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KRTAP5-6 Gene

protein-coding   GIFtS: 36

GC11P001509
keratin associated protein 5-6
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
keratin associated protein 5-61 2
KRTAP5.61 2 3
Keratin-associated protein 5.62 3
Ultrahigh sulfur keratin-associated protein 5.62 3
keratin-associated protein 5-62
KAP5.63

External Ids:    HGNC: 236001   Entrez Gene: 4400232   Ensembl: ENSG000002058647   UniProtKB: Q6L8G93   

Export aliases for KRTAP5-6 gene to outside databases

Previous GC identifers: GC00U913941 GC11P001675 GC11P001718


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: KRA56_HUMAN, Q6L8G9
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix,
consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant
hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The
matrix proteins include the high-sulfur and high-glycine-tyrosine keratins


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRTAP5-6 gene promoter:
         GR-alpha   POU3F2   Chx10   HSF1 (long)   FOXF2   AhR   Arnt   FOXO4   FOXD1   POU2F1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for KRTAP5-6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for KRTAP5-6 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

KRTAP5-6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRTAP5-6 gene location

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P001509:  view genomic region     (about GC identifiers)

Start:
1,509,449 bp from pter
End:
1,510,009 bp from pter
Size:
561 bases
Orientation:
plus strand

1 alternative location:
Chr11+ 1,718,425-1,718,985     
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: KRA56_HUMAN, Q6L8G9 (See protein sequence)
Recommended Name: Keratin-associated protein 5-6  
Size: 129 amino acids; 11784 Da
Subunit: Interacts with hair keratins
Secondary accessions: A1L452

Explore the universe of human proteins at neXtProt for KRTAP5-6: NX_Q6L8G9 

REFSEQ proteins: NP_001012416.1  

ENSEMBL proteins: 
ENSP00000371595 


Human Recombinant Proteins 
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OriGene Protein Over-expression Lysate: KRTAP5-6
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1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0045095 keratin filament IEA--
About this table

KRTAP5-6 for ontologies           About GeneDecksing



Antibodies for KRTAP5-6: 
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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KRTAP5-6 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR002494 Keratin_B2

Graphical View of Domain Structure for InterPro Entry Q6L8G9

ProtoNet protein and cluster: Q6L8G9

1 Blocks protein family: IPB001007 von Willebrand factor

UniProtKB/Swiss-Prot: KRA56_HUMAN, Q6L8G9
Similarity: Belongs to the KRTAP type 5 family


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: KRA56_HUMAN, Q6L8G9
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix,
consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant
hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The
matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
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Sigma-Aldrich siRNA for KRTAP5-6
Sigma-Aldrich shRNA for KRTAP5-6
OriGene 29mer shRNA kits in GFP-retroviral vector: KRTAP5-6
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OriGene siRNA: KRTAP5-6
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KRTAP5-6 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KRTAP5-6 
Search SABiosciences for Assays for microRNAs that regulate KRTAP5-6

Gene
Editing:
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Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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OriGene GFP tagged cDNA clones in CMV expression vector: KRTAP5-6
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: KRTAP5-6
OriGene untagged cDNA clones in CMV expression vector: KRTAP5-6
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Cell
Lines:
  
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(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for KRTAP5-6 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRTAP5-6

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KRTAP5-6


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for KRTAP5-6
Sigma-Aldrich shRNA for KRTAP5-6
OriGene 29mer shRNA kits in GFP-retroviral vector: KRTAP5-6
OriGene shRNA RFP: KRTAP5-6
OriGene basic RS shRNA: KRTAP5-6
OriGene siRNA: KRTAP5-6
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KRTAP5-6 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of KRTAP5-6 
Search SABiosciences for Assays for microRNAs that regulate KRTAP5-6
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: KRTAP5-6
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: KRTAP5-6
OriGene untagged cDNA clones in CMV expression vector: KRTAP5-6
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: KRTAP5-6 
Primers: OriGene genome-wide validated SYBR primer pairs: KRTAP5-6
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for KRTAP5-6: PPH65947A

REFSEQ mRNAs for KRTAP5-6 gene: 

NM_001012416.1  

Additional cDNA sequence: 

AB126075.1 BC130399.1 BC133035.1 

1 DOTS entry:

DT.102837616 

1 AceView cDNA sequence:

AB126075 

highest scoring ESTs for KRTAP5-6:

AB126075 BC130399 NM_001012416 

Unigene Cluster for KRTAP5-6:

Keratin associated protein 5-6
Hs.534863
Unigene Representative Sequence: AB126075


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000382160(uc001lua.2)

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

KRTAP5-6 expression in normal and diseased human tissues

1 Data from GNF BioGPS
    About these images

KRTAP5-6 gene expression
KRTAP5-6 gene electronic northern expression
KRTAP5-6 gene sage expression
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.534863

UniProtKB/Swiss-Prot: KRA56_HUMAN, Q6L8G9
Tissue specificity: Expressed in hair root and not in skin. Expressed also in liver and skeletal muscle

Primers: OriGene genome-wide validated SYBR primer pairs: KRTAP5-6
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for KRTAP5-6: PPH65947A
    SABiosciences Custom PCR Arrays for KRTAP5-6 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KRTAP5-6 gene from 2 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
cow
(Bos taurus)
KRTAP5-61   -- keratin associated protein 5-6 87.08(n)
89.92(a)
540854  XM_879446.2  XP_884539.2 
mouse
(Mus musculus)
Gm22625 2 (39.13 cM) predicted gene 2262   -- -
About this table        Species with no ortholog for KRTAP5-6

ENSEMBL Gene Tree for KRTAP5-6 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for KRTAP5-6 gene
KRTAP9-32  KRTAP4-42  KRTAP9-12  KRTAP5-102  KRTAP4-72  KRTAP9-62  KRTAP4-52  KRTAP5-42  
KRTAP4-22  KRTAP9-42  KRTAP4-12  KRTAP9-72  KRTAP17-12  KRTAP4-92  KRTAP9-92  KRTAP4-122  
ENSG000002412412  KRTAP5-52  KRTAP5-22  KRTAP5-112  KRTAP5-72  KRTAP4-82  KRTAP5-82  KRTAP5-12  
KRTAP9-22  KRTAP5-32  KRTAP9-82  KRTAP4-62  KRTAP4-112  KRTAP4-32  

KRTAP5-6 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/39 NCBI SNPs in KRTAP5-6 are shown (see all 39)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 11 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs5185551,2
H1718191(+) ACACAG/AAAGGA 1 -- ng513Minor allele frequency- A:0.00NS EA 296
rs5572201,2
H1719302(-) TCTCAG/TGTCCT 1 -- ng314Minor allele frequency- T:0.00NS EA 410
rs47527431,2
C,F,1717577(+) ACCCAC/TGGGTG 1 -- ng519Minor allele frequency- T:0.09NS EA NA 896
rs47527441,2
C,F,A,H,1718266(+) ACTATA/GTACAC 1 -- ng5120Minor allele frequency- G:0.12NS EA NA WA 1158
rs47527451,2
--1718467(+) AATCCA/TCCAGA 1 -- ut51 ese30--------
rs47527461,2
C,F,A,H,1719381(+) acaaaC/Aaaaaa 1 -- ng313Minor allele frequency- A:0.10NA 80
rs110403101,2
C,F,A,1716663(+) GTTTCT/CATCCC 1 -- ng5120Minor allele frequency- C:0.17NS EA NA WA 1642
rs125775601,2
H1719038(+) TCATTC/ATTCAT 1 -- ng314Minor allele frequency- A:0.00NS EA 414
rs169275071,2
C,F,1716749(+) CCGGTT/CCATTG 1 -- ng5118Minor allele frequency- C:0.08NA NS EA 1566
rs284630391,2
--1717155(+) TTCTGC/TCCTGA 1 -- ng510--------
About this table

HapMap Linkage Disequilibrium images for KRTAP5-6 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for KRTAP5-6: --

QIAGEN SeqTarget long-range PCR primers for resequencing KRTAP5-6 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

3 PubMed articles for KRTAP5-6 gene integrated from 7 sources:
(articles sorted by number of sources associating them with KRTAP5-6)
  1. Identification of two novel clusters of ultrahigh-sulfur keratin- associated protein genes on human chromosome 11. (PubMed id 15144888)1, 2, 3 Yahagi S....Shimizu N. (2004)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 440023 HGNC: 23600 AceView: LOC440023 Ensembl:ENSG00000205864 euGenes: HUgn440023
ECgene: KRTAP5-6 H-InvDB: KRTAP5-6

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for KRTAP5-6 gene:
Search GeneIP for patents involving KRTAP5-6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
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About This Section

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 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for KRTAP5-6
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of KRTAP5-6
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