Aliases &
Descriptions
for KLK13 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| kallikrein-related peptidase 131 2 | | kallikrein-132 | | KLK-L41 2 3 | | DKFZp586J19232 | | KLKL42 3 5 | | kallikrein-like gene 42 | | kallikrein 131 2 | | EC 3.4.21.-3 | | Kallikrein-like protein 42 3 | | |
Export aliases for KLK13 gene to outside databasesPrevious GC identifers: GC19M052189 GC19M051920 GC19M056235 GC19M056251 GC19M051559 |
Summaries
for KLK13 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KLK13:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests thatmany kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other diseasebiomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19.Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. Anadditional transcript variant has been identified, but its full length sequence has not been determined. (provided byRefSeq)
Gene Wiki entry for KLK13 |
Genomic Views
for KLK13 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KLK13 gene promoter:
GCNF-2 GCNF-1 NF-E2 NF-E2 p45 Bach2 MyoD AP-1 c-Fos c-Jun Fra-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLK13
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.33KLK13 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M047892: view genomic region
(about GC identifiers)
Start:
|
47,892,411 bp from pter |
End:
|
47,901,418 bp from pter |
Size:
|
9,008 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr19- 51,559,463-51,568,367 |
RefSeq DNA sequence:- NC_000019.9 NT_011109.16
|
Proteins
for KLK13 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: KLK13_HUMAN, Q9UKR3 (See
protein sequence)Recommended Name: Kallikrein-13 precursor Size: 277 amino acids; 30570 Da
Subcellular location: Secreted (Probable)
Secondary accessions: A7UNK6 Q9Y433Explore the universe of human proteins at neXtProt for KLK13: NX_Q9UKR3
REFSEQ proteins: NP_056411.1
ENSEMBL proteins: ENSP00000156476 ENSP00000365995 ENSP00000334079 ENSP00000392640 ENSP00000365997
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
KLK13 for ontologies About GeneDecksing
Antibodies for KLK13:
Assays for KLK13: |
Protein
Domains/
Families
for KLK13 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KLK13 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UKR3ProtoNet protein and cluster: Q9UKR3 2 Blocks protein families: IPB001254 Serine protease IPB001314 Chymotrypsin serine protease family (S1) signature
UniProtKB/Swiss-Prot: KLK13_HUMAN, Q9UKR3Similarity: Belongs to the peptidase S1 family. Kallikrein subfamilySimilarity: Contains 1 peptidase S1 domain |
Gene Function
for KLK13 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6): About this table
KLK13 for ontologies About GeneDecksing
|
Pathways & Interactions
for KLK13 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for KLK13
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLK13
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
KLK13 for ontologies About GeneDecksing
|
Drugs & Compounds
for KLK13 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
KLK13 for compounds About GeneDecksing
 Browse Tocris compounds for KLK13
2  Novoseek chemical compound relationships for KLK13 gene
About this table
|
Transcripts
for KLK13 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for KLK13 gene: NM_015596.1 Additional cDNA sequence: AB108823.1 AB108824.1 AB451465.1 AL050220.1 AY923171.1 AY923172.1 AY923173.1 AY923174.1 AY923175.1 BC069334.1 BC069543.1 6 DOTS entries: DT.100741572 DT.65285181 DT.92422253 DT.121487859 DT.121487868 DT.99996047 24/25 AceView cDNA sequences (see all 25): AB108823 AB108824 NM_015596 AI889574 BX106071 AA846771 BQ027298 AA399955 AL050220 BC069543 BC069334 AI002101 BE716310 AW243944 AI032327 BE716321 AA401397 BE715189 BF354061 AW189585 BE184351 BF354651 BF354621 BQ356844
 highest scoring ESTs for KLK13:AL050220 BC069334 BC069543 AA401397 AB108823 AB108824 AI032327 AW243944 AY923171 AY923172 Unigene Cluster for KLK13: Kallikrein-related peptidase 13 Hs.165296 [show with all ESTs]Unigene Representative Sequence: AY923172
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for KLK13 (see all 8)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
|---|
|
| SP1: | | | | | - | | | | | | | | | | - | | - | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | | | | | | | - | | - | | | | | | | | | | |
| SP4: | | | | | - | | - | | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | - | | - | | | | | | - | | - | | - | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for KLK13
5 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000156476(uc002pvn.2 uc002pvo.2 uc002pvp.2 uc002pvq.2 uc002pvr.2)
ENST00000376799(uc010eon.2) ENST00000335422(uc010eoo.2) ENST00000441527(uc002pvl.2 uc002pvm.2)
ENST00000376801
|
Expression
for KLK13 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| KLK13 expression in normal and diseased human tissues
1 / 2 / 3 6 probe-sets matching KLK13 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 36406_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.58 |
0.86 |
AA401397 |
0.60 |
1.00 |
0.82 |
1 |
| 36407_at2, 3
|
U95-A |
1 |
0.81 |
1.00 |
0.82 |
1.14 |
AL050220 |
1.00 |
1.00 |
1.00 |
1 |
| 205783_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_015596 |
0.60 |
1.00 |
0.82 |
1 |
| 217315_s_at2, 3
|
U133-A |
1 |
0.55 |
1.00 |
-- |
-- |
AL050220 |
1.00 |
1.00 |
1.00 |
1 |
| 205783_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 217315_s_at2
|
U133Plus2 |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
KLK13 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TGGGCAACCT
SOURCE GeneReport for Unigene cluster: Hs.165296
Expression variation in blood from EXPOLDB for KLK13 UniProtKB/Swiss-Prot: KLK13_HUMAN, Q9UKR3Tissue specificity: Expressed in prostate, breast, testis and salivary gland
SABiosciences Custom PCR Arrays for KLK13
|
Orthologs
for KLK13 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KLK13 gene from 5/6 species (see all 6)
About this table Species with no ortholog for KLK13
ENSEMBL Gene Tree for KLK13 (if available) |
Paralogs
for KLK13 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for KLK13 gene
- KLK62 KLK122 KLK22 KLK102 KLK12 KLK152 KLK52 KLK42
- KLK112 KLK72 KLK82 KLK32 KLK92
KLK13 for paralogs About GeneDecksing
|
Genomic Variants
for KLK13 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 19 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for KLK13 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for KLK13
2 CNVs: 48034 58886 | | QIAGEN SeqTarget long-range PCR primers for resequencing KLK13 |
|
Disorders & Mutations
for KLK13 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KLK13 for disorders About GeneDecksing
OMIM: 605505
2 Novoseek disease relationships for KLK13 gene
About this table
Human Genome Epidemiology (HuGE) Navigator: KLK13 (1 document)
Export disorders and mutations for KLK13 gene to outside databases
|
Medical News
for KLK13 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for KLK13 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/25 PubMed articles for KLK13 gene, integrated from 7 sources (see all 25):
(articles sorted by number of sources associating them with KLK13)- Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues. (PubMed id 10766816)1, 2, 7 Yousef G.M.... Diamandis E.P. (2000)
- Understanding the accuracy of statistical haplotype inference with sequence data of known phase. (PubMed id 17922479)1, 2 Andres A.M....Hixson J.E. (2007)
- Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PubMed id 16800723)1, 3 (2006)
- A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PubMed id 16800724)1, 3 Lundwall A....Yousef G.M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Human kallikrein gene 13 (KLK13) expression by quantitative RT-PCR: an independent indicator of favourable prognosis in breast cancer. (PubMed id 11986781)1, 7 Chang A....Diamandis E.P. (2002)
- Identification and molecular characterization of five novel kallikrein gene 13 (KLK13; KLK-L4) splice variants: differential expression in the human testis and testicular cancer. (PubMed id 11848466)1, 7 Chang A.... Diamandis E.P. (2001)
- Complex formation between human kallikrein 13 and serum protease inhibitors. (PubMed id 14687906)1, 7 Kapadia C....Diamandis E.P. (2004)
- Human kallikrein 13 involvement in extracellular matrix degradation. (PubMed id 15381110)1, 7 Kapadia C....Diamandis E.P. (2004)
|
External Searches for KLK13 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KLK13 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLK13 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KLK13 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for KLK13 gene:
Search GeneIP for patents involving KLK13
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KLK13 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for KLK13 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for KLK13 |
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