Aliases &
Descriptions
for KLK9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| kallikrein-related peptidase 91 2 | | kallikrein 91 | | KLK-L31 2 3 | | kallikrein-92 | | Kallikrein-like protein 32 3 | | EC 3.4.21.-3 | | KLKL32 5 | | |
Export aliases for KLK9 gene to outside databasesPrevious GC identifers: GC19M052136 GC19M051867 GC19M056181 GC19M056192 GC19M056197 GC19M056194 GC19M051505 |
Summaries
for KLK9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KLK9:
The protein encoded by this gene is a kallikrein-related serine protease. This gene is activated by steroid hormones ina human breast cancer cell line, making it a good marker for cancer detection. The encoded protein is found primarilyin the cytoplasm.
|
Genomic Views
for KLK9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KLK9 gene promoter:
GR-alpha GR-beta C/EBPbeta MZF-1 AP-4 NF-1 Hlf RFX1 NF-kappaB NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLK9
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.41 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.33KLK9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M047838: view genomic region
(about GC identifiers)
Start:
|
47,838,535 bp from pter |
End:
|
47,845,658 bp from pter |
Size:
|
7,124 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr19- 51,505,769-51,512,890 |
RefSeq DNA sequence:- NC_000019.9 NT_011109.16
|
Proteins
for KLK9 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: KLK9_HUMAN, Q9UKQ9 (See
protein sequence)Recommended Name: Kallikrein-9 precursor Size: 250 amino acids; 27513 Da
Subcellular location: Secreted (Probable)Explore the universe of human proteins at neXtProt for KLK9: NX_Q9UKQ9
REFSEQ proteins: NP_036447.1
ENSEMBL proteins: ENSP00000250366 ENSP00000366028
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
NAS | -- |
About this table
KLK9 for ontologies About GeneDecksing
Antibodies for KLK9:
Assays for KLK9: |
Protein
Domains/
Families
for KLK9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KLK9 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UKQ9ProtoNet protein and cluster: Q9UKQ9 2 Blocks protein families: IPB001254 Serine protease IPB001314 Chymotrypsin serine protease family (S1) signature
UniProtKB/Swiss-Prot: KLK9_HUMAN, Q9UKQ9Similarity: Belongs to the peptidase S1 family. Kallikrein subfamilySimilarity: Contains 1 peptidase S1 domain |
Gene Function
for KLK9 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
KLK9 for ontologies About GeneDecksing
|
Pathways & Interactions
for KLK9 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for KLK9
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLK9
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
NAS | -- |
About this table
KLK9 for ontologies About GeneDecksing
|
Drugs & Compounds
for KLK9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for KLK9
|
Transcripts
for KLK9 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for KLK9 gene: NM_012315.1 Additional cDNA sequence: DQ267419.1 2 DOTS entries: DT.121457224 DT.102821852 24/47 AceView cDNA sequences (see all 47): AY359036 AB009849 AF095742 BF915088 AB008390 NM_144506 BI041913 NM_012315 NM_007196 BM762825 BX282429 AY566267 AL551079 NM_144507 BC040887 AY551001 NM_144505 CR601157 AA343629 AB008927 BF032818 AI963941 BE501242 BF038501
 highest scoring ESTs for KLK9:AA583908 AY551001 NM_012315 BG003899 DQ267419 AA401047 AA587273 AI470221 AI566249 AI916929 Unigene Cluster for KLK9: Kallikrein-related peptidase 9 Hs.448942 [show with all ESTs]Unigene Representative Sequence: DQ267419
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000250366(uc002puw.1 uc002pux.1) ENST00000376832(uc002puv.1 uc010eol.1)
|
Expression
for KLK9 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| KLK9 expression in normal and diseased human tissues
1 / 2 / 3 2 probe-sets matching KLK9 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 233687_s_at2
|
U133-B |
2 |
0.55 |
0.86 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 233687_s_at2
|
U133Plus2 |
2 |
0.55 |
0.86 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GAGAACTGAG
SOURCE GeneReport for Unigene cluster: Hs.448942
UniProtKB/Swiss-Prot: KLK9_HUMAN, Q9UKQ9Tissue specificity: Skin, thymus, trachea, cerebellum and spinal cord
SABiosciences Custom PCR Arrays for KLK9
|
Orthologs
for KLK9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KLK9 gene from 4 species
About this table Species with no ortholog for KLK9
ENSEMBL Gene Tree for KLK9 (if available) |
Paralogs
for KLK9 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for KLK9 gene
- KLK132 KLK62 KLK122 KLK22 KLK102 KLK12 KLK152 KLK52
- KLK42 KLK112 KLK72 KLK82 KLK32
KLK9 for paralogs About GeneDecksing
|
Genomic Variants
for KLK9 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 19 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for KLK9 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KLK9
1 CNV: 67588 | | QIAGEN SeqTarget long-range PCR primers for resequencing KLK9 |
|
Disorders & Mutations
for KLK9 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KLK9 for disorders About GeneDecksing
OMIM: 605504
Human Genome Epidemiology (HuGE) Navigator: KLK9 (1 document)
Export disorders and mutations for KLK9 gene to outside databases
|
Medical News
for KLK9 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for KLK9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
8 PubMed articles for KLK9 gene integrated from 7 sources:
(articles sorted by number of sources associating them with KLK9)- The expanded human kallikrein gene family: locus characterization and molecular cloning of a new member, KLK-L3. (PubMed id 10783266)1, 2, 7 Yousef G.M. and Diamandis E.P. (2000)
- A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. (PubMed id 16800724)1, 3 Lundwall A....Yousef G.M. (2006)
- Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005. (PubMed id 16800723)1, 3 (2006)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. (PubMed id 11054574)1, 2 Gan L.... Wang K. (2000)
- Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4. (PubMed id 10652563)1, 2 Yousef G.M.... Diamandis E.P. (1999)
- Blood biomarker levels to aid discovery of cancer-rel ated single-nucleotide polymorphisms: kallikreins and prostate cancer. (PubMed id 20424135)1 Klein R.J....Lilja H. (2010)
- Quantitative expression of the human kallikrein gene 9 (KLK9) in ovarian cancer: a new independent and favorable prognostic marker. (PubMed id 11691797)1 Yousef G.M....Katsaros D. (2001)
|
External Searches for KLK9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KLK9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLK9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KLK9 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for KLK9 gene:
Search GeneIP for patents involving KLK9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KLK9 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for KLK9 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for KLK9 |
| |
|
|
