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MAPKAP1 Gene

protein-coding   GIFtS: 53

GC09M097812
mitogen-activated protein kinase associated protein 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for MAPKAP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
mitogen-activated protein kinase associated protein 11 2     target of rapamycin complex 2 subunit MAPKAP12
MIP11 2 3     stress-activated map kinase interacting protein 12
SIN11 2 3     SIN1b2
MGC27451 2     OTTHUMP000000221372
Stress-activated map kinase-interacting protein 12 3     OTTHUMP000000221412
Mitogen-activated protein kinase 2-associated protein 12 3     MEKK2-interacting protein 12
mSIN12 3     SIN1g2
TORC2 subunit MAPKAP12 3     JC3102
SAPK-interacting protein 12 3     stress-activated protein kinase-interacting 12
ras inhibitor MGC27452     

External Ids:    HGNC: 187521   Entrez Gene: 791092   Ensembl: ENSG000001194877   UniProtKB: Q9BPZ73   

Export aliases for MAPKAP1 gene to outside databases

Previous GC identifers: GC09M119314 GC09M119846 GC09M121653 GC09M123576 GC09M125280 GC09M127239 GC09M128199


Summaries
for MAPKAP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAPKAP1:
This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase.
Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation
sites as well as alternate 3' UTRs have been identified for transcripts of this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: SIN1_HUMAN, Q9BPZ7
Function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is
activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function
upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine
nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a
critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of
AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at
'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for
complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and
autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and
ATF2-mediated transcription

Gene Wiki entry for MAPKAP1

Genomic Views
for MAPKAP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAPKAP1 gene promoter:
         Egr-1   STAT1beta   STAT1alpha   STAT1   AP-1   c-Jun   c-Fos   PPAR-gamma1   PPAR-gamma2   p53   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for MAPKAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MAPKAP1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q34.11

MAPKAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPKAP1 gene location

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M097812:  view genomic region     (about GC identifiers)

Start:
 97,812,310 bp from pter
End:
 98,082,113 bp from pter
Size:
 269,804 bases
Orientation:
 minus strand

1 alternative location:
Chr9- 128,199,672-128,469,513     
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  

Proteins
for MAPKAP1 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: SIN1_HUMAN, Q9BPZ7 (See protein sequence)
Recommended Name: Target of rapamycin complex 2 subunit MAPKAP1  
Size: 522 amino acids; 59123 Da
Subunit: Interacts with IFNAR2 (By similarity). All isoforms except isoform 4 can be incorporated into the mammalian
target of rapamycin complex 2 (mTORC2) which contains FRAP1, LST8, PRR5, RICTOR and MAPKAP1. Contrary to mTORC1,
mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts with ATF2, MAP3K2 and MAPK8. Interacts
with GTP-bound HRAS and KRAS
Subcellular location: Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus
Secondary accessions: A8K1Z5 B1AMA4 B7Z309 Q00426 Q5JSV5 Q5JSV6 Q5JSV9 Q658R0 Q699U1 Q699U2 Q699U3
Q699U4 Q6GVJ0 Q6GVJ1 Q6GVJ2
Alternative splicing: 6 isoforms:  Q9BPZ7-1   Q9BPZ7-2   Q9BPZ7-3   Q9BPZ7-4   Q9BPZ7-5   Q9BPZ7-6   

Explore the universe of human proteins at neXtProt for MAPKAP1: NX_Q9BPZ7 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (6 alternative transcripts): 
    NP_001006618.1  NP_001006619.1  NP_001006620.1  NP_001006621.1  NP_001006622.1  NP_077022.1  


    ENSEMBL proteins: 
    ENSP00000408359 ENSP00000417766 ENSP00000377624 ENSP00000377627 ENSP00000362604 ENSP00000362597 
    ENSP00000265961 ENSP00000412485 ENSP00000362602 ENSP00000390024 ENSP00000362596 ENSP00000265960 
    ENSP00000400182 ENSP00000362610 ENSP00000377621 ENSP00000418607 ENSP00000362595 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 2): MAPKAP1
    GenScript Custom Purified and Recombinant Proteins Services for MAPKAP1 
    Novus Biologicals Proteins for MAPKAP1
    Novus Biologicals Lysate for MAPKAP1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005829 cytosol EXP15718470
    GO:0005886 plasma membrane IEA--
    GO:0016023 cytoplasmic membrane-bounded vesicle IEA--
    About this table

    MAPKAP1 for ontologies           About GeneDecksing



    Antibodies for MAPKAP1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for MAPKAP1
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 2): MAPKAP1
    GenScript Custom Superior Antibodies Services for MAPKAP1 
    Novus Biologicals Antibodies for MAPKAP1
    Browse antibodies at Epitomics

    Assays for MAPKAP1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAPKAP1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MAPKAP1 

    Protein Domains/
    Families
    for MAPKAP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAPKAP1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR008828 SIN1

    Graphical View of Domain Structure for InterPro Entry Q9BPZ7

    ProtoNet protein and cluster: Q9BPZ7

    1 Blocks protein family: IPB008828 Stress-activated map kinase interacting 1

    UniProtKB/Swiss-Prot: SIN1_HUMAN, Q9BPZ7
    Similarity: Belongs to the SIN1 family


    Gene Function
    for MAPKAP1 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: SIN1_HUMAN, Q9BPZ7
    Function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is
    activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function
    upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine
    nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a
    critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of
    AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at
    'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for
    complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and
    autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and
    ATF2-mediated transcription

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for MAPKAP1
    Sigma-Aldrich shRNA for MAPKAP1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 6): MAPKAP1
    OriGene shRNA RFP (see all 6): MAPKAP1
    OriGene basic RS shRNA (see all 6): MAPKAP1
    OriGene siRNA (see all 6): MAPKAP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MAPKAP1 
    miRNA:Sigma-Aldrich microRNA Mimics for MAPKAP1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MAPKAP1 
    7 SABiosciences Assays for microRNAs that regulate MAPKAP1:
    hsa-miR-607 hsa-miR-513b hsa-miR-1276 hsa-miR-539 hsa-miR-1236 hsa-miR-1826 hsa-miR-7

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): MAPKAP1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): MAPKAP1
    OriGene untagged cDNA clones in CMV expression vector (see all 6): MAPKAP1
    OriGene 3'-UTR clone (see all 6): MAPKAP1 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 6): MAPKAP1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for MAPKAP1 

    1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017016 Ras GTPase binding NAS1849280
    About this table

    MAPKAP1 for ontologies           About GeneDecksing

    Animal Models: 2 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Mapkap1):

    cellularlethality-prenatal/perinatal

    MAPKAP1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAPKAP1 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    MAPKAP1 for pathways           About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  MAPKAP1
        mTOR Signaling

        SABiosciences Pathway-Focused PCR Array including MAPKAP1: PAHS-098A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for MAPKAP1
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAPKAP1

    5/10 Interacting proteins for MAPKAP1 (ENSP000003625973 Q9BPZ72) via UniProtKB, MINT, and/or STRING (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RICTORQ6R3272STRING: ENSP00000349959 MINT-7556061 MINT-6948596 MINT-7556024 MINT-6948610 MINT-7556076
    MTORP423452MINT-7556061 MINT-6948596 MINT-7556024 MINT-6948610 MINT-7556076
    STK38Q152082MINT-7556061 MINT-7556024 MINT-7556076
    CDC42EP1Q005872MINT-67645
    RPTORQ8N1222MINT-7556024
    About this table

    5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006950 response to stress IEA--
    GO:0008150 biological_process ND--
    GO:0023034 intracellular signaling pathway TAS--
    GO:0031295 T cell costimulation TAS--
    GO:0048011 nerve growth factor receptor signaling pathway TAS--
    About this table

    MAPKAP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAPKAP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    MAPKAP1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAPKAP1
    2 Novoseek chemical compound relationships for MAPKAP1 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sin-1 87.9 32 17303383 (7), 18687895 (7), 15363842 (2)
    rantes 62.5 1 10940894 (1)
    About this table



    Transcripts
    for MAPKAP1 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for MAPKAP1
    Sigma-Aldrich shRNA for MAPKAP1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 6): MAPKAP1
    OriGene shRNA RFP (see all 6): MAPKAP1
    OriGene basic RS shRNA (see all 6): MAPKAP1
    OriGene siRNA (see all 6): MAPKAP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MAPKAP1 
    miRNA: Sigma-Aldrich microRNA Mimics for MAPKAP1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MAPKAP1 
    7 SABiosciences Assays for microRNAs that regulate MAPKAP1:
    hsa-miR-607 hsa-miR-513b hsa-miR-1276 hsa-miR-539 hsa-miR-1236 hsa-miR-1826 hsa-miR-7
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): MAPKAP1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): MAPKAP1
    OriGene untagged cDNA clones in CMV expression vector (see all 6): MAPKAP1
    OriGene 3'-UTR Clone (see all 6): MAPKAP1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 6): MAPKAP1 
    Primers: OriGene genome-wide validated SYBR primer pairs: MAPKAP1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for MAPKAP1: PPH16946A

    REFSEQ mRNAs for MAPKAP1 gene (6 alternative transcripts): 

    NM_001006617.1  NM_001006618.1  NM_001006619.1  NM_001006620.1  NM_001006621.1  NM_024117.3  

    Additional cDNA sequence: 

    AK290060.1 AK295364.1 AK298841.1 AK309507.1 AK310361.1 AK316149.1 AL833042.1 AY425957.1 
    AY524429.1 AY524430.1 AY524431.1 AY524432.1 AY633624.1 AY633625.1 AY633626.1 BC002326.2 
    BC003044.1 BC035236.1 M37191.1 

    24 DOTS entries:

    DT.452044  DT.95263279  DT.97787260  DT.100823123  DT.92444889  DT.121146878  DT.100823130  DT.100823131 
    DT.121146949  DT.97862546  DT.100823129  DT.100753399  DT.100823125  DT.101984665  DT.121146985  DT.99942775 
    DT.206813  DT.92444870  DT.95226049  DT.121146914  DT.91747111  DT.92444866  DT.92444879  DT.121146900 

    24/478 AceView cDNA sequences (see all 478):

    CB988955 CA312318 AW852183 BC035236 AW014028 BM142305 BM800437 AY524429 
    BQ635959 AW377520 BE257458 AY524430 BU630149 BQ215660 AA319137 AA832463 
    BG750854 BF477085 BM825025 BM469959 AI289599 AA551023 AI277355 AI096749 

    highest scoring ESTs for MAPKAP1:

    AA341882 AA477022 AI416971 AL525506 AL558243 AW245710 AW246397 BE294429 BE295381 BE388918 

    Unigene Cluster for MAPKAP1:

    Mitogen-activated protein kinase associated protein 1
    Hs.495138  [show with all ESTs]
    Unigene Representative Sequence: NM_001006617


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MAPKAP1

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                                                                
    SP2:                                                        -     -                                 
    SP3:                                                        -     -     -                           
    SP4:                                                  -     -     -                                 

    About this scheme

    ECgene alternative splicing isoforms for MAPKAP1
    18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000427078 ENST00000496658 ENST00000468896 ENST00000394060(uc004bqa.2)
    ENST00000437973 ENST00000394063 ENST00000373505(uc004bpv.2 uc004bpw.2 uc004bpx.2 uc004bpy.2 uc004bpz.2 uc010mxa.2)
    ENST00000373498 ENST00000350766 ENST00000483937 ENST00000444226 ENST00000373503
    ENST00000433483 ENST00000473837(uc010mxb.1) ENST00000496063 ENST00000373497(uc011lzt.1 uc010mwz.2 uc011lzu.1 uc011lzv.1)
    ENST00000265960 ENST00000420643

    Expression
    for MAPKAP1 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    MAPKAP1 expression in normal and diseased human tissues

    1  / 2  / 3

    13 probe-sets matching MAPKAP1 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    59749_at2, 3 U95-C 1 1.00 1.00 0.65 1.13 AI478190 0.60 1.00 0.82 1
    1906_at2, 3 U95-A 1 1.00 1.00 0.86 0.85 HG511-HT511 0.20 1.00 0.72 1
    65919_at2, 3 U95-C 1 1.00 1.00 0.85 1.20 AI416971 0.80 1.00 0.91 1
    46231_at2, 3 U95-B 1 1.00 1.00 0.73 1.05 AA477022 0.80 1.00 0.91 1
    76321_at2, 3 U95-E 1 0.62 1.00 0.56 0.80 AA975642 0.60 1.00 0.82 1
    222426_at2, 3 U133-B 1 1.00 1.00 -- -- BG499947 0.40 1.00 0.76 1
    229846_s_at2, 3 U133-B 1 1.00 1.00 -- -- BF939919 0.40 1.00 0.76 1
    217808_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_024117 0.60 1.00 0.82 1
    229845_at2, 3 U133-B 1 0.55 1.00 -- -- BF939919 0.40 1.00 0.76 1
    222426_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    229846_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    217808_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    229845_at2 U133Plus2 1 0.55 1.00 -- -- -- -- -- -- --
    About this table

    MAPKAP1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    MAPKAP1 gene expression
    MAPKAP1 gene electronic northern expression
    MAPKAP1 gene sage expression
    About these images

    CGAP SAGE TAG: CTGATGAATT

    SOURCE GeneReport for Unigene cluster: Hs.495138

    UniProtKB/Swiss-Prot: SIN1_HUMAN, Q9BPZ7
    Tissue specificity: Ubiquitously expressed, with highest levels in heart and skeletal muscle

    Primers: OriGene genome-wide validated SYBR primer pairs: MAPKAP1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for MAPKAP1: PPH16946A
        SABiosciences Expression via Pathway-Focused PCR Array including MAPKAP1: PAHS-098A 


    Orthologs
    for MAPKAP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for MAPKAP1 gene from 5/11 species (see all 11)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 MAPKAP11   -- mitogen-activated protein kinase associated protein more 95.27(n)
    99.04(a)    		 480724  XM_858063.1  XP_863156.1 
    cow
    (Bos taurus)    		 MAPKAP11   -- mitogen-activated protein kinase associated protein more 95.06(n)
    99.38(a)    		 533861  XM_874263.2  XP_879356.2 
    rat
    (Rattus norvegicus)    		 Mapkap11   -- mitogen-activated protein kinase associated protein more 92.59(n)
    96.93(a)    		 296648  NM_001011964.1  NP_001011964.1 
    mouse
    (Mus musculus)    		 Mapkap11 , 5 2 (22.84 cM)5
    		 mitogen-activated protein kinase associated protein more1, 5 92.46(n)1
    97.13(a)1    		 2277431  NM_177345.31  NP_796319.11 
     AI5915295  AK0279325  (see all 19)
    chicken
    (Gallus gallus)    		 MAPKAP11   -- mitogen-activated protein kinase associated protein more 82.76(n)
    89.85(a)    		 395627  NM_204826.1  NP_990157.1 
    About this table        Species with no ortholog for MAPKAP1

    ENSEMBL Gene Tree for MAPKAP1 (if available)

    Paralogs
    for MAPKAP1 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    		  --

    Genomic Variants
    for MAPKAP1 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/2109 NCBI SNPs in MAPKAP1 are shown (see all 2109)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 9 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs11291,2
    		C,F,A,128199873(+) ACGCTC/TCTGTT 4 -- ut31 ese322Minor allele frequency- T:0.19MN NS EA NA 3198
    rs122021,2
    		C,F,A,128200299(-) AAGGGG/CCCACA 4 -- ut31 ese312Minor allele frequency- C:0.20MN EA NS NA WA 1862
    rs4716251,2
    		C,F,H,128350964(+) TGTTTT/CATCTG 5 -- int117Minor allele frequency- C:0.12NS EA NA WA 910
    rs4731371,2
    		--128290959(-) tagtaA/Gagatg 5 -- int10--------
    rs4734261,2
    		C,F,O,A,128406988(+) TATTGG/CAAACT 5 -- int113Minor allele frequency- C:0.41NS EA NA WA 700
    rs4735631,2
    		H128397556(+) GTTTGT/GGGCAC 5 -- int14Minor allele frequency- G:0.00NS EA 416
    rs4744891,2
    		C,F,O,A,H,128317881(-) CAGCAC/GTGTGT 5 -- int111Minor allele frequency- G:0.31NS EA WA NA 568
    rs4752451,2
    		C,H,128407158(+) TACATC/ATTAAC 5 -- int18Minor allele frequency- A:0.28NA WA 64
    rs4768191,2
    		C,F,A,128362737(-) TCTTAC/TCTCTA 5 -- int115Minor allele frequency- T:0.46NS EA NA WA 990
    rs4778131,2
    		C,F,A,128416874(+) TCATGT/CCTTAA 5 -- int113Minor allele frequency- C:0.43NS EA NA WA 706
    About this table

    HapMap Linkage Disequilibrium images for MAPKAP1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MAPKAP1: --

    QIAGEN SeqTarget long-range PCR primers for resequencing MAPKAP1 

    Disorders & Mutations
    for MAPKAP1 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAPKAP1 for disorders           About GeneDecksing

    OMIM: 610558

    2 Novoseek disease relationships for MAPKAP1 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 23.6 1 9042178 (1)
    tumors 0 1 9042178 (1)
    About this table

    Human Genome Epidemiology (HuGE) Navigator: MAPKAP1 (6 documents)

    Export disorders and mutations for MAPKAP1 gene to outside databases

    Medical News
    for MAPKAP1 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for MAPKAP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/42 PubMed articles for MAPKAP1 gene, integrated from 7 sources (see all 42):
    (articles sorted by number of sources associating them with MAPKAP1)
    1. Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene. (PubMed id 15363842)1, 2, 3, 7 Schroder W.... Sculley T. (2004)
    2. Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling. (PubMed id 17303383)1, 2, 7 Schroder W.A.... Bushell G. (2007)
    3. Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation. (PubMed id 15988011)1, 2, 7 Cheng J.... Su B. (2005)
    4. Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway. (PubMed id 17054722)1, 2 Makino C.... Ishii S. (2006)
    5. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. (PubMed id 16962653)1, 2 Jacinto E....Su B. (2006)
    6. Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. (PubMed id 17043309)1, 2 Yang Q....Guan K.L. (2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. (PubMed id 16919458)1, 2 Frias M.A.... Sabatini D.M. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae. (PubMed id 1849280)1, 2 Colicelli J....Wigler M. (1991)

    External Searches for MAPKAP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing MAPKAP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79109 HGNC: 18752 AceView: MAPKAP1 Ensembl:ENSG00000119487 euGenes: HUgn79109
    ECgene: MAPKAP1 H-InvDB: MAPKAP1

    Other Databases showing MAPKAP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAPKAP1 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for MAPKAP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for MAPKAP1 gene:
    Search GeneIP for patents involving MAPKAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for MAPKAP1 gene

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    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

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     ELISAs and CLIAs for MAPKAP1
           

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