y. (2008)
BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase. (PubMed id 18303015)¹ Rondou P....Van Craenenbroeck K. (2008)
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)¹ Lim J.... Zoghbi H.Y. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 59349	HGNC: 19360	AceView: KLHL12	Ensembl:ENSG00000117153	euGenes: HUgn59349
ECgene: KLHL12	H-InvDB: KLHL12

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for KLHL12 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for KLHL12 gene:
Search GeneIP for patents involving KLHL12

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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	siRNA
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	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KLHL12
	SeqTarget long-range PCR primers for resequencing KLHL12
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for KLHL12
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KLHL12

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	Regulatory tfbs in KLHL12 promoter
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GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

KLHL12 gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

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KLHL12 Gene

protein-coding GIFtS: 48

Aliases &
Descriptions
for KLHL12 gene

Summaries
for KLHL12 gene

Genomic Views
for KLHL12 gene

Proteins
for KLHL12 gene

Protein Domains/
Families
for KLHL12 gene

Gene Function
for KLHL12 gene

Pathways & Interactions
for KLHL12 gene

Drugs & Compounds
for KLHL12 gene

Transcripts
for KLHL12 gene

Expression
for KLHL12 gene

Orthologs
for KLHL12 gene

Paralogs
for KLHL12 gene

Genomic Variants
for KLHL12 gene

Disorders & Mutations
for KLHL12 gene

Medical News
for KLHL12 gene

Publications
for KLHL12 gene

External Searches for KLHL12 gene

Genome Databases showing KLHL12 gene

Other Databases showing KLHL12 gene

Specialized Databases showing KLHL12 gene

Intellectual Property
for KLHL12 gene

Products
for KLHL12 gene

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Advanced Search

Export list of displayed genes

KLHL12 Gene

protein-coding GIFtS: 48

Aliases & Descriptionsfor KLHL12 gene

Summariesfor KLHL12 gene

Genomic Viewsfor KLHL12 gene

Proteinsfor KLHL12 gene

Protein Domains/Familiesfor KLHL12 gene

Gene Functionfor KLHL12 gene

Pathways & Interactionsfor KLHL12 gene

Drugs & Compoundsfor KLHL12 gene

Transcriptsfor KLHL12 gene

Expression for KLHL12 gene

Orthologsfor KLHL12 gene

Paralogsfor KLHL12 gene

Genomic Variantsfor KLHL12 gene

Disorders & Mutationsfor KLHL12 gene

Medical Newsfor KLHL12 gene

Publicationsfor KLHL12 gene

External Searches for KLHL12 gene

Genome Databases showing KLHL12 gene

Other Databases showing KLHL12 gene

Specialized Databases showing KLHL12 gene

Intellectual Propertyfor KLHL12 gene

Productsfor KLHL12 gene

View Random Gene

Aliases &
Descriptions
for KLHL12 gene

Summaries
for KLHL12 gene

Genomic Views
for KLHL12 gene

Proteins
for KLHL12 gene

Protein Domains/
Families
for KLHL12 gene

Gene Function
for KLHL12 gene

Pathways & Interactions
for KLHL12 gene

Drugs & Compounds
for KLHL12 gene

Transcripts
for KLHL12 gene

Expression
for KLHL12 gene

Orthologs
for KLHL12 gene

Paralogs
for KLHL12 gene

Genomic Variants
for KLHL12 gene

Disorders & Mutations
for KLHL12 gene

Medical News
for KLHL12 gene

Publications
for KLHL12 gene

Intellectual Property
for KLHL12 gene

Products
for KLHL12 gene