Aliases &
Descriptions
for MAP3K3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| mitogen-activated protein kinase kinase kinase 31 2 | | MEKK32 3 | | MAPKKK31 2 3 | | MEK kinase 32 3 | | MEKK 32 3 | | MAP/ERK kinase kinase 32 | | MAPK/ERK kinase kinase 32 3 | | EC 2.7.11.253 |
Export aliases for MAP3K3 gene to outside databasesPrevious GC identifers: GC17P061350 GC17P064126 GC17P062040 GC17P062173 GC17P059053 GC17P061699 |
Summaries
for MAP3K3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAP3K3:
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain isclosely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blotanalysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates thestress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activatingSEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcriptionfrom a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway.Alternatively spliced transcript variants encoding distinct isoforms have been observed. (provided by RefSeq)
UniProtKB/Swiss-Prot: M3K3_HUMAN, Q99759Function: Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 andDDIT3 transcriptional regulators
Gene Wiki entry for MAP3K3 |
Genomic Views
for MAP3K3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAP3K3 gene promoter:
AP-1 NF-kappaB1 NF-kappaB FOXJ2 (long isoform) AhR HNF-1A GR-alpha NF-AT2 NF-AT3 NF-AT4
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAP3K3
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MAP3K3  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q23.3 Ensembl cytogenetic band: 17q23.3 HGNC cytogenetic band: 17qMAP3K3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P057077: view genomic region
(about GC identifiers)
Start:
|
57,077,975 bp from pter |
End:
|
57,141,816 bp from pter |
Size:
|
63,842 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr17+ 61,699,801-61,773,667 |
RefSeq DNA sequence:- NC_000017.10 NT_010783.15
|
Proteins
for MAP3K3 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: M3K3_HUMAN, Q99759 (See
protein sequence)Recommended Name: Mitogen-activated protein kinase kinase kinase 3 Size: 626 amino acids; 70898 Da
Cofactor: Magnesium
Subunit: Binds both upstream activators and downstream substrates in multimolecular complexes. Part of a complex withMAP2K3, RAC1 and CCM2. Interacts with MAP2K5 and SPAG9
PDB structures from  and Proteopedia  :2C60 (3D)
2JRH (3D)
2O2V (3D)
2PPH (3D)
Secondary accessions: B2RCW2 Q5BKZ6 Q8N3I9Alternative splicing: 2 isoforms: Q99759-1 Q99759-2 Explore the universe of human proteins at neXtProt for MAP3K3: NX_Q99759
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_002392.2 NP_976226.1
ENSEMBL proteins: ENSP00000354927 ENSP00000354485
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): About this table
MAP3K3 for ontologies About GeneDecksing
Antibodies for MAP3K3:
Assays for MAP3K3: |
Protein
Domains/
Families
for MAP3K3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAP3K3 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q99759ProtoNet protein and cluster: Q99759 1 Blocks protein family: IPB000270 Octicosapeptide/Phox/Bem1p
UniProtKB/Swiss-Prot: M3K3_HUMAN, Q99759Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinasesubfamilySimilarity: Contains 1 OPR domainSimilarity: Contains 1 protein kinase domain |
Gene Function
for MAP3K3 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: M3K3_HUMAN, Q99759Function: Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 andDDIT3 transcriptional regulatorsCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated by phosphorylation on Thr-530 (By similarity)Enzyme Number (IUBMB): EC 2.7.11.25
5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8): About this table
MAP3K3 for ontologies About GeneDecksing
Animal Models: 7 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Map3k3):
MAP3K3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MAP3K3 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
MAP3K3 for pathways About GeneDecksing
3  Millipore Pathways for MAP3K3
5/14  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for MAP3K3 (see all 14)
1 
Cell Signaling Technology (CST) Pathway for MAP3K3
3  Kegg Pathways (Kegg details for MAP3K3):
SABiosciences Pathway-Focused PCR Array including MAP3K3: PAHS-061A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for MAP3K3
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP3K3
5/213 Interacting proteins for MAP3K3 (ENSP000003549273 Q997591, 2) via UniProtKB, MINT, and/or STRING (see all 213)About this table
5 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
MAP3K3 for ontologies About GeneDecksing
|
Drugs & Compounds
for MAP3K3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
MAP3K3 for compounds About GeneDecksing
 Browse Tocris compounds for MAP3K3
3  Novoseek chemical compound relationships for MAP3K3 gene
About this table
|
Transcripts
for MAP3K3 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for MAP3K3 gene (2 alternative transcripts): NM_002401.3 NM_203351.1 Additional cDNA sequence: AF172823.1 AK225784.1 AK308152.1 AK315305.1 AL834303.1 BC008336.1 BC010464.1 BC018021.1 BC090859.1 BC093672.1 BC093674.1 BC143224.1 BC143235.1 DQ454151.1 U78876.1 10 DOTS entries: DT.113632 DT.100781709 DT.445173 DT.100707638 DT.102830397 DT.40270938 DT.97864206 DT.100687871 DT.120925588 DT.100781708 24/208 AceView cDNA sequences (see all 208): BQ002723 BQ008632 BU188732 BQ059664 AA443212 AL834303 AW327780 NM_002401 BU729165 BQ231997 BQ052108 AA995176 BU172112 CB306334 BM541688 AA443920 BQ896921 AI033449 AU141033 BU633068 BG231756 BC008336 AX775741 AI312609
 highest scoring ESTs for MAP3K3:AI950930 U78876 AA225263 AA326273 AA339085 AA353216 AA443212 AA443251 AA443920 AA565120 Unigene Cluster for MAP3K3: Mitogen-activated protein kinase kinase kinase 3 Hs.29282 [show with all ESTs]Unigene Representative Sequence: NM_203351
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K3
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for MAP3K3
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000361357(uc002jbe.2 uc002jbf.2 uc002jbh.2) ENST00000361733(uc002jbg.2 uc010wpo.1 uc010wpp.1)
|
Expression
for MAP3K3 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| MAP3K3 expression in normal and diseased human tissues
1 / 2 / 3 8 probe-sets matching MAP3K3 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 44635_at2, 3
|
U95-B |
1 |
0.94 |
1.00 |
0.70 |
0.99 |
AI950930 |
1.00 |
1.00 |
1.00 |
1 |
| 1330_at2, 3
|
U95-A |
1 |
0.94 |
1.00 |
0.80 |
0.36 |
U78876 |
1.00 |
1.00 |
1.00 |
1 |
| 79338_at2, 3
|
U95-E |
1 |
0.38 |
1.00 |
0.80 |
0.99 |
R72968 |
0.60 |
0.75 |
0.68 |
1 |
| 43929_at2, 3
|
U95-B |
1 |
0.31 |
1.00 |
0.81 |
1.02 |
AA225263 |
0.80 |
1.00 |
0.91 |
1 |
| 227131_at2, 3
|
U133-B |
1 |
0.91 |
1.00 |
-- |
-- |
BG231756 |
0.80 |
1.00 |
0.91 |
1 |
| 203514_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
BF971923 |
0.80 |
1.00 |
0.91 |
1 |
| 227131_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 203514_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
MAP3K3 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.29282
Expression variation in blood from EXPOLDB for MAP3K3 SABiosciences Expression via Pathway-Focused PCR Array including MAP3K3: PAHS-061A
|
Orthologs
for MAP3K3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for MAP3K3 gene from 5/9 species (see all 9)
About this table Species with no ortholog for MAP3K3
ENSEMBL Gene Tree for MAP3K3 (if available) |
Paralogs
for MAP3K3 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for MAP3K3 gene
- MAP3K142 YSK42 MAP3K22
MAP3K3 for paralogs About GeneDecksing
|
Genomic Variants
for MAP3K3 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 17 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for MAP3K3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MAP3K3
1 CNV: 102504 | | QIAGEN SeqTarget long-range PCR primers for resequencing MAP3K3 |
|
Disorders & Mutations
for MAP3K3 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAP3K3 for disorders About GeneDecksing
OMIM: 602539
3 Novoseek disease relationships for MAP3K3 gene
About this table
Human Genome Epidemiology (HuGE) Navigator: MAP3K3 (2 documents)
Export disorders and mutations for MAP3K3 gene to outside databases
|
Medical News
for MAP3K3 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for MAP3K3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/91 PubMed articles for MAP3K3 gene, integrated from 7 sources (see all 91):
(articles sorted by number of sources associating them with MAP3K3)- Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein kinase/ERK kinase kinase 3 (MEKK) derivative. (PubMed id 9006902)1, 2, 3, 7 Ellinger-Ziegelbauer H.C.... Siebenlist U. (1997)
- PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway. (PubMed id 12912994)1, 2, 7 Nakamura K. and Johnson G.L. (2003)
- Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3. (PubMed id 14661019)1, 2, 7 Huang Q.... Su B. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. (PubMed id 14743216)1, 2 Bouwmeester T....Superti-Furga G. (2004)
- Overexpression of MEKK3 confers resistance to apoptosis through activation of NFkappaB. (PubMed id 14662759)1, 7 Samanta A.K....Liao W.S. (2004)
- Phosphorylation of MEKK3 at threonine 294 promotes 14-3-3 association to inhibit nuclear factor kappaB activation. (PubMed id 18308725)1, 7 Matitau A.E. and Scheid M.P. (2008)
- Phosphorylation of Thr-516 and Ser-520 in the kinase activation loop of MEKK3 is required for lysophosphatidic acid-mediated optimal IkappaB kinase beta (IKKbeta)/nuclear factor-kappaB (NF-kappaB) activation. (PubMed id 20068038)1, 7 Sun W....Yang J. (2010 Mar 12)
- TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation. (PubMed id 16260783)1, 7 Blonska M....Lin X. (2005)
- The essential role of MEKK3 in TNF-induced NF-kappaB activation. (PubMed id 11429546)1, 7 Yang J....Su B. (2001)
|
External Searches for MAP3K3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAP3K3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAP3K3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAP3K3 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MAP3K3 gene:
Search GeneIP for patents involving MAP3K3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAP3K3 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 | Antibodies & Assays for MAP3K3 (MEKK3) |
| | | | Search Tocris compounds for MAP3K3 |
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