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LASP1 Gene

protein-coding   GIFtS: 59

GC17P032821
LIM and SH3 protein 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
LIM and SH3 protein 11 2     MLN 502 3
MLN501 2 3 5     LIM and SH3 domain protein 12
Lasp-11 2     OTTHUMP000001642392
Metastatic lymph node gene 50 protein2 3     LASP-13

External Ids:    HGNC: 65131   Entrez Gene: 39272   Ensembl: ENSG000000028347   UniProtKB: Q148473   

Export aliases for LASP1 gene to outside databases

Previous GC identifers: GC17P036529 GC17P039024 GC17P036936 GC17P037401 GC17P034280 GC17P037026


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LASP1:
This gene encodes a member of a LIM protein subfamily characterized by a LIM motif and a domain of Src homology region
3. The encoded protein functions as an actin-binding protein and possibly in cytoskeletal organization. (provided by
RefSeq)

UniProtKB/Swiss-Prot: LASP1_HUMAN, Q14847
Function: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent
changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the
parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity)

Gene Wiki entry for LASP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LASP1 gene promoter:
         CREB   deltaCREB   RORalpha2   GATA-1   GATA-2   GATA-3   CHOP-10   C/EBPalpha   POU2F1   GCNF-1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for LASP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for LASP1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11-q21.3   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11-q21.3

LASP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LASP1 gene location

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P032821:  view genomic region     (about GC identifiers)

Start:
32,821,270 bp from pter
End:
32,873,230 bp from pter
Size:
51,961 bases
Orientation:
plus strand

1 alternative location:
Chr17+ 37,026,256-37,078,023     
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: LASP1_HUMAN, Q14847 (See protein sequence)
Recommended Name: LIM and SH3 domain protein 1  
Size: 261 amino acids; 29717 Da
Subunit: Interacts with F-actin (By similarity)
Subcellular location: Cytoplasm, cell cortex (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Associated
with the F-actin rich cortical cytoskeleton (By similarity)
PDB structures from and Proteopedia :
3I35 (3D)    
Secondary accessions: Q96ED2 Q96IG0
Alternative splicing: 2 isoforms:  Q14847-1   Q14847-2   

Explore the universe of human proteins at neXtProt for LASP1: NX_Q14847 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_006139.1  

    ENSEMBL proteins: 
    ENSP00000325240 ENSP00000391897 ENSP00000393348 ENSP00000392853 ENSP00000414803 ENSP00000401048 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: LASP1
    OriGene Protein Over-expression Lysate: LASP1
    GenScript Custom Purified and Recombinant Proteins Services for LASP1 
    Novus Biologicals Proteins for LASP1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    GO:0005856 cytoskeleton IEA--
    GO:0005886 plasma membrane ----
    GO:0005925 focal adhesion ----
    GO:0005938 cell cortex IEA--
    About this table

    LASP1 for ontologies           About GeneDecksing



    Antibodies for LASP1: 
    Millipore Mono- and Polyclonal Antibodies for the study of LASP1
    Sigma-Aldrich Antibodies for LASP1
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 2): LASP1
    GenScript Custom Superior Antibodies Services for LASP1 
    Novus Biologicals Antibodies for LASP1
    Browse antibodies at Epitomics

    Assays for LASP1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LASP1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for LASP1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    LASP1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000900 Nebulin_35r-motif
     IPR013998 Nebulin
     IPR001452 SH3_domain
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q14847

    ProtoNet protein and cluster: Q14847

    2 Blocks protein families:
    IPB001452 SH3 domain signature
    IPB001781 Zn-binding protein


    UniProtKB/Swiss-Prot: LASP1_HUMAN, Q14847
    Similarity: Contains 1 LIM zinc-binding domain
    Similarity: Contains 2 nebulin repeats
    Similarity: Contains 1 SH3 domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: LASP1_HUMAN, Q14847
    Function: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent
    changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the
    parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity)

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for LASP1
    Sigma-Aldrich shRNA Panels and shRNA for LASP1
    OriGene 29mer shRNA kits in GFP-retroviral vector: LASP1
    OriGene shRNA RFP: LASP1
    OriGene basic RS shRNA: LASP1
    OriGene siRNA: LASP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of LASP1 
    miRNA:Sigma-Aldrich microRNA Mimics for LASP1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of LASP1 
    8/11 SABiosciences Assays for microRNAs that regulate LASP1 (see all 11):
    hsa-miR-206 hsa-miR-1226 hsa-miR-1321 hsa-miR-128 hsa-miR-133b hsa-miR-1 hsa-miR-665 hsa-miR-133a

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: LASP1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: LASP1
    OriGene untagged cDNA clones in CMV expression vector: LASP1
    OriGene 3'-UTR clone: LASP1 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for LASP1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for LASP1 

    Genatlas biochemistry entry for LASP1:
    LIM and SH3 protein 1,actin binding protein,amplified in breast cancer,metastatic axillary lymph
    nodes,cDNA50,potentially involved in a signaling pathway for the organization of the cytoskeleton

    5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779 actin binding IEA--
    GO:0005070 SH3/SH2 adaptor activity TAS7589475
    GO:0005515 protein binding IPI16189514
    GO:0008270 zinc ion binding IEA--
    GO:0015075 ion transmembrane transporter activity ISS--
    About this table

    LASP1 for ontologies           About GeneDecksing

    Animal Models: 6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Lasp1):

    cardiovascular systemdigestive/alimentaryendocrine/exocrine glandgrowth/sizereproductive system
    skeleton

    LASP1 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    LASP1 for pathways           About GeneDecksing

    1 Millipore Pathway for LASP1
        Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation

        SABiosciences Custom Pathway-Focused PCR Arrays for LASP1 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LASP1

    4 Interacting proteins for LASP1 (Q148471, 2) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDFIQ997501, 2EBI-742828,EBI-724076 MINT-67947
    TRIP13Q156451, 2EBI-742828,EBI-358993 MINT-66300
    FHL3Q136432MINT-67591
    PLSCR1O151622MINT-66313
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811 ion transport ISS--
    About this table

    LASP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LASP1


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for LASP1
    Sigma-Aldrich shRNA Panels and shRNA for LASP1
    OriGene 29mer shRNA kits in GFP-retroviral vector: LASP1
    OriGene shRNA RFP: LASP1
    OriGene basic RS shRNA: LASP1
    OriGene siRNA: LASP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of LASP1 
    miRNA: Sigma-Aldrich microRNA Mimics for LASP1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of LASP1 
    8/11 SABiosciences Assays for microRNAs that regulate LASP1 (see all 11):
    hsa-miR-206 hsa-miR-1226 hsa-miR-1321 hsa-miR-128 hsa-miR-133b hsa-miR-1 hsa-miR-665 hsa-miR-133a
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: LASP1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: LASP1
    OriGene untagged cDNA clones in CMV expression vector: LASP1
    OriGene 3'-UTR Clone: LASP1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for LASP1 
    Primers: OriGene genome-wide validated SYBR primer pairs: LASP1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for LASP1: PPH17187A

    REFSEQ mRNAs for LASP1 gene: 

    NM_006148.2  

    Additional cDNA sequence: 

    AK095958.1 AK289847.1 AK294704.1 AK295522.1 AK296092.1 AK307868.1 AK309933.1 AY358253.1 
    BC007367.2 BC007560.1 BC012460.1 CR604349.1 X82456.1 

    24/39 DOTS entries (see all 39):

    DT.219536  DT.98083914  DT.100061169  DT.92071080  DT.100675532  DT.97818959  DT.120896350  DT.100649842 
    DT.92407416  DT.100059716  DT.95377448  DT.120896359  DT.100675538  DT.100764548  DT.75119038  DT.91895016 
    DT.100675529  DT.120896203  DT.120896352  DT.100644005  DT.100675534  DT.100675535  DT.100675542  DT.100893925 

    24/984 AceView cDNA sequences (see all 984):

    BM856382 BM713671 AA122353 AA767480 BM833806 CA946509 BM839764 CK819273 
    AA834479 AL532968 BE328013 NM_032192 T33826 BX506001 CD245068 AW882123 
    AI679490 BU541964 CA398051 BQ891748 BM046300 AI275233 BE017991 AW661888 

    highest scoring ESTs for LASP1:

    X82456 AA022732 AA022824 AA035778 AA043214 AA043215 AA056356 AA074317 AA102155 AA121101 

    Unigene Cluster for LASP1:

    LIM and SH3 protein 1
    Hs.548018  [show with all ESTs]
    Unigene Representative Sequence: NM_006148


    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for LASP1 (see all 8)

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13
    SP1:                    -           -           -                                                                     
    SP2:                                -           -                                                                     
    SP3:                    -           -     -     -                                                                     
    SP4:                                -           -           -     -     -                                             
    SP5:                                            -                                                                     

    About this scheme

    ECgene alternative splicing isoforms for LASP1
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000318008 ENST00000419929 ENST00000429030 ENST00000435347(uc002hra.2 uc010cvq.2 uc010wdz.1)
    ENST00000443937(uc010wdy.1) ENST00000433206

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    LASP1 expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching LASP1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    36181_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 X82456 1.00 0.90 0.95 1
    200618_at2, 3 U133-A 1 1.00 1.00 -- -- NM_006148 0.60 0.83 0.73 1
    200618_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    LASP1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    LASP1 gene expression
    LASP1 gene electronic northern expression
    LASP1 gene sage expression
    About these images

    CGAP SAGE TAG: CACTTTTGGG

    SOURCE GeneReport for Unigene cluster: Hs.548018

    Expression variation in blood from EXPOLDB for LASP1

    Primers: OriGene genome-wide validated SYBR primer pairs: LASP1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for LASP1: PPH17187A
        SABiosciences Custom PCR Arrays for LASP1 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for LASP1 gene from 5/11 species (see all 11)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LASP11   -- LIM and SH3 protein 1 92.45(n)
    96.48(a)
    608624  XM_846621.1  XP_851714.1 
    chimpanzee
    (Pan troglodytes)
    LASP11   -- LIM and SH3 protein 1 99.36(n)
    100(a)
    454620  XM_511445.2  XP_511445.2 
    cow
    (Bos taurus)
    LASP11   -- LIM and SH3 protein 1 93.08(n)
    96.15(a)
    532851  NM_001035394.1  NP_001030471.1 
    rat
    (Rattus norvegicus)
    Lasp11   -- LIM and SH3 protein 1 90.93(n)
    96.93(a)
    29278  NM_032613.2  NP_116002.1 
    mouse
    (Mus musculus)
    Lasp11 , 5 11 (61.10 cM)5
    LIM and SH3 protein 11, 5 91.19(n)1
    96.17(a)1
    167961  NM_010688.31  NP_034818.11 
     AA4086295  AK0344045  (see all 34)
    About this table        Species with no ortholog for LASP1

    ENSEMBL Gene Tree for LASP1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for LASP1 gene
    NRAP2  NEB2  NEBL2  

    LASP1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/573 NCBI SNPs in LASP1 are shown (see all 573)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs286841,2
    C,A,37030013(-) ACCCTG/CGCCGG 1 -- int17Minor allele frequency- C:0.28MN NA WA 314
    rs829741,2
    C,A,H,37064942(-) CTGGGA/GGGAGT 1 -- int19Minor allele frequency- G:0.32NA EA WA 222
    rs829761,2
    C,A,H,37064673(-) AGTGAC/TCCCTG 1 -- int19Minor allele frequency- T:0.05EA NA WA 1666
    rs829771,2
    C,F,O,A,H,37064348(+) CCATCA/GCTAAT 1 -- int117Minor allele frequency- G:0.05EA NA NS WA 634
    rs1129011,2
    C,F,A,H,37048253(-) gtgatA/Cctccc 1 -- int110Minor allele frequency- C:0.47NA EA WA 338
    rs1704921,2
    C,F,O,H,37037771(-) AAACAG/CGAGGA 1 -- int117Minor allele frequency- C:0.18NS EA NA 1138
    rs2262121,2
    C,F,O,A,H,37036554(-) TAAAAC/TGCAGA 1 -- int124Minor allele frequency- N:0.00EA NA MN NS WA 1686
    rs2262131,2
    C,F,O,A,H,37036488(-) AGGCTA/GCTTGA 1 -- int118Minor allele frequency- G:0.11NA NS EA WA 1054
    rs2262141,2
    C,F,O,A,37036179(-) TTCCTC/TTACCC 1 -- int1 trp312Minor allele frequency- T:0.26NA NS EA WA 688
    rs2262151,2
    C,F,O,A,37034818(-) AGACAG/CGTCAC 1 -- int115Minor allele frequency- C:0.25NA NS EA WA 782
    About this table

    HapMap Linkage Disequilibrium images for LASP1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for LASP1: --

    QIAGEN SeqTarget long-range PCR primers for resequencing LASP1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    LASP1 for disorders           About GeneDecksing

    OMIM: 602920

    1 Novoseek disease relationship for LASP1 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 38.6 13 20461080 (4), 16430883 (2), 12883659 (1), 17211471 (1) (see all 6)
    About this table

    1 PharmGKB disease relationship for LASP1 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872
    About this table

    Human Genome Epidemiology (HuGE) Navigator: LASP1 (2 documents)

    Export disorders and mutations for LASP1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/40 PubMed articles for LASP1 gene, integrated from 7 sources (see all 40):
    (articles sorted by number of sources associating them with LASP1)
    1. Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. (PubMed id 7490069)1, 2, 3 Tomasetto C.L.... Rio M.-C. (1995)
    2. Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains. (PubMed id 7589475)1, 2, 7 Tomasetto C....Rio M.-C. (1995)
    3. Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PubMed id 16094384)1, 2 Tao W.A.... Aebersold R. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    6. Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase. (PubMed id 15465019)1, 7 Keicher C....Butt E. (2004)
    7. Nuclear localisation of LASP-1 correlates with poor l ong-term survival in female breast cancer. (PubMed id 20461080)1, 7 Frietsch J.J....Butt E. (2010)
    8. Silencing of LASP-1 influences zyxin localization, inhibits proliferation and reduces migration in breast cancer cells. (PubMed id 16430883)1, 7 Grunewald T.G....Butt E. (2006)
    9. Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1. (PubMed id 15004028)1, 7 Li B.... Trueb B. (2004)
    10. Lasp-1, a novel type of actin-binding protein accumulating in cell membrane extensions. (PubMed id 9848085)1, 7 Schreiber V....Rio M.C. (1998)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3927 HGNC: 6513 AceView: LASP1andPPP1R1B Ensembl:ENSG00000002834 euGenes: HUgn3927
    ECgene: LASP1 H-InvDB: LASP1

    (According to HUGE)
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    NameDescription
    ATLAS Chromosomes in Cancer entry for LASP1 Genetics and Cytogenetics in Oncology and Haematology

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