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LGALS8 Gene

protein-coding   GIFtS: 59

GC01P207138
lectin, galactoside-binding, soluble, 8
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
lectin, galactoside-binding, soluble, 81 2     galectin 82
PCTA-11 2 3     OTTHUMP000000379582
Po66 carbohydrate-binding protein2 3     OTTHUMP000000379572
Prostate carcinoma tumor antigen 12 3     galectin-82
Gal-82 3     OTTHUMP000000379602
Po66-CBP2 3     galectin-8g2
PCTA12 5     Po66 carbohydrate binding protein2

External Ids:    HGNC: 65691   Entrez Gene: 39642   Ensembl: ENSG000001169777   UniProtKB: O002143   

Export aliases for LGALS8 gene to outside databases

Previous GC identifers: GC01P234819 GC01P232135 GC01P232978 GC01P233722 GC01P233007 GC01P234748 GC01P236681


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LGALS8:
This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved
carbohydrate recognition domains. The galectins have been implicated in many essential functions including
development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA
splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell
interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. (provided by
RefSeq)

Gene Wiki entry for LGALS8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LGALS8 gene promoter:
         NF-E2   NF-E2 p45   RORalpha2   ER-alpha   Bach2   CUTL1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for LGALS8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for LGALS8 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q43   Ensembl cytogenetic band:  1q43   HGNC cytogenetic band: 1q43

LGALS8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LGALS8 gene location

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P207138:  view genomic region     (about GC identifiers)

Start:
207,138,232 bp from pter
End:
207,170,012 bp from pter
Size:
31,781 bases
Orientation:
plus strand

1 alternative location:
Chr1+ 236,681,300-236,716,281     
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: LEG8_HUMAN, O00214 (See protein sequence)
Recommended Name: Galectin-8  
Size: 317 amino acids; 35808 Da
Subcellular location: Cytoplasm (Probable)
Sequence caution: Sequence=AAB51605.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAD45402.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAD45403.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAD45404.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=AAD45404.1; Type=Miscellaneous discrepancy; Note=Probable cloning
artifact; Sequence=AAH15818.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH16486.2;
Type=Erroneous initiation; Note=Translation N-terminally extended;
PDB structures from and Proteopedia :
2YRO (3D)    2YV8 (3D)    2YXS (3D)    
Secondary accessions: O15215 Q5T3P5 Q5T3Q4 Q8TEV1 Q96B92 Q9BXC8 Q9H584 Q9H585 Q9UEZ6 Q9UP32 Q9UP33
Q9UP34
Alternative splicing: 2 isoforms:  O00214-1   O00214-2   

Explore the universe of human proteins at neXtProt for LGALS8: NX_O00214 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (4 alternative transcripts): 
    NP_006490.3  NP_963837.1  NP_963838.1  NP_963839.1  


    ENSEMBL proteins: 
    ENSP00000393116 ENSP00000385999 ENSP00000407428 ENSP00000342139 ENSP00000418349 ENSP00000410843 
    ENSP00000413278 ENSP00000405504 ENSP00000309576 ENSP00000355542 ENSP00000408657 ENSP00000348572 
    ENSP00000355543 ENSP00000398630 ENSP00000238181 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    R&D Systems Recombinant & Natural Proteins for LGALS8 (Galectin-8)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: LGALS8
    OriGene Protein Over-expression Lysate (see all 2): LGALS8
    GenScript Custom Purified and Recombinant Proteins Services for LGALS8 
    Novus Biologicals Proteins for LGALS8
    Novus Biologicals Lysates for LGALS8
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615 extracellular space TAS8692978
    GO:0005737 cytoplasm IEA--
    About this table

    LGALS8 for ontologies           About GeneDecksing



    Antibodies for LGALS8: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for LGALS8
    R&D Systems Antibodies for LGALS8 (Galectin-8)
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for LGALS8 
    Novus Biologicals Antibodies for LGALS8
    Browse antibodies at Epitomics

    Assays for LGALS8: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LGALS8 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    LGALS8 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001079 Galectin_CRD
     IPR013320 ConA-like_subgrp
     IPR008985 ConA-like_lec_gl

    Graphical View of Domain Structure for InterPro Entry O00214

    ProtoNet protein and cluster: O00214

    1 Blocks protein family: IPB001079 Galectin

    UniProtKB/Swiss-Prot: LEG8_HUMAN, O00214
    Domain: Contains two homologous but distinct carbohydrate-binding domains
    Similarity: Contains 2 galectin domains


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for LGALS8
    Sigma-Aldrich shRNA for LGALS8
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 7): LGALS8
    OriGene shRNA RFP (see all 7): LGALS8
    OriGene basic RS shRNA (see all 7): LGALS8
    OriGene siRNA (see all 4): LGALS8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of LGALS8 
    miRNA:Sigma-Aldrich microRNA Mimics for LGALS8
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of LGALS8 
    Search SABiosciences for Assays for microRNAs that regulate LGALS8

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): LGALS8
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): LGALS8
    OriGene untagged cDNA clones in CMV expression vector (see all 7): LGALS8
    OriGene 3'-UTR clone (see all 4): LGALS8 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 4): LGALS8 
    Sino Biological Human cDNA Clone for LGALS8

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for LGALS8 

    1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005529 sugar binding IEA--
    About this table

    LGALS8 for ontologies           About GeneDecksing

    Animal Models: 1 MGI mutant phenotype (inferred from 1 allele(MGI details for Lgals8):

    behavior/neurological

    LGALS8 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for LGALS8 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LGALS8

    2 Interacting proteins for LGALS8 (O002142) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TGIF1Q155832MINT-6798878 MINT-6799089 MINT-6799024 MINT-6799071 MINT-6799039 MINT-6799002 MINT-6799057 MINT-6798916 MINT-6798824 MINT-6798990
    CALCOCO2Q131372MINT-66055
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    LGALS8 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LGALS8
    5 Novoseek chemical compound relationships for LGALS8 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lactose 41.5 5 12881409 (2), 12851289 (2), 11839721 (1)
    galactose 38.6 1 11839721 (1)
    polysaccharide 31.4 10 18456665 (2), 12851289 (1), 16319083 (1)
    wortmannin 27 3 12569102 (2)
    phosphatidylinositol 9.4 1 16501058 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for LGALS8
    Sigma-Aldrich shRNA for LGALS8
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 7): LGALS8
    OriGene shRNA RFP (see all 7): LGALS8
    OriGene basic RS shRNA (see all 7): LGALS8
    OriGene siRNA (see all 4): LGALS8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of LGALS8 
    miRNA: Sigma-Aldrich microRNA Mimics for LGALS8
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of LGALS8 
    Search SABiosciences for Assays for microRNAs that regulate LGALS8
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): LGALS8
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): LGALS8
    OriGene untagged cDNA clones in CMV expression vector (see all 7): LGALS8
    OriGene 3'-UTR Clone (see all 4): LGALS8 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 4): LGALS8 
    Primers: OriGene genome-wide validated SYBR primer pairs: LGALS8
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for LGALS8: PPH07239A

    REFSEQ mRNAs for LGALS8 gene (4 alternative transcripts): 

    NM_006499.3  NM_201543.1  NM_201544.1  NM_201545.1  

    Additional cDNA sequence: 

    AB209914.1 AF074000.1 AF074001.1 AF074002.1 AF342815.1 AF342816.1 AF468213.1 AK098613.1 
    AK296061.1 AY037304.1 BC015818.1 BC016486.2 CR593714.1 CR606435.1 CR617625.1 EF467046.1 
    X91790.1 

    24/35 DOTS entries (see all 35):

    DT.92447363  DT.100880001  DT.449762  DT.100652904  DT.95347194  DT.95347201  DT.121380907  DT.121380804 
    DT.100880010  DT.100880002  DT.100879997  DT.91655611  DT.95347200  DT.121380931  DT.121380806  DT.121380893 
    DT.100842062  DT.100880007  DT.121380801  DT.91981411  DT.92447381  DT.100843015  DT.95347182  DT.100695075 

    24/240 AceView cDNA sequences (see all 240):

    BM792741 AW468736 AV651843 AA827672 AL599555 AA152069 AI886585 AA149823 
    AI079533 AA909823 CK825220 BF476642 AI114709 AA477189 AA479792 BE220019 
    AI417974 BQ227149 AA436617 BM789333 AA836949 AK001857 AW613828 CA413253 

    highest scoring ESTs for LGALS8:

    AA587987 AA744264 AA806702 AA863226 AA885888 AF074001 AF342816 AF468213 AI076837 AI377938 

    Unigene Cluster for LGALS8:

    Lectin, galactoside-binding, soluble, 8
    Hs.4082  [show with all ESTs]
    Unigene Representative Sequence: AB209914


    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for LGALS8 (see all 11)

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a ·
    SP1:        -     -     -                                   -                 -     -           -     -                 -     -                       -         
    SP2:                                                        -                 -     -           -     -     -     -     -     -                       -         
    SP3:              -     -                                   -                                                                                                   
    SP4:                    -                                   -                                                                                                   
    SP5:                                                        -                 -     -                                                                           

    ExUns: 15b · 15c
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            

    About this scheme

    ECgene alternative splicing isoforms for LGALS8
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000432200 ENST00000406509 ENST00000434231 ENST00000341872 ENST00000493812(uc001hxy.1 uc001hxz.1 uc009xgg.1 uc001hyb.1 uc001hyc.1)
    ENST00000416919 ENST00000442397 ENST00000323938 ENST00000475670 ENST00000454943
    ENST00000352231(uc001hxw.1) ENST00000366583 ENST00000489586 ENST00000450372
    ENST00000356238 ENST00000366584(uc001hya.1) ENST00000430527 ENST00000481485


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    LGALS8 expression in normal and diseased human tissues

    1  / 2  / 3

    11 probe-sets matching LGALS8 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    1846_at2, 3 U95-A 1 0.56 1.00 1.00 1.00 L78132 0.60 0.75 0.68 1
    208934_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF342815 0.60 0.75 0.68 1
    208936_x_at2, 3 U133-A 1 1.00 1.00 -- -- AF074000 0.60 0.75 0.68 1
    210732_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF342816 0.80 1.00 0.91 1
    208935_s_at2, 3 U133-A 1 0.64 1.00 -- -- L78132 0.60 0.75 0.68 1
    210731_s_at2 U133-A 1 0.46 1.00 -- -- -- -- -- -- --
    208934_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    208936_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    210732_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    208935_s_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
    210731_s_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    About this table

    LGALS8 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    LGALS8 gene expression
    LGALS8 gene electronic northern expression
    LGALS8 gene sage expression
    About these images

    CGAP SAGE TAG: GTGCTGAAAT

    SOURCE GeneReport for Unigene cluster: Hs.4082

    Expression variation in blood from EXPOLDB for LGALS8

    UniProtKB/Swiss-Prot: LEG8_HUMAN, O00214
    Tissue specificity: Ubiquitous. Selective expression by prostate carcinomas versus normal prostate and benign prostatic
    hypertrophy

    Primers: OriGene genome-wide validated SYBR primer pairs: LGALS8
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for LGALS8: PPH07239A
        SABiosciences Custom PCR Arrays for LGALS8 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for LGALS8 gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LGALS81   -- lectin, galactoside-binding, soluble, 8 89.73(n)
    85.71(a)
    479193  XM_536335.2  XP_536335.2 
    chimpanzee
    (Pan troglodytes)
    LGALS81   -- lectin, galactoside-binding, soluble, 8 98.79(n)
    97.77(a)
    743841  XM_001157611.1  XP_001157611.1 
    cow
    (Bos taurus)
    LGALS81   -- lectin, galactoside-binding, soluble, 8 85.81(n)
    83.75(a)
    506977  NM_001045954.1  NP_001039419.1 
    rat
    (Rattus norvegicus)
    Lgals81   -- lectin, galactoside-binding, soluble, 8 84.07(n)
    81.33(a)
    116641  NM_053862.2  NP_446314.2 
    mouse
    (Mus musculus)
    Lgals81 , 5 13 (4.64 cM)5
    lectin, galactose binding, soluble 81, 5 82.07(n)1
    79.75(a)1
    560481  NM_018886.31  NP_061374.11 
     AA0007415  AA7109575  (see all 31)
    About this table        Species with no ortholog for LGALS8

    ENSEMBL Gene Tree for LGALS8 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for LGALS8 gene
    HSPC1592  LGALS32  LGALS92  LGALS9C2  LGALS72  LGALS7B2  LGALS42  LGALS122  
    LGALS9B2  

    LGALS8 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/655 NCBI SNPs in LGALS8 are shown (see all 655)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs11601,2
    C,F,A,236711586(+) ATTAGG/ATCCTG 4 -- ut3120Minor allele frequency- A:0.50NA EA MN NS 3284
    rs86981,2
    C,F,A,236712857(+) GAAATC/TGCTAG 4 -- ut31 ese36Minor allele frequency- T:0.46MN NA EA WA 493
    rs100771,2
    C,F,236713287(+) TTTAAA/TCTCAA 4 -- ng315Minor allele frequency- T:0.09MN EA WA NA 326
    rs157011,2
    C,F,O,A,236711323(+) ATTTAT/CTGTGA 8 /Y syn1 ref110Minor allele frequency- C:0.48EA NS NA WA 2176
    rs7603711,2
    --236710113(+) GTTAAA/GTATAT 4 -- int11Minor allele frequency- G:0.00MN 184
    rs8194111,2
    C,H,236691693(+) aaaaaC/ACCCCC 4 -- int11Minor allele frequency- A:0.00NA 2
    rs8194121,2
    C,A,236691892(+) tgtcaC/Tccagg 4 -- int15Minor allele frequency- T:0.20NA WA 10
    rs8194131,2
    A236693629(+) GTAACC/TTGTGA 4 -- int10--------
    rs8194141,2
    C,F,A,H,236694232(+) TTTTAG/AAAATA 4 -- int110Minor allele frequency- A:0.32NA EA WA 250
    rs8194151,2
    C,F,A,236694490(+) ATATCC/TGGTGC 4 -- int125Minor allele frequency- T:0.27NS EA NA WA 1680
    About this table

    HapMap Linkage Disequilibrium images for LGALS8 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for LGALS8
         5 CNVs: 53259 48282 48281 71495 71494
         1 Indel: 71496

    QIAGEN SeqTarget long-range PCR primers for resequencing LGALS8 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    LGALS8 for disorders           About GeneDecksing

    OMIM: 606099

    10/18 Novoseek disease relationships for LGALS8 gene (see all 18)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neoplastic processes 60.1 1 11748478 (1)
    neoplastic transformation 58 4 19009371 (1), 14758080 (1)
    cholesteatoma 57.3 2 11404618 (1), 11568623 (1)
    squamous cell cancer 43.9 4 11795826 (1), 11748478 (1)
    colon cancer 33.8 7 11839721 (6), 14758080 (1)
    neoplastic disease 32.7 1 15811318 (1)
    lupus erythematosus systemic 26.6 5 16554922 (2), 16368432 (1), 19276072 (1), 19395456 (1)
    lung tumor 25.7 4 11396139 (2)
    carcinoma 25.4 2 10852818 (1), 20044599 (1)
    lung carcinoma 24.9 6 11675018 (2), 11396139 (1)
    About this table

    Human Genome Epidemiology (HuGE) Navigator: LGALS8 (1 document)

    Export disorders and mutations for LGALS8 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/65 PubMed articles for LGALS8 gene, integrated from 7 sources (see all 65):
    (articles sorted by number of sources associating them with LGALS8)
    1. Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family. (PubMed id 8692978)1, 2, 3, 7 Su Z.-Z.... Fisher P.B. (1996)
    2. Molecular characterization of prostate carcinoma tumor antigen-1, PCTA-1, a human galectin-8 related gene. (PubMed id 10980616)1, 2, 7 Gopalkrishnan R.V....Fisher P.B. (2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Galectin-8. A new rat lectin, related to galectin-4. (PubMed id 7852431)1, 3 Hadari Y.R....Zick Y. (1995)
    5. Galectin-8 expression decreases in cancer compared with normal and dysplastic human colon tissue and acts significantly on human colon cancer cell migration as a suppressor. (PubMed id 11839721)1, 7 Nagy N....Gabius H.J. (2002)
    6. Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis. (PubMed id 10852818)1, 7 Hadari Y.R....Zick Y. (2000)
    7. Dimeric Galectin-8 induces phosphatidylserine exposure in leukocytes through polylactosamine recognition by the C-terminal domain. (PubMed id 18456665)1, 7 Stowell S.R....Cummings R.D. (2008)
    8. Galectin-8 binds specific beta1 integrins and induces polarized spreading highlighted by asymmetric lamellipodia in Jurkat T cells. (PubMed id 16368432)1, 7 Carcamo C....Soza A. (2006)
    9. Cyclin-dependent kinase inhibitors and JNK act as molecular switches, regulating the choice between growth arrest and apoptosis induced by galectin-8. (PubMed id 15753078)1, 7 Arbel-Goren R....Zick Y. (2005)
    10. Galectin-8 modulates neutrophil function via interaction with integrin alphaM. (PubMed id 12881409)1, 7 Nishi N....Nakamura T. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3964 HGNC: 6569 AceView: FLJ10359 Ensembl:ENSG00000116977 euGenes: HUgn3964
    ECgene: LGALS8 H-InvDB: LGALS8

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for LGALS8 Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_other_832
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_other_833
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_other_834

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for LGALS8 gene:
    Search GeneIP for patents involving LGALS8

    Licensable Technologies for LGALS8 gene:
     Tufts University:  Use of Galectins to treat dry eye syndrome
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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