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MAGEB5 Gene

protein-coding   GIFtS: 34

GC0XP023972
melanoma antigen family B, 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
melanoma antigen family B, 51 2     MAGE-B5 antigen2 3
CT3.31 2 3     MAGE family testis and tumor-specific protein2
MAGE-B51 2     cancer/testis antigen family 3, member 32
Cancer/testis antigen 3.32 3     melanoma-associated antigen B52

External Ids:    HGNC: 237951   Entrez Gene: 3475412   Ensembl: ENSG000001884087   UniProtKB: Q9BZ813   

Export aliases for MAGEB5 gene to outside databases

Previous GC identifers: GC0XU900004 GC0XP025596 GC0XP025995 GC0XP026144 GC0XP026234


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAGEB5 gene promoter:
         HNF-1A   Sox9   Pbx1a   E4BP4   Hlf   C/EBPalpha   RORalpha2   MRF-2   POU2F1   AML1a   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for MAGEB5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.3   Ensembl cytogenetic band:  Xp21.3   HGNC cytogenetic band: Xp22

MAGEB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAGEB5 gene location

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP023972:  view genomic region     (about GC identifiers)

Start:
23,972,837 bp from pter
End:
23,974,797 bp from pter
Size:
1,961 bases
Orientation:
plus strand

1 alternative location:
ChrX+ 26,235,419-26,236,387     
RefSeq DNA sequence:
NC_000023.10  NT_167197.1  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: MAGB5_HUMAN, Q9BZ81 (See protein sequence)
Recommended Name: Melanoma-associated antigen B5  
Size: 275 amino acids; 31906 Da

Explore the universe of human proteins at neXtProt for MAGEB5: NX_Q9BZ81 



ENSEMBL proteins: 
ENSP00000368315 


Human Recombinant Proteins 
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1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005575 cellular_component ND--
About this table

MAGEB5 for ontologies           About GeneDecksing



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Uscn ELISAs and CLIAs for MAGEB5 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MAGEB5 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR002190 MAGE

Graphical View of Domain Structure for InterPro Entry Q9BZ81

ProtoNet protein and cluster: Q9BZ81

UniProtKB/Swiss-Prot: MAGB5_HUMAN, Q9BZ81
Similarity: Contains 1 MAGE domain


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
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Sigma-Aldrich siRNA for MAGEB5
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miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MAGEB5 
Search SABiosciences for Assays for microRNAs that regulate MAGEB5

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for MAGEB5 

1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003674 molecular_function ND--
About this table

MAGEB5 for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for MAGEB5 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAGEB5

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008150 biological_process ND--
About this table

MAGEB5 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MAGEB5


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for MAGEB5
Browse shRNA at Sigma-Aldrich
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Browse OriGene siRNA
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MAGEB5 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MAGEB5 
Search SABiosciences for Assays for microRNAs that regulate MAGEB5
Clones: Browse FLAG tag genes at Sigma-Aldrich
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for MAGEB5 
Primers:Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for MAGEB5: PPH14599A

Additional cDNA sequence: XM_293407.6 

1 DOTS entry:

DT.75134306 

2 AceView cDNA sequences:

BE552290 AI954607 

highest scoring ESTs for MAGEB5:

AI954607 BE552290 CR747535 AL133110 XM_293407 

Unigene Cluster for MAGEB5:

Melanoma antigen family B, 5
Hs.224079  [show with all ESTs]
Unigene Representative Sequence: XM_293407


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000379029

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

MAGEB5 expression in normal and diseased human tissues

1  / 3 Data from Genenote  (Publications) and GNF BioGPS
    About these images

MAGEB5 gene expression
MAGEB5 gene electronic northern expression
MAGEB5 gene sage expression
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.224079

UniProtKB/Swiss-Prot: MAGB5_HUMAN, Q9BZ81
Tissue specificity: Expressed in testis. Not expressed in other normal tissues, but is expressed in tumors of different
histological origins

Primers:Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for MAGEB5: PPH14599A
    SABiosciences Custom PCR Arrays for MAGEB5 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MAGEB5 gene from 4 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
MAGEB51   -- melanoma antigen family B, 5 71.63(n)
57.95(a)
480870  XM_537986.2  XP_537986.2 
cow
(Bos taurus)
MAGEB51   -- melanoma antigen family B, 5 75.27(n)
63.44(a)
782551  XM_001251181.1  XP_001251182.1 
rat
(Rattus norvegicus)
Mageb51   -- melanoma antigen, family B, 5 70(n)
55.45(a)
302442  XM_228606.1  XP_228606.1 
mouse
(Mus musculus)
Mageb51 , 5 X (40.50 cM)5
melanoma antigen, family B, 51, 5 64.55(n)1
49.25(a)1
742711  XM_284719.31  XP_284719.11 
 AC0258745  AK0068075  (see all 7)
About this table        Species with no ortholog for MAGEB5

ENSEMBL Gene Tree for MAGEB5 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for MAGEB5 gene
MAGEB62  MAGEB22  MAGEB32  MAGEB172  MAGEB102  MAGEB12  MAGEB42  MAGEB182  

MAGEB5 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
QIAGEN SeqTarget long-range PCR primers for resequencing MAGEB5 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MAGEB5 for disorders           About GeneDecksing

OMIM: 300466

Locus Specific Mutation Databases (LSDB): MAGEB5

Export disorders and mutations for MAGEB5 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

2 PubMed articles for MAGEB5 gene integrated from 7 sources:
(articles sorted by number of sources associating them with MAGEB5)
  1. MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression. (PubMed id 10861452)1, 2, 3 Lucas S.... Boon T. (2000)
  2. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 347541 HGNC: 23795 AceView: MAGEB5 Ensembl:ENSG00000188408 euGenes: HUgn347541
ECgene: MAGEB5 H-InvDB: MAGEB5

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
ATLAS Chromosomes in Cancer entry for MAGEB5 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for MAGEB5 gene:
Search GeneIP for patents involving MAGEB5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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 ELISAs and CLIAs for MAGEB5
       

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