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KRT18 Gene

protein-coding GIFtS: 67

GC12P050386

keratin 18
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
keratin 18¹ ²		cytokeratin 18²
Cell proliferation-inducing gene 46 protein² ³		keratin, type I cytoskeletal 18²
K18² ³		keratin-18²
CYK18² ³		cell proliferation-inducing protein 46²
CK-18² ³		Cytokeratin-18³
cytokeratin-18²		Keratin-18³

External Ids:	HGNC: 6430¹	Entrez Gene: 3875²	Ensembl: ENSG00000111057⁷	UniProtKB: P05783³

Export aliases for KRT18 gene to outside databases

Previous GC identifers: GC12M053340 GC12M053554 GC12P053059 GC12P051630 GC12P051631 GC12P051632 GC12P053343

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRT18:

KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin

8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single

layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript

variants encoding the same protein have been found for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: K1C18_HUMAN, P05783

Function: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When

phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma

membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection

Gene Wiki entry for KRT18 (Keratin 18)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KRT18 gene promoter:
         GATA-1   HNF-4alpha2   STAT3   COUP-TF1   Nkx3-1 v1   Nkx3-1 v2   Nkx3-1   Nkx3-1 v3   Nkx3-1 v4   p53
         Other transcription factors

Search SABiosciences Chromatin IP Primers for KRT18

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13

KRT18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT18 gene location

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P050386: view genomic region (about GC identifiers)

Start:	50,386,471 bp from pter
End:	50,390,501 bp from pter
Size:	4,031 bases
Orientation:	plus strand

1 alternative location:

Chr12+ 53,342,655-53,346,684

RefSeq DNA sequence:

NC_000012.11 NT_029419.12

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: K1C18_HUMAN, P05783 (See protein sequence)

Recommended Name: Keratin, type I cytoskeletal 18

Size: 430 amino acids; 48058 Da

Subunit: Heterotetramer of two type I and two type II keratins. Keratin-18 associates with keratin-8. Interacts with

the thrombin-antithrombin complex (By similarity). Interacts with PNN, HCV core protein and mutated CFTR. Interacts

with YWHAE, YWHAH and YWHAZ only when phosphorylated. Interacts with DNAJB6, TCHP and TRADD

Subcellular location: Cytoplasm, perinuclear region

Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to

basic; 56-70 kDa)

Secondary accessions: Q53G38 Q5U0N8 Q9BW26

Explore the universe of human proteins at neXtProt for KRT18: NX_P05783

Post-translational modifications:

Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver.

Phosphorylation increases by IL-6¹

Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3,

caspase-6 or caspase-7¹

O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_000215.1 NP_954657.1

ENSEMBL proteins:

ENSP00000373489 ENSP00000373487

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): KRT18
	GenScript Custom Purified and Recombinant Proteins Services for KRT18
	Novus Biologicals Proteins for KRT18
	Novus Biologicals Lysates for KRT18
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for KRT18

5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	16424149
GO:0005815	microtubule organizing center	IDA	18000879
GO:0005882	intermediate filament	TAS	2434380
GO:0034451	centriolar satellite	IDA	18000879
GO:0045095	keratin filament	IDA	16424149

About this table

KRT18 for ontologies About GeneDecksing

Antibodies for KRT18:

	Millipore Mono- and Polyclonal Antibodies for the study of KRT18
	Sigma-Aldrich Antibody Arrays and Antibodies for KRT18
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for KRT18
	OriGene Antibodies (see all 8): KRT18
	GenScript Custom Superior Antibodies Services for KRT18
	Novus Biologicals Antibodies for KRT18
	Epitomics antibodies for KRT18

Assays for KRT18:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for KRT18
	Enzo Life Sciences assays for KRT18
	Uscn ELISAs and CLIAs for KRT18

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KRT18 for domains About GeneDecksing

4 InterPro domains/families:

IPR018039 Intermediate_filament_CS

IPR001664 IF

IPR002957 Keratin_I

IPR016044 F

Graphical View of Domain Structure for InterPro Entry P05783

ProtoNet protein and cluster: P05783

2 Blocks protein families:

IPB001664 Intermediate filament protein

IPB002957 Type I keratin signature

UniProtKB/Swiss-Prot: K1C18_HUMAN, P05783

Similarity: Belongs to the intermediate filament family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: K1C18_HUMAN, P05783

Function: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When

phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma

membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection

Induction: By IL6/interleukin-6

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for KRT18 Sigma-Aldrich shRNA Panels and shRNA for KRT18
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): KRT18 OriGene shRNA RFP (see all 2): KRT18 OriGene basic RS shRNA (see all 2): KRT18 OriGene siRNA (see all 2): KRT18
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KRT18

miRNA:		Sigma-Aldrich microRNA Mimics for KRT18 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KRT18
		Search SABiosciences for Assays for microRNAs that regulate KRT18

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): KRT18 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): KRT18 OriGene untagged cDNA clones in CMV expression vector (see all 2): KRT18 OriGene 3'-UTR clone (see all 2): KRT18 Browse MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): KRT18
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for KRT18

Genatlas biochemistry entry for KRT18:

keratin 18,type I,early embryonic simple epithelia,dimerizing with KRT8,including a 3' locus control region KRT18-LCR

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	IEA	--
GO:0005515	protein binding	IPI	17353931

About this table

KRT18 for ontologies About GeneDecksing

Animal Models: 4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Krt18):

embryogenesis

growth/size

lethality-prenatal/perinatal

liver/biliary system

KRT18 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

KRT18 for pathways About GeneDecksing

1 Millipore Pathway for KRT18

Cytoskeleton remodeling Keratin filaments

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for KRT18

ILK Signaling

1 Kegg Pathway (Kegg details for KRT18):

hsa05130 Pathogenic Escherichia coli infection

SABiosciences Pathway-Focused PCR Arrays including KRT18 (see all 3): PAHS-005A PAHS-055A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for KRT18

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KRT18

5/89 Interacting proteins for KRT18 (P05783^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 89)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KRT8	P05787¹^,²	EBI-297888,EBI-297852 MINT-7899812
CLEC3B	P05452¹	EBI-297888,EBI-1047626
DNAJB6	O75190¹	EBI-297888,EBI-1053164
MCC	P23508¹	EBI-297888,EBI-307531
PPM1B	O75688¹	EBI-297888,EBI-1047039

About this table

5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007049	cell cycle	IEA	--
GO:0009653	anatomical structure morphogenesis	TAS	2434380
GO:0043000	Golgi to plasma membrane CFTR protein transport	IDA	15529338
GO:0043066	negative regulation of apoptosis	IDA	11684708
GO:0044419	interspecies interaction between organisms	IEA	--

About this table

KRT18 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

KRT18 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KRT18
10/77 Novoseek chemical compound relationships for KRT18 gene (see all 77)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
new fuchsin	75.2	2	7521088 (1), 7682210 (1)
nash	55.7	25	19585618 (4), 19378390 (3), 19891019 (3), 19906783 (2) (see all 6)
griseofulvin	49.9	4	8770877 (3), 10952237 (1)
matrigel	41.8	1	12021244 (1)
paraffin	40.9	10	9816144 (1), 15597196 (1), 17912630 (1), 1694766 (1) (see all 8)
glycogen	35.4	6	17492221 (1), 19092233 (1), 19063660 (1), 19781766 (1)
dutp	33.7	2	12015537 (1), 15194561 (1)
diethyl dithiocarbamate	29.8	2	17187412 (2)
estrogen	28.4	6	18300793 (1), 18715613 (1), 20340005 (1), 18360284 (1) (see all 5)
progesterone	26.7	11	18300793 (1), 18715613 (1), 20340005 (1), 12835305 (1) (see all 7)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for KRT18 Sigma-Aldrich shRNA Panels and shRNA for KRT18
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): KRT18 OriGene shRNA RFP (see all 2): KRT18 OriGene basic RS shRNA (see all 2): KRT18 OriGene siRNA (see all 2): KRT18
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KRT18

miRNA:		Sigma-Aldrich microRNA Mimics for KRT18 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KRT18
		Search SABiosciences for Assays for microRNAs that regulate KRT18

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): KRT18 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): KRT18 OriGene untagged cDNA clones in CMV expression vector (see all 2): KRT18 OriGene 3'-UTR Clone (see all 2): KRT18 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): KRT18

Primers:		OriGene genome-wide validated SYBR primer pairs: KRT18 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for KRT18: PPH00452A

REFSEQ mRNAs for KRT18 gene (2 alternative transcripts):

NM_000224.2 NM_199187.1

Additional cDNA sequence:

AK129587.1 AK223093.1 AK308506.1 AK313988.1 AY762101.1 BC000180.2 BC000698.2 BC004253.1

BC008636.1 BC009754.2 BC020982.1 BC072017.1 BT019412.1 CR594446.1 CR595810.1 CR596888.1

CR597901.1 CR598014.1 CR599586.1 CR600203.1 CR600648.1 CR601746.1 CR603302.1 CR603470.1

CR603763.1 CR603859.1 CR604760.1 CR604789.1 CR605941.1 CR606789.1 CR609248.1 CR609809.1

CR609857.1 CR610278.1 CR610685.1 CR610807.1 CR611058.1 CR613989.1 CR616576.1 CR616919.1

CR619082.1 CR619165.1 CR620895.1 CR621642.1 CR622312.1 CR622674.1 CR622676.1 CR623435.1

CR623563.1 CR625199.1 CR625896.1 X12876.1 X12881.1 X12883.1

24/102 DOTS entries (see all 102):

DT.91779938 DT.91780003 DT.97824751 DT.97807695 DT.91779860 DT.97863493 DT.91779932 DT.100772221

DT.121117764 DT.121117671 DT.121118642 DT.100709494 DT.100700193 DT.100858944 DT.121118265 DT.100700176

DT.450789 DT.121118571 DT.100700188 DT.100860177 DT.91779894 DT.121118049 DT.95366609 DT.121118032

24/3236 AceView cDNA sequences (see all 3236):

BQ896668 BU542998 BM563817 BU955841 AA132109 BQ689816 BM978162 BQ953873

BE794269 BQ688579 AA577313 BE394643 BE740083 BQ420485 BE908174 BU857095

CA489094 BI253425 BU539801 BU185646 BM773453 BU538396 BG328600 BQ686169

highest scoring ESTs for KRT18:

X12883 AA053143 AA053376 AA053587 AA074028 AA074741 AA074930 AA075475 AA079273 AA079300

Unigene Cluster for KRT18:

Keratin 18

Hs.406013 [show with all ESTs]

Unigene Representative Sequence: CR616919

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for KRT18 (see all 10)

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	^	9a	·	9b	·	9c	·	9d	·	9e	^	10a	·	10b
SP1:																	-
SP2:																	-																								-
SP3:			-		-												-
SP4:																	-
SP5:													-				-

About this scheme

ECgene alternative splicing isoforms for KRT18
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000388837(uc009zmn.1 uc001sbe.2) ENST00000388835(uc001sbf.1 uc001sbg.2 uc009zmo.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

KRT18 expression in normal and diseased human tissues

¹ / ² / ³

4 probe-sets matching KRT18 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
88043_g_at²^{, 3}	U95-E	22	1.00	0.58	0.99	1.15	AI984261	0.80	1.00	0.91	1
35766_at²^{, 3}	U95-A	28	1.00	0.56	1.00	0.86	X12883	1.00	1.00	1.00	1
201596_x_at²^{, 3}	U133-A	15	1.00	0.67	--	--	NM_000224	0.60	1.00	0.82	1
201596_x_at²	U133Plus2	15	1.00	0.67	--	--	--	--	--	--	--

About this table

KRT18 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

KRT18 gene electronic northern expression

About these images

CGAP SAGE TAG: CAAACCATCC GAGTTGCTGC

SOURCE GeneReport for Unigene cluster: Hs.406013

Expression variation in blood from EXPOLDB for KRT18

UniProtKB/Swiss-Prot: K1C18_HUMAN, P05783

Tissue specificity: Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in

lymph nodes of breast carcinoma

Primers:		OriGene genome-wide validated SYBR primer pairs: KRT18 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for KRT18: PPH00452A

SABiosciences Expression via Pathway-Focused PCR Arrays including KRT18 (see all 3): PAHS-005A PAHS-055A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KRT18 gene from 5/9 species (see all 9)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KRT18¹	--	keratin 18	89.59(n) 89.28(a)	477601 XM_534794.2 XP_534794.1
chimpanzee (Pan troglodytes)	KRT18¹	--	keratin 18	99.92(n) 100(a)	451923 XM_509083.2 XP_509083.2
cow (Bos taurus)	KRT18¹	--	keratin 18	89.28(n) 88.81(a)	506480 XM_582930.3 XP_582930.2
rat (Rattus norvegicus)	Krt18¹	--	keratin 18	84.16(n) 86.46(a)	294853 NM_053976.1 NP_446428.1
mouse (Mus musculus)	Krt18^{1 , 5}	15 (57.22 cM)⁵	keratin 18^{1, 5}	85.19(n)¹ 88.36(a)¹	16668¹ NM_010664.1¹ NP_034794.1¹ AK145413⁵ AK167072⁵ (see all 21)

About this table Species with no ortholog for KRT18

ENSEMBL Gene Tree for KRT18 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KRT18 gene

KRT18P14² KRT20² KRT18P20² KRT23²

KRT18 for paralogs About GeneDecksing

Pseudogenes

61 related pseudogenes

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs1049159^1,2	--	53345327(+)	`GCCCCA/CAAATC`	4	P	syn¹ ref¹ ese³		0	--	--	--	--
rs1492241^1,2	C,F,	53343493(-)	`GTATGC/TCCAAC`	2	--	int¹		3		NA EA WA	210
rs2070876^1,2	C,F,O,A,H,	53344830(+)	`AAGACT/CGTTCT`	2	--	int¹		27		EA NA NS WA	3162
rs2682294^1,2	F,	53346912(+)	`GGGAAT/CTGTGG`	2	--	ng3¹		4		NS EA	420
rs3741442^1,2	C,F,	53346750(+)	`CAGTCC/TCATCC`	2	--	ng3¹		9		EA NA NS	2132
rs7308151^1,2	C,F,A,	53346848(+)	`CTTCTG/CAGAGA`	2	--	ng3¹		12		NS EA NA	990
rs9630301^1,2	C	53341708(+)	`TCCTAA/GAACTG`	2	--	ng5¹		0	--	--	--	--
rs11170343^1,2	C	53344610(+)	`ACACCA/GATATC`	4	N D	ref¹ mis¹ ese³		4		NS EA	416
rs11551622^1,2	--	53344636(+)	`GAGACA/CGAGAT`	4	T	ref¹ syn¹ ese³		0	--	--	--	--
rs11551625^1,2	--	53344545(+)	`GACAGA/TGCTGG`	4	E V	ref¹ mis¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for KRT18 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KRT18: --

QIAGEN SeqTarget long-range PCR primers for resequencing KRT18

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KRT18 for disorders About GeneDecksing

OMIM: 148070

UniProtKB/Swiss-Prot: K1C18_HUMAN, P05783

Defects in KRT18 are a cause of cryptogenic cirrhosis [MIM:215600]

10/96 Novoseek disease relationships for KRT18 gene (see all 96)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
liver diseases	60.7	23	17971926 (4), 19769633 (3), 17105587 (2), 19587454 (2) (see all 10)
tumors	59.3	158	19302716 (4), 11014572 (3), 15331168 (3), 16762691 (3) (see all 99)
carcinoma	59.1	49	19407366 (3), 11787851 (2), 7536188 (2), 11669590 (2) (see all 32)
epithelial tumor	55.2	3	15102669 (1), 7688814 (1)
fatty liver	49.8	11	19769633 (3), 19881359 (2), 18852641 (1), 19707105 (1) (see all 5)
breast carcinoma	49.3	13	9816144 (2), 17545523 (2), 10825002 (1), 18715613 (1) (see all 9)
carcinoma squamous cell	47.7	24	11038661 (4), 19755983 (2), 1690512 (2), 1374358 (1) (see all 17)
hepatitis alcoholic	46.5	5	16762691 (2), 15365314 (1), 19769633 (1), 18618253 (1)
metastasis	46.5	21	19529960 (5), 10825002 (1), 18715613 (1), 19615282 (1) (see all 7)
breast cancer	41.2	39	10209854 (4), 17545523 (4), 9816144 (2), 15102669 (2) (see all 21)

About this table

Human Gene Mutation Database (HGMD): KRT18
Genetic Association Database (GAD): KRT18
Human Genome Epidemiology (HuGE) Navigator: KRT18 (4 documents)

Export disorders and mutations for KRT18 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/784 PubMed articles for KRT18 gene, integrated from 7 sources (see all 784):
(articles sorted by number of sources associating them with KRT18)

Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins. (PubMed id 9524113)^{1, 2, 7} Ku N.O.... Omary M.B. (1998)
Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis. (PubMed id 9298992)^{1, 2, 7} Caulin C.... Oshima R.G. (1997)
Identification and mutational analysis of the glycosylation sites of human keratin 18. (PubMed id 7538124)^{1, 2, 7} Ku N.-O. and Omary M.B. (1995)
Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization. (PubMed id 7523419)^{1, 2, 7} Ku N.O. and Omary M.B. (1994)
Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network. (PubMed id 16424149)^{1, 2, 7} Lipecka J.... Davezac N. (2006)
Global proteomic approach unmasks involvement of keratins 8 and 18 in the delivery of cystic fibrosis transmembrane conductance regulator (CFTR)/deltaF508-CFTR to the plasma membrane. (PubMed id 15529338)^{1, 2, 7} Davezac N.... Edelman A. (2004)
Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD. (PubMed id 11684708)^{1, 2, 7} Inada H.... Inagaki M. (2001)
Mutation of human keratin 18 in association with cryptogenic cirrhosis. (PubMed id 9011570)^{1, 2, 7} Ku N.-O.... Omary M.B. (1997)
Embryonic simple epithelial keratins 8 and 18: chromosomal location emphasizes difference from other keratin pairs. (PubMed id 1705144)^{1, 3, 7} Waseem A.... Lane E.B. (1990)
New consensus nomenclature for mammalian keratins. (PubMed id 16831889)^{1, 3} Schweizer J....Wright M.W. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3875	HGNC: 6430	AceView: KRT18	Ensembl:ENSG00000111057	euGenes: HUgn3875
ECgene: KRT18	Kegg: 3875	H-InvDB: KRT18

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for KRT18	Genetics and Cytogenetics in Oncology and Haematology
Human Intermediate Filament Mutation Database	http://www.interfil.org

Intellectual Property for KRT18 gene
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Patent Information for KRT18 gene:
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KRT18 Gene

protein-coding GIFtS: 67

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