Aliases &
Descriptions
for LGALS7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| lectin, galactoside-binding, soluble, 71 2 | | galectin 72 | | GAL71 2 | | HKL-143 | | LGALS7A1 2 | | Gal-73 | | PIG11 3 | | p53-induced gene 1 protein3 | | TP53I11 | | PI73 | | galectin-72 | | |
Export aliases for LGALS7 gene to outside databasesPrevious GC identifers: GC19P039892 GC19P039671 GC19P043955 GC19P043971 GC19P043939 GC19M043954 GC19M039261 |
Summaries
for LGALS7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for LGALS7:
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrixinteractions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed inkeratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:653499) isfound adjacent to, but on the opposite strand on chromosome 19. (provided by RefSeq)
UniProtKB/Swiss-Prot: LEG7_HUMAN, P47929Function: Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control.Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release
Gene Wiki entry for LGALS7 |
Genomic Views
for LGALS7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LGALS7 gene promoter:
p53 YY1 Bach2 JunD JunB c-Jun c-Fos AP-1 Fra-1 Bach1
Other transcription factors
Search SABiosciences Chromatin IP Primers for LGALS7
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.13LGALS7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P035727: view genomic region
(about GC identifiers)
Start:
|
35,727,171 bp from pter |
End:
|
35,729,720 bp from pter |
Size:
|
2,550 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr19- 39,261,608-39,264,157 |
RefSeq DNA sequence:- NC_000019.9 NT_011109.16
|
Proteins
for LGALS7 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: LEG7_HUMAN, P47929 (See
protein sequence)Recommended Name: Galectin-7 Size: 136 amino acids; 15075 Da
Subunit: Monomer
Subcellular location: Cytoplasm. Nucleus. Secreted (Potential). Note=May be secreted by a non-classical secretorypathway
PDB structures from  and Proteopedia  :1BKZ (3D)
2GAL (3D)
3GAL (3D)
4GAL (3D)
5GAL (3D)
Secondary accessions: Q6IB87Explore the universe of human proteins at neXtProt for LGALS7: NX_P47929
REFSEQ proteins: NP_002298.1
ENSEMBL proteins: ENSP00000367891
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
LGALS7 for ontologies About GeneDecksing
Antibodies for LGALS7:
Assays for LGALS7: |
Protein
Domains/
Families
for LGALS7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LGALS7 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P47929ProtoNet protein and cluster: P47929 1 Blocks protein family: IPB001079 Galectin
UniProtKB/Swiss-Prot: LEG7_HUMAN, P47929Similarity: Contains 1 galectin domain |
Gene Function
for LGALS7 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: LEG7_HUMAN, P47929Function: Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control.Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c releaseInduction: By TP53/p53
Genatlas biochemistry entry for LGALS7:lectin,galactoside-beta binding,soluble 71 Gene Ontology (GO) molecular function term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005529 | sugar binding |
-- | -- |
About this table
LGALS7 for ontologies About GeneDecksing
|
Pathways & Interactions
for LGALS7 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for LGALS7
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LGALS7
2 Interacting proteins for LGALS7 (P479292) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006915 | apoptosis |
-- | -- | | GO:0007157 | heterophilic cell-cell adhesion |
-- | -- |
About this table
LGALS7 for ontologies About GeneDecksing
|
Drugs & Compounds
for LGALS7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
LGALS7 for compounds About GeneDecksing
 Browse Tocris compounds for LGALS7
5  Novoseek chemical compound relationships for LGALS7 gene
About this table
|
Transcripts
for LGALS7 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for LGALS7 gene: NM_002307.3 Additional cDNA sequence: CR456917.1 3 DOTS entries: DT.97805209 DT.315778 DT.121497722 24/56 AceView cDNA sequences (see all 56): CN478604 AI202604 AW015224 AI826905 AI094346 AI201871 BV197147 BM020432 AW516753 BG211253 BC061588 BF197794 CR456917 BC073743 BC042911 AI417987 L07769 AI969775 AI143778 AI659838 AI420402 AA689478 BM020275 BU536530
 highest scoring ESTs for LGALS7:BX105129 AA046978 BC061588 L07769 U06643 W61024 AA024773 AA055535 AA583791 NM_002307 Unigene Cluster for LGALS7: Lectin, galactoside-binding, soluble, 7 Hs.707031 [show with all ESTs]Unigene Representative Sequence: BM913998
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000378626(uc002oje.3)
|
Expression
for LGALS7 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| LGALS7 expression in normal and diseased human tissues
1 / 2 / 3 1 probe-set matching LGALS7 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 38608_at2, 3
|
U95-A |
2 |
0.75 |
0.50 |
1.00 |
1.00 |
AA010777 |
0.60 |
0.56 |
0.58 |
1 |
About this table
LGALS7 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.707031
Expression variation in blood from EXPOLDB for LGALS7 UniProtKB/Swiss-Prot: LEG7_HUMAN, P47929Tissue specificity: Mainly expressed in stratified squamous epithelium
SABiosciences Custom PCR Arrays for LGALS7
|
Orthologs
for LGALS7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for LGALS7 gene from 3 species
About this table Species with no ortholog for LGALS7
ENSEMBL Gene Tree for LGALS7 (if available) |
Paralogs
for LGALS7 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for LGALS7 gene
- LGALS7B1 2 LGALS82 HSPC1592 LGALS32 LGALS92 LGALS9C2 LGALS42 LGALS9B2
- LGALS122
LGALS7 for paralogs About GeneDecksing
|
Genomic Variants
for LGALS7 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 19 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for LGALS7 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for LGALS7
1 Indel: 33325
1 Inversion: 37203 | | QIAGEN SeqTarget long-range PCR primers for resequencing LGALS7 |
|
Disorders & Mutations
for LGALS7 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LGALS7 for disorders About GeneDecksing
OMIM: 600615
8 Novoseek disease relationships for LGALS7 gene
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| carcinoma squamous cell |
38.9 |
4 |
10500176 (1), 19012243 (1), 11706006 (1), 16315769 (1) |
| carcinoma |
23.1 |
6 |
18315601 (1), 16315769 (1), 17283157 (1), 9697310 (1) (see all 5) |
| colon carcinoma |
21.1 |
2 |
11706006 (1), 15313906 (1) |
| cancer |
19.9 |
13 |
17283157 (3), 16429325 (1), 13679866 (1), 18418527 (1) (see all 10) |
| lymphoma |
18.6 |
15 |
15958565 (4), 19596268 (3), 17363605 (2), 19012243 (1) (see all 5) |
| metastasis |
11.7 |
5 |
20382700 (4), 16197887 (1) |
| shock |
8.25 |
2 |
17330866 (1), 19507834 (1) |
| tumors |
6.47 |
13 |
15313906 (3), 9307301 (2), 17363605 (2), 10500176 (1) (see all 7) |
About this table
Export disorders and mutations for LGALS7 gene to outside databases
|
Medical News
for LGALS7 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for LGALS7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/70 PubMed articles for LGALS7 gene, integrated from 7 sources (see all 70):
(articles sorted by number of sources associating them with LGALS7)- Cloning, expression, and chromosome mapping of human galectin-7. (PubMed id 7534301)1, 2, 3, 7 Madsen P.... Celis J.E. (1995)
- Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid. (PubMed id 7729568)1, 2, 3, 7 Magnaldo T....Darmon M. (1995)
- Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. (PubMed id 11706006)1, 2, 7 Kuwabara I.... Liu F.T. (2002)
- Structural basis for the recognition of carbohydrates by human galectin-7. (PubMed id 9760227)1, 2, 7 Leonidas D.D....Acharya K.R. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Expression of Galectin-3 and Galectin-7 in thyroid malignancy as potential diagnostic indicators. (PubMed id 18418527)1, 7 Than T.H....Abdullah M.S. (2008)
- Overexpression of galectin-7, a myoepithelial cell ma rker, enhances spontaneous metastasis of breast cancer cells. (PubMed id 20382700)1, 7 Demers M....St-Pierre Y. (2010)
- Galectin-7: will the lectin's activity establish clinical correlations in head and neck squamous cell and basal cell carcinomas? (PubMed id 19012243)1, 7 Cada Z....Gabius H.J. (2009)
- Induction of matrix metalloproteinase-9 by galectin-7 through p38 MAPK signaling in HeLa human cervical epithelial adenocarcinoma ce lls. (PubMed id 19885589)1, 7 Park J.E....Cho M. (2009)
- Galectin-7, a marker of all types of stratified epithelia. (PubMed id 9697310)1, 7 Magnaldo T....Darmon M. (1998)
|
External Searches for LGALS7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LGALS7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LGALS7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LGALS7 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| ATLAS Chromosomes in Cancer entry for LGALS7 | Genetics and Cytogenetics in Oncology and Haematology | | Functional Glycomics Gateway - Glycan Binding | http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Stlect_00143 |
|
| | |
About This Section
| Patent Information for LGALS7 gene:
Search GeneIP for patents involving LGALS7
Licensable Technologies for LGALS7 gene:GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LGALS7 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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