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KLK2 Gene

protein-coding GIFtS: 64

GC19P047711

kallikrein-related peptidase 2
(Previous names: kallikrein 2, prostatic )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
kallikrein-related peptidase 2¹ ²		KLK2A2²
kallikrein 2, prostatic¹ ²		hK2²
Tissue kallikrein-2² ³		MGC12201²
Glandular kallikrein-1² ³		kallikrein-2²
hGK-1² ³		EC 3.4.21.35³
glandular kallikrein 2²

External Ids:	HGNC: 6363¹	Entrez Gene: 3817²	Ensembl: ENSG00000167751⁷	UniProtKB: P20151³

Export aliases for KLK2 gene to outside databases

Previous GC identifers: GC19P052005 GC19P051737 GC19P056052 GC19P056068 GC19P051376

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: KLK2_HUMAN, P20151

Function: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin

Gene Wiki entry for KLK2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KLK2 gene promoter:
         Max1   NF-kappaB   NF-kappaB1   c-Myc   c-Rel   p53   p300   AP-2rep   E4BP4   YY1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for KLK2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.33

KLK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK2 gene location

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P047711: view genomic region (about GC identifiers)

Start:	47,711,579 bp from pter
End:	47,718,718 bp from pter
Size:	7,140 bases
Orientation:	plus strand

1 alternative location:

Chr19+ 51,376,689-51,383,822

RefSeq DNA sequence:

NC_000019.9 NT_011109.16

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: KLK2_HUMAN, P20151 (See protein sequence)

Recommended Name: Kallikrein-2 precursor

Size: 261 amino acids; 28671 Da

Secondary accessions: Q15946 Q9UJZ9

Alternative splicing: 3 isoforms: P20151-1 P20151-2 P20151-3

Explore the universe of human proteins at neXtProt for KLK2: NX_P20151

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001002231.1 NP_005542.1

ENSEMBL proteins:

ENSP00000313581 ENSP00000350748 ENSP00000395423 ENSP00000375686

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for KLK2 (Kallikrein 2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates
	GenScript Custom Purified and Recombinant Proteins Services for KLK2
	Novus Biologicals Protein for KLK2
	Novus Biologicals Lysate for KLK2
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

Antibodies for KLK2:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for KLK2
	R&D Systems Antibodies for KLK2 (Kallikrein 2)
	OriGene Antibodies: KLK2
	GenScript Custom Superior Antibodies Services for KLK2
	Novus Biologicals Antibodies for KLK2
	Epitomics antibodies for KLK2

Assays for KLK2:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript KLK2-Activity-based Protease Assay for Compound Screening
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KLK2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KLK2 for domains About GeneDecksing

4 InterPro domains/families:

IPR001314 Peptidase_S1A

IPR001254 Peptidase_S1_S6

IPR018114 Peptidase_S1/S6_AS

IPR009003 Ser/Cys_Pept_Trypsin-like

Graphical View of Domain Structure for InterPro Entry P20151

ProtoNet protein and cluster: P20151

2 Blocks protein families:

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

UniProtKB/Swiss-Prot: KLK2_HUMAN, P20151

Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily

Similarity: Contains 1 peptidase S1 domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: KLK2_HUMAN, P20151

Function: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin

Catalytic activity: Preferential cleavage of Arg- -Xaa bonds in small molecule substrates. Highly selective action to

release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met- -Xaa or Leu- -Xaa

Enzyme Number (IUBMB): EC 3.4.21.35

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for KLK2 Sigma-Aldrich shRNA for KLK2
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): KLK2 OriGene shRNA RFP (see all 3): KLK2 OriGene basic RS shRNA (see all 3): KLK2 OriGene siRNA (see all 3): KLK2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KLK2

miRNA:		Sigma-Aldrich microRNA Mimics for KLK2 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KLK2
		Search SABiosciences for Assays for microRNAs that regulate KLK2

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): KLK2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): KLK2 OriGene untagged cDNA clones in CMV expression vector (see all 2): KLK2 OriGene 3'-UTR clone (see all 2): KLK2 Browse MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): KLK2
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for KLK2

Genatlas biochemistry entry for KLK2:

kallikrein 2,glandular,expressed in the prostate,complexing with protease inhibitor 6 in prostate cancer tissue

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0004252	serine-type endopeptidase activity	IEA	--
GO:0008233	peptidase activity	IEA	--

About this table

KLK2 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

KLK2 for pathways About GeneDecksing

1 Millipore Pathway for KLK2

Cell adhesion ECM remodeling

5/10 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for KLK2 (see all 10)

	MSP-RON Signaling Pathway
	Axonal Guidance Signaling
	Lysine Degradation
	Intrinsic Prothrombin Activation Pathway
	ERK5 Signaling

SABiosciences Pathway-Focused PCR Array including KLK2: PAHS-014A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for KLK2

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KLK2

5/10 Interacting proteins for KLK2 (ENSP00000313581³) via UniProtKB, MINT, and/or STRING (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NCOA2	ENSP00000267974³	STRING: ENSP00000267974
SRC	ENSP00000362659³	STRING: ENSP00000362659
CARM1	ENSP00000325690³	STRING: ENSP00000325690
SERPINA5	ENSP00000333203³	STRING: ENSP00000333203
SERPINF2	ENSP00000371493³	STRING: ENSP00000371493

About this table

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--

About this table

KLK2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

KLK2 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KLK2
6 Novoseek chemical compound relationships for KLK2 gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
serine	63.9	14	10438493 (1), 10583401 (1), 20128684 (1), 10024471 (1) (see all 11)
progestins	50	2	9205072 (1)
dihydrotestosterone	46.5	2	1370633 (1), 20043108 (1)
testosterone	41.8	24	10197620 (4), 9241247 (3), 12767274 (2), 1370633 (1) (see all 8)
steroid	14.8	3	11948967 (1), 19147544 (1), 9205072 (1)
oligonucleotide	12.3	3	7515392 (1), 1691151 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for KLK2 Sigma-Aldrich shRNA for KLK2
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): KLK2 OriGene shRNA RFP (see all 3): KLK2 OriGene basic RS shRNA (see all 3): KLK2 OriGene siRNA (see all 3): KLK2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KLK2

miRNA:		Sigma-Aldrich microRNA Mimics for KLK2 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KLK2
		Search SABiosciences for Assays for microRNAs that regulate KLK2

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): KLK2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): KLK2 OriGene untagged cDNA clones in CMV expression vector (see all 2): KLK2 OriGene 3'-UTR Clone (see all 2): KLK2 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): KLK2

Primers:		OriGene genome-wide validated SYBR primer pairs: KLK2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for KLK2: PPH01003A

REFSEQ mRNAs for KLK2 gene (2 alternative transcripts):

NM_001002231.1 NM_005551.3

Additional cDNA sequence:

AF188745.1 AF188746.1 AF188747.1 AK300527.1 AK300549.1 AK300566.1 AK309968.1 AK309969.1

AK309973.1 AK309982.1 AK309985.1 AK315890.1 AY429509.1 AY429510.1 BC005196.1 BT006650.1

CR589977.1 S39329.1

24/35 DOTS entries (see all 35):

DT.121490814 DT.422516 DT.121490591 DT.101963585 DT.85101208 DT.87046802 DT.95359387 DT.121490632

DT.121490749 DT.85104723 DT.91756917 DT.100689427 DT.91966580 DT.91756926 DT.101986345 DT.121490688

DT.75147406 DT.91858807 DT.92416838 DT.97838927 DT.95264855 DT.95264857 DT.85104722 DT.99973681

24/1035 AceView cDNA sequences (see all 1035):

AI989309 CF121099 BF588664 CF140275 NM_001002231 BX504463 CA488291 AA613267

AA526834 CA454861 T29510 AA468282 BF588850 BQ930682 BF477226 U17040

BF477017 AA595465 AA532387 BF476624 BQ933904 BF588642 BF477330 BQ276292

highest scoring ESTs for KLK2:

S39329 AA225966 AA226113 AA229535 AA243985 AA244099 AA244206 AA259243 AA420690 AA467761

Unigene Cluster for KLK2:

Kallikrein-related peptidase 2

Hs.515560 [show with all ESTs]

Unigene Representative Sequence: NM_001002231

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for KLK2 (see all 17)

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	·	8d	·	8e	^	9	^	10a	·	10b	^	11a	·
SP1:																	-		-		-																				-		-		-		-		-
SP2:																	-		-		-																						-		-		-		-
SP3:																	-		-		-								-														-		-		-		-
SP4:							-		-		-						-		-		-
SP5:																	-		-		-		-

ExUns:	11b	·	11c	·	11d
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for KLK2
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000325321 ENST00000358049(uc010eog.2 uc010yck.1 uc002ptu.2 uc002ptv.2 uc002ptt.2 uc010ycl.1 uc010ycm.1 uc010eoh.2)

ENST00000423722 ENST00000391810

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

KLK2 expression in normal and diseased human tissues

¹ / ² / ³

10 probe-sets matching KLK2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41721_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.14	AA658877	0.80	1.00	0.91	1
83531_at²^{, 3}	U95-E	1	0.94	1.00	0.97	1.01	AA534173	0.60	1.00	0.82	1
217_at²^{, 3}	U95-A	1	0.81	1.00	0.99	0.93	S39329	1.00	1.00	1.00	1
209855_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF188747	0.80	1.00	0.91	1
209854_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA595465	0.80	1.00	0.91	1
210339_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC005196	0.80	1.00	0.91	1
209855_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209854_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210339_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555545_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

About this table

KLK2 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

KLK2 gene electronic northern expression

About these images

CGAP SAGE TAG: CTGTGGTTAA

SOURCE GeneReport for Unigene cluster: Hs.515560

Expression variation in blood from EXPOLDB for KLK2

Primers:		OriGene genome-wide validated SYBR primer pairs: KLK2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for KLK2: PPH01003A

SABiosciences Expression via Pathway-Focused PCR Array including KLK2: PAHS-014A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KLK2 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KLK2¹	--	kallikrein-related peptidase 2	72.33(n) 61.78(a)	403967 NM_001003284.1 NP_001003284.1
chimpanzee (Pan troglodytes)	KLK2¹	--	kallikrein-related peptidase 2	99.36(n) 98.47(a)	748637 XM_001174026.1 XP_001174026.1
mouse (Mus musculus)	Klk1⁵ Klk1b1¹	7 (28.74 cM)⁵	kallikrein 1⁵ kallikrein 1-related peptidase b1¹	67.05(n)¹ 59.77(a)¹	16623¹ NM_010645.2¹ NP_034775.1¹ AK002278⁵ BC010754⁵ (see all 14)
fruit fly (Drosophila melanogaster)	CG17239³	22D5	--	36(a)	--

About this table Species with no ortholog for KLK2

ENSEMBL Gene Tree for KLK2 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KLK2 gene

KLK13² KLK6² KLK12² KLK10² KLK1² KLK15² KLK5² KLK4²

KLK11² KLK7² KLK8² KLK3² KLK9²

KLK2 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs4846^1,2	C,	51382263(+)	`CAAGGA/TTGACG`	2	--	ut3¹ ese³		1	MN	184
rs6070^1,2	C,F,H,	51380110(+)	`CCCAGT/ATTTTC`	2	--	int¹		16	EA MN NS NA WA	2432
rs6071^1,2	--	51380124(+)	`GACCCA/GTAGTC`	2	--	int¹		1	MN	184
rs6072^1,2	C	51377982(+)	`GTGCCA/C/GTGCCC`	6	M L V	mis¹ ref¹ ese³		1	NA	68
rs9884^1,2	--	51382298(+)	`TGGGGG/CCACTG`	2	--	ut3¹ ese³		1	MN	184
rs11090^1,2	--	51382216(+)	`ATCACT/CGAGGA`	2	--	ut3¹ ese³		1	MN	184
rs169178^1,2	C,F,	51383110(+)	`ttcaaG/Aggtga`	2	--	ut3¹ ese³		8	MN NS EA NA WA	726
rs187930^1,2	C,F,	51383350(+)	`gccttC/Attttc`	2	--	ut3¹ trp³		16	MN NS EA NA WA	1574
rs198970^1,2	--	51377908(+)	`AACCCT/ACAGCT`	2	--	int¹		3	EA NA	62
rs198971^1,2	C,A,H	51378986(+)	`ggaggC/Gagagg`	2	--	int¹ trp³		3	NA WA	6

About this table

HapMap Linkage Disequilibrium images for KLK2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KLK2: --

QIAGEN SeqTarget long-range PCR primers for resequencing KLK2

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KLK2 for disorders About GeneDecksing

OMIM: 147960

9 Novoseek disease relationships for KLK2 gene

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer	78.2	93	17085659 (6), 16322300 (3), 8950360 (3), 11967950 (3) (see all 41)
benign prostatic hyperplasia	61.3	6	1370633 (1), 10583401 (1), 11753974 (1), 16104903 (1) (see all 5)
prostatic diseases	56.8	3	15378521 (1), 9033261 (1)
prostate carcinoma	55	12	11753974 (4), 8889697 (1), 7664987 (1), 11745444 (1) (see all 7)
cancer	37.9	21	9187691 (3), 20424135 (2), 10209959 (1), 19147544 (1) (see all 13)
metastasis	18	6	15100735 (2), 11486050 (1), 10209959 (1), 11745444 (1)
tumors	17.3	28	9033261 (5), 18627344 (3), 9187691 (2), 8889697 (1) (see all 12)
breast cancer	15.5	9	9205072 (4), 10675891 (1), 11782391 (1), 19372141 (1) (see all 5)
adenocarcinoma	0	5	9187691 (3), 1691151 (1)

About this table

Genetic Association Database (GAD): KLK2
Human Genome Epidemiology (HuGE) Navigator: KLK2 (19 documents)

Export disorders and mutations for KLK2 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/144 PubMed articles for KLK2 gene, integrated from 7 sources (see all 144):
(articles sorted by number of sources associating them with KLK2)

Single nucleotide polymorphism of the human kallikrein-2 gene highly correlates with serum human kallikrein-2 levels and in combination enhances prostate cancer detection. (PubMed id 12805332)^{1, 4, 7} Nam R.K....Narod S.A. (2003)
Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. (PubMed id 11054574)^{1, 2, 7} Gan L.... Wang K. (2000)
Identification of three new alternate human kallikrein 2 transcripts: evidence of long transcript and alternative splicing. (PubMed id 10544017)^{1, 2, 7} Liu X.F.... Pastan I. (1999)
Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PubMed id 16800723)^{1, 3} (2006)
A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PubMed id 16800724)^{1, 3} Lundwall A....Yousef G.M. (2006)
Human kallikrein-2 gene polymorphism is associated with the occurrence of prostate cancer. (PubMed id 15643194)^{1, 4} Chiang C.H....Chen K.K. (2005)
An unappreciated role for RNA surveillance. (PubMed id 14759258)^{1, 2} Hillman R.T.... Brenner S.E. (2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Altered frequency of a promoter polymorphism of the kinin B2 receptor gene in hypertensive African-Americans. (PubMed id 11130770)^{1, 4} Gainer J.V....Bachvarov D.R. (2000)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3817	HGNC: 6363	AceView: KLK3andKLK2	Ensembl:ENSG00000167751	euGenes: HUgn3817
ECgene: KLK2	H-InvDB: KLK2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for KLK2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for KLK2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for KLK2 gene:
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(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
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