Aliases &
Descriptions
for KSR1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| kinase suppressor of ras 11 2 | | KSR2 3 5 | | RSU21 2 | | kinase suppressor of ras1 | | OTTHUMP000001629312 |
Export aliases for KSR1 gene to outside databasesPrevious GC identifers: GC17P022899 GC17P025799 |
Summaries
for KSR1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: KSR1_HUMAN, Q8IVT5Function: Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation andactivity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity
Gene Wiki entry for KSR1 |
Genomic Views
for KSR1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KSR1 gene promoter:
C/EBPbeta NF-kappaB1 NF-kappaB PPAR-gamma2 PPAR-gamma1 Bach1 Elk-1 IRF-1 IRF-7A GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KSR1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q11.1-q11.2 Ensembl cytogenetic band: 17q11.1 HGNC cytogenetic band: 17p11.1KSR1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P022092: view genomic region
(about GC identifiers)
Start:
|
22,006,077 bp from pter |
End:
|
22,157,867 bp from pter |
Size:
|
151,791 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr17+ 25,799,036-25,953,461 |
RefSeq DNA sequence:- NC_000017.10 NT_010799.15
|
Proteins
for KSR1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: KSR1_HUMAN, Q8IVT5 (See
protein sequence)Recommended Name: Kinase suppressor of Ras 1 Size: 921 amino acids; 102032 Da
Subunit: Interacts with HSPCA/HSP90, YWHAB/14-3-3, CDC37, MAP2K/MEK, MARK3, PPP2R1A and PPP2CA. Also interacts with RAFand MAPK/ERK, in a Ras-dependent manner (By similarity). The binding of 14-3-3 proteins to phosphorylated KSR preventsthe membrane localization
Subcellular location: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Note=Inunstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs.Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm tothe cell periphery (By similarity)
Secondary accessions: Q13476Alternative splicing: 3 isoforms: Q8IVT5-1 Q8IVT5-2 Q8IVT5-3 Explore the universe of human proteins at neXtProt for KSR1: NX_Q8IVT5
Post-translational modifications:
Phosphorylated on Ser-309 and, to a higher extent, on Ser-404 by MARK3. Dephosphorylated on Ser-404 by PPP2CA. Inresting cells, phosphorylated KSR1 is cytoplasmic and in stimulated cells, dephosphorylated KSR1 ismembrane-associated (By similarity)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_055053.1
ENSEMBL proteins: ENSP00000381958 ENSP00000268763 ENSP00000323178 ENSP00000381955 ENSP00000381952
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
KSR1 for ontologies About GeneDecksing
Antibodies for KSR1:
Assays for KSR1: |
Protein
Domains/
Families
for KSR1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KSR1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IVT5ProtoNet protein and cluster: Q8IVT5 UniProtKB/Swiss-Prot: KSR1_HUMAN, Q8IVT5Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase familySimilarity: Contains 1 phorbol-ester/DAG-type zinc fingerSimilarity: Contains 1 protein kinase domain |
Gene Function
for KSR1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: KSR1_HUMAN, Q8IVT5Function: Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation andactivity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity
5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
KSR1 for ontologies About GeneDecksing
Animal Models: 9 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Ksr1):
KSR1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for KSR1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
KSR1 for pathways About GeneDecksing
2  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for KSR1
1 
Cell Signaling Technology (CST) Pathway for KSR1
SABiosciences Pathway-Focused PCR Array including KSR1: PAHS-061A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for KSR1
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KSR1
3 Interacting proteins for KSR1 (Q8IVT51 ENSP000003231783) via UniProtKB, MINT, and/or STRINGAbout this table
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
KSR1 for ontologies About GeneDecksing
|
Drugs & Compounds
for KSR1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for KSR1
|
Transcripts
for KSR1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for KSR1 gene: NM_014238.1 Additional cDNA sequence: AK095721.1 AK124344.1 AK130719.1 BC035488.1 BC037586.1 BC042106.1 U43586.1 11 DOTS entries: DT.75101380 DT.40118322 DT.95378650 DT.100786396 DT.95218803 DT.101972616 DT.120966531 DT.100758649 DT.99946344 DT.102824541 DT.91818885 24/85 AceView cDNA sequences (see all 85): AI458861 CB268574 BC037586 BX092902 AI536645 AI184584 BM989782 C02393 AI809969 CA942123 BX108666 AW182775 AW166454 AW150241 AA863493 BC042106 AA379849 AA984147 BI756651 BX504469 BF510390 BI086433 BI829205 AW297601
 highest scoring ESTs for KSR1:U43586 AA234420 AA984147 AI458861 AW511156 BM989782 BX108666 AA236392 AA379849 AA863493 Unigene Cluster for KSR1: Kinase suppressor of ras 1 Hs.133534 [show with all ESTs]Unigene Representative Sequence: NM_014238
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for KSR1 (see all 7)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | |
About this scheme
ECgene alternative splicing isoforms for KSR1
5 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000398988(uc002gzo.1) ENST00000268763 ENST00000319524(uc010crg.2 uc002gzm.2 uc002gzn.2)
ENST00000398985(uc002gzl.1) ENST00000398982(uc002gzj.1)
|
Expression
for KSR1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| KSR1 expression in normal and diseased human tissues
1 / 2 / 3 10 probe-sets matching KSR1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 1716_at2, 3
|
U95-A |
1 |
0.75 |
1.00 |
-0.31 |
0.30 |
U43586 |
1.00 |
0.85 |
0.93 |
1 |
| 80554_s_at2, 3
|
U95-E |
1 |
0.44 |
1.00 |
0.91 |
1.29 |
AW004040 |
0.60 |
1.00 |
0.82 |
1 |
| 92089_at2, 3
|
U95-D |
1 |
0.38 |
1.00 |
0.70 |
0.58 |
AA984147 |
0.80 |
1.00 |
0.91 |
1 |
| 84487_at*2, 3
|
U95-E |
1 |
0.75 |
1.00 |
0.96 |
1.13 |
AI090141 |
0.60 |
1.00 |
0.82 |
1 |
| 213769_at2, 3
|
U133-A |
1 |
0.64 |
1.00 |
-- |
-- |
AA971768 |
0.60 |
1.00 |
0.82 |
1 |
| 213767_at2, 3
|
U133-A |
1 |
0.55 |
1.00 |
-- |
-- |
U43586 |
1.00 |
0.85 |
0.93 |
1 |
| 235252_at2, 3
|
U133-B |
1 |
0.46 |
1.00 |
-- |
-- |
AI090141 |
0.60 |
1.00 |
0.82 |
1 |
| 213769_at2
|
U133Plus2 |
1 |
0.64 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 213767_at2
|
U133Plus2 |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 235252_at2
|
U133Plus2 |
1 |
0.46 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
KSR1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CCCTCTGTGC
SOURCE GeneReport for Unigene cluster: Hs.133534
SABiosciences Expression via Pathway-Focused PCR Array including KSR1: PAHS-061A
|
Orthologs
for KSR1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KSR1 gene from 5/10 species (see all 10)
About this table Species with no ortholog for KSR1
ENSEMBL Gene Tree for KSR1 (if available) |
Paralogs
for KSR1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for KSR1 gene
- TNNI3K2 ZAK2 MAP3K122 MAP3K132 KSR22 ILK2
KSR1 for paralogs About GeneDecksing
|
Genomic Variants
for KSR1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 17 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for KSR1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for KSR1
2 CNVs: 4029 5333
1 Indel: 60228 | | QIAGEN SeqTarget long-range PCR primers for resequencing KSR1 |
|
Disorders & Mutations
for KSR1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KSR1 for disorders About GeneDecksing
OMIM: 601132
Human Genome Epidemiology (HuGE) Navigator: KSR1 (1 document)
Export disorders and mutations for KSR1 gene to outside databases
|
Medical News
for KSR1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for KSR1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/47 PubMed articles for KSR1 gene, integrated from 7 sources (see all 47):
(articles sorted by number of sources associating them with KSR1)- KSR, a novel protein kinase required for RAS signal transduction. (PubMed id 8521512)1, 2, 3 Therrien M....Rubin G.M. (1995)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- MAP kinase module: the Ksr connection. (PubMed id 12007434)1, 2 Roy F. and Therrien M. (2002)
- Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression. (PubMed id 9858547)1, 7 Cacace A.M....Morrison D.K. (1999)
- C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. (PubMed id 11741534)1, 7 Muller J....Morrison D.K. (2001)
- Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP. (PubMed id 14724641)1, 7 Matheny S.A....White M.A. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
|
External Searches for KSR1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KSR1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KSR1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KSR1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for KSR1 gene:
Search GeneIP for patents involving KSR1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KSR1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
 | Antibodies & Assays for KSR1 (KSR) |
| | | | Search Tocris compounds for KSR1 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for KSR1 |
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