Aliases &
Descriptions
for KRT84 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| keratin 841 2 | | keratin, type II cuticular Hb42 | | keratin, hair, basic, 41 2 | | HB42 | | Type-II keratin Kb242 3 | | keratin-842 | | Type II hair keratin Hb42 3 | | hard keratin, type II, 42 | | KRTHB42 3 | | type II hair keratin 42 | | K842 3 | | Keratin-843 | | Hb-41 | | |
Export aliases for KRT84 gene to outside databasesPrevious GC identifers: GC12M051058 GC12M052771 |
Summaries
for KRT84 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KRT84:
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basicprotein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered ina region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. Onesubfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includesKRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin is containedprimarily in the filiform tongue papilla, among other hair keratins. (provided by RefSeq)
|
Genomic Views
for KRT84 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KRT84 gene promoter:
p53 AP-4 Cart-1 C/EBPalpha FOXL1 AREB6 MRF-2 POU3F2 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b)
Other transcription factors
Search SABiosciences Chromatin IP Primers for KRT84
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13KRT84 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M049815: view genomic region
(about GC identifiers)
Start:
|
49,815,148 bp from pter |
End:
|
49,822,969 bp from pter |
Size:
|
7,822 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr12- 52,771,596-52,779,417 |
RefSeq DNA sequence:- NC_000012.11 NT_029419.12
|
Proteins
for KRT84 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: KRT84_HUMAN, Q9NSB2 (See
protein sequence)Recommended Name: Keratin, type II cuticular Hb4 Size: 600 amino acids; 64842 Da
Subunit: Heterotetramer of two type I and two type II keratins
Miscellaneous: There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic)
Secondary accessions: B2RA43 Q6ISB0 Q701L6Explore the universe of human proteins at neXtProt for KRT84: NX_Q9NSB2
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_149034.2
ENSEMBL proteins: ENSP00000257951
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0045095 | keratin filament |
IEA | -- | | GO:0045111 | intermediate filament cytoskeleton |
-- | -- |
About this table
KRT84 for ontologies About GeneDecksing
Antibodies for KRT84:
Assays for KRT84: |
Protein
Domains/
Families
for KRT84 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KRT84 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NSB2ProtoNet protein and cluster: Q9NSB2 3 Blocks protein families: IPB001664 Intermediate filament protein IPB002957 Type I keratin signature IPB003054 Type II keratin signature
UniProtKB/Swiss-Prot: KRT84_HUMAN, Q9NSB2Similarity: Belongs to the intermediate filament family |
Gene Function
for KRT84 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
1 Gene Ontology (GO) molecular function term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030280 | structural constituent of epidermis |
NAS | -- |
About this table
KRT84 for ontologies About GeneDecksing
|
Pathways & Interactions
for KRT84 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for KRT84
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRT84
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | 10692104 | | GO:0045616 | regulation of keratinocyte differentiation |
IEA | -- |
About this table
KRT84 for ontologies About GeneDecksing
|
Drugs & Compounds
for KRT84 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for KRT84
|
Transcripts
for KRT84 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for KRT84 gene: NM_033045.3 Additional cDNA sequence: AJ628420.1 AK314030.1 BC069647.1 2 DOTS entries: DT.99950980 DT.121119174 3 AceView cDNA sequences: NM_033045 BC069647 AJ628420
 highest scoring ESTs for KRT84:AJ628420 BC069647 DA761960 NM_033045 DA765938 Unigene Cluster for KRT84: Keratin 84 Hs.272336 [show with all ESTs]Unigene Representative Sequence: BC069647
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000257951(uc001sah.1)
|
Expression
for KRT84 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| KRT84 expression in normal and diseased human tissues
1 / 2 2 probe-sets matching KRT84 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 217031_at*2
|
U133-A |
NULL |
0.00 |
0.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 217031_at*2
|
U133Plus2 |
NULL |
0.00 |
0.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TAGATGCTCC
SOURCE GeneReport for Unigene cluster: Hs.272336
UniProtKB/Swiss-Prot: KRT84_HUMAN, Q9NSB2Tissue specificity: Expressed in the hair follicle
SABiosciences Custom PCR Arrays for KRT84
|
Orthologs
for KRT84 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KRT84 gene from 5 species
About this table Species with no ortholog for KRT84
ENSEMBL Gene Tree for KRT84 (if available) |
Paralogs
for KRT84 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for KRT84 gene
- KRT121P2 KRT832 KRT862 KRT82 KRT812 KRT852 KRT8P112 KRT72
- KRT822
KRT84 for paralogs About GeneDecksing
|
Genomic Variants
for KRT84 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for KRT84
8 CNVs: 4778 9695 66223 30601 23297 53570 2984 8730 | | QIAGEN SeqTarget long-range PCR primers for resequencing KRT84 |
|
Disorders & Mutations
for KRT84 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KRT84 for disorders About GeneDecksing
OMIM: 602766
Export disorders and mutations for KRT84 gene to outside databases
|
Medical News
for KRT84 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for KRT84 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/11 PubMed articles for KRT84 gene, integrated from 7 sources (see all 11):
(articles sorted by number of sources associating them with KRT84)- New consensus nomenclature for mammalian keratins. (PubMed id 16831889)1, 3 Schweizer J....Wright M.W. (2006)
- Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PubMed id 15737194)1, 2 Rogers M.A....Schweizer J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization of a 300 kbp region of human DNA containing the type II hair keratin. (PubMed id 10692104)1, 2 Rogers M.A.... Schweizer J. (2000)
- The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins. (PubMed id 2431943)1, 3 Heid H.W....Franke W.W. (1986)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for KRT84 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KRT84 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KRT84 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KRT84 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for KRT84 gene:
Search GeneIP for patents involving KRT84
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KRT84 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for KRT84 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for KRT84 |
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