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KLK3 Gene

protein-coding GIFtS: 63

GC19P047693

kallikrein-related peptidase 3
(Previous names: kallikrein 3, (prostate specific antigen) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: APS)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
kallikrein-related peptidase 3¹ ²		prostate-specific antigen²
PSA¹ ² ³ ⁵		kallikrein-3²
APS² ³ ⁵		gamma-seminoprotein²
P-30 antigen² ³		KLK2A1²
kallikrein 3, (prostate specific antigen)¹		Seminin³
seminin²		EC 3.4.21.77³
hK3²		Kallikrein-3³
semenogelase²		Semenogelase³
prostate specific antigen²		Gamma-seminoprotein³

External Ids:	HGNC: 6364¹	Entrez Gene: 354²	Ensembl: ENSG00000142515⁷	UniProtKB: P07288³

Export aliases for KLK3 gene to outside databases

Previous GC identifers: GC19P051987 GC19P051719 GC19P056034 GC19P056049 GC19P051358

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLK3:

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that

many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease

biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its

protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of

seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this

protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma.

Alternate splicing of this gene generates several transcript variants encoding different isoforms. (provided by

RefSeq)

UniProtKB/Swiss-Prot: KLK3_HUMAN, P07288

Function: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum

Gene Wiki entry for KLK3 (Prostate specific antigen)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KLK3 gene promoter:
         Max1   NF-kappaB1   NF-kappaB   c-Myc   c-Rel   AP-2alphaA   AP-2gamma   p53   STAT3   Nkx3-1 v3
         Other transcription factors

Search SABiosciences Chromatin IP Primers for KLK3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.41

KLK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK3 gene location

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P047693: view genomic region (about GC identifiers)

Start:	47,693,102 bp from pter
End:	47,698,947 bp from pter
Size:	5,846 bases
Orientation:	plus strand

1 alternative location:

Chr19+ 51,358,171-51,364,020

RefSeq DNA sequence:

NC_000019.9 NT_011109.16

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: KLK3_HUMAN, P07288 (See protein sequence)

Recommended Name: Prostate-specific antigen precursor

Size: 261 amino acids; 28741 Da

Subcellular location: Secreted

Sequence caution: Sequence=AAD14185.1; Type=Erroneous initiation;

PDB structures from and Proteopedia :

1PFA (3D)

2PSA (3D)

2ZCH (3D)

2ZCK (3D)

2ZCL (3D)

Secondary accessions: Q16272 Q86TG8

Explore the universe of human proteins at neXtProt for KLK3: NX_P07288

REFSEQ proteins (4 alternative transcripts):

NP_001025218.1 NP_001025219.1 NP_001025221.1 NP_001639.1

ENSEMBL proteins:

ENSP00000393628 ENSP00000314459 ENSP00000314151 ENSP00000353829 ENSP00000403108 ENSP00000401523

Human Recombinant Proteins

	Millipore Purified and/or Recombinant KLK3 Protein
	Sigma-Aldrich Proteins for KLK3
	R&D Systems Recombinant & Natural Proteins for KLK3 (Kallikrein 3/PSA)
	Enzo Life Sciences proteins for KLK3
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: KLK3
	GenScript Custom Purified and Recombinant Proteins Services for KLK3
	Novus Biologicals Protein for KLK3
	Novus Biologicals Lysates for KLK3
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--

About this table

KLK3 for ontologies About GeneDecksing

Antibodies for KLK3:

	Millipore Mono- and Polyclonal Antibodies for the study of KLK3
	Sigma-Aldrich Antibodies for KLK3
	R&D Systems Antibodies for KLK3 (Kallikrein 3/PSA)
	OriGene Antibodies: KLK3
	GenScript Custom Superior Antibodies Services for KLK3
	Novus Biologicals Antibodies for KLK3
	Epitomics antibodies for KLK3

Assays for KLK3:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for KLK3 (Kallikrein 3/PSA)
	GenScript Custom Assay Services for KLK3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KLK3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KLK3 for domains About GeneDecksing

4 InterPro domains/families:

IPR001314 Peptidase_S1A

IPR001254 Peptidase_S1_S6

IPR018114 Peptidase_S1/S6_AS

IPR009003 Ser/Cys_Pept_Trypsin-like

Graphical View of Domain Structure for InterPro Entry P07288

ProtoNet protein and cluster: P07288

2 Blocks protein families:

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

UniProtKB/Swiss-Prot: KLK3_HUMAN, P07288

Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily

Similarity: Contains 1 peptidase S1 domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: KLK3_HUMAN, P07288

Function: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum

Catalytic activity: Preferential cleavage: -Tyr- -Xaa-

Enzyme regulation: Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This

inhibition is relieved by exposure to semenogelins, which are avid zinc binders

Enzyme Number (IUBMB): EC 3.4.21.77

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for KLK3 Sigma-Aldrich shRNA for KLK3
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 6): KLK3 OriGene shRNA RFP (see all 6): KLK3 OriGene basic RS shRNA (see all 6): KLK3 OriGene siRNA (see all 6): KLK3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KLK3

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KLK3
		Search SABiosciences for Assays for microRNAs that regulate KLK3

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): KLK3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): KLK3 OriGene untagged cDNA clones in CMV expression vector (see all 6): KLK3 OriGene 3'-UTR clone (see all 4): KLK3 Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: KLK3
		Sino Biological Human cDNA Clone for KLK3

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for KLK3

Genatlas biochemistry entry for KLK3:

kallikrein 3,prostate specific antigen,serine protease,overexpressed in prostate and breast carcinomas

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0004252	serine-type endopeptidase activity	TAS	--
GO:0008233	peptidase activity	IEA	--
GO:0008236	serine-type peptidase activity	TAS	2470553

About this table

KLK3 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

KLK3 for pathways About GeneDecksing

2 Millipore Pathways for KLK3

	Transcription Androgen Receptor nuclear signaling
	Cell adhesion ECM remodeling

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for KLK3

Prostate Cancer Signaling

2 Kegg Pathways (Kegg details for KLK3):

	hsa05200 Pathways in cancer
	hsa05215 Prostate cancer

SABiosciences Pathway-Focused PCR Arrays including KLK3: PAHS-015A PAHS-072A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for KLK3

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KLK3

5/85 Interacting proteins for KLK3 (ENSP00000314151³) via UniProtKB, MINT, and/or STRING (see all 85)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SERPINA5	ENSP00000333203³	STRING: ENSP00000333203
AR	ENSP00000363822³	STRING: ENSP00000363822
BRCA1	ENSP00000350283³	STRING: ENSP00000350283
CARM1	ENSP00000325690³	STRING: ENSP00000325690
CASP8	ENSP00000351273³	STRING: ENSP00000351273

About this table

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0016525	negative regulation of angiogenesis	NAS	10675891

About this table

KLK3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

KLK3 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KLK3
10/123 Novoseek chemical compound relationships for KLK3 gene (see all 123)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
estramustine	89.2	63	17942366 (4), 10076535 (3), 10687988 (3), 16729913 (2) (see all 39)
bicalutamide	87.7	158	9112515 (6), 7513530 (5), 15134983 (3), 19902465 (3) (see all 70)
testosterone	86.5	2207	18843272 (11), 11421528 (9), 12539223 (9), 7541588 (7) (see all 99)
estramustine phosphate	83.9	49	18634439 (5), 16882080 (5), 16037707 (4), 7542158 (3) (see all 19)
cpsa	83.3	257	11834399 (6), 10736503 (5), 10759671 (4), 12384160 (4) (see all 52)
flutamide	83.1	186	11706524 (7), 8558675 (7), 9112515 (6), 10705202 (6) (see all 71)
finasteride	80.7	389	9426721 (10), 9586598 (9), 9218012 (9), 9649261 (8) (see all 99)
pt-2a	80.7	12	15073852 (4), 11176395 (1), 15711264 (1), 10569562 (1) (see all 7)
docetaxel	79.8	226	19575420 (6), 18487550 (4), 18990177 (4), 19920389 (4) (see all 99)
prostascint	78.9	28	10617872 (3), 11920467 (2), 11113745 (2), 10850293 (2) (see all 15)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for KLK3 Sigma-Aldrich shRNA for KLK3
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 6): KLK3 OriGene shRNA RFP (see all 6): KLK3 OriGene basic RS shRNA (see all 6): KLK3 OriGene siRNA (see all 6): KLK3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KLK3

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KLK3
		Search SABiosciences for Assays for microRNAs that regulate KLK3

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): KLK3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): KLK3 OriGene untagged cDNA clones in CMV expression vector (see all 6): KLK3 OriGene 3'-UTR Clone (see all 4): KLK3 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: KLK3

Primers:		OriGene genome-wide validated SYBR primer pairs: KLK3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for KLK3: PPH01002A

REFSEQ mRNAs for KLK3 gene (4 alternative transcripts):

NM_001030047.1 NM_001030048.1 NM_001030050.1 NM_001648.2

Additional cDNA sequence:

AF335477.1 AF335478.1 AJ310937.1 AJ310938.1 AJ459782.1 AJ459783.1 AJ459784.1 AJ512346.1

AK311887.1 AK312933.1 BC005307.1 BC050595.2 BC056665.1 BT019862.1 DQ641251.1 M21895.1

M21896.1 M21897.1 M26663.1 S75755.1 U17040.1 X05332.1 X07730.1 X75682.1

24/54 DOTS entries (see all 54):

DT.92412919 DT.92461817 DT.101987510 DT.95208239 DT.455621 DT.87016872 DT.92029956 DT.100060506

DT.92461821 DT.87016874 DT.95208245 DT.95208246 DT.95208227 DT.87002147 DT.92367459 DT.87079599

DT.121490621 DT.95208221 DT.455618 DT.121490734 DT.100735196 DT.206121 DT.91966580 DT.100643341

24/1035 AceView cDNA sequences (see all 1035):

BF477003 BF592190 AI659871 BF060872 NM_001648 BX508845 CF141000 BF477226

CF146776 CA487655 CF139149 BF477158 AA468282 BF588850 BX099872 AI685510

BF475515 CA454861 BQ925109 CR589977 NM_145864 AA588496 BF477330 BF588642

highest scoring ESTs for KLK3:

X05332 AA177118 AA216409 AA224955 AA224994 AA225043 AA225114 AA225137 AA225508 AA226222

Unigene Cluster for KLK3:

Kallikrein-related peptidase 3

Hs.171995 [show with all ESTs]

Unigene Representative Sequence: AF335478

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for KLK3 (see all 13)

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	·	4d	^	5	^	6a	·	6b	·	6c	·	6d	·	6e	·	6f
SP1:											-		-		-										-								-		-
SP2:													-		-										-								-		-
SP3:											-		-		-						-				-								-
SP4:											-		-		-						-				-								-		-
SP5:											-		-		-										-								-

About this scheme

ECgene alternative splicing isoforms for KLK3
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000422986 ENST00000326052 ENST00000326003 ENST00000360617(uc010ycj.1 uc002ptr.1 uc002pts.1 uc010eof.1)

ENST00000444635 ENST00000435152(uc002ptp.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

KLK3 expression in normal and diseased human tissues

¹ / ² / ³

14 probe-sets matching KLK3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40794_at²^{, 3}	U95-A	1	1.00	1.00	0.94	0.88	X05332	1.00	1.00	1.00	1
1805_g_at²^{, 3}	U95-A	1	1.00	1.00	0.94	0.84	X07730	0.80	1.00	0.91	1
1662_r_at²^{, 3}	U95-A	1	1.00	1.00	0.82	1.29	HG2261-HT2351	0.20	1.00	0.72	1
1514_g_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.73	HG2261-HT2352	0.20	1.00	0.72	1
1804_at²^{, 3}	U95-A	1	0.94	1.00	0.97	1.36	X07730	0.80	1.00	0.91	1
1513_at²^{, 3}	U95-A	2	0.81	0.92	0.88	0.77	HG2261-HT2352	0.20	1.00	0.72	1
76108_at²^{, 3}	U95-E	1	0.69	1.00	0.57	1.32	AA225045	0.60	1.00	0.82	1
1661_i_at²^{, 3}	U95-A	1	0.57	1.00	0.96	1.08	HG2261-HT2351	0.20	1.00	0.72	1
69598_at*²^{, 3}	U95-E	1	--	--	0.88	0.64	AI669704	0.40	1.00	0.76	1
89468_at*²^{, 3}	U95-E	1	--	--	-0.23	1.59	AA614254	0.20	1.00	0.72	1
204582_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001648	0.60	1.00	0.82	1
204583_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U17040	0.80	1.00	0.91	1
204582_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204583_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

KLK3 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

KLK3 gene electronic northern expression

About these images

CGAP SAGE TAG: GGATGGGGAT

SOURCE GeneReport for Unigene cluster: Hs.171995

Expression variation in blood from EXPOLDB for KLK3

Primers:		OriGene genome-wide validated SYBR primer pairs: KLK3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for KLK3: PPH01002A

SABiosciences Expression via Pathway-Focused PCR Arrays including KLK3: PAHS-015A PAHS-072A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

ENSEMBL Gene Tree for KLK3 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KLK3 gene

KLK13² KLK6² KLK12² KLK2² KLK10² KLK1² KLK15² KLK5²

KLK4² KLK11² KLK7² KLK8² KLK9²

KLK3 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs6998^1,2	C,F,	51363661(+)	`GTGGGG/ATACAG`	4	--	ut3¹ ese³		23		MN NS EA NA	1952
rs11573^1,2	C,F,H,	51359497(+)	`GCAGGT/CGCTGC`	10	/G	syn¹ ref¹		8		NA WA	140
rs12040^1,2	--	51363827(+)	`CTGGGA/GAGCCT`	4	--	ut3¹		1		MN	184
rs12101^1,2	--	51363628(+)	`GGACAC/TAGATA`	4	--	ut3¹ ese³		1		MN	184
rs12863^1,2	--	51363898(+)	`AGGAGA/GGGGAC`	4	--	ut3¹ ese³ trp³		1		MN	184
rs12946^1,2	C,F,	51361315(+)	`CACAGC/TCTGTT`	7	S	ref¹ syn¹ int¹		6		MN NA WA	498
rs174776^1,2	C,F,H,	51359852(+)	`TGTGTC/TCCTCT`	4	--	int¹ ut3¹		23		EA NA NS WA	1214
rs266859^1,2	C,A,H,	51356800(+)	`tcaatA/Ggcgtg`	4	--	ng5¹		5		NA WA	130
rs266860^1,2	--	51356296(+)	`ggagtA/Gcagtg`	4	--	ng5¹		0	--	--	--	--
rs266875^1,2	C,A,	51361937(+)	`AAGGCA/GTCTGC`	3	--	int¹		6		MN EA WA NA	328

About this table

HapMap Linkage Disequilibrium images for KLK3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KLK3: --

QIAGEN SeqTarget long-range PCR primers for resequencing KLK3

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KLK3 for disorders About GeneDecksing

OMIM: 176820

10/94 Novoseek disease relationships for KLK3 gene (see all 94)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer	98.8	14595	9372881 (10), 11391681 (9), 12187207 (9), 7537603 (9) (see all 99)
prostate carcinoma	94.2	1143	10951348 (6), 16419068 (6), 8847816 (5), 15578715 (5) (see all 99)
benign prostatic hyperplasia	93.6	1011	9674713 (6), 8791046 (4), 15044396 (4), 7516808 (3) (see all 99)
prostatic adenocarcinoma	91.5	266	7525979 (5), 17963516 (3), 8958315 (2), 11106075 (2) (see all 99)
recurrent prostate cancer	89.2	69	9126236 (2), 9338734 (2), 16609031 (2), 1279216 (1) (see all 49)
prostatic diseases	88.9	229	7551887 (3), 11720279 (3), 12394676 (3), 7685140 (3) (see all 99)
prostatic intraepithelial neoplasia	88.6	187	10524873 (8), 7686984 (7), 8709305 (4), 7541850 (3) (see all 81)
androgen suppression	87.7	91	9166947 (4), 10477903 (4), 14712491 (3), 11685725 (2) (see all 49)
cancer	87.1	3881	7514689 (8), 11743285 (7), 1283897 (7), 9145718 (7) (see all 99)
stage prostate cancer	86.3	61	11999465 (2), 18411775 (2), 9649289 (2), 14675918 (1) (see all 44)

About this table

Human Gene Mutation Database (HGMD): KLK3
Genetic Association Database (GAD): KLK3
Human Genome Epidemiology (HuGE) Navigator: KLK3 (124 documents)

Export disorders and mutations for KLK3 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/3651 PubMed articles for KLK3 gene, integrated from 7 sources (see all 3651):
(articles sorted by number of sources associating them with KLK3)

Sequence of a cDNA clone encompassing the complete mature human prostate specific antigen (PSA) and an unspliced leader sequence. (PubMed id 2456523)^{1, 2, 3} Schulz P....Fittler F. (1988)
Molecular cloning of human prostate specific antigen cDNA. (PubMed id 2436946)^{1, 2, 3} Lundwall A. and Lilja H. (1987)
Polymorphism in ARE-I region of prostate-specific antigen gene associated with low serum testosterone level and high-grade prostate cancer. (PubMed id 15893813)^{1, 4, 7} Schatzl G....Gsur A. (2005)
Correlation of prostate-specific antigen promoter polymorphisms with clinicopathological characteristics in breast cancer. (PubMed id 12168876)^{1, 4, 7} Yang Q....Kakudo K. (2002)
Androgen receptor and prostate-specific antigen gene polymorphisms and breast cancer in African-American women. (PubMed id 16365023)^{1, 4, 7} Wang W....Ingles S.A. (2005)
Substrate specificity of prostate-specific antigen (PSA). (PubMed id 9751643)^{1, 2, 7} Coombs G.S.... Corey D.R. (1998)
Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody. (PubMed id 18187150)^{1, 2, 7} Menez R....Stura E.A. (2008)
Role of androgen metabolism genes CYP1B1, PSA/KLK3, and CYP11alpha in prostate cancer risk and aggressiveness. (PubMed id 16172228)^{1, 4, 7} Cicek M.S....Witte J.S. (2005)
The impact of polymorphism on prostate specific antigen gene on the risk, tumor volume and pathological stage of prostate cancer. (PubMed id 15017213)^{1, 4, 7} Chiang C.H....Hong C.J. (2004)
Association between genetic polymorphisms in the prostate-specific antigen gene promoter and serum prostate-specific antigen levels. (PubMed id 12865450)^{1, 4, 7} Cramer S.D....Xu J. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 354	HGNC: 6364	AceView: KLK3andKLK2	Ensembl:ENSG00000142515	euGenes: HUgn354
ECgene: KLK3	Kegg: 354	H-InvDB: KLK3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for KLK3	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Prostate_specific_antigen

Intellectual Property for KLK3 gene
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Patent Information for KLK3 gene:
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protein-coding GIFtS: 63

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recurrent cancer
stable disease
ADENOSIS SCLEROSING
Prostatism
nonmetastatic
Cancer Relapse
Acute prostatitis
prostate cancer stage C
Nocturia
Residual Cancer
Urological Cancer
aggressiveness
Bone Diseases
Breast Cancer
primary tumor
Chronic prostatitis
Adenocarcinoma
refractory cancer
prostate cancer stage A
Carcinoma Transitional Cell
Cancer
disease characteristic
FIBROCYSTIC BREAST DISEASE
Obstruction
premalignant
OBSTRUCTIVE UROPATHY
Urogenital Diseases
Urinary Tract Diseases
local cancer
ANDROGEN DEFICIENCY
MEN 3
BONE LESION
latent cancer prostate
evaluable disease
Gynecomastia
prostate cancer stage B
URINARY TRACT INFECTION ACUTE
Disease regression
cancer recurrence
prostate cancer
Impotence
Tumors
Metastasis
Prostatic Neoplasms
recurrent prostate cancer
prostatic adenocarcinoma
Urethral Stricture
progressive disease
Prostatic Hyperplasia
bladder cancer
measurable disease
Prostatitis granulomatous
Proctitis
Hyperplasia
Intraepithelial Neoplasms
HYPOGONADISM MALE
PROSTATE NODULE
locally advanced cancer
BONE TUMOR
Carcinoma
bilateral cancer
RECTAL BLEEDING
PROSTATE CARCINOMA
METASTATIC CARCINOMA
Erectile Dysfunction
Carcinoma Endometrioid
metastatic cancer
Breast Cysts
regional cancer
Second Malignancy
Prostatitis
Nodular prostate
small cell lung cancer
Prostatic Adenoma
Carcinoma Undifferentiated
prostate cancer stage D
Carcinoma Mucinous
Fowlpox
stage prostate cancer
benign prostatic hyperplasia
Adenocarcinoma Clear Cell
Bleeding
Prostatic Intraepithelial Neoplasia
solid tumor
MICTURITION DISORDER
Carcinoma Intraductal
androgen suppression
Occult Malignancy
WITHDRAWAL SYNDROME
Prostatic Diseases
residual disease
bone metastases
Hypogonadism
adenocarcinoma bladder

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KLK3 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor KLK3 gene

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