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MAP4K1 Gene

protein-coding GIFtS: 58

GC19M035526

mitogen-activated protein kinase kinase kinase kinase 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
mitogen-activated protein kinase kinase kinase kinase 1¹ ²		MEKKK 1² ³
HPK1¹ ² ³ ⁵		hematopoietic progenitor kinase 1²
MAPK/ERK kinase kinase kinase 1² ³		Hematopoietic progenitor kinase³
MEK kinase kinase 1² ³		EC 2.7.11.1³

External Ids:	HGNC: 6863¹	Entrez Gene: 11184²	Ensembl: ENSG00000104814⁷	UniProtKB: Q92918³

Export aliases for MAP4K1 gene to outside databases

Previous GC identifers: GC19M039692 GC19M039469 GC19M043754 GC19M043770 GC19M039078

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: M4K1_HUMAN, Q92918

Function: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal

pathway. May play a role in hematopoietic lineage decisions and growth regulation

Gene Wiki entry for MAP4K1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MAP4K1 gene promoter:
         AP-1   NF-kappaB1   c-Fos   c-Jun   CUTL1   NF-kappaB   ZID   POU2F1   GATA-1   NRSF form 1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for MAP4K1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MAP4K1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1-q13.4 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.1-q13.4

MAP4K1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP4K1 gene location

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M035526: view genomic region (about GC identifiers)

Start:	35,526,409 bp from pter
End:	35,555,215 bp from pter
Size:	28,807 bases
Orientation:	minus strand

1 alternative location:

Chr19- 39,078,281-39,108,643

RefSeq DNA sequence:

NC_000019.9 NT_011109.16

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: M4K1_HUMAN, Q92918 (See protein sequence)

Recommended Name: Mitogen-activated protein kinase kinase kinase kinase 1

Size: 833 amino acids; 91296 Da

Cofactor: Magnesium

Subunit: Interacts with MAP3K1

Explore the universe of human proteins at neXtProt for MAP4K1: NX_Q92918

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001036065.1 NP_009112.1

ENSEMBL proteins:

ENSP00000380066 ENSP00000221409 ENSP00000396383

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates
	GenScript Custom Purified and Recombinant Proteins Services for MAP4K1
	Novus Biologicals Proteins for MAP4K1
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

Antibodies for MAP4K1:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for MAP4K1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for MAP4K1 (HPK1)
	OriGene Antibodies (see all 2): MAP4K1
	GenScript Custom Superior Antibodies Services for MAP4K1
	Novus Biologicals Antibodies for MAP4K1
	Epitomics antibodies for MAP4K1

Assays for MAP4K1:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MAP4K1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MAP4K1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MAP4K1 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR017441 Protein_kinase_ATP_BS

IPR002290 Ser/Thr_prot_kinase_dom

IPR011009 Kinase-like_dom

IPR000719 Prot_kinase_cat_dom

IPR001180 Citron

Graphical View of Domain Structure for InterPro Entry Q92918

ProtoNet protein and cluster: Q92918

1 Blocks protein family: IPB001180 Citron-like

UniProtKB/Swiss-Prot: M4K1_HUMAN, Q92918

Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily

Similarity: Contains 1 CNH domain

Similarity: Contains 1 protein kinase domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: M4K1_HUMAN, Q92918

Function: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal

pathway. May play a role in hematopoietic lineage decisions and growth regulation

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Number (IUBMB): EC 2.7.11.1

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Sigma-Aldrich Nano Scale siRNA for MAP4K1 Sigma-Aldrich siRNA Panels and esiRNA and siRNA for MAP4K1 Sigma-Aldrich shRNA Panels and shRNA for MAP4K1
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): MAP4K1 OriGene shRNA RFP (see all 2): MAP4K1 OriGene basic RS shRNA (see all 2): MAP4K1 OriGene siRNA (see all 2): MAP4K1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MAP4K1

miRNA:		Sigma-Aldrich microRNA Mimics for MAP4K1 Sigma-Aldrich microRNA target validation systems for MAP4K1
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MAP4K1
		Search SABiosciences for Assays for microRNAs that regulate MAP4K1

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): MAP4K1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): MAP4K1 OriGene untagged cDNA clones in CMV expression vector (see all 4): MAP4K1 OriGene 3'-UTR clone (see all 2): MAP4K1 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for MAP4K1
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for MAP4K1

Genatlas biochemistry entry for MAP4K1:

mitogen-activated kinase kinase kinase kinase 1,nuclear,predominantly expressed in hematopoietic cells,binding MAP3K1

(MEKK1) activating the JNK/SAPK kinase pathway

5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004672	protein kinase activity	TAS	8824585
GO:0004674	protein serine/threonine kinase activity	IDA	8824585
GO:0005083	small GTPase regulator activity	IEA	--
GO:0005515	protein binding	IPI	17474147

About this table

MAP4K1 for ontologies About GeneDecksing

Animal Models: 2 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Map4k1):

hematopoietic system

immune system

MAP4K1 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

MAP4K1 for pathways About GeneDecksing

1 Millipore Pathway for MAP4K1

Signal transduction JNK pathway

5 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for MAP4K1

	TGF-β Signaling
	p38 MAPK Signaling
	Reelin Signaling in Neurons
	SAPK/JNK Signaling
	Wnt/β-catenin Signaling

1 Kegg Pathway (Kegg details for MAP4K1):

hsa04010 MAPK signaling pathway

SABiosciences Pathway-Focused PCR Arrays including MAP4K1: PAHS-054A PAHS-061A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for MAP4K1

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MAP4K1

5/32 Interacting proteins for MAP4K1 (ENSP00000221409³ Q92918^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 32)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GRB2	P62993¹^,²	STRING: ENSP00000339007 EBI-881,EBI-401755 MINT-7212988 MINT-7213120 MINT-7212968 MINT-7213066 MINT-7213002 MINT-7213078 MINT-7253194
NCK1	P16333¹^,²	STRING: ENSP00000288986 EBI-881,EBI-389883 MINT-7213100 MINT-7213019 MINT-7247854 MINT-7249558
ABL1	P00519¹^,²	STRING: ENSP00000361423 EBI-881,EBI-375543 MINT-7243318 MINT-7213035 MINT-7244806
CRK	P46108¹^,²	STRING: ENSP00000300574 EBI-881,EBI-886 MINT-7254804 MINT-7253998
FYN	P06241¹^,²	EBI-881,EBI-515315 MINT-7246558 MINT-7245946

About this table

5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000185	activation of MAPKKK activity	IC	11053428
GO:0006468	protein phosphorylation	IDA	8824585
GO:0006950	response to stress	IDA	8824585
GO:0007243	intracellular protein kinase cascade	IDA	8824585
GO:0007257	activation of JUN kinase activity	TAS	8824585

About this table

MAP4K1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

MAP4K1 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MAP4K1
3 Novoseek chemical compound relationships for MAP4K1 gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
threonine	64.9	15	9346925 (3), 9891069 (1), 9820741 (1), 15364934 (1) (see all 8)
serine	51.8	10	9346925 (1), 9891069 (1), 9820741 (1), 15364934 (1) (see all 7)
tyrosine	22.9	11	9346925 (3), 11279207 (2), 15743830 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Sigma-Aldrich Nano Scale siRNA for MAP4K1 Sigma-Aldrich siRNA Panels and esiRNA and siRNA for MAP4K1 Sigma-Aldrich shRNA Panels and shRNA for MAP4K1
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): MAP4K1 OriGene shRNA RFP (see all 2): MAP4K1 OriGene basic RS shRNA (see all 2): MAP4K1 OriGene siRNA (see all 2): MAP4K1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MAP4K1

miRNA:		Sigma-Aldrich microRNA Mimics for MAP4K1 Sigma-Aldrich microRNA target validation systems for MAP4K1
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MAP4K1
		Search SABiosciences for Assays for microRNAs that regulate MAP4K1

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): MAP4K1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): MAP4K1 OriGene untagged cDNA clones in CMV expression vector (see all 4): MAP4K1 OriGene 3'-UTR Clone (see all 2): MAP4K1 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for MAP4K1

Primers:		OriGene genome-wide validated SYBR primer pairs: MAP4K1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for MAP4K1: PPH01788A

REFSEQ mRNAs for MAP4K1 gene (2 alternative transcripts):

NM_001042600.1 NM_007181.4

Additional cDNA sequence:

AK303267.1 CR590852.1 CR597185.1 CR599547.1 U66464.1

10 DOTS entries:

DT.100748776 DT.99993411 DT.97785383 DT.100720540 DT.97843110 DT.100748775 DT.40117714 DT.97825790

DT.121471144 DT.97792486

24/115 AceView cDNA sequences (see all 115):

BQ073002 CR590852 CR599547 AW575048 T50313 BQ437081 BM665397 BG389576

CR597185 AA749288 BQ430312 AL560823 BM479454 AL561215 AW408358 BQ064376

BM693263 BX345201 CD623848 BG397984 BQ639344 BG397271 BQ441919 AL582504

highest scoring ESTs for MAP4K1:

U66464 AA213920 BI518900 BI772412 AA251722 AA278218 AL560823 AL561618 AW403057 AW403902

Unigene Cluster for MAP4K1:

Mitogen-activated protein kinase kinase kinase kinase 1

Hs.95424 [show with all ESTs]

Unigene Representative Sequence: NM_007181

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MAP4K1 (see all 6)

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15	^	16	^	17
SP1:									-		-						-
SP2:																	-
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for MAP4K1
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000396857(uc002oiw.1 uc002oix.1 uc002oiy.1) ENST00000221409

ENST00000423454(uc010xug.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

MAP4K1 expression in normal and diseased human tissues

¹ / ² / ³

7 probe-sets matching MAP4K1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
138_at²^{, 3}	U95-A	1	0.81	1.00	1.00	1.00	U66464	1.00	1.00	1.00	1
214339_s_at²^{, 3}	U133-A	1	0.73	1.00	--	--	AA744529	0.40	1.00	0.76	1
214219_x_at²^{, 3}	U133-A	1	0.64	1.00	--	--	BE646618	0.20	1.00	0.72	1
206296_x_at²^{, 3}	U133-A	1	0.64	1.00	--	--	NM_007181	0.60	1.00	0.82	1
214339_s_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--
214219_x_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--
206296_x_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--

About this table

MAP4K1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

MAP4K1 gene electronic northern expression

About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.95424

Expression variation in blood from EXPOLDB for MAP4K1

UniProtKB/Swiss-Prot: M4K1_HUMAN, Q92918

Tissue specificity: Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also

expressed at very low levels in lung, kidney, mammary glands and small intestine

Primers:		OriGene genome-wide validated SYBR primer pairs: MAP4K1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for MAP4K1: PPH01788A

SABiosciences Expression via Pathway-Focused PCR Arrays including MAP4K1: PAHS-054A PAHS-061A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MAP4K1 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MAP4K1¹	--	mitogen-activated protein kinase kinase kinase kinase more	90.16(n) 93.29(a)	484527 XM_862399.1 XP_867492.1
cow (Bos taurus)	MAP4K1¹	--	mitogen-activated protein kinase kinase kinase kinase more	91.25(n) 96.21(a)	522002 NM_001075825.1 NP_001069293.1
rat (Rattus norvegicus)	Map4k1¹	--	mitogen activated protein kinase kinase kinase kinase more	85.27(n) 87.67(a)	292763 XM_214883.4 XP_214883.3
mouse (Mus musculus)	Map4k1^{1 , 5}	7 (16.94 cM)⁵	mitogen-activated protein kinase kinase kinase kinase more^{1, 5}	84.7(n)¹ 86.45(a)¹	26411¹ NM_008279.2¹ NP_032305.2¹ AK143215⁵ AK146273⁵ (see all 9)
fruit fly (Drosophila melanogaster)	CG7097³	56C1--4	protein amino acid phosphorylation receptor signaling more	52(a)	--

About this table Species with no ortholog for MAP4K1

ENSEMBL Gene Tree for MAP4K1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MAP4K1 gene

MAP4K5² MAP4K3² STK10² MAP4K2² SLK²

MAP4K1 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs750437^1,2	C,F,A,	39104450(-)	`CCCCGG/AGATCC`	1	--	int¹		7		EA NA NS	680
rs750438^1,2	C,F,A,	39104375(-)	`GTGTCG/TCTTGA`	1	--	int¹		12		NA EA MN NS WA	1054
rs1978443^1,2	C,F,A,	39091033(-)	`ACAGTT/CGGGCA`	1	--	int¹		15		NS EA NA WA	1050
rs1978444^1,2	C,A,	39091029(-)	`TTGGGC/GAGAGA`	1	--	int¹		6		MN NS EA WA	644
rs2080987^1,2	C,	39081987(-)	`ttcatC/Tatggt`	1	--	int¹		0	--	--	--	--
rs2098657^1,2	C,A	39092610(-)	`caaaaC/Gtccat`	1	--	int¹		0	--	--	--	--
rs2098658^1,2	C	39081956(-)	`cttgaA/Cctcag`	1	--	int¹		0	--	--	--	--
rs2287731^1,2	C,F,	39101879(-)	`TGGTAC/TGAGAG`	1	--	int¹		8		NS EA NA WA	626
rs2287732^1,2	C,F,A,	39101870(-)	`AGAGTA/GACAGG`	1	--	int¹		11		NS EA NA WA	630
rs2287733^1,2	C,F,A,	39101669(-)	`CAAGAT/CCCTCA`	1	--	int¹		17		EA NA NS WA	2238

About this table

HapMap Linkage Disequilibrium images for MAP4K1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MAP4K1: --

QIAGEN SeqTarget long-range PCR primers for resequencing MAP4K1

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MAP4K1 for disorders About GeneDecksing

OMIM: 601983

1 Novoseek disease relationship for MAP4K1 gene

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	2	19141650 (2)

About this table

Export disorders and mutations for MAP4K1 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/52 PubMed articles for MAP4K1 gene, integrated from 7 sources (see all 52):
(articles sorted by number of sources associating them with MAP4K1)

Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. (PubMed id 8824585)^{1, 2, 3, 7} Hu M.C.-T.... Tan T.-H. (1996)
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)^{1, 2} Wissing J.... Daub H. (2007)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{1, 2} Beausoleil S.A....Gygi S.P. (2004)
Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase. (PubMed id 9891069)^{1, 7} Ling P....Tan T.H. (1999)
Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1. (PubMed id 15364934)^{1, 7} Zhou G....Tan T.H. (2004)
Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling. (PubMed id 11279207)^{1, 7} Ling P....Tan T.H. (2001)
Proteasome-mediated degradation and functions of hematopoietic progenitor kinase 1 in pancreatic cancer. (PubMed id 19141650)^{1, 7} Wang H....Wang H. (2009)
Caspase-mediated cleavage and functional changes of hematopoietic progenitor kinase 1 (HPK1). (PubMed id 10602493)^{1, 7} Chen Y.R....Tan T.H. (1999)
Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase D1. (PubMed id 15743830)^{1, 7} Arnold R....Kiefer F. (2005)
Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes. (PubMed id 11313918)^{1, 7} Ma W....Liu M. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 11184	HGNC: 6863	AceView: MAP4K1	Ensembl:ENSG00000104814	euGenes: HUgn11184
ECgene: MAP4K1	Kegg: 11184	H-InvDB: MAP4K1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for MAP4K1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for MAP4K1 gene:
Search GeneIP for patents involving MAP4K1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	Millipore Custom Antibody & Bulk Services
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Antibodies & Assays for MAP4K1 (HPK1)

	Regulatory tfbs in MAP4K1 promoter
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ELISAs and CLIAs for MAP4K1

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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