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Aliases & Descriptionsfor KRTAP5-6 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions keratin associated protein 5-61 2 KRTAP5.61 2 3 Keratin-associated protein 5.62 3 Ultrahigh sulfur keratin-associated protein 5.62 3 keratin-associated protein 5-62 KAP5.63
Export aliases for KRTAP5-6 gene to outside databases Previous GC identifers: GC00U913941 GC11P001675 GC11P001718
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Summariesfor KRTAP5-6 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: KRA56_HUMAN, Q6L8G9 Function : In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix,consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins
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Genomic Viewsfor KRTAP5-6 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the KRTAP5-6 gene promoter: GR-alpha POU3F2 Chx10 HSF1 (long) FOXF2 AhR Arnt FOXO4 FOXD1 POU2F1 Other transcription factors Search SABiosciences Chromatin IP Primers for KRTAP5-6 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for KRTAP5-6
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5 KRTAP5-6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P001509: view genomic region
(about GC identifiers )
Start:
1,509,449 bp from pter
End:
1,510,009 bp from pter
Size:
561 bases
Orientation:
plus strand
1 alternative location : Chr 11+ 1,718,425-1,718,985
RefSeq DNA sequence: NC_000011.9 NT_009237.18
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Proteinsfor KRTAP5-6 gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: KRA56_HUMAN, Q6L8G9 (See
protein sequence )Recommended Name: Keratin-associated protein 5-6 Size : 129 amino acids; 11784 Da
Subunit : Interacts with hair keratins
Secondary accessions : A1L452Explore the universe of human proteins at neXtProt for KRTAP5-6: NX_Q6L8G9
REFSEQ proteins: NP_001012416.1 ENSEMBL proteins: ENSP00000371595 Human Recombinant Proteins 1 Gene Ontology (GO) cellular component term (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0045095 keratin filament
IEA --
About this table
KRTAP5-6 for ontologies About GeneDecksing Antibodies for KRTAP5-6: Assays for KRTAP5-6:
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Protein
Domains/ Familiesfor KRTAP5-6 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
KRTAP5-6 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q6L8G9 ProtoNet protein and cluster: Q6L8G9
1 Blocks protein family : IPB001007 von Willebrand factor UniProtKB/Swiss-Prot: KRA56_HUMAN, Q6L8G9 Similarity : Belongs to the KRTAP type 5 family
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Gene Functionfor KRTAP5-6 gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: KRA56_HUMAN, Q6L8G9 Function : In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix,consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins
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Pathways & Interactionsfor KRTAP5-6 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section SABiosciences Custom Pathway-Focused PCR Arrays for KRTAP5-6 Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRTAP5-6
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Drugs & Compoundsfor KRTAP5-6 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for KRTAP5-6
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Transcriptsfor KRTAP5-6 gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for KRTAP5-6 gene: NM_001012416.1
Additional cDNA sequence: AB126075.1 BC130399.1 BC133035.1
1 DOTS entry : DT.102837616
1 AceView cDNA sequence :
AB126075
highest scoring ESTs for KRTAP5-6 :AB126075 BC130399 NM_001012416 Unigene Cluster for KRTAP5-6:
Keratin associated protein 5-6 Hs.534863 Unigene Representative Sequence: AB126075 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000382160 (uc001lua.2 )
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Expression for KRTAP5-6 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section KRTAP5-6 expression in normal and diseased human tissues 1 Data from GNF BioGPS About these images
About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.534863 UniProtKB/Swiss-Prot: KRA56_HUMAN, Q6L8G9 Tissue specificity : Expressed in hair root and not in skin. Expressed also in liver and skeletal muscle
SABiosciences Custom PCR Arrays for KRTAP5-6
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Orthologsfor KRTAP5-6 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for KRTAP5-6 gene from 2 species
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
cow (Bos taurus)
KRTAP5-61
--
keratin associated protein 5-6
87.08(n) 89.92(a)
540854 XM_879446.2 XP_884539.2
mouse (Mus musculus)
Gm22625
2 (39.13 cM)
predicted gene 2262
--
-
About this table Species with no ortholog for KRTAP5-6 ENSEMBL Gene Tree for KRTAP5-6 (if available)
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Paralogsfor KRTAP5-6 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for KRTAP5-6 gene KRTAP9-3 2 KRTAP4-4 2 KRTAP9-1 2 KRTAP5-10 2 KRTAP4-7 2 KRTAP9-6 2 KRTAP4-5 2 KRTAP5-4 2 KRTAP4-2 2 KRTAP9-4 2 KRTAP4-1 2 KRTAP9-7 2 KRTAP17-1 2 KRTAP4-9 2 KRTAP9-9 2 KRTAP4-12 2 ENSG00000241241 2 KRTAP5-5 2 KRTAP5-2 2 KRTAP5-11 2 KRTAP5-7 2 KRTAP4-8 2 KRTAP5-8 2 KRTAP5-1 2 KRTAP9-2 2 KRTAP5-3 2 KRTAP9-8 2 KRTAP4-6 2 KRTAP4-11 2 KRTAP4-3 2
KRTAP5-6 for paralogs About GeneDecksing
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Genomic Variantsfor KRTAP5-6 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 11 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for KRTAP5-6 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for KRTAP5-6: --
QIAGEN SeqTarget long-range PCR primers for resequencing KRTAP5-6
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Disorders & Mutationsfor KRTAP5-6 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Medical Newsfor KRTAP5-6 gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor KRTAP5-6 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 3 PubMed articles for KRTAP5-6 gene integrated from 7 sources : (articles sorted by number of sources associating them with KRTAP5-6) Identification of two novel clusters of ultrahigh-sulfur keratin- associated protein genes on human chromosome 11. (PubMed id 15144888) 1 , 2 , 3 Yahagi S....Shimizu N. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for KRTAP5-6 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing KRTAP5-6 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing KRTAP5-6 gene
(According to HUGE )
About This Section --
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Specialized Databases showing KRTAP5-6 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for KRTAP5-6 gene: Search GeneIP for patents involving KRTAP5-6 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor KRTAP5-6 gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
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