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KLK5 Gene

protein-coding GIFtS: 55

GC19M047780

kallikrein-related peptidase 5
(Previous name: kallikrein 5 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
kallikrein-related peptidase 5¹ ²		Kallikrein-like protein 2² ³
SCTE¹ ² ³ ⁵		KLKL2² ⁵
KLK-L2¹ ² ³		kallikrein-5²
kallikrein 5¹ ²		EC 3.4.21.-³
Stratum corneum tryptic enzyme² ³

External Ids:	HGNC: 6366¹	Entrez Gene: 25818²	Ensembl: ENSG00000167754⁷	UniProtKB: Q9Y337³

Export aliases for KLK5 gene to outside databases

Previous GC identifers: GC19M052075 GC19M051807 GC19M056122 GC19M056138 GC19M051446

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLK5:

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that

many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease

biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its

expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in

desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein.

(provided by RefSeq)

UniProtKB/Swiss-Prot: KLK5_HUMAN, Q9Y337

Function: May be involved in desquamation

Gene Wiki entry for KLK5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KLK5 gene promoter:
         ATF   COUP-TF1   HNF-4alpha2   GCNF-2   GCNF-1   PPAR-gamma1   PPAR-gamma2   GATA-1   ITF-2   Tal-1beta
         Other transcription factors

Search SABiosciences Chromatin IP Primers for KLK5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.33

KLK5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLK5 gene location

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M047780: view genomic region (about GC identifiers)

Start:	47,779,285 bp from pter
End:	47,788,696 bp from pter
Size:	9,412 bases
Orientation:	minus strand

1 alternative location:

Chr19- 51,446,561-51,456,344

RefSeq DNA sequence:

NC_000019.9 NT_011109.16

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: KLK5_HUMAN, Q9Y337 (See protein sequence)

Recommended Name: Kallikrein-5 precursor

Size: 293 amino acids; 32019 Da

Subunit: Interacts with SPINK9

Subcellular location: Secreted

PDB structure from and Proteopedia :

2PSX (3D)

2PSY (3D)

Secondary accessions: Q9HBG8

Explore the universe of human proteins at neXtProt for KLK5: NX_Q9Y337

REFSEQ proteins (3 alternative transcripts):

NP_001070959.1 NP_001070960.1 NP_036559.1

ENSEMBL proteins:

ENSP00000337733 ENSP00000375685 ENSP00000403445

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for KLK5 (Kallikrein 5)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): KLK5
	GenScript Custom Purified and Recombinant Proteins Services for KLK5
	Novus Biologicals Proteins for KLK5
	Novus Biologicals Lysate for KLK5
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	--
GO:0005615	extracellular space	TAS	10608802

About this table

KLK5 for ontologies About GeneDecksing

Antibodies for KLK5:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for KLK5
	R&D Systems Antibodies for KLK5 (Kallikrein 5)
	OriGene Antibodies: KLK5
	GenScript Custom Superior Antibodies Services for KLK5
	Novus Biologicals Antibodies for KLK5
	Browse antibodies at Epitomics

Assays for KLK5:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript KLK5-Activity-based Protease Assay for Compound Screening
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KLK5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KLK5 for domains About GeneDecksing

4 InterPro domains/families:

IPR001314 Peptidase_S1A

IPR001254 Peptidase_S1_S6

IPR018114 Peptidase_S1/S6_AS

IPR009003 Ser/Cys_Pept_Trypsin-like

Graphical View of Domain Structure for InterPro Entry Q9Y337

ProtoNet protein and cluster: Q9Y337

2 Blocks protein families:

IPB001254 Serine protease

IPB001314 Chymotrypsin serine protease family (S1) signature

UniProtKB/Swiss-Prot: KLK5_HUMAN, Q9Y337

Similarity: Belongs to the peptidase S1 family. Kallikrein subfamily

Similarity: Contains 1 peptidase S1 domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: KLK5_HUMAN, Q9Y337

Function: May be involved in desquamation

Enzyme regulation: Inhibited by Zn2+

Enzyme Number (IUBMB): EC 3.4.21.-

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and siRNA for KLK5 Sigma-Aldrich shRNA for KLK5
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): KLK5 OriGene shRNA RFP (see all 4): KLK5 OriGene basic RS shRNA (see all 4): KLK5 OriGene siRNA (see all 4): KLK5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KLK5

miRNA:		Sigma-Aldrich microRNA Mimics for KLK5 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KLK5
		1 SABiosciences Assays for microRNA that regulate KLK5:
		hsa-miR-185

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): KLK5 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): KLK5 OriGene untagged cDNA clones in CMV expression vector (see all 3): KLK5 Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for KLK5
		Sino Biological Human cDNA Clone for KLK5

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for KLK5

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0004252	serine-type endopeptidase activity	NAS	11054574
GO:0005515	protein binding	IPI	19194479
GO:0008233	peptidase activity	IEA	--
GO:0008236	serine-type peptidase activity	TAS	10514489

About this table

KLK5 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

KLK5 for pathways About GeneDecksing

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for KLK5

Lysine Degradation

SABiosciences Pathway-Focused PCR Array including KLK5: PAHS-005A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for KLK5

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KLK5

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	NAS	--
GO:0008544	epidermis development	TAS	10514489
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway	IDA	16885167

About this table

KLK5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

KLK5 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Enzo Life Sciences drugs & compounds for KLK5

Browse Tocris compounds for KLK5
3 Novoseek chemical compound relationships for KLK5 gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
serine	66.1	15	12890555 (1), 15004490 (1), 15140227 (1), 20090765 (1) (see all 9)
progestins	59.4	2	10608802 (1), 15004490 (1)
steroid	1.93	1	11948967 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and siRNA for KLK5 Sigma-Aldrich shRNA for KLK5
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): KLK5 OriGene shRNA RFP (see all 4): KLK5 OriGene basic RS shRNA (see all 4): KLK5 OriGene siRNA (see all 4): KLK5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KLK5

miRNA:		Sigma-Aldrich microRNA Mimics for KLK5 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KLK5
		1 SABiosciences Assays for microRNA that regulate KLK5:
		hsa-miR-185

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): KLK5 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): KLK5 OriGene untagged cDNA clones in CMV expression vector (see all 3): KLK5 Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for KLK5

Primers:		OriGene genome-wide validated SYBR primer pairs: KLK5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for KLK5: PPH00425A

REFSEQ mRNAs for KLK5 gene (3 alternative transcripts):

NM_001077491.1 NM_001077492.1 NM_012427.4

Additional cDNA sequence:

AF168768.2 AF435980.1 AF435981.1 AK223421.1 AY279380.1 AY279381.1 AY359010.1 BC008036.2

BT006867.1

4 DOTS entries:

DT.309895 DT.100765127 DT.95154818 DT.91744955

24/58 AceView cDNA sequences (see all 58):

AY359010 AY461805 AA595959 BM840511 AY279381 BM842755 W73168 BM763825

W68361 BM840509 BF514439 W73140 AY279380 BF513278 BM763568 BE899189

BG680075 BE898385 AA862032 BM838406 BM845065 BG680921 BV179852 BE898407

highest scoring ESTs for KLK5:

AF168768 AF435980 AF435981 AI002163 AY279380 AY279381 AY359010 BC008036 BE075958 BE272355

Unigene Cluster for KLK5:

Kallikrein-related peptidase 5

Hs.50915 [show with all ESTs]

Unigene Representative Sequence: AY359010

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for KLK5

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8
SP1:					-
SP2:
SP3:					-		-
SP4:							-
SP5:

About this scheme

ECgene alternative splicing isoforms for KLK5
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000336334(uc002pug.2) ENST00000391809(uc002pue.2) ENST00000448298(uc002puf.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

KLK5 expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching KLK5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
46897_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AI002163	0.80	1.00	0.91	1
222242_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
222242_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

KLK5 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

KLK5 gene electronic northern expression

About these images

CGAP SAGE TAG: TCTCCTGGAC

SOURCE GeneReport for Unigene cluster: Hs.50915

UniProtKB/Swiss-Prot: KLK5_HUMAN, Q9Y337

Tissue specificity: Expressed in skin, breast, brain and testis. Expressed at the stratum granulosum of palmar skin

Primers:		OriGene genome-wide validated SYBR primer pairs: KLK5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for KLK5: PPH00425A

SABiosciences Expression via Pathway-Focused PCR Array including KLK5: PAHS-005A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KLK5 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KLK5¹	--	kallikrein-related peptidase 5	81.46(n) 77.82(a)	484353 XM_541469.2 XP_541469.2
chimpanzee (Pan troglodytes)	KLK5¹	--	kallikrein-related peptidase 5	99.09(n) 99.32(a)	748162 XM_001159973.1 XP_001159973.1
cow (Bos taurus)	KLK5¹	--	kallikrein-related peptidase 5	80.48(n) 76.07(a)	617418 XM_869968.2 XP_875061.2
rat (Rattus norvegicus)	Klk5¹	--	kallikrein related-peptidase 5	72.16(n) 67.7(a)	690603 XM_001074943.1 XP_001074943.1
mouse (Mus musculus)	Klk5^{1 , 5}	7 (28.30 cM)⁵	kallikrein related-peptidase 5^{1, 5}	75.6(n)¹ 70.45(a)¹	68668¹ NM_026806.2¹ NP_081082.1¹ AI324874⁵ AK003996⁵ (see all 7)

About this table Species with no ortholog for KLK5

ENSEMBL Gene Tree for KLK5 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KLK5 gene

KLK13² KLK6² KLK12² KLK2² KLK10² KLK1² KLK15² KLK4²

KLK11² KLK7² KLK8² KLK3² KLK9²

KLK5 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs183854^1,2	C,F,H,	51452250(-)	`CTAACG/AACCTC`	6	/N /D	mis¹ ref¹		16	MN NS EA NA WA	1036
rs268900^1,2	C,A,	51452970(-)	`gagggC/Ttggtg`	3	--	int¹		3	NA WA	6
rs268901^1,2	C,A,	51452800(-)	`GGAGCG/ATATAT`	3	--	int¹		4	NA EA WA	212
rs268902^1,2	C,F,A,H,	51451687(-)	`aaacaG/Agtaaa`	3	--	int¹		6	NS EA NA WA	406
rs268903^1,2	C,F,A,H,	51451668(-)	`ggcgcG/Agtggc`	3	--	int¹		6	NA WA	12
rs268904^1,2	C,F,A,H	51451593(-)	`gagacC/Tagcct`	3	--	int¹		6	NA WA	12
rs268905^1,2	C,F,A,	51450929(-)	`ggaagA/Gaaaag`	3	--	int¹ trp³		101	NS EA PA EU CA WA NA	6464
rs268906^1,2	C,F,A,H	51449964(-)	`gtggcG/Aggcgc`	3	--	int¹		4	NA WA	8
rs268907^1,2	C,F,A	51449901(-)	`gaggcA/Ggaact`	3	--	int¹		4	NA WA	8
rs268908^1,2	C,F,A,	51449806(-)	`agaaaT/GCACAT`	3	--	int¹		7	NS EA NA WA	416

About this table

HapMap Linkage Disequilibrium images for KLK5 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KLK5: --

QIAGEN SeqTarget long-range PCR primers for resequencing KLK5

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KLK5 for disorders About GeneDecksing

OMIM: 605643

6 Novoseek disease relationships for KLK5 gene

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ovarian cancer	52.6	6	11237385 (3), 15004490 (1), 12727843 (1), 12738725 (1)
ovarian carcinoma	43.3	1	11237385 (1)
breast cancer	12.5	4	11948967 (2), 12385949 (1), 10608802 (1)
prostate cancer	2.52	4	11948967 (3), 15627884 (1)
tumors	0	8	12385949 (3), 15627884 (1)
cancer	0	3	11948967 (2), 12738725 (1)

About this table

Human Genome Epidemiology (HuGE) Navigator: KLK5 (1 document)

Export disorders and mutations for KLK5 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/58 PubMed articles for KLK5 gene, integrated from 7 sources (see all 58):
(articles sorted by number of sources associating them with KLK5)

Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation. (PubMed id 10514489)^{1, 2, 3, 7} Brattsand M. and Egelrud T. (1999)
The new kallikrein-like gene, KLK-L2. Molecular chara cterization, mapping, tissue expression, and hormonal regulation. (PubMed id 10608802)^{1, 3, 7} Yousef G.M. and Diamandis E.P. (1999)
SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor. (PubMed id 19194479)^{1, 2, 7} Brattsand M.... Egelrud T. (2009)
Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin. (PubMed id 17012259)^{1, 3, 7} Yamasaki K....Gallo R.L. (2006)
Structural basis of the zinc inhibition of human tissue kallikrein 5. (PubMed id 17881000)^{1, 2} Debela M.... Bode W. (2007)
Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PubMed id 16800723)^{1, 3} (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. (PubMed id 11054574)^{1, 2} Gan L.... Wang K. (2000)
Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4. (PubMed id 10652563)^{1, 2} Yousef G.M.... Diamandis E.P. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 25818	HGNC: 6366	AceView: KLK5	Ensembl:ENSG00000167754	euGenes: HUgn25818
ECgene: KLK5	H-InvDB: KLK5

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for KLK5	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for KLK5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for KLK5 gene:
Search GeneIP for patents involving KLK5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KLK5		Antibodies for KLK5
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KLK5		microRNA Mimics for KLK5
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
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	Antibodies for KLK5 (Kallikrein 5)		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for KLK5 (Kallikrein 5)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KLK5
	SeqTarget long-range PCR primers for resequencing KLK5
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KLK5

	GenScript Custom Purified and Recombinant Proteins Services for KLK5		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for KLK5
	GenScript KLK5-Activity-based typehere Assay for Compound Screening		GenScript Custom Superior Antibodies Services for KLK5
	GenScript Custom overexpressing Cell Line Services for KLK5		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in KLK5 promoter
	Search Chromatin IP Primers for KLK5
	RT² qPCR Primer Assay for KLK5
	GNC Network for KLK5
	Assays for microRNAs that regulate KLK5
	SABiosciences PCR Arrays including KLK5

Search Tocris compounds for KLK5

	Browse Sino Biological Proteins and Antibodies
	cDNA Clones for KLK5
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Drugs for KLK5
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for KLK5
	Proteins for KLK5
	Lysates for KLK5

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for KLK5

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

KLK5 gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

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KLK5 Gene

protein-coding GIFtS: 55

Aliases &
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for KLK5 gene

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for KLK5 gene

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for KLK5 gene

Proteins
for KLK5 gene

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for KLK5 gene

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for KLK5 gene

Pathways & Interactions
for KLK5 gene

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for KLK5 gene

Transcripts
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Expression
for KLK5 gene

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for KLK5 gene

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for KLK5 gene

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for KLK5 gene

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for KLK5 gene

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Export list of displayed genes

KLK5 Gene

protein-coding GIFtS: 55

Aliases & Descriptionsfor KLK5 gene

Summariesfor KLK5 gene

Genomic Viewsfor KLK5 gene

Proteinsfor KLK5 gene

Protein Domains/Familiesfor KLK5 gene

Gene Functionfor KLK5 gene

Pathways & Interactionsfor KLK5 gene

Drugs & Compoundsfor KLK5 gene

Transcriptsfor KLK5 gene

Expression for KLK5 gene

Orthologsfor KLK5 gene

Paralogsfor KLK5 gene

Genomic Variantsfor KLK5 gene

Disorders & Mutationsfor KLK5 gene

Medical Newsfor KLK5 gene

Publicationsfor KLK5 gene

External Searches for KLK5 gene

Genome Databases showing KLK5 gene

Other Databases showing KLK5 gene

Specialized Databases showing KLK5 gene

Intellectual Propertyfor KLK5 gene

Productsfor KLK5 gene

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Aliases &
Descriptions
for KLK5 gene

Summaries
for KLK5 gene

Genomic Views
for KLK5 gene

Proteins
for KLK5 gene

Protein Domains/
Families
for KLK5 gene

Gene Function
for KLK5 gene

Pathways & Interactions
for KLK5 gene

Drugs & Compounds
for KLK5 gene

Transcripts
for KLK5 gene

Expression
for KLK5 gene

Orthologs
for KLK5 gene

Paralogs
for KLK5 gene

Genomic Variants
for KLK5 gene

Disorders & Mutations
for KLK5 gene

Medical News
for KLK5 gene

Publications
for KLK5 gene

Intellectual Property
for KLK5 gene

Products
for KLK5 gene