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MAP3K3 Gene

protein-coding   GIFtS: 67

GC17P057077
mitogen-activated protein kinase kinase kinase 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: MEKK3)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
mitogen-activated protein kinase kinase kinase 31 2     MEKK32 3
MAPKKK31 2 3     MEK kinase 32 3
MEKK 32 3     MAP/ERK kinase kinase 32
MAPK/ERK kinase kinase 32 3     EC 2.7.11.253

External Ids:    HGNC: 68551   Entrez Gene: 42152   Ensembl: ENSG000001989097   UniProtKB: Q997593   

Export aliases for MAP3K3 gene to outside databases

Previous GC identifers: GC17P061350 GC17P064126 GC17P062040 GC17P062173 GC17P059053 GC17P061699


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAP3K3:
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is
closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot
analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the
stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating
SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription
from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway.
Alternatively spliced transcript variants encoding distinct isoforms have been observed. (provided by RefSeq)

UniProtKB/Swiss-Prot: M3K3_HUMAN, Q99759
Function: Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and
DDIT3 transcriptional regulators

Gene Wiki entry for MAP3K3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP3K3 gene promoter:
         AP-1   NF-kappaB1   NF-kappaB   FOXJ2 (long isoform)   AhR   HNF-1A   GR-alpha   NF-AT2   NF-AT3   NF-AT4   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for MAP3K3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MAP3K3 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.3   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q

MAP3K3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K3 gene location

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P057077:  view genomic region     (about GC identifiers)

Start:
57,077,975 bp from pter
End:
57,141,816 bp from pter
Size:
63,842 bases
Orientation:
plus strand

1 alternative location:
Chr17+ 61,699,801-61,773,667     
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: M3K3_HUMAN, Q99759 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase 3  
Size: 626 amino acids; 70898 Da
Cofactor: Magnesium
Subunit: Binds both upstream activators and downstream substrates in multimolecular complexes. Part of a complex with
MAP2K3, RAC1 and CCM2. Interacts with MAP2K5 and SPAG9
PDB structures from and Proteopedia :
2C60 (3D)    2JRH (3D)    2O2V (3D)    2PPH (3D)    
Secondary accessions: B2RCW2 Q5BKZ6 Q8N3I9
Alternative splicing: 2 isoforms:  Q99759-1   Q99759-2   

Explore the universe of human proteins at neXtProt for MAP3K3: NX_Q99759 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_002392.2  NP_976226.1  


    ENSEMBL proteins: 
    ENSP00000354927 ENSP00000354485 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for MAP3K3
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: MAP3K3
    GenScript Custom Purified and Recombinant Proteins Services for MAP3K3 
    Novus Biologicals Proteins for MAP3K3
    Novus Biologicals Lysates for MAP3K3
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829 cytosol EXP19903815
    About this table

    MAP3K3 for ontologies           About GeneDecksing



    Antibodies for MAP3K3: 
    Millipore Mono- and Polyclonal Antibodies for the study of MAP3K3
    Sigma-Aldrich Antibodies for MAP3K3
    R&D Systems Antibodies for MAP3K3 (MEKK3)
    Cell Signaling Technology (CST) Antibodies for MAP3K3  (MEKK3)
    OriGene Antibodies (see all 2): MAP3K3
    GenScript Custom Superior Antibodies Services for MAP3K3 
    Novus Biologicals Antibodies for MAP3K3
    Epitomics antibodies for MAP3K3

    Assays for MAP3K3: 
    Millipore Kits and Assays for the Analysis of MAP3K3
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAP3K3 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MAP3K3 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MAP3K3 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR002290 Ser/Thr_prot_kinase_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR000270 OPR_PB1
     IPR017442 Se/Thr_prot_kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q99759

    ProtoNet protein and cluster: Q99759

    1 Blocks protein family: IPB000270 Octicosapeptide/Phox/Bem1p

    UniProtKB/Swiss-Prot: M3K3_HUMAN, Q99759
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 OPR domain
    Similarity: Contains 1 protein kinase domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: M3K3_HUMAN, Q99759
    Function: Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and
    DDIT3 transcriptional regulators
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-530 (By similarity)
    Enzyme Number (IUBMB): EC 2.7.11.25 

    Inhib.
    RNA:
        
    Millipore RNAi Products for the Analysis of MAP3K3 Gene knock-down
    Sigma-Aldrich Nano Scale siRNA for MAP3K3
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for MAP3K3
    Sigma-Aldrich shRNA Panels and shRNA for MAP3K3
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): MAP3K3
    OriGene shRNA RFP (see all 2): MAP3K3
    OriGene basic RS shRNA (see all 2): MAP3K3
    OriGene siRNA (see all 2): MAP3K3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MAP3K3 
    miRNA:Sigma-Aldrich microRNA Mimics for MAP3K3
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MAP3K3 
    8/11 SABiosciences Assays for microRNAs that regulate MAP3K3 (see all 11):
    hsa-miR-647 hsa-miR-548d-3p hsa-miR-188-5p hsa-miR-657 hsa-miR-1271 hsa-miR-200a hsa-miR-132 hsa-miR-141

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): MAP3K3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): MAP3K3
    OriGene untagged cDNA clones in CMV expression vector (see all 3): MAP3K3
    OriGene 3'-UTR clone (see all 2): MAP3K3 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): MAP3K3 
    Sino Biological Human cDNA Clone for MAP3K3

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for MAP3K3 

    5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004672 protein kinase activity IDA15001576
    GO:0004674 protein serine/threonine kinase activity IEA--
    GO:0004709 MAP kinase kinase kinase activity IEA--
    GO:0005515 protein binding IPI15001576
    About this table

    MAP3K3 for ontologies           About GeneDecksing

    Animal Models: 7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Map3k3):

    cardiovascular systemcraniofacialembryogenesishematopoietic systemimmune system
    lethality-prenatal/perinatalmuscle

    MAP3K3 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    MAP3K3 for pathways           About GeneDecksing

    3 Millipore Pathways for MAP3K3
        Immune response Function of MEF2 in T lymphocytes
    Signal transduction JNK pathway
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis

    5/14 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  MAP3K3 (see all 14)
        B Cell Receptor Signaling
    ERK5 Signaling
    RANK Signaling in Osteoclasts
    Xenobiotic Metabolism Signaling
    CD27 Signaling in Lymphocytes

    1 Cell Signaling Technology (CST) Pathway for MAP3K3
        NF-kB Signaling

    3 Kegg Pathways  (Kegg details for MAP3K3):
        hsa04010 MAPK signaling pathway
    hsa04722 Neurotrophin signaling pathway
    hsa04912 GnRH signaling pathway

        SABiosciences Pathway-Focused PCR Array including MAP3K3: PAHS-061A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for MAP3K3
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP3K3

    5/213 Interacting proteins for MAP3K3 (ENSP000003549273 Q997591, 2) via UniProtKB, MINT, and/or STRING (see all 213)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRAF7Q6Q0C01, 2EBI-307281,EBI-307556 MINT-47880 MINT-48476
    YWHAEP622582STRING: ENSP00000264335 MINT-8006198 MINT-48369 MINT-47986 MINT-8007302
    MAP2K5Q131632STRING: ENSP00000346493 MINT-47996 MINT-48511
    CHUKO151112STRING: ENSP00000359424 MINT-48382
    IKBKBO149202STRING: ENSP00000339151 MINT-48434
    About this table

    5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165 MAPKKK cascade TAS9006902
    GO:0006468 protein phosphorylation ----
    GO:0007243 intracellular protein kinase cascade IDA15001576
    GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade IEP12761501
    GO:0046777 protein autophosphorylation IDA15001576
    About this table

    MAP3K3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    MAP3K3 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAP3K3
    3 Novoseek chemical compound relationships for MAP3K3 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 42.9 2 11343802 (2)
    arsenite 34.4 1 10618720 (1)
    serine 16.7 7 11343802 (4), 12392720 (1), 16362041 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Millipore RNAi Products for the Analysis of MAP3K3 Gene knock-down
    Sigma-Aldrich Nano Scale siRNA for MAP3K3
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for MAP3K3
    Sigma-Aldrich shRNA Panels and shRNA for MAP3K3
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): MAP3K3
    OriGene shRNA RFP (see all 2): MAP3K3
    OriGene basic RS shRNA (see all 2): MAP3K3
    OriGene siRNA (see all 2): MAP3K3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MAP3K3 
    miRNA: Sigma-Aldrich microRNA Mimics for MAP3K3
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MAP3K3 
    8/11 SABiosciences Assays for microRNAs that regulate MAP3K3 (see all 11):
    hsa-miR-647 hsa-miR-548d-3p hsa-miR-188-5p hsa-miR-657 hsa-miR-1271 hsa-miR-200a hsa-miR-132 hsa-miR-141
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): MAP3K3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): MAP3K3
    OriGene untagged cDNA clones in CMV expression vector (see all 3): MAP3K3
    OriGene 3'-UTR Clone (see all 2): MAP3K3 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): MAP3K3 
    Primers: OriGene genome-wide validated SYBR primer pairs: MAP3K3
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for MAP3K3: PPH00722A

    REFSEQ mRNAs for MAP3K3 gene (2 alternative transcripts): 

    NM_002401.3  NM_203351.1  

    Additional cDNA sequence: 

    AF172823.1 AK225784.1 AK308152.1 AK315305.1 AL834303.1 BC008336.1 BC010464.1 BC018021.1 
    BC090859.1 BC093672.1 BC093674.1 BC143224.1 BC143235.1 DQ454151.1 U78876.1 

    10 DOTS entries:

    DT.113632  DT.100781709  DT.445173  DT.100707638  DT.102830397  DT.40270938  DT.97864206  DT.100687871 
    DT.120925588  DT.100781708 

    24/208 AceView cDNA sequences (see all 208):

    BQ002723 BQ008632 BU188732 BQ059664 AA443212 AL834303 AW327780 NM_002401 
    BU729165 BQ231997 BQ052108 AA995176 BU172112 CB306334 BM541688 AA443920 
    BQ896921 AI033449 AU141033 BU633068 BG231756 BC008336 AX775741 AI312609 

    highest scoring ESTs for MAP3K3:

    AI950930 U78876 AA225263 AA326273 AA339085 AA353216 AA443212 AA443251 AA443920 AA565120 

    Unigene Cluster for MAP3K3:

    Mitogen-activated protein kinase kinase kinase 3
    Hs.29282  [show with all ESTs]
    Unigene Representative Sequence: NM_203351


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K3

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                        -                                                                     
    SP2:                                                                                                                              
    SP3:                                                                                                                    -         
    SP4:                                                                                                                              
    SP5:                                                                                                                              

    About this scheme

    ECgene alternative splicing isoforms for MAP3K3
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361357(uc002jbe.2 uc002jbf.2 uc002jbh.2) ENST00000361733(uc002jbg.2 uc010wpo.1 uc010wpp.1)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    MAP3K3 expression in normal and diseased human tissues

    1  / 2  / 3

    8 probe-sets matching MAP3K3 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    44635_at2, 3 U95-B 1 0.94 1.00 0.70 0.99 AI950930 1.00 1.00 1.00 1
    1330_at2, 3 U95-A 1 0.94 1.00 0.80 0.36 U78876 1.00 1.00 1.00 1
    79338_at2, 3 U95-E 1 0.38 1.00 0.80 0.99 R72968 0.60 0.75 0.68 1
    43929_at2, 3 U95-B 1 0.31 1.00 0.81 1.02 AA225263 0.80 1.00 0.91 1
    227131_at2, 3 U133-B 1 0.91 1.00 -- -- BG231756 0.80 1.00 0.91 1
    203514_at2, 3 U133-A 1 0.91 1.00 -- -- BF971923 0.80 1.00 0.91 1
    227131_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    203514_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table

    MAP3K3 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    MAP3K3 gene expression
    MAP3K3 gene electronic northern expression
    MAP3K3 gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.29282

    Expression variation in blood from EXPOLDB for MAP3K3

    Primers: OriGene genome-wide validated SYBR primer pairs: MAP3K3
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for MAP3K3: PPH00722A
        SABiosciences Expression via Pathway-Focused PCR Array including MAP3K3: PAHS-061A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for MAP3K3 gene from 5/9 species (see all 9)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    MAP3K31   -- mitogen-activated protein kinase kinase kinase 3 93.08(n)
    97.6(a)
    480481  XM_537600.2  XP_537600.2 
    cow
    (Bos taurus)
    MAP3K31   -- mitogen-activated protein kinase kinase kinase 3 92.64(n)
    97.24(a)
    508943  XM_880929.2  XP_886022.2 
    rat
    (Rattus norvegicus)
    Map3k31   -- mitogen activated protein kinase kinase kinase 3 89.88(n)
    96.33(a)
    303604  XM_221034.4  XP_221034.3 
    mouse
    (Mus musculus)
    Map3k31 , 5 11 (68.89 cM)5
    mitogen-activated protein kinase kinase kinase 31, 5 90.52(n)1
    96.65(a)1
    264061  NM_011947.21  NP_036077.11 
     AK1371275  AK1422785  (see all 13)
    chicken
    (Gallus gallus)
    MAP3K31   -- mitogen-activated protein kinase kinase kinase 3 80.18(n)
    88.17(a)
    419954  XM_418076.2  XP_418076.2 
    About this table        Species with no ortholog for MAP3K3

    ENSEMBL Gene Tree for MAP3K3 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for MAP3K3 gene
    MAP3K142  YSK42  MAP3K22  

    MAP3K3 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/540 NCBI SNPs in MAP3K3 are shown (see all 540)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs156371,2
    C,F,A,H,61772050(-) GCCCCG/CACCGT 2 -- ut31 ese317Minor allele frequency- C:0.18MN EA NA NS WA 2580
    rs9924161,2
    C,F,A,H,61745905(-) CCACCT/GCCATC 2 -- int112Minor allele frequency- G:0.24NS EA NA WA 769
    rs10604651,2
    --61758592(-) TGTATC/TAGGTA 2 -- int11Minor allele frequency- T:0.00MN 184
    rs18773161,2
    C,F,A,H,61766880(-) CAGAGG/TAGAGC 2 -- int110Minor allele frequency- T:0.11EA NS NA WA 2168
    rs21754931,2
    --61741075(-) tcttgC/Ttatgt 2 -- int10--------
    rs22296731,2
    C,F,61770954(+) CCACCC/G/TTGGGC 6 P syn1 ref19MN NS EA NA 678
    rs23199901,2
    C,A,61705397(+) agtagC/Ttggga 2 -- int10--------
    rs28741211,2
    C,F,A,61731024(+) AATTCC/TGTTCT 2 -- int17Minor allele frequency- T:0.25NS EA NA WA 536
    rs37855741,2
    C,F,61763185(-) AAAGCA/GCTTAG 2 -- int112Minor allele frequency- G:0.31NS EA NA WA 1044
    rs43742311,2
    --61737116(+) ttgaaC/Ttcctg 2 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for MAP3K3 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MAP3K3
         1 CNV: 102504

    QIAGEN SeqTarget long-range PCR primers for resequencing MAP3K3 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MAP3K3 for disorders           About GeneDecksing

    OMIM: 602539

    3 Novoseek disease relationships for MAP3K3 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 33.8 6 14662759 (1), 17116170 (1), 19843958 (1), 15047705 (1) (see all 6)
    tumors 8.9 7 19517469 (2), 14662759 (1), 19843958 (1), 16260783 (1) (see all 6)
    cancer 0 3 14662759 (2), 19517469 (1)
    About this table

    Human Genome Epidemiology (HuGE) Navigator: MAP3K3 (2 documents)

    Export disorders and mutations for MAP3K3 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/91 PubMed articles for MAP3K3 gene, integrated from 7 sources (see all 91):
    (articles sorted by number of sources associating them with MAP3K3)
    1. Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein kinase/ERK kinase kinase 3 (MEKK) derivative. (PubMed id 9006902)1, 2, 3, 7 Ellinger-Ziegelbauer H.C.... Siebenlist U. (1997)
    2. PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway. (PubMed id 12912994)1, 2, 7 Nakamura K. and Johnson G.L. (2003)
    3. Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3. (PubMed id 14661019)1, 2, 7 Huang Q.... Su B. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. (PubMed id 14743216)1, 2 Bouwmeester T....Superti-Furga G. (2004)
    6. Overexpression of MEKK3 confers resistance to apoptosis through activation of NFkappaB. (PubMed id 14662759)1, 7 Samanta A.K....Liao W.S. (2004)
    7. Phosphorylation of MEKK3 at threonine 294 promotes 14-3-3 association to inhibit nuclear factor kappaB activation. (PubMed id 18308725)1, 7 Matitau A.E. and Scheid M.P. (2008)
    8. Phosphorylation of Thr-516 and Ser-520 in the kinase activation loop of MEKK3 is required for lysophosphatidic acid-mediated optimal IkappaB kinase beta (IKKbeta)/nuclear factor-kappaB (NF-kappaB) activation. (PubMed id 20068038)1, 7 Sun W....Yang J. (2010 Mar 12)
    9. TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation. (PubMed id 16260783)1, 7 Blonska M....Lin X. (2005)
    10. The essential role of MEKK3 in TNF-induced NF-kappaB activation. (PubMed id 11429546)1, 7 Yang J....Su B. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4215 HGNC: 6855 AceView: MAP3K3 Ensembl:ENSG00000198909 euGenes: HUgn4215
    ECgene: MAP3K3 Kegg: 4215 H-InvDB: MAP3K3

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for MAP3K3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for MAP3K3 gene:
    Search GeneIP for patents involving MAP3K3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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