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KRT18 Gene

protein-coding   GIFtS: 67

GC12P050386
keratin 18
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
keratin 181 2     cytokeratin 182
Cell proliferation-inducing gene 46 protein2 3     keratin, type I cytoskeletal 182
K182 3     keratin-182
CYK182 3     cell proliferation-inducing protein 462
CK-182 3     Cytokeratin-183
cytokeratin-182     Keratin-183

External Ids:    HGNC: 64301   Entrez Gene: 38752   Ensembl: ENSG000001110577   UniProtKB: P057833   

Export aliases for KRT18 gene to outside databases

Previous GC identifers: GC12M053340 GC12M053554 GC12P053059 GC12P051630 GC12P051631 GC12P051632 GC12P053343


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRT18:
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin
8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single
layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript
variants encoding the same protein have been found for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: K1C18_HUMAN, P05783
Function: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When
phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma
membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection

Gene Wiki entry for KRT18 (Keratin 18)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRT18 gene promoter:
         GATA-1   HNF-4alpha2   STAT3   COUP-TF1   Nkx3-1 v1   Nkx3-1 v2   Nkx3-1   Nkx3-1 v3   Nkx3-1 v4   p53   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for KRT18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13

KRT18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRT18 gene location

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P050386:  view genomic region     (about GC identifiers)

Start:
50,386,471 bp from pter
End:
50,390,501 bp from pter
Size:
4,031 bases
Orientation:
plus strand

1 alternative location:
Chr12+ 53,342,655-53,346,684     
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: K1C18_HUMAN, P05783 (See protein sequence)
Recommended Name: Keratin, type I cytoskeletal 18  
Size: 430 amino acids; 48058 Da
Subunit: Heterotetramer of two type I and two type II keratins. Keratin-18 associates with keratin-8. Interacts with
the thrombin-antithrombin complex (By similarity). Interacts with PNN, HCV core protein and mutated CFTR. Interacts
with YWHAE, YWHAH and YWHAZ only when phosphorylated. Interacts with DNAJB6, TCHP and TRADD
Subcellular location: Cytoplasm, perinuclear region
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to
basic; 56-70 kDa)
Secondary accessions: Q53G38 Q5U0N8 Q9BW26

Explore the universe of human proteins at neXtProt for KRT18: NX_P05783 

Post-translational modifications:

  • Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver.
  • Phosphorylation increases by IL-61
  • Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3,
  • caspase-6 or caspase-71
  • O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_000215.1  NP_954657.1  


    ENSEMBL proteins: 
    ENSP00000373489 ENSP00000373487 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 2): KRT18
    GenScript Custom Purified and Recombinant Proteins Services for KRT18 
    Novus Biologicals Proteins for KRT18
    Novus Biologicals Lysates for KRT18
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for KRT18

    5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IDA16424149
    GO:0005815 microtubule organizing center IDA18000879
    GO:0005882 intermediate filament TAS2434380
    GO:0034451 centriolar satellite IDA18000879
    GO:0045095 keratin filament IDA16424149
    About this table

    KRT18 for ontologies           About GeneDecksing



    Antibodies for KRT18: 
    Millipore Mono- and Polyclonal Antibodies for the study of KRT18
    Sigma-Aldrich Antibody Arrays and Antibodies for KRT18
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for KRT18 
    OriGene Antibodies (see all 8): KRT18
    GenScript Custom Superior Antibodies Services for KRT18 
    Novus Biologicals Antibodies for KRT18
    Epitomics antibodies for KRT18

    Assays for KRT18: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KRT18 
    Enzo Life Sciences assays for KRT18
    Uscn ELISAs and CLIAs for KRT18 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    KRT18 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR018039 Intermediate_filament_CS
     IPR001664 IF
     IPR002957 Keratin_I
     IPR016044 F

    Graphical View of Domain Structure for InterPro Entry P05783

    ProtoNet protein and cluster: P05783

    2 Blocks protein families:
    IPB001664 Intermediate filament protein
    IPB002957 Type I keratin signature


    UniProtKB/Swiss-Prot: K1C18_HUMAN, P05783
    Similarity: Belongs to the intermediate filament family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: K1C18_HUMAN, P05783
    Function: Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When
    phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma
    membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection
    Induction: By IL6/interleukin-6

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for KRT18
    Sigma-Aldrich shRNA Panels and shRNA for KRT18
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): KRT18
    OriGene shRNA RFP (see all 2): KRT18
    OriGene basic RS shRNA (see all 2): KRT18
    OriGene siRNA (see all 2): KRT18
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KRT18 
    miRNA:Sigma-Aldrich microRNA Mimics for KRT18
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KRT18 
    Search SABiosciences for Assays for microRNAs that regulate KRT18

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): KRT18
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): KRT18
    OriGene untagged cDNA clones in CMV expression vector (see all 2): KRT18
    OriGene 3'-UTR clone (see all 2): KRT18 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): KRT18 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for KRT18 

    Genatlas biochemistry entry for KRT18:
    keratin 18,type I,early embryonic simple epithelia,dimerizing with KRT8,including a 3' locus control region KRT18-LCR

    2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198 structural molecule activity IEA--
    GO:0005515 protein binding IPI17353931
    About this table

    KRT18 for ontologies           About GeneDecksing

    Animal Models: 4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Krt18):

    embryogenesisgrowth/sizelethality-prenatal/perinatalliver/biliary system

    KRT18 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    KRT18 for pathways           About GeneDecksing

    1 Millipore Pathway for KRT18
        Cytoskeleton remodeling Keratin filaments

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  KRT18
        ILK Signaling

    1 Kegg Pathway  (Kegg details for KRT18):
        hsa05130 Pathogenic Escherichia coli infection

        SABiosciences Pathway-Focused PCR Arrays including KRT18 (see all 3): PAHS-005A PAHS-055A  

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for KRT18
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KRT18

    5/89 Interacting proteins for KRT18 (P057831, 2) via UniProtKB, MINT, and/or STRING (see all 89)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT8P057871, 2EBI-297888,EBI-297852 MINT-7899812
    CLEC3BP054521EBI-297888,EBI-1047626
    DNAJB6O751901EBI-297888,EBI-1053164
    MCCP235081EBI-297888,EBI-307531
    PPM1BO756881EBI-297888,EBI-1047039
    About this table

    5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049 cell cycle IEA--
    GO:0009653 anatomical structure morphogenesis TAS2434380
    GO:0043000 Golgi to plasma membrane CFTR protein transport IDA15529338
    GO:0043066 negative regulation of apoptosis IDA11684708
    GO:0044419 interspecies interaction between organisms IEA--
    About this table

    KRT18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    KRT18 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRT18
    10/77 Novoseek chemical compound relationships for KRT18 gene (see all 77)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    new fuchsin 75.2 2 7521088 (1), 7682210 (1)
    nash 55.7 25 19585618 (4), 19378390 (3), 19891019 (3), 19906783 (2) (see all 6)
    griseofulvin 49.9 4 8770877 (3), 10952237 (1)
    matrigel 41.8 1 12021244 (1)
    paraffin 40.9 10 9816144 (1), 15597196 (1), 17912630 (1), 1694766 (1) (see all 8)
    glycogen 35.4 6 17492221 (1), 19092233 (1), 19063660 (1), 19781766 (1)
    dutp 33.7 2 12015537 (1), 15194561 (1)
    diethyl dithiocarbamate 29.8 2 17187412 (2)
    estrogen 28.4 6 18300793 (1), 18715613 (1), 20340005 (1), 18360284 (1) (see all 5)
    progesterone 26.7 11 18300793 (1), 18715613 (1), 20340005 (1), 12835305 (1) (see all 7)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for KRT18
    Sigma-Aldrich shRNA Panels and shRNA for KRT18
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): KRT18
    OriGene shRNA RFP (see all 2): KRT18
    OriGene basic RS shRNA (see all 2): KRT18
    OriGene siRNA (see all 2): KRT18
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KRT18 
    miRNA: Sigma-Aldrich microRNA Mimics for KRT18
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KRT18 
    Search SABiosciences for Assays for microRNAs that regulate KRT18
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): KRT18
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): KRT18
    OriGene untagged cDNA clones in CMV expression vector (see all 2): KRT18
    OriGene 3'-UTR Clone (see all 2): KRT18 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): KRT18 
    Primers: OriGene genome-wide validated SYBR primer pairs: KRT18
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for KRT18: PPH00452A

    REFSEQ mRNAs for KRT18 gene (2 alternative transcripts): 

    NM_000224.2  NM_199187.1  

    Additional cDNA sequence: 

    AK129587.1 AK223093.1 AK308506.1 AK313988.1 AY762101.1 BC000180.2 BC000698.2 BC004253.1 
    BC008636.1 BC009754.2 BC020982.1 BC072017.1 BT019412.1 CR594446.1 CR595810.1 CR596888.1 
    CR597901.1 CR598014.1 CR599586.1 CR600203.1 CR600648.1 CR601746.1 CR603302.1 CR603470.1 
    CR603763.1 CR603859.1 CR604760.1 CR604789.1 CR605941.1 CR606789.1 CR609248.1 CR609809.1 
    CR609857.1 CR610278.1 CR610685.1 CR610807.1 CR611058.1 CR613989.1 CR616576.1 CR616919.1 
    CR619082.1 CR619165.1 CR620895.1 CR621642.1 CR622312.1 CR622674.1 CR622676.1 CR623435.1 
    CR623563.1 CR625199.1 CR625896.1 X12876.1 X12881.1 X12883.1 

    24/102 DOTS entries (see all 102):

    DT.91779938  DT.91780003  DT.97824751  DT.97807695  DT.91779860  DT.97863493  DT.91779932  DT.100772221 
    DT.121117764  DT.121117671  DT.121118642  DT.100709494  DT.100700193  DT.100858944  DT.121118265  DT.100700176 
    DT.450789  DT.121118571  DT.100700188  DT.100860177  DT.91779894  DT.121118049  DT.95366609  DT.121118032 

    24/3236 AceView cDNA sequences (see all 3236):

    BQ896668 BU542998 BM563817 BU955841 AA132109 BQ689816 BM978162 BQ953873 
    BE794269 BQ688579 AA577313 BE394643 BE740083 BQ420485 BE908174 BU857095 
    CA489094 BI253425 BU539801 BU185646 BM773453 BU538396 BG328600 BQ686169 

    highest scoring ESTs for KRT18:

    X12883 AA053143 AA053376 AA053587 AA074028 AA074741 AA074930 AA075475 AA079273 AA079300 

    Unigene Cluster for KRT18:

    Keratin 18
    Hs.406013  [show with all ESTs]
    Unigene Representative Sequence: CR616919


    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for KRT18 (see all 10)

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b
    SP1:                                                  -                                                                                       
    SP2:                                                  -                                                                       -               
    SP3:        -     -                                   -                                                                                       
    SP4:                                                  -                                                                                       
    SP5:                                      -           -                                                                                       

    About this scheme

    ECgene alternative splicing isoforms for KRT18
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000388837(uc009zmn.1 uc001sbe.2) ENST00000388835(uc001sbf.1 uc001sbg.2 uc009zmo.2)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    KRT18 expression in normal and diseased human tissues

    1  / 2  / 3

    4 probe-sets matching KRT18 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    88043_g_at2, 3 U95-E 22 1.00 0.58 0.99 1.15 AI984261 0.80 1.00 0.91 1
    35766_at2, 3 U95-A 28 1.00 0.56 1.00 0.86 X12883 1.00 1.00 1.00 1
    201596_x_at2, 3 U133-A 15 1.00 0.67 -- -- NM_000224 0.60 1.00 0.82 1
    201596_x_at2 U133Plus2 15 1.00 0.67 -- -- -- -- -- -- --
    About this table

    KRT18 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    KRT18 gene expression
    KRT18 gene electronic northern expression
    KRT18 gene sage expression
    About these images

    CGAP SAGE TAG: CAAACCATCC GAGTTGCTGC

    SOURCE GeneReport for Unigene cluster: Hs.406013

    Expression variation in blood from EXPOLDB for KRT18

    UniProtKB/Swiss-Prot: K1C18_HUMAN, P05783
    Tissue specificity: Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in
    lymph nodes of breast carcinoma

    Primers: OriGene genome-wide validated SYBR primer pairs: KRT18
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for KRT18: PPH00452A
        SABiosciences Expression via Pathway-Focused PCR Arrays including KRT18 (see all 3): PAHS-005A PAHS-055A  


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for KRT18 gene from 5/9 species (see all 9)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    KRT181   -- keratin 18 89.59(n)
    89.28(a)
    477601  XM_534794.2  XP_534794.1 
    chimpanzee
    (Pan troglodytes)
    KRT181   -- keratin 18 99.92(n)
    100(a)
    451923  XM_509083.2  XP_509083.2 
    cow
    (Bos taurus)
    KRT181   -- keratin 18 89.28(n)
    88.81(a)
    506480  XM_582930.3  XP_582930.2 
    rat
    (Rattus norvegicus)
    Krt181   -- keratin 18 84.16(n)
    86.46(a)
    294853  NM_053976.1  NP_446428.1 
    mouse
    (Mus musculus)
    Krt181 , 5 15 (57.22 cM)5
    keratin 181, 5 85.19(n)1
    88.36(a)1
    166681  NM_010664.11  NP_034794.11 
     AK1454135  AK1670725  (see all 21)
    About this table        Species with no ortholog for KRT18

    ENSEMBL Gene Tree for KRT18 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for KRT18 gene
    KRT18P142  KRT202  KRT18P202  KRT232  

    KRT18 for paralogs           About GeneDecksing


    Pseudogenes
    61 related pseudogenes



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/57 NCBI SNPs in KRT18 are shown (see all 57)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs10491591,2
    --53345327(+) GCCCCA/CAAATC 4 P syn1 ref1 ese30--------
    rs14922411,2
    C,F,53343493(-) GTATGC/TCCAAC 2 -- int13Minor allele frequency- T:0.12NA EA WA 210
    rs20708761,2
    C,F,O,A,H,53344830(+) AAGACT/CGTTCT 2 -- int127Minor allele frequency- C:0.50EA NA NS WA 3162
    rs26822941,2
    F,53346912(+) GGGAAT/CTGTGG 2 -- ng314Minor allele frequency- C:0.01NS EA 420
    rs37414421,2
    C,F,53346750(+) CAGTCC/TCATCC 2 -- ng319Minor allele frequency- T:0.44EA NA NS 2132
    rs73081511,2
    C,F,A,53346848(+) CTTCTG/CAGAGA 2 -- ng3112Minor allele frequency- C:0.06NS EA NA 990
    rs96303011,2
    C53341708(+) TCCTAA/GAACTG 2 -- ng510--------
    rs111703431,2
    C53344610(+) ACACCA/GATATC 4 N D ref1 mis1 ese34Minor allele frequency- G:0.00NS EA 416
    rs115516221,2
    --53344636(+) GAGACA/CGAGAT 4 T ref1 syn1 ese30--------
    rs115516251,2
    --53344545(+) GACAGA/TGCTGG 4 E V ref1 mis10--------
    About this table

    HapMap Linkage Disequilibrium images for KRT18 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KRT18: --

    QIAGEN SeqTarget long-range PCR primers for resequencing KRT18 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KRT18 for disorders           About GeneDecksing

    OMIM: 148070

    UniProtKB/Swiss-Prot: K1C18_HUMAN, P05783

  • Defects in KRT18 are a cause of cryptogenic cirrhosis [MIM:215600]
  • 10/96 Novoseek disease relationships for KRT18 gene (see all 96)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    liver diseases 60.7 23 17971926 (4), 19769633 (3), 17105587 (2), 19587454 (2) (see all 10)
    tumors 59.3 158 19302716 (4), 11014572 (3), 15331168 (3), 16762691 (3) (see all 99)
    carcinoma 59.1 49 19407366 (3), 11787851 (2), 7536188 (2), 11669590 (2) (see all 32)
    epithelial tumor 55.2 3 15102669 (1), 7688814 (1)
    fatty liver 49.8 11 19769633 (3), 19881359 (2), 18852641 (1), 19707105 (1) (see all 5)
    breast carcinoma 49.3 13 9816144 (2), 17545523 (2), 10825002 (1), 18715613 (1) (see all 9)
    carcinoma squamous cell 47.7 24 11038661 (4), 19755983 (2), 1690512 (2), 1374358 (1) (see all 17)
    hepatitis alcoholic 46.5 5 16762691 (2), 15365314 (1), 19769633 (1), 18618253 (1)
    metastasis 46.5 21 19529960 (5), 10825002 (1), 18715613 (1), 19615282 (1) (see all 7)
    breast cancer 41.2 39 10209854 (4), 17545523 (4), 9816144 (2), 15102669 (2) (see all 21)
    About this table

    Human Gene Mutation Database (HGMD): KRT18
    Genetic Association Database (GAD): KRT18
    Human Genome Epidemiology (HuGE) Navigator: KRT18 (4 documents)

    Export disorders and mutations for KRT18 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/784 PubMed articles for KRT18 gene, integrated from 7 sources (see all 784):
    (articles sorted by number of sources associating them with KRT18)
    1. Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins. (PubMed id 9524113)1, 2, 7 Ku N.O.... Omary M.B. (1998)
    2. Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis. (PubMed id 9298992)1, 2, 7 Caulin C.... Oshima R.G. (1997)
    3. Identification and mutational analysis of the glycosylation sites of human keratin 18. (PubMed id 7538124)1, 2, 7 Ku N.-O. and Omary M.B. (1995)
    4. Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization. (PubMed id 7523419)1, 2, 7 Ku N.O. and Omary M.B. (1994)
    5. Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network. (PubMed id 16424149)1, 2, 7 Lipecka J.... Davezac N. (2006)
    6. Global proteomic approach unmasks involvement of keratins 8 and 18 in the delivery of cystic fibrosis transmembrane conductance regulator (CFTR)/deltaF508-CFTR to the plasma membrane. (PubMed id 15529338)1, 2, 7 Davezac N.... Edelman A. (2004)
    7. Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD. (PubMed id 11684708)1, 2, 7 Inada H.... Inagaki M. (2001)
    8. Mutation of human keratin 18 in association with cryptogenic cirrhosis. (PubMed id 9011570)1, 2, 7 Ku N.-O.... Omary M.B. (1997)
    9. Embryonic simple epithelial keratins 8 and 18: chromosomal location emphasizes difference from other keratin pairs. (PubMed id 1705144)1, 3, 7 Waseem A.... Lane E.B. (1990)
    10. New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3875 HGNC: 6430 AceView: KRT18 Ensembl:ENSG00000111057 euGenes: HUgn3875
    ECgene: KRT18 Kegg: 3875 H-InvDB: KRT18

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for KRT18 Genetics and Cytogenetics in Oncology and Haematology
    Human Intermediate Filament Mutation Databasehttp://www.interfil.org

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for KRT18 gene:
    Search GeneIP for patents involving KRT18

    GeneCards and IP:
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