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MAP3K5 Gene

protein-coding   GIFtS: 63

GC06M134442
mitogen-activated protein kinase kinase kinase 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: MEKK5)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
mitogen-activated protein kinase kinase kinase 51 2     ASK-12 3
ASK11 2 3 5     MAPK/ERK kinase kinase 52 3
MAPKKK51 2 3 5     MEKK 52 3
MEKK52 3 5     apoptosis signal regulating kinase 12
Apoptosis signal-regulating kinase 12 3     MAP/ERK kinase kinase 52
MEK kinase 52 3     EC 2.7.11.253

External Ids:    HGNC: 68571   Entrez Gene: 42172   Ensembl: ENSG000001974427   UniProtKB: Q996833   

Export aliases for MAP3K5 gene to outside databases

Previous GC identifers: GC06M136500 GC06M136725 GC06M136858 GC06M136919


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAP3K5:
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK),
MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its
downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are
highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids
with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human
heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and
activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and
293 cells; MAPKKK5 does not activate MAPK/ERK. (provided by RefSeq)

UniProtKB/Swiss-Prot: M3K5_HUMAN, Q99683
Function: Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6,
which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death

Gene Wiki entry for MAP3K5 (ASK1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP3K5 gene promoter:
         AP-1   HSF1 (long)   c-Fos   c-Jun   C/EBPalpha   PPAR-gamma1   PPAR-gamma2   NF-kappaB   NF-kappaB1   p53   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for MAP3K5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MAP3K5 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.33   Ensembl cytogenetic band:  6q23.3   HGNC cytogenetic band: 6q22.33

MAP3K5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K5 gene location

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M134442:  view genomic region     (about GC identifiers)

Start:
134,442,506 bp from pter
End:
134,677,689 bp from pter
Size:
235,184 bases
Orientation:
minus strand

1 alternative location:
Chr6- 136,878,185-137,113,656     
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: M3K5_HUMAN, Q99683 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase 5  
Size: 1374 amino acids; 154537 Da
Cofactor: Magnesium
Subunit: Homodimer when inactive. Binds both upstream activators and downstream substrates in multimolecular complexes.
Associates with and inhibited by HIV-1 Nef. Interacts with DAB2IP and PPM1L. Interacts with ARRB2
PDB structures from and Proteopedia :
2CLQ (3D)    
Secondary accessions: Q5THN3 Q99461

Explore the universe of human proteins at neXtProt for MAP3K5: NX_Q99683 

Post-translational modifications:

  • Dephosphorylated and activated by PGAM51
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_005914.1  

    ENSEMBL proteins: 
    ENSP00000356742 ENSP00000351908 ENSP00000348104 


    Human Recombinant Proteins 
    Millipore Purified and/or Recombinant MAP3K5 Protein
    Sigma-Aldrich Proteins for MAP3K5
    R&D Systems Recombinant & Natural Proteins for MAP3K5 (ASK1)
    Enzo Life Sciences proteins for MAP3K5
    OriGene Purified Protein: MAP3K5
    OriGene Protein Over-expression Lysate: MAP3K5
    GenScript Custom Purified and Recombinant Proteins Services for MAP3K5 
    Novus Biologicals Protein for MAP3K5
    Novus Biologicals Lysates for MAP3K5
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins


    Antibodies for MAP3K5: 
    Millipore Mono- and Polyclonal Antibodies for the study of MAP3K5
    Sigma-Aldrich Antibodies for MAP3K5
    R&D Systems Antibodies for MAP3K5 (ASK1)
    Cell Signaling Technology (CST) Antibodies for MAP3K5  (ASK1 Kinase)
    OriGene Antibodies (see all 8): MAP3K5
    GenScript Custom Superior Antibodies Services for MAP3K5 
    Novus Biologicals Antibodies for MAP3K5
    Epitomics antibodies for MAP3K5

    Assays for MAP3K5: 
    Millipore Kits and Assays for the Analysis of MAP3K5
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAP3K5 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MAP3K5 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_prot_kinase_dom
     IPR010993 Sterile_alpha_motif_homology
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_prot_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q99683

    ProtoNet protein and cluster: Q99683

    UniProtKB/Swiss-Prot: M3K5_HUMAN, Q99683
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: M3K5_HUMAN, Q99683
    Function: Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6,
    which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-838, inhibited by
    phosphorylation at Ser-966 and Ser-1033. Binds to, and stabilizes MAP3K6 and is activated by MAP3K6 by phosphorylation
    on Thr-838
    Induction: By TNF. Inhibited by HIV-1 Nef
    Enzyme Number (IUBMB): EC 2.7.11.25 

    Inhib.
    RNA:
        
    Millipore RNAi Products for the Analysis of MAP3K5 Gene knock-down
    Sigma-Aldrich Nano Scale siRNA for MAP3K5
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for MAP3K5
    Sigma-Aldrich shRNA Panels and shRNA for MAP3K5
    OriGene 29mer shRNA kits in GFP-retroviral vector: MAP3K5
    OriGene shRNA RFP: MAP3K5
    OriGene basic RS shRNA: MAP3K5
    OriGene siRNA: MAP3K5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MAP3K5 
    miRNA:Sigma-Aldrich microRNA Mimics for MAP3K5
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MAP3K5 
    8/18 SABiosciences Assays for microRNAs that regulate MAP3K5 (see all 18):
    hsa-miR-30c hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-106a hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-93

    Gene
    Editing:
    Sigma-Aldrich CompoZr Knockout ZFN for MAP3K5 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: MAP3K5
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: MAP3K5
    OriGene untagged cDNA clones in CMV expression vector (see all 2): MAP3K5
    OriGene 3'-UTR clone: MAP3K5 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: MAP3K5 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for MAP3K5 

    Genatlas biochemistry entry for MAP3K5:
    mitogen activated protein (MAP/ERK) kinase kinase kinase 5

    5/11 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 11):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0000287 magnesium ion binding IDA17210579
    GO:0004672 protein kinase activity ----
    GO:0004674 protein serine/threonine kinase activity IEA--
    GO:0004709 MAP kinase kinase kinase activity IDA17210579
    About this table

    MAP3K5 for ontologies           About GeneDecksing

    Animal Models: 4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Map3k5):

    cardiovascular systemcellularhomeostasis/metabolismtumorigenesis

    MAP3K5 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    MAP3K5 for pathways           About GeneDecksing

    5/7 Millipore Pathways for MAP3K5 (see all 7)
        Development Angiotensin signaling via beta-Arrestin
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Apoptosis and survival FAS signaling cascades
    Signal transduction JNK pathway
    Apoptosis and survival Lymphotoxin-beta receptor signaling

    5/32 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  MAP3K5 (see all 32)
        FGF Signaling
    PI3K/AKT Signaling
    RAR Activation
    Role of MAPK Signaling in the Pathogenesis of Influenza
    SAPK/JNK Signaling

    3 Cell Signaling Technology (CST) Pathways for MAP3K5
        Death Receptor Signaling
    Akt/PKB Signaling
    SAPK/JNK Signaling Cascades

    4 Kegg Pathways  (Kegg details for MAP3K5):
        hsa04010 MAPK signaling pathway
    hsa04141 Protein processing in endoplasmic reticulum
    hsa04722 Neurotrophin signaling pathway
    hsa05014 Amyotrophic lateral sclerosis (ALS)

        SABiosciences Pathway-Focused PCR Arrays including MAP3K5: PAHS-051A PAHS-3012A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for MAP3K5
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP3K5

    5/67 Interacting proteins for MAP3K5 (ENSP000003519083 Q996831, 2) via UniProtKB, MINT, and/or STRING (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631041, 2STRING: ENSP00000309503 EBI-476263,EBI-347088 MINT-8007339
    AKT1P317491STRING: ENSP00000270202 EBI-476263,EBI-296087
    DAXXQ9UER71STRING: ENSP00000363668 EBI-476263,EBI-77321
    FASP254451STRING: ENSP00000360942 EBI-476263,EBI-494743
    TRAF2Q129331STRING: ENSP00000352685 EBI-476263,EBI-355744
    About this table

    5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165 MAPKKK cascade IDA17210579
    GO:0000187 activation of MAPK activity ----
    GO:0006468 protein phosphorylation ----
    GO:0006915 apoptosis IEA--
    GO:0007257 activation of JUN kinase activity TAS8974401
    About this table

    MAP3K5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    MAP3K5 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAP3K5
    10/30 Novoseek chemical compound relationships for MAP3K5 gene (see all 30)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sp 600125 69.8 3 19405983 (1), 20200402 (1), 19735704 (1)
    sb 203580 64.9 7 12968034 (1), 20112989 (1)
    oxygen 52.3 36 16644673 (2), 17724081 (2), 9651337 (1), 16515547 (1) (see all 23)
    n acetylcysteine 48.6 14 19405983 (2), 9651337 (1), 12244106 (1), 20112989 (1) (see all 9)
    h2o2 46.4 35 17456047 (4), 11920685 (3), 14668614 (3), 18501712 (3) (see all 13)
    serine 35.2 23 16644673 (2), 15598880 (1), 17504983 (1), 15094778 (1) (see all 12)
    threonine 34.8 15 15598880 (1), 17504983 (1), 20364819 (1), 15094778 (1) (see all 9)
    ebselen 32 1 14713291 (1)
    ly294002 29.9 4 15782121 (2), 18054391 (1), 12869527 (1)
    nadph 28.9 5 17015265 (2), 18155167 (1), 18028450 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Millipore RNAi Products for the Analysis of MAP3K5 Gene knock-down
    Sigma-Aldrich Nano Scale siRNA for MAP3K5
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for MAP3K5
    Sigma-Aldrich shRNA Panels and shRNA for MAP3K5
    OriGene 29mer shRNA kits in GFP-retroviral vector: MAP3K5
    OriGene shRNA RFP: MAP3K5
    OriGene basic RS shRNA: MAP3K5
    OriGene siRNA: MAP3K5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MAP3K5 
    miRNA: Sigma-Aldrich microRNA Mimics for MAP3K5
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MAP3K5 
    8/18 SABiosciences Assays for microRNAs that regulate MAP3K5 (see all 18):
    hsa-miR-30c hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-106a hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-93
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: MAP3K5
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: MAP3K5
    OriGene untagged cDNA clones in CMV expression vector (see all 2): MAP3K5
    OriGene 3'-UTR Clone: MAP3K5 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: MAP3K5 
    Primers: OriGene genome-wide validated SYBR primer pairs: MAP3K5
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for MAP3K5: PPH00744A

    REFSEQ mRNAs for MAP3K5 gene: 

    NM_005923.3  

    Additional cDNA sequence: 

    AB209093.1 AK293953.1 AK294507.1 AK310942.1 BC054503.2 BC088829.1 D84476.2 U67156.1 

    10 DOTS entries:

    DT.451805  DT.91700170  DT.92009713  DT.100722589  DT.100751512  DT.121322417  DT.91702811  DT.121322370 
    DT.40117449  DT.95109734 

    24/106 AceView cDNA sequences (see all 106):

    BM981228 AI827010 BF914042 BG926856 BQ188173 AW052036 AA854544 AL133790 
    BM718016 AA235088 AA651664 BG402936 BQ894240 BC054503 AW955152 AW104096 
    AW662187 AI042050 BM798051 AW664529 BM990052 CD621373 AA973986 BE672574 

    highest scoring ESTs for MAP3K5:

    U67156 BC054503 BE244561 BE244927 BE245096 BU181215 D84476 AA057432 AA150828 AA226694 

    Unigene Cluster for MAP3K5:

    Mitogen-activated protein kinase kinase kinase 5
    Hs.186486  [show with all ESTs]
    Unigene Representative Sequence: U67156


    GeneLoc Exon Structure

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367768 ENST00000463140 ENST00000359015(uc011edj.1 uc011edk.1 uc003qhc.2 uc010kgw.1)
    ENST00000355845

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    MAP3K5 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching MAP3K5 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    1327_s_at2, 3 U95-A 1 0.75 1.00 1.00 1.00 U67156 1.00 1.00 1.00 1
    203836_s_at2, 3 U133-A 1 1.00 1.00 -- -- D84476 0.80 1.00 0.91 1
    203837_at2, 3 U133-A 1 0.64 1.00 -- -- NM_005923 0.60 1.00 0.82 1
    203836_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    203837_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
    About this table

    MAP3K5 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    MAP3K5 gene expression
    MAP3K5 gene electronic northern expression
    MAP3K5 gene sage expression
    About these images

    CGAP SAGE TAG: CTTGAACTGT

    SOURCE GeneReport for Unigene cluster: Hs.186486

    UniProtKB/Swiss-Prot: M3K5_HUMAN, Q99683
    Tissue specificity: Abundantly expressed in heart and pancreas

    Primers: OriGene genome-wide validated SYBR primer pairs: MAP3K5
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for MAP3K5: PPH00744A
        SABiosciences Expression via Pathway-Focused PCR Arrays including MAP3K5: PAHS-051A PAHS-3012A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for MAP3K5 gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    MAP3K51   -- mitogen-activated protein kinase kinase kinase 5 91.61(n)
    95.54(a)
    476215  XM_533420.2  XP_533420.2 
    chimpanzee
    (Pan troglodytes)
    MAP3K51   -- mitogen-activated protein kinase kinase kinase 5 99.61(n)
    99.71(a)
    463023  XM_001171211.1  XP_001171211.1 
    mouse
    (Mus musculus)
    Map3k51 , 5 10 (9.35 cM)5
    mitogen-activated protein kinase kinase kinase 51, 5 86.76(n)1
    94.61(a)1
    264081  NM_008580.31  NP_032606.31 
     AB0067875  AK0337265  (see all 10)
    chicken
    (Gallus gallus)
    MAP3K51   -- mitogen-activated protein kinase kinase kinase 5 80.65(n)
    87.94(a)
    421688  XM_419725.2  XP_419725.2 
    zebrafish
    (Danio rerio)
    map3k51   -- mitogen-activated protein kinase kinase kinase 5 68.2(n)
    73.85(a)
    555703  XM_678295.3  XP_683387.3 
    About this table        Species with no ortholog for MAP3K5

    ENSEMBL Gene Tree for MAP3K5 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for MAP3K5 gene
    MAP3K12  MAP3K152  MAP3K82  MAP3K62  

    MAP3K5 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/2175 NCBI SNPs in MAP3K5 are shown (see all 2175)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs111381,2
    136878434(-) TCAATT/GACTGT 1 -- ut31 ese31Minor allele frequency- G:0.00MN 184
    rs115031,2
    --136878332(-) TTAAGT/CTTCTG 1 -- ut31 ese31Minor allele frequency- C:0.00MN 184
    rs7200651,2
    A137104236(-) TCAAAC/GTCCTG 1 -- int10--------
    rs7203441,2
    C,F,A,H,137048442(-) atataC/Gtgtct 1 -- int110Minor allele frequency- G:0.37NS EA NA WA 634
    rs7203451,2
    C,F,O,A,H,137048261(-) TTTCAC/TCTGTT 1 -- int111Minor allele frequency- T:0.38NS EA NA WA 770
    rs7423051,2
    --136938098(+) tgatcC/Tgccag 1 -- int10--------
    rs7608621,2
    C,F,A,136909664(+) TCTTCT/CGCTAG 1 -- int1 trp3112Minor allele frequency- C:0.34NS EA NA PA EU CA WA 7638
    rs7608631,2
    C,F,A,136909716(+) gccacA/Ggcatc 1 -- int18Minor allele frequency- G:0.28NS EA NA WA 620
    rs8771921,2
    C,F,O,A,136949734(+) GTTTTA/CATTTC 1 -- int111Minor allele frequency- C:0.15MN NS EA NA WA 882
    rs8771931,2
    C,F,A,136949784(+) GATTAC/TGTATT 1 -- int13Minor allele frequency- T:0.19EA WA 140
    About this table

    HapMap Linkage Disequilibrium images for MAP3K5 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MAP3K5: --

    QIAGEN SeqTarget long-range PCR primers for resequencing MAP3K5 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MAP3K5 for disorders           About GeneDecksing

    OMIM: 602448

    10/22 Novoseek disease relationships for MAP3K5 gene (see all 22)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 50.3 35 9651337 (1), 12591926 (1), 19799997 (1), 12819028 (1) (see all 19)
    tumors 30.6 36 15034865 (2), 9651337 (1), 19799997 (1), 16787350 (1) (see all 20)
    neurodegenerative diseases 25.1 5 19456270 (3), 16472116 (1), 20364819 (1)
    shock 13.9 15 12077134 (5), 12391142 (4), 16038411 (2)
    cardiac hypertrophy 12.7 3 18759454 (1), 16987025 (1), 15824197 (1)
    cancer 9.56 2 17034356 (1), 18380010 (1)
    prostatic adenocarcinoma 6.98 2 12968034 (1)
    cell damage 3.95 1 16195372 (1)
    virus infection 0 2 16764692 (2)
    ischemia 0 1 19052195 (1)
    About this table

    1 PharmGKB disease relationship for MAP3K5 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872 12730115
    About this table

    Locus Specific Mutation Databases (LSDB): MAP3K5
    Human Genome Epidemiology (HuGE) Navigator: MAP3K5 (7 documents)

    Export disorders and mutations for MAP3K5 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
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    10/341 PubMed articles for MAP3K5 gene, integrated from 7 sources (see all 341):
    (articles sorted by number of sources associating them with MAP3K5)
    1. AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3. (PubMed id 12813029)1, 2, 7 Zhang R.... Min W. (2003)
    2. Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cepsilon. (PubMed id 17456047)1, 2, 7 Saito J....Tamura S. (2007)
    3. Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen- activated protein kinase kinase kinase in a heteromeric complex with ASK1. (PubMed id 17210579)1, 2, 7 Takeda K.... Ichijo H. (2007)
    4. Activation of apoptosis signal-regulating kinase 1 by the stress- induced activating phosphorylation of pre-formed oligomer. (PubMed id 11920685)1, 2, 7 Tobiume K.... Ichijo H. (2002)
    5. Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034. (PubMed id 15094778)1, 2, 7 Fujii K.... Fu H. (2004)
    6. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. (PubMed id 8974401)1, 2, 7 Ichijo H.... Gotoh Y. (1997)
    7. AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2- induced ASK1-JNK activation. (PubMed id 15310755)1, 2, 7 Zhang H.... Min W. (2004)
    8. HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell. (PubMed id 11298454)1, 2, 7 Geleziunas R.... Greene W.C. (2001)
    9. Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx. (PubMed id 9743501)1, 2, 7 Chang H.Y.... Baltimore D. (1998)
    10. Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1. (PubMed id 19590015)1, 2 Takeda K.... Ichijo H. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4217 HGNC: 6857 AceView: MAP3K5 Ensembl:ENSG00000197442 euGenes: HUgn4217
    ECgene: MAP3K5 Kegg: 4217 H-InvDB: MAP3K5

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for MAP3K5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for MAP3K5 gene:
    Search GeneIP for patents involving MAP3K5

    GeneCards and IP:
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