Aliases &
Descriptions
for KRT20 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| keratin 201 2 | | KRT212 5 | | K201 2 3 | | keratin-202 | | CK201 2 | | keratin, type I cytoskeletal 202 | | MGC354231 2 | | cytokeratin 202 | | Protein IT2 3 | | cytokeratin-202 | | CK-202 3 | | Cytokeratin-203 | | CD202 5 | | Keratin-203 |
Export aliases for KRT20 gene to outside databasesPrevious GC identifers: GC17M038532 GC17M041208 GC17M038940 GC17M039405 GC17M036285 GC17M039030 |
Summaries
for KRT20 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KRT20:
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteinsresponsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins.The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Thiscytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in thegastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21.(provided by RefSeq)
UniProtKB/Swiss-Prot: K1C20_HUMAN, P35900Function: Plays a significant role in maintaining keratin filament organization in intestinal epithelia. Whenphosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity)
|
Genomic Views
for KRT20 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KRT20 gene promoter:
PPAR-gamma1 PPAR-gamma2 p53 Fra-1 JunB JunD c-Jun c-Fos AP-1 c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for KRT20
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21.2KRT20 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M034826: view genomic region
(about GC identifiers)
Start:
|
34,826,490 bp from pter |
End:
|
34,835,854 bp from pter |
Size:
|
9,365 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr17- 39,030,852-39,041,479 |
RefSeq DNA sequence:- NC_000017.10 NT_010783.15
|
Proteins
for KRT20 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: K1C20_HUMAN, P35900 (See
protein sequence)Recommended Name: Keratin, type I cytoskeletal 20 Size: 424 amino acids; 48487 Da
Subunit: Heterotetramer of two type I and two type II keratins. Associates with KRT8
Subcellular location: Cytoplasm
Developmental stage: First detected at embryonic week 8 in individual 'converted' simple epithelial cells of thedeveloping intestinal mucosa. In later fetal stages, synthesis extends over most goblet cells and a variable number ofvillus enterocytes. In the developing gastric and intestinal mucosa, expressed in all enterocytes and goblet cells aswell as certain 'low-differentiated' columnar cells, whereas the neuroendocrine and Paneth cells are negative
Miscellaneous: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral tobasic; 56-70 kDa)
Secondary accessions: B2R6W7Explore the universe of human proteins at neXtProt for KRT20: NX_P35900
Post-translational modifications:
Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the laterstages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury (By similarity)1
Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-2281
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_061883.1
ENSEMBL proteins: ENSP00000167588
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
KRT20 for ontologies About GeneDecksing
Antibodies for KRT20:
Assays for KRT20: |
Protein
Domains/
Families
for KRT20 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KRT20 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P35900ProtoNet protein and cluster: P35900 2 Blocks protein families: IPB001664 Intermediate filament protein IPB002957 Type I keratin signature
UniProtKB/Swiss-Prot: K1C20_HUMAN, P35900Similarity: Belongs to the intermediate filament family |
Gene Function
for KRT20 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: K1C20_HUMAN, P35900Function: Plays a significant role in maintaining keratin filament organization in intestinal epithelia. Whenphosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity)
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
KRT20 for ontologies About GeneDecksing
|
Pathways & Interactions
for KRT20 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for KRT20
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KRT20
5/12 Interacting proteins for KRT20 (P359002) via UniProtKB, MINT, and/or STRING (see all 12)About this table
4 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
KRT20 for ontologies About GeneDecksing
|
Drugs & Compounds
for KRT20 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
KRT20 for compounds About GeneDecksing
 Browse Tocris compounds for KRT20
10/17  Novoseek chemical compound relationships for KRT20 gene (see all 17)
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| mucicarmine |
78.6 |
7 |
11106075 (1), 9208972 (1), 9870855 (1), 19132778 (1) (see all 6) |
| paraffin |
53.9 |
21 |
10976695 (1), 10093825 (1), 11668468 (1), 10705819 (1) (see all 15) |
| estrogen |
50.7 |
57 |
11028811 (2), 12715337 (2), 9160304 (2), 12217766 (1) (see all 49) |
| progesterone |
50 |
45 |
9160304 (2), 12217766 (1), 14506675 (1), 15086841 (1) (see all 39) |
| hematoxylin |
47.5 |
9 |
12189500 (1), 10926813 (1), 15589579 (1), 15363204 (1) (see all 7) |
| b 723 |
40.5 |
5 |
11106075 (2), 15589579 (1), 12481020 (1), 12647218 (1) |
| ribonucleic acid |
1.42 |
2 |
9817302 (1), 12498994 (1) |
| tyrosine |
1.03 |
1 |
16547650 (1) |
| sucrose |
0 |
3 |
17378731 (1) |
| iron |
0 |
2 |
16243134 (1), 18603673 (1) |
About this table
|
Transcripts
for KRT20 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for KRT20 gene: NM_019010.2 Additional cDNA sequence: AK312744.1 BC031559.1 X73502.1 4 DOTS entries: DT.211402 DT.95162475 DT.120986558 DT.91829085 24/60 AceView cDNA sequences (see all 60): BC031559 NM_019010 BQ326166 AI821179 AA522447 AA471027 BX098834 BQ317223 BQ316025 BI762148 AI732381 BI762117 BG386855 X73502 AI732166 AA133469 T29686 AW842995 BQ316026 AW853840 BQ319047 BQ317839 AA524060 BQ326177
 highest scoring ESTs for KRT20:X73502 BC031559 BG386855 BI762117 BI762148 BQ316483 BQ326177 BQ326197 BX483738 AA133469 Unigene Cluster for KRT20: Keratin 20 Hs.84905 [show with all ESTs]Unigene Representative Sequence: BC031559
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000482529 ENST00000167588(uc002hvl.2)
|
Expression
for KRT20 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| KRT20 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching KRT20 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 40694_at2, 3
|
U95-A |
1 |
0.50 |
1.00 |
1.00 |
1.00 |
X73502 |
1.00 |
1.00 |
1.00 |
1 |
| 213953_at2, 3
|
U133-A |
1 |
0.46 |
1.00 |
-- |
-- |
AI732381 |
0.60 |
1.00 |
0.82 |
1 |
| 213953_at2
|
U133Plus2 |
1 |
0.46 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
KRT20 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TAAATTGCAA
SOURCE GeneReport for Unigene cluster: Hs.84905
Expression variation in blood from EXPOLDB for KRT20 UniProtKB/Swiss-Prot: K1C20_HUMAN, P35900Tissue specificity: Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa.Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of thegingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa
SABiosciences Custom PCR Arrays for KRT20
|
Orthologs
for KRT20 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KRT20 gene from 5/7 species (see all 7)
About this table Species with no ortholog for KRT20
ENSEMBL Gene Tree for KRT20 (if available) |
Paralogs
for KRT20 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for KRT20 gene
- KRT18P142 KRT182 KRT18P202 KRT232
KRT20 for paralogs About GeneDecksing
|
Genomic Variants
for KRT20 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
| | | QIAGEN SeqTarget long-range PCR primers for resequencing KRT20 |
|
Disorders & Mutations
for KRT20 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KRT20 for disorders About GeneDecksing
OMIM: 608218
10/94 Novoseek disease relationships for KRT20 gene (see all 94)
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| carcinoma merkel cell |
90.5 |
58 |
11175640 (5), 10027519 (4), 10728812 (4), 10976695 (2) (see all 29) |
| carcinoma mucinous |
81.7 |
20 |
12352188 (2), 14645698 (1), 14668551 (1), 15362373 (1) (see all 13) |
| adenocarcinoma |
81.6 |
279 |
15371952 (5), 11745209 (5), 15333652 (5), 18156982 (4) (see all 99) |
| carcinoma |
79.7 |
167 |
1371204 (5), 11341356 (4), 11419977 (3), 11488072 (3) (see all 99) |
| metastatic carcinoma |
79.2 |
25 |
12172048 (3), 9822920 (2), 9067104 (2), 14668551 (1) (see all 20) |
| carcinoma neuroendocrine |
79.2 |
16 |
20182342 (2), 15010880 (2), 10937047 (1), 16508780 (1) (see all 12) |
| metastasis |
76.1 |
152 |
11419977 (6), 16980943 (5), 17890913 (5), 17058136 (4) (see all 79) |
| tumors |
74.4 |
490 |
16980943 (7), 15245962 (7), 11301341 (7), 11144928 (6) (see all 99) |
| extramammary pagets disease |
73 |
5 |
9989849 (2), 10777264 (1) |
| carcinoma transitional cell |
71.2 |
23 |
9817302 (2), 11490230 (2), 9067104 (2), 11693559 (2) (see all 16) |
About this table
Human Genome Epidemiology (HuGE) Navigator: KRT20 (1 document)
Export disorders and mutations for KRT20 gene to outside databases
|
Medical News
for KRT20 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for KRT20 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/826 PubMed articles for KRT20 gene, integrated from 7 sources (see all 826):
(articles sorted by number of sources associating them with KRT20)- The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas. (PubMed id 8359595)1, 2, 3, 7 Moll R.... Franke W.W. (1993)
- Keratin 20 helps maintain intermediate filament organization in intestinal epithelia. (PubMed id 12857878)1, 2, 7 Zhou Q....Omary M.B. (2003)
- [Significance of cytokeratin gene (CK-20 mRNA) expression in metastatic lymph nodes in colon carcinoma patients] (PubMed id 12515621)1, 3, 7 Ye X....Chen T. (2002)
- An immunohistological study of cytokeratin 20 in human and mammalian oral epithelium. (PubMed id 10973561)1, 2, 7 Barrett A.W.... Berkovitz B.K.B. (2000)
- New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
- Keratin 20 serine 13 phosphorylation is a stress and intestinal goblet cell marker. (PubMed id 16608857)1, 2 Zhou Q.... Omary M.B. (2006)
- Global phosphoproteome of HT-29 human colon adenocarcinoma cells. (PubMed id 16083285)1, 2 Kim J.-E.... White F.M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Differential localization by in situ hybridization of distinct keratin mRNA species during intestinal epithelial cell development and differentiation. (PubMed id 7689500)1, 2 Calnek D. and Quaroni A. (1993)
- Identification of protein IT of the intestinal cytoskeleton as a novel type I cytokeratin with unusual properties and expression patterns. (PubMed id 1696264)1, 2 Moll R.... Franke W.W. (1990)
|
External Searches for KRT20 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KRT20 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KRT20 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KRT20 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for KRT20 gene:
Search GeneIP for patents involving KRT20
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KRT20 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| | | |
 |
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| | |
 |  |  |  | |
| |  | Search Tocris compounds for KRT20 |
| |  |  |  |  | | | | | | Recombinant Protein for KRT20 |
|
 | | | ELISAs and CLIAs for KRT20 |
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