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KLK5 Gene

protein-coding   GIFtS: 55

GC19M047780
kallikrein-related peptidase 5
(Previous name: kallikrein 5 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
kallikrein-related peptidase 51 2     Kallikrein-like protein 22 3
SCTE1 2 3 5     KLKL22 5
KLK-L21 2 3     kallikrein-52
kallikrein 51 2     EC 3.4.21.-3
Stratum corneum tryptic enzyme2 3     

External Ids:    HGNC: 63661   Entrez Gene: 258182   Ensembl: ENSG000001677547   UniProtKB: Q9Y3373   

Export aliases for KLK5 gene to outside databases

Previous GC identifers: GC19M052075 GC19M051807 GC19M056122 GC19M056138 GC19M051446


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLK5:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that
many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease
biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its
expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in
desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein.
(provided by RefSeq)

UniProtKB/Swiss-Prot: KLK5_HUMAN, Q9Y337
Function: May be involved in desquamation

Gene Wiki entry for KLK5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLK5 gene promoter:
         ATF   COUP-TF1   HNF-4alpha2   GCNF-2   GCNF-1   PPAR-gamma1   PPAR-gamma2   GATA-1   ITF-2   Tal-1beta   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for KLK5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.33

KLK5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK5 gene location

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M047780:  view genomic region     (about GC identifiers)

Start:
47,779,285 bp from pter
End:
47,788,696 bp from pter
Size:
9,412 bases
Orientation:
minus strand

1 alternative location:
Chr19- 51,446,561-51,456,344     
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: KLK5_HUMAN, Q9Y337 (See protein sequence)
Recommended Name: Kallikrein-5 precursor  
Size: 293 amino acids; 32019 Da
Subunit: Interacts with SPINK9
Subcellular location: Secreted
PDB structure from and Proteopedia :
2PSX (3D)    2PSY (3D)    
Secondary accessions: Q9HBG8

Explore the universe of human proteins at neXtProt for KLK5: NX_Q9Y337 

REFSEQ proteins (3 alternative transcripts): 
NP_001070959.1  NP_001070960.1  NP_036559.1  


ENSEMBL proteins: 
ENSP00000337733 ENSP00000375685 ENSP00000403445 


Human Recombinant Proteins 
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich
R&D Systems Recombinant & Natural Proteins for KLK5 (Kallikrein 5)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate (see all 2): KLK5
GenScript Custom Purified and Recombinant Proteins Services for KLK5 
Novus Biologicals Proteins for KLK5
Novus Biologicals Lysate for KLK5
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region NAS--
GO:0005615 extracellular space TAS10608802
About this table

KLK5 for ontologies           About GeneDecksing



Antibodies for KLK5: 
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for KLK5
R&D Systems Antibodies for KLK5 (Kallikrein 5)
OriGene Antibodies: KLK5
GenScript Custom Superior Antibodies Services for KLK5 
Novus Biologicals Antibodies for KLK5
Browse antibodies at Epitomics

Assays for KLK5: 
Browse Kits and Assays available from Millipore
Browse ELISAs at Sigma-Aldrich
OriGene Custom Immunoassay Development 
Browse OriGene Fluorogenic Cell Assay Kits 
Browse R&D Systems for biochemical assays
GenScript KLK5-Activity-based Protease Assay for Compound Screening 
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for KLK5 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KLK5 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR001314 Peptidase_S1A
 IPR001254 Peptidase_S1_S6
 IPR018114 Peptidase_S1/S6_AS
 IPR009003 Ser/Cys_Pept_Trypsin-like

Graphical View of Domain Structure for InterPro Entry Q9Y337

ProtoNet protein and cluster: Q9Y337

2 Blocks protein families:
IPB001254 Serine protease
IPB001314 Chymotrypsin serine protease family (S1) signature


UniProtKB/Swiss-Prot: KLK5_HUMAN, Q9Y337
Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily
Similarity: Contains 1 peptidase S1 domain


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: KLK5_HUMAN, Q9Y337
Function: May be involved in desquamation
Enzyme regulation: Inhibited by Zn2+
Enzyme Number (IUBMB): EC 3.4.21.- 

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and siRNA for KLK5
Sigma-Aldrich shRNA for KLK5
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): KLK5
OriGene shRNA RFP (see all 4): KLK5
OriGene basic RS shRNA (see all 4): KLK5
OriGene siRNA (see all 4): KLK5
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KLK5 
miRNA:Sigma-Aldrich microRNA Mimics for KLK5
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KLK5 
1 SABiosciences Assays for microRNA that regulate KLK5:
hsa-miR-185

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): KLK5
OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): KLK5
OriGene untagged cDNA clones in CMV expression vector (see all 3): KLK5
Browse 3'-UTR reporter clones for miRNA target validation 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for KLK5 
Sino Biological Human cDNA Clone for KLK5

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for KLK5 

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003824 catalytic activity ----
GO:0004252 serine-type endopeptidase activity NAS11054574
GO:0005515 protein binding IPI19194479
GO:0008233 peptidase activity IEA--
GO:0008236 serine-type peptidase activity TAS10514489
About this table

KLK5 for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


KLK5 for pathways           About GeneDecksing

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  KLK5
    Lysine Degradation

    SABiosciences Pathway-Focused PCR Array including KLK5: PAHS-005A 

    Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for KLK5
    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLK5

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006508 proteolysis NAS--
GO:0008544 epidermis development TAS10514489
GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway IDA16885167
About this table

KLK5 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

KLK5 for compounds           About GeneDecksing

Browse Small Molecules at Sigma-Aldrich
Enzo Life Sciences drugs & compounds for KLK5

Browse Tocris compounds for KLK5
3 Novoseek chemical compound relationships for KLK5 gene
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
serine 66.1 15 12890555 (1), 15004490 (1), 15140227 (1), 20090765 (1) (see all 9)
progestins 59.4 2 10608802 (1), 15004490 (1)
steroid 1.93 1 11948967 (1)
About this table



(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and siRNA for KLK5
Sigma-Aldrich shRNA for KLK5
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): KLK5
OriGene shRNA RFP (see all 4): KLK5
OriGene basic RS shRNA (see all 4): KLK5
OriGene siRNA (see all 4): KLK5
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KLK5 
miRNA: Sigma-Aldrich microRNA Mimics for KLK5
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KLK5 
1 SABiosciences Assays for microRNA that regulate KLK5:
hsa-miR-185
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): KLK5
OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): KLK5
OriGene untagged cDNA clones in CMV expression vector (see all 3): KLK5
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for KLK5 
Primers: OriGene genome-wide validated SYBR primer pairs: KLK5
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for KLK5: PPH00425A

REFSEQ mRNAs for KLK5 gene (3 alternative transcripts): 

NM_001077491.1  NM_001077492.1  NM_012427.4  

Additional cDNA sequence: 

AF168768.2 AF435980.1 AF435981.1 AK223421.1 AY279380.1 AY279381.1 AY359010.1 BC008036.2 
BT006867.1 

4 DOTS entries:

DT.309895  DT.100765127  DT.95154818  DT.91744955 

24/58 AceView cDNA sequences (see all 58):

AY359010 AY461805 AA595959 BM840511 AY279381 BM842755 W73168 BM763825 
W68361 BM840509 BF514439 W73140 AY279380 BF513278 BM763568 BE899189 
BG680075 BE898385 AA862032 BM838406 BM845065 BG680921 BV179852 BE898407 

highest scoring ESTs for KLK5:

AF168768 AF435980 AF435981 AI002163 AY279380 AY279381 AY359010 BC008036 BE075958 BE272355 

Unigene Cluster for KLK5:

Kallikrein-related peptidase 5
Hs.50915  [show with all ESTs]
Unigene Representative Sequence: AY359010


GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for KLK5

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:              -                                       
SP2:                                                      
SP3:              -     -                                 
SP4:                    -                                 
SP5:                                                      

About this scheme

ECgene alternative splicing isoforms for KLK5
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000336334(uc002pug.2) ENST00000391809(uc002pue.2) ENST00000448298(uc002puf.2)


(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

KLK5 expression in normal and diseased human tissues

1  / 2  / 3

3 probe-sets matching KLK5 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
46897_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AI002163 0.80 1.00 0.91 1
222242_s_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --
222242_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table

KLK5 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
KLK5 gene expression
KLK5 gene electronic northern expression
KLK5 gene sage expression
About these images

CGAP SAGE TAG: TCTCCTGGAC

SOURCE GeneReport for Unigene cluster: Hs.50915

UniProtKB/Swiss-Prot: KLK5_HUMAN, Q9Y337
Tissue specificity: Expressed in skin, breast, brain and testis. Expressed at the stratum granulosum of palmar skin

Primers: OriGene genome-wide validated SYBR primer pairs: KLK5
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for KLK5: PPH00425A
    SABiosciences Expression via Pathway-Focused PCR Array including KLK5: PAHS-005A 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KLK5 gene from 5 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
KLK51   -- kallikrein-related peptidase 5 81.46(n)
77.82(a)
484353  XM_541469.2  XP_541469.2 
chimpanzee
(Pan troglodytes)
KLK51   -- kallikrein-related peptidase 5 99.09(n)
99.32(a)
748162  XM_001159973.1  XP_001159973.1 
cow
(Bos taurus)
KLK51   -- kallikrein-related peptidase 5 80.48(n)
76.07(a)
617418  XM_869968.2  XP_875061.2 
rat
(Rattus norvegicus)
Klk51   -- kallikrein related-peptidase 5 72.16(n)
67.7(a)
690603  XM_001074943.1  XP_001074943.1 
mouse
(Mus musculus)
Klk51 , 5 7 (28.30 cM)5
kallikrein related-peptidase 51, 5 75.6(n)1
70.45(a)1
686681  NM_026806.21  NP_081082.11 
 AI3248745  AK0039965  (see all 7)
About this table        Species with no ortholog for KLK5

ENSEMBL Gene Tree for KLK5 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for KLK5 gene
KLK132  KLK62  KLK122  KLK22  KLK102  KLK12  KLK152  KLK42  
KLK112  KLK72  KLK82  KLK32  KLK92  

KLK5 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/195 NCBI SNPs in KLK5 are shown (see all 195)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 19 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs1838541,2
C,F,H,51452250(-) CTAACG/AACCTC 6 /N /D mis1 ref116Minor allele frequency- A:0.00MN NS EA NA WA 1036
rs2689001,2
C,A,51452970(-) gagggC/Ttggtg 3 -- int13Minor allele frequency- T:0.33NA WA 6
rs2689011,2
C,A,51452800(-) GGAGCG/ATATAT 3 -- int14Minor allele frequency- A:0.43NA EA WA 212
rs2689021,2
C,F,A,H,51451687(-) aaacaG/Agtaaa 3 -- int16Minor allele frequency- A:0.17NS EA NA WA 406
rs2689031,2
C,F,A,H,51451668(-) ggcgcG/Agtggc 3 -- int16Minor allele frequency- A:0.33NA WA 12
rs2689041,2
C,F,A,H51451593(-) gagacC/Tagcct 3 -- int16Minor allele frequency- T:0.33NA WA 12
rs2689051,2
C,F,A,51450929(-) ggaagA/Gaaaag 3 -- int1 trp3101Minor allele frequency- N:0.00NS EA PA EU CA WA NA 6464
rs2689061,2
C,F,A,H51449964(-) gtggcG/Aggcgc 3 -- int14Minor allele frequency- A:0.25NA WA 8
rs2689071,2
C,F,A51449901(-) gaggcA/Ggaact 3 -- int14Minor allele frequency- G:0.25NA WA 8
rs2689081,2
C,F,A,51449806(-) agaaaT/GCACAT 3 -- int17Minor allele frequency- G:0.31NS EA NA WA 416
About this table

HapMap Linkage Disequilibrium images for KLK5 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for KLK5: --

QIAGEN SeqTarget long-range PCR primers for resequencing KLK5 

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KLK5 for disorders           About GeneDecksing

OMIM: 605643

6 Novoseek disease relationships for KLK5 gene

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
ovarian cancer 52.6 6 11237385 (3), 15004490 (1), 12727843 (1), 12738725 (1)
ovarian carcinoma 43.3 1 11237385 (1)
breast cancer 12.5 4 11948967 (2), 12385949 (1), 10608802 (1)
prostate cancer 2.52 4 11948967 (3), 15627884 (1)
tumors 0 8 12385949 (3), 15627884 (1)
cancer 0 3 11948967 (2), 12738725 (1)
About this table

Human Genome Epidemiology (HuGE) Navigator: KLK5 (1 document)

Export disorders and mutations for KLK5 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

10/58 PubMed articles for KLK5 gene, integrated from 7 sources (see all 58):
(articles sorted by number of sources associating them with KLK5)
  1. Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation. (PubMed id 10514489)1, 2, 3, 7 Brattsand M. and Egelrud T. (1999)
  2. The new kallikrein-like gene, KLK-L2. Molecular chara cterization, mapping, tissue expression, and hormonal regulation. (PubMed id 10608802)1, 3, 7 Yousef G.M. and Diamandis E.P. (1999)
  3. SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor. (PubMed id 19194479)1, 2, 7 Brattsand M.... Egelrud T. (2009)
  4. Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin. (PubMed id 17012259)1, 3, 7 Yamasaki K....Gallo R.L. (2006)
  5. Structural basis of the zinc inhibition of human tissue kallikrein 5. (PubMed id 17881000)1, 2 Debela M.... Bode W. (2007)
  6. Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PubMed id 16800723)1, 3 (2006)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  9. Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. (PubMed id 11054574)1, 2 Gan L.... Wang K. (2000)
  10. Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4. (PubMed id 10652563)1, 2 Yousef G.M.... Diamandis E.P. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 25818 HGNC: 6366 AceView: KLK5 Ensembl:ENSG00000167754 euGenes: HUgn25818
ECgene: KLK5 H-InvDB: KLK5

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
ATLAS Chromosomes in Cancer entry for KLK5 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for KLK5 gene:
Search GeneIP for patents involving KLK5

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(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services

 Predesigned and custom siRNAs for KLK5 Antibodies for KLK5
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for KLK5 microRNA Mimics for KLK5
 "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
 Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
 Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
 Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
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 Antibodies for KLK5 (Kallikrein 5)   Cell Culture Products  
 ELISAs   Flow Cytometry Kits  
 Primer Pairs   Kinase Activity Assays/Reagents  
 ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
 Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
 DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
 Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
 Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for KLK5 (Kallikrein 5)  
 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Lysates
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 siRNA
 Custom Immunoassay Development
 Fluorogenic Cell Assay Kits
 miRNA Primers for qPCR Assays
 3' UTR Clones for miRNA Target Studies
 miRNA Expression Plasmids

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KLK5
 SeqTarget long-range PCR primers for resequencing KLK5
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KLK5
 GenScript Custom Purified and Recombinant Proteins Services for KLK5 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for KLK5
 GenScript KLK5-Activity-based typehere Assay for Compound Screening GenScript Custom Superior Antibodies Services for KLK5
 GenScript Custom overexpressing Cell Line Services for KLK5 CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in KLK5 promoter
 Search Chromatin IP Primers for KLK5
 RT2 qPCR Primer Assay for KLK5
 GNC Network for KLK5
 Assays for microRNAs that regulate KLK5
 SABiosciences PCR Arrays including KLK5
 Search Tocris compounds for KLK5
 Browse Sino Biological Proteins and Antibodies
 cDNA Clones for KLK5
 Antibodies/Proteins Production Services
 Rabbit Monoclonal Antibody Platform
 Bulk Purchasing
 Drugs for KLK5
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 Antibodies for KLK5
 Proteins for KLK5
 Lysates for KLK5
 Browse antibodies at Epitomics
 Browse ProSpec Recombinant Proteins

 ELISAs and CLIAs for KLK5
       

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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