Home
GeneCards Guide
Suite
- GeneALaCart
- GeneDecks
- GeneIP
- GeneNote
- GeneAnnot
- GeneLoc
- GeneTide
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

MAPT Gene

protein-coding GIFtS: 74

GC17P039635

microtubule-associated protein tau
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: DDPAC, MAPTL)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
microtubule-associated protein tau¹ ²		PPND¹ ²
MTBT1¹ ² ³ ⁵		Neurofibrillary tangle protein² ³
TAU¹ ² ³		Paired helical filament-tau² ³
MSTD¹ ² ⁵		MAPTL² ³
MTBT2¹ ²		PHF-tau² ³
FTDP-17¹ ²		DDPAC² ⁵
FLJ31424¹ ²		tau¹
MGC138549¹ ²		G protein beta1/gamma2 subunit-interacting factor 1²

External Ids:	HGNC: 6893¹	Entrez Gene: 4137²	Ensembl: ENSG00000186868⁷	UniProtKB: P10636³

Export aliases for MAPT gene to outside databases

Previous GC identifers: GC17P043566 GC17P046217 GC17P043982 GC17P044447 GC17P041327

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAPT:

This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated

alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the

nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated

with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia,

cortico-basal degeneration and progressive supranuclear palsy. (provided by RefSeq)

UniProtKB/Swiss-Prot: TAU_HUMAN, P10636

Function: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of

neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane

components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau

localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow

plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization

Gene Wiki entry for MAPT (Tau protein)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MAPT gene promoter:
         CREB   STAT1   STAT1beta   STAT1alpha   deltaCREB   HNF-4alpha2   PPAR-gamma2   PPAR-gamma1   RFX1   ATF-2
         Other transcription factors

Search SABiosciences Chromatin IP Primers for MAPT

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MAPT

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.1 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21

MAPT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAPT gene location

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P039635: view genomic region (about GC identifiers)

Start:	39,635,406 bp from pter
End:	39,768,427 bp from pter
Size:	133,022 bases
Orientation:	plus strand

1 alternative location:

Chr17-,ALT_REF_LOCI_9 44,071,113-44,212,878

RefSeq DNA sequence:

NC_000017.10 NT_010783.15 NT_167251.1

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: TAU_HUMAN, P10636 (See protein sequence)

Recommended Name: Microtubule-associated protein tau

Size: 758 amino acids; 78878 Da

Subunit: Interacts with PSMC2 through SQSTM1 (By similarity). Interacts with SQSTM1 when polyubiquitinated. Interacts

with FKBP4 (By similarity)

Subcellular location: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm,

cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association with

plasma membrane components

Developmental stage: Four-repeat (type II) tau is expressed in an adult-specific manner and is not found in fetal

brain, whereas three-repeat (type I) tau is found in both adult and fetal brain

PDB structure from and Proteopedia :

1I8H (3D)

3FQP (3D)

Secondary accessions: P18518 Q14799 Q15549 Q15550 Q15551 Q1RMF6 Q53YB1 Q5CZI7 Q5XWF0 Q6QT54 Q9UDJ3

Q9UMH0 Q9UQ96

Alternative splicing: 9 isoforms: P10636-1 P10636-2 P10636-3 P10636-4 P10636-5 P10636-6 P10636-7 P10636-8

P10636-9 (Additional isoforms seem to exist. Isoforms differ from each other by the presence or absence of up to 5 of the 15 exons. One of these optional exons contains the additional tau/MAP repeat)

Explore the universe of human proteins at neXtProt for MAPT: NX_P10636

Post-translational modifications:

Phosphorylation at serine and threonine residues in S-P or T-P motifs by proline-directed protein kinases (PDPK: CDK1,

CDK5, GSK-3, MAPK) (only 2-3 sites per protein in interphase, seven-fold increase in mitosis, and in PHF-tau), and at

serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK) in Alzheimer diseased brains.

Phosphorylation decreases with age. Phosphorylation within tau's repeat domain or in flanking regions seems to reduce

tau's interaction with, respectively, microtubules or plasma membrane components. Phosphorylation on Ser-610, Ser-622,

Ser-641 and Ser-673 in several isoforms during mitosis¹

Polyubiquitinated. Requires functional TRAF6 and may provoke SQSTM1-dependent degradation by the proteasome (By

similarity). PHF-tau can be modified by three different forms of polyubiquitination. 'Lys-48'-linked

polyubiquitination is the major form, 'Lys-6'-linked and 'Lys-11'-linked polyubiquitination also occur¹

Glycation of PHF-tau, but not normal brain tau. Glycation is a non-enzymatic post-translational modification that

involves a covalent linkage between a sugar and an amino group of a protein molecule forming ketoamine. Subsequent

oxidation, fragmentation and/or cross-linking of ketoamine leads to the production of advanced glycation endproducts

(AGES). Glycation may play a role in stabilizing PHF aggregation leading to tangle formation in AD¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (6 alternative transcripts):

NP_001116538.2 NP_001116539.1 NP_005901.2 NP_058518.1 NP_058519.3 NP_058525.1

ENSEMBL proteins:

ENSP00000340820 ENSP00000303214 ENSP00000346287 ENSP00000262410 ENSP00000340438 ENSP00000302706

ENSP00000334886 ENSP00000413056

Human Recombinant Proteins

	Millipore Purified and/or Recombinant MAPT Protein
	Sigma-Aldrich Proteins and AQUA Peptides for MAPT
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for MAPT
	OriGene Purified Proteins (see all 3): MAPT OriGene Protein Over-expression Lysate (see all 3): MAPT
	GenScript Custom Purified and Recombinant Proteins Services for MAPT
	Novus Biologicals Proteins for MAPT
	Novus Biologicals Lysates for MAPT
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

5/11 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 11):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	EXP	10899937
GO:0005856	cytoskeleton	IEA	--
GO:0005874	microtubule	IEA	--
GO:0005875	microtubule associated complex	TAS	10747907

About this table

MAPT for ontologies About GeneDecksing

Antibodies for MAPT:

	Millipore Mono- and Polyclonal Antibodies for the study of MAPT
	Sigma-Aldrich Antibody Arrays and Antibodies for MAPT
	R&D Systems Antibodies for MAPT (Tau)
	Cell Signaling Technology (CST) Antibodies for MAPT (Tau)
	OriGene Antibodies (see all 13): MAPT
	GenScript Custom Superior Antibodies Services for MAPT
	Novus Biologicals Antibodies for MAPT
	Epitomics antibodies for MAPT

Assays for MAPT:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MAPT
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MAPT

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MAPT for domains About GeneDecksing

3 InterPro domains/families:

IPR002955 Tau_protein

IPR001084 Tau_tubulin-bd

IPR015562 Map_tau

Graphical View of Domain Structure for InterPro Entry P10636

ProtoNet protein and cluster: P10636

2 Blocks protein families:

IPB001084 Tubulin-binding Tau protein

IPB002955 Tau protein signature

UniProtKB/Swiss-Prot: TAU_HUMAN, P10636

Domain: The tau/MAP repeat binds to tubulin. Type I isoforms contain 3 repeats while type II isoforms contain 4 repeats

Similarity: Contains 4 Tau/MAP repeats

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: TAU_HUMAN, P10636

Function: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of

neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane

components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau

localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow

plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for MAPT Sigma-Aldrich shRNA Panels and shRNA for MAPT
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 7): MAPT OriGene shRNA RFP (see all 7): MAPT OriGene basic RS shRNA (see all 7): MAPT OriGene siRNA (see all 7): MAPT
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MAPT

miRNA:		Sigma-Aldrich microRNA Mimics for MAPT Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MAPT
		6 SABiosciences Assays for microRNAs that regulate MAPT:
		hsa-miR-579 hsa-miR-361-3p hsa-miR-657 hsa-miR-532-3p hsa-miR-1308 hsa-miR-1324

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): MAPT OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): MAPT OriGene untagged cDNA clones in CMV expression vector (see all 7): MAPT OriGene 3'-UTR clone (see all 6): MAPT Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for MAPT
		Sino Biological Human cDNA Clone for MAPT

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for MAPT

Genatlas biochemistry entry for MAPT:

microtubule (beta) associated protein tau 1,primary component of paired helical filaments with six alternatively

spliced forms in normal adult brain,regulating the transport of vesicles or organelles along

microtubules,phosphorylated by CDK5 and other kinases with decrease of affinity for microtubules,forming tangles of

paired helical filaments (PHF) consisting of hyperphosphorylated tau protein observed in Alzheimer disease (triplet

PHF-tau),overexpressed in extraskeletal myxoid chondrosarcoma and chordoma

5/9 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 9):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005200	structural constituent of cytoskeleton	TAS	2498079
GO:0005515	protein binding	IPI	16446437
GO:0008017	microtubule binding	IDA	1918161
GO:0008034	lipoprotein binding	--	--
GO:0017124	SH3 domain binding	IPI	9763511

About this table

MAPT for ontologies About GeneDecksing

Animal Models: 12 MGI mutant phenotypes (inferred from 16 alleles) (MGI details for Mapt):

behavior/neurological	cellular	growth/size	lethality-postnatal	life span-post-weaning/aging
muscle	nervous system	no phenotypic analysis	normal	other
skin/coat/nails	vision/eye

MAPT for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

MAPT for pathways About GeneDecksing

4 Millipore Pathways for MAPT

	Neurophysiological process Receptor-mediated axon growth repulsion
	Cytoskeleton remodeling Slit-Robo signaling
	Cytoplasmic microtubules
	Cytoskeleton remodeling Reverse signaling by ephrin B

5/6 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for MAPT (see all 6)

	CDK5 Signaling
	14-3-3-mediated Signaling
	p70S6K Signaling
	Amyloid Processing
	Reelin Signaling in Neurons

1 Cell Signaling Technology (CST) Pathway for MAPT

SAPK/JNK Signaling Cascades

2 Kegg Pathways (Kegg details for MAPT):

	hsa04010 MAPK signaling pathway
	hsa05010 Alzheimer's disease

SABiosciences Pathway-Focused PCR Arrays including MAPT: PAHS-057A PAHS-088A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for MAPT

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MAPT

5/56 Interacting proteins for MAPT (ENSP00000340820³ P10636^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 56)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GSK3A	P49840¹	STRING: ENSP00000222330 EBI-366182,EBI-1044067
STUB1	Q9UNE7¹	STRING: ENSP00000219548 EBI-366182,EBI-357085
AATF	Q9NY61²	STRING: ENSP00000225402 MINT-49642 MINT-49641
FYN	P06241²	STRING: ENSP00000357656 MINT-7212444 MINT-7212427
GSK3B	P49841²	STRING: ENSP00000324806 MINT-3974171 MINT-3974216

About this table

5/10 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 10):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000226	microtubule cytoskeleton organization	IDA	1057175
GO:0006915	apoptosis	TAS	--
GO:0006921	cellular component disassembly involved in apoptosis	TAS	--
GO:0007026	negative regulation of microtubule depolymerization	IEA	--
GO:0021987	cerebral cortex development	IMP	--

About this table

MAPT for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

MAPT for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MAPT
10/103 Novoseek chemical compound relationships for MAPT gene (see all 103)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
glycogen	75.5	236	8809831 (5), 15075227 (4), 16951581 (3), 9666118 (3) (see all 99)
ammonium polyphosphate	65.8	7	8797796 (3), 16877359 (1), 9839715 (1)
thioflavine s	64.9	10	1759562 (2), 10446806 (1), 15814784 (1), 20448485 (1) (see all 7)
okadaic acid	61.2	87	8494335 (4), 7723735 (4), 8414191 (3), 7693894 (3) (see all 39)
thioflavin	60.7	6	19266322 (2), 17082178 (1), 14975751 (1)
map4	59.4	9	15642108 (2), 1905296 (1), 7854050 (1), 9144194 (1) (see all 8)
threonine	49.9	32	15913839 (2), 17362433 (1), 9736660 (1), 11078890 (1) (see all 22)
silver	47.4	29	9708963 (2), 10768809 (2), 7692696 (1), 7521944 (1) (see all 21)
serine	44.9	49	8486651 (3), 9079670 (2), 9199504 (2), 15913839 (2) (see all 33)
maltolate	39.4	1	9401741 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for MAPT Sigma-Aldrich shRNA Panels and shRNA for MAPT
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 7): MAPT OriGene shRNA RFP (see all 7): MAPT OriGene basic RS shRNA (see all 7): MAPT OriGene siRNA (see all 7): MAPT
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MAPT

miRNA:		Sigma-Aldrich microRNA Mimics for MAPT Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MAPT
		6 SABiosciences Assays for microRNAs that regulate MAPT:
		hsa-miR-579 hsa-miR-361-3p hsa-miR-657 hsa-miR-532-3p hsa-miR-1308 hsa-miR-1324

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): MAPT OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): MAPT OriGene untagged cDNA clones in CMV expression vector (see all 7): MAPT OriGene 3'-UTR Clone (see all 6): MAPT Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for MAPT

Primers:		OriGene genome-wide validated SYBR primer pairs: MAPT Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for MAPT: PPH05972A

REFSEQ mRNAs for MAPT gene (6 alternative transcripts):

NM_001123066.3 NM_001123067.3 NM_005910.5 NM_016834.4 NM_016835.4 NM_016841.4

Additional cDNA sequence:

AB073354.1 AF456477.1 AK055986.1 AK095802.1 AK299658.1 AK299704.1 AY526356.1 AY730549.1

BC000558.2 BC032572.1 BC040444.1 BC061892.1 BC071830.1 BC094805.1 BC098281.1 BC099721.1

BC101936.1 BC114504.1 BC114948.1 BT006772.1 CR599561.1 CR623207.1 J03778.1 X14474.1

20 DOTS entries:

DT.100836823 DT.415460 DT.97813963 DT.100836827 DT.100000370 DT.100836820 DT.91775673 DT.100836816

DT.100836818 DT.75182379 DT.91775685 DT.100836817 DT.100836831 DT.95166690 DT.95166953 DT.95193501

DT.75102946 DT.91775667 DT.95166983 DT.95176899

24/343 AceView cDNA sequences (see all 343):

BM668364 AA687444 CF455771 BU902265 BU500730 AW250075 F21582 BM714680

AI650263 BX420493 AI650254 AA338920 AA223656 AI363314 F07063 AA323145

AA323128 BM927039 BM714407 BC040444 AI365507 AI276210 BC032572 M25298

highest scoring ESTs for MAPT:

J03778 X14474 AA001000 AA001560 AA016081 AA017000 AA018628 AA018724 AA019126 AA019127

Unigene Cluster for MAPT:

Microtubule-associated protein tau

Hs.101174 [show with all ESTs]

Unigene Representative Sequence: NM_001123066

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MAPT (see all 7)

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15a	·	15b
SP1:													-
SP2:									-				-		-		-				-				-
SP3:							-		-				-		-		-				-				-
SP4:							-		-				-		-		-				-				-				-
SP5:									-		-		-		-		-				-				-				-

About this scheme

ECgene alternative splicing isoforms for MAPT
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000344290(uc010dau.2 uc002ijr.3 uc002ijs.3 uc002ijx.3 uc002ijt.3 uc002iju.3 uc002ijv.3)

ENST00000351559 ENST00000354326 ENST00000262410 ENST00000340799 ENST00000347967

ENST00000334239 ENST00000420682

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

MAPT expression in normal and diseased human tissues

¹ / ² / ³

18 probe-sets matching MAPT gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
80210_at²^{, 3}	U95-E	1	1.00	1.00	0.90	1.81	W23141	0.60	1.00	0.82	1
113_i_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.60	X14474	1.00	0.90	0.95	1
310_s_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.56	J03778	1.00	0.90	0.95	1
114_r_at²^{, 3}	U95-A	1	1.00	1.00	-0.05	0.12	X14474	1.00	0.90	0.95	1
38629_at²^{, 3}	U95-A	1	0.94	1.00	0.73	1.30	J03778	1.00	0.90	0.95	1
331_at²^{, 3}	U95-A	1	0.75	1.00	0.57	1.00	HG2566-HT4867	0.20	1.00	0.72	1
203929_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI056359	0.80	1.00	0.91	1
225379_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA199717	0.80	1.00	0.91	1
206401_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	J03778	1.00	0.90	0.95	1
203928_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI870749	0.80	1.00	0.91	1
203930_s_at²^{, 3}	U133-A	1	0.91	1.00	--	--	NM_016835	0.60	1.00	0.82	1
233117_at*²^{, 3}	U133-B	1	0.46	1.00	--	--	AU158686	0.40	1.00	0.76	1
203929_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
225379_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206401_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203928_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203930_s_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--
233117_at*²	U133Plus2	1	0.46	1.00	--	--	--	--	--	--	--

About this table

MAPT for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

MAPT gene electronic northern expression

About these images

CGAP SAGE TAG: AAATCATCTT

SOURCE GeneReport for Unigene cluster: Hs.101174

Expression variation in blood from EXPOLDB for MAPT

UniProtKB/Swiss-Prot: TAU_HUMAN, P10636

Tissue specificity: Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the

others are expressed in the central nervous system

Primers:		OriGene genome-wide validated SYBR primer pairs: MAPT Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for MAPT: PPH05972A

SABiosciences Expression via Pathway-Focused PCR Arrays including MAPT: PAHS-057A PAHS-088A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MAPT gene from 5/7 species (see all 7)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MAPT¹	--	microtubule-associated protein tau	86.49(n) 83.97(a)	480488 XM_844939.1 XP_850032.1
chimpanzee (Pan troglodytes)	MAPT¹	--	microtubule-associated protein tau	99.47(n) 99.34(a)	450177 NM_001009068.1 NP_001009068.1
mouse (Mus musculus)	Mapt⁵	11 (67.79 cM)	microtubule-associated protein tau	--	Z12133
zebrafish (Danio rerio)	BI981282.1²	--	--	74.26(n)	BI981282.1
worm (Caenorhabditis elegans)	ptl-1¹	--	Protein with Tau-Like repeats	42.19(n) 29.69(a)	175230 NM_001027407.2 NP_001022578.1

About this table Species with no ortholog for MAPT

ENSEMBL Gene Tree for MAPT (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MAPT gene

MAP4² MAP2²

MAPT for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs7521^1,2	C,F,A	44105395(+)	`CCTGCG/AGCTTC`	12	--	ut3¹ ese³		11		MN NS EA NA WA	972
rs7687^1,2	C,F	44103296(+)	`TCTTTT/CCCCCC`	12	--	ut3¹ ese³ trp³		12		MN NA NS EA	940
rs8712^1,2	C	44101871(+)	`GAGGGA/GGAAGG`	12	--	ut3¹ trp³		7		MN EA NS NA	662
rs9468^1,2	C,F,O,A	44101563(+)	`ATAATT/CGTGGA`	12	--	ut3¹		12		MN NS EA NA	938
rs171425^1,2	--	44019086(+)	`tgcctG/Tccttc`	6	--	int¹ trp³		0	--	--	--	--
rs171426^1,2	C,A,H	44019086(+)	`TTCCTG/TCCTTC`	6	--	int¹		0	--	--	--	--
rs190266^1,2	--	44019061(+)	`ttcccC/Tccttc`	6	--	int¹ trp³		0	--	--	--	--
rs242554^1,2	C,A	44039365(+)	`CGATCC/TCCTGA`	6	--	int¹		5		NA WA	10
rs242555^1,2	F	43991514(+)	`aaaaaA/Tttaat`	6	--	int¹		0	--	--	--	--
rs242556^1,2	C,F,O,A,H	44002250(+)	`CCAGAT/ATTTTC`	6	--	int¹ trp³		19		MN NA NS EA	1586

About this table

HapMap Linkage Disequilibrium images for MAPT (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 12 variations for MAPT
     9 CNVs: 2226 34480 34570 8850 4038 8848 2225 0801 8851
     2 Indels: 60234 40184
     1 Inversion: 37194

QIAGEN SeqTarget long-range PCR primers for resequencing MAPT

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MAPT for disorders About GeneDecksing

OMIM: 157140

UniProtKB/Swiss-Prot: TAU_HUMAN, P10636

Note=In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by

tangles of paired helical filaments (PHF) and straight filaments, mainly composed of hyperphosphorylated forms of TAU

(PHF-TAU or AD P-TAU)

Defects in MAPT are a cause of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP17)

[MIM:600274, 172700]; also called frontotemporal dementia (FTD), pallido-ponto-nigral degeneration (PPND) or

historically termed Pick complex. This form of frontotemporal dementia is characterized by presenile dementia with

behavioral changes, deterioration of cognitive capacities and loss of memory. In some cases, parkinsonian symptoms are

prominent. Neuropathological changes include frontotemporal atrophy often associated with atrophy of the basal

ganglia, substantia nigra, amygdala. In most cases, protein tau deposits are found in glial cells and/or neurons

Note=Defects in MAPT are a cause of corticobasal degeneration (CBD). It is marked by extrapyramidal signs and

apraxia and can be associated with memory loss. Neuropathologic features may overlap Alzheimer disease, progressive

supranuclear palsy, and Parkinson disease

Defects in MAPT are a cause of progressive supranuclear palsy type 1 (PSNP1) [MIM:601104, 260540]; also

abbreviated as PSP and also known as Steele-Richardson-Olszewski syndrome. PSNP1 is characterized by akinetic-rigid

syndrome, supranuclear gaze palsy, pyramidal tract dysfunction, pseudobulbar signs and cognitive capacities

deterioration. Neurofibrillary tangles and gliosis but no amyloid plaques are found in diseased brains. Most cases

appear to be sporadic, with a significant association with a common haplotype including the MAPT gene and the flanking

regions. Familial cases show an autosomal dominant pattern of transmission with incomplete penetrance; genetic

analysis of a few cases showed the occurrence of tau mutations, including a deletion of Asn-613

10/93 Novoseek disease relationships for MAPT gene (see all 93)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tauopathies	97.7	677	11810404 (5), 15814784 (5), 18346207 (5), 12435607 (5) (see all 99)
paired helical filament	97.6	517	18783251 (3), 1639844 (3), 9062894 (3), 7694533 (3) (see all 99)
neurofibrillary tangles	97.1	610	11932941 (4), 15056457 (3), 9686275 (3), 11786218 (3) (see all 99)
frontotemporal dementia	96	581	18591058 (4), 15376481 (4), 11585254 (3), 10436346 (3) (see all 99)
alzheimers disease	94.8	1534	17168644 (5), 7838376 (5), 7830071 (5), 8506352 (4) (see all 99)
supranuclear palsy progressive	93.7	219	10209184 (4), 12151839 (3), 10534245 (3), 9781517 (2) (see all 99)
picks disease	92	143	8960316 (5), 8928611 (4), 12368187 (4), 11117542 (3) (see all 76)
neuropil threads	90.5	48	1904481 (2), 16106214 (2), 8396836 (1), 7521944 (1) (see all 34)
senile plaques	89.8	149	15977985 (3), 15658002 (3), 1652752 (2), 7680597 (1) (see all 99)
neurodegenerative diseases	89.8	450	11578782 (4), 10320789 (4), 15056452 (4), 15495240 (3) (see all 99)

About this table

1 PharmGKB disease relationship for MAPT gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Parkinson Disease	GN	15297935

About this table

GeneTests: MAPT

Frontotemporal Dementia with Parkinsonism-17

Locus Specific Mutation Databases (LSDB): MAPT
Human Gene Mutation Database (HGMD): MAPT
Genetic Association Database (GAD): MAPT
Human Genome Epidemiology (HuGE) Navigator: MAPT (126 documents)

Export disorders and mutations for MAPT gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

International Study Reveals Gene Mutations as Underlying Risk for Most Common Form of Parkinson's Disease

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/2117 PubMed articles for MAPT gene, integrated from 7 sources (see all 2117):
(articles sorted by number of sources associating them with MAPT)

Familial atypical progressive supranuclear palsy associated with homozigosity for the delN296 mutation in the tau gene. (PubMed id 11220749)^{1, 2, 4, 7} Pastor P.... Oliva R. (2001)
Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17. (PubMed id 9641683)^{1, 2, 4, 7} Hutton M.... Heutink P. (1998)
Linkage disequilibrium and association of MAPT H1 in Parkinson disease. (PubMed id 15297935)^{1, 4, 5} Skipper L....Farrer M. (2004)
Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau. (PubMed id 3131773)^{1, 2, 3} Goedert M.... Klug A. (1988)
The role of tau (MAPT) in frontotemporal dementia and related tauopathies. (PubMed id 15365985)^{1, 2, 7} Rademakers R.... van Broeckhoven C. (2004)
A polymorphism within intron 11 of the tau gene is not increased in frequency in patients with sporadic Alzheimer's disease, nor does it influence the extent of tau pathology in the brain. (PubMed id 11988340)^{1, 4, 7} Green E.K....Mann D.M. (2002)
Frequency of tau gene mutations in familial and sporadic cases of non-Alzheimer dementia. (PubMed id 11255441)^{1, 4, 7} Poorkaj P....Bird T.D. (2001)
Pick's disease is associated with mutations in the tau gene. (PubMed id 11117542)^{1, 2, 7} Pickering-Brown S.... Hutton M. (2000)
Mutational analysis of the tau gene in progressive supranuclear palsy. (PubMed id 10534245)^{1, 2, 7} Higgins J.J.... Loveless J.M. (1999)
The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease. (PubMed id 9614189)^{1, 2, 7} Illenberger S.... Mandelkow E. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4137	HGNC: 6893	AceView: MAPT	Ensembl:ENSG00000186868	euGenes: HUgn4137
ECgene: MAPT	Kegg: 4137	H-InvDB: MAPT

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MAPT	Genetics and Cytogenetics in Oncology and Haematology
Alzheimer Research Forum	http://www.alzforum.org/res/com/mut/tau/default.asp
Protein Spotlight	http://www.expasy.org/spotlight/back_issues/sptlt068.shtml
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MAPT
Wikipedia	http://en.wikipedia.org/wiki/Tau_protein

Intellectual Property for MAPT gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for MAPT gene:
Search GeneIP for patents involving MAPT

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MAPT		Antibodies for MAPT
	Super-pooled esiRNAs for MAPT		Proteins for MAPT
	Lentivirus-delivered shRNAs for MAPT		microRNA Mimics for MAPT
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

	Antibodies for MAPT (Tau)		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MAPT
	SeqTarget long-range PCR primers for resequencing MAPT
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MAPT
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MAPT

	GenScript Custom Purified and Recombinant Proteins Services for MAPT		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for MAPT
	GenScript Custom Assay Services for MAPT		GenScript Custom Superior Antibodies Services for MAPT
	GenScript Custom overexpressing Cell Line Services for MAPT		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for MAPT (Tau)

	Regulatory tfbs in MAPT promoter
	Search Chromatin IP Primers for MAPT
	RT² qPCR Primer Assay for MAPT
	GNC Network for MAPT
	Assays for microRNAs that regulate MAPT
	SABiosciences PCR Arrays including MAPT

Search Tocris compounds for MAPT

	Browse Sino Biological Proteins and Antibodies
	cDNA Clones for MAPT
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Proteins for MAPT
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for MAPT
	Proteins for MAPT
	Lysates for MAPT

Antibodies for MAPT

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for MAPT

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

View Random Gene

Category
GIFtS Group

The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

MAPT gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

Advanced Search

Export list of displayed genes

MAPT Gene

protein-coding GIFtS: 74

Aliases &
Descriptions
for MAPT gene

Summaries
for MAPT gene

Genomic Views
for MAPT gene

Proteins
for MAPT gene

Protein Domains/
Families
for MAPT gene

Gene Function
for MAPT gene

Pathways & Interactions
for MAPT gene

Drugs & Compounds
for MAPT gene

Transcripts
for MAPT gene

Expression
for MAPT gene

Orthologs
for MAPT gene

Paralogs
for MAPT gene

Genomic Variants
for MAPT gene

Disorders & Mutations
for MAPT gene

Medical News
for MAPT gene

Publications
for MAPT gene

External Searches for MAPT gene

Genome Databases showing MAPT gene

Other Databases showing MAPT gene

Specialized Databases showing MAPT gene

Intellectual Property
for MAPT gene

Products
for MAPT gene

View Random Gene

Supranuclear Palsy Progressive
Spinocerebellar Ataxias
Dementia
Down Syndrome
Astrocytosis
Aphasia Progressive
Malaria
Myositis Inclusion Body
Retrograde Degeneration
cognitive disorder
Aphasia Primary Progressive
cognitive dysfunction
Scrapie
Niemann-Picks Disease Type C
Paralysis
Distal Myopathies
Teratocarcinoma
Ischemia
Breast Cancer
Dementia Presenile
Memory impairment
Brain Ischemia
Semantic Dementia
Adenocarcinoma
AIDS
Amyloidosis
disability
ENCEPHALOPATHY
Cancer
FRONTOTEMPORAL DEMENTIA
CREUTZFELDT-JAKOB DISEASE
Hydrocephalus
Apraxias
PARKINSON DISEASE, AUTOSOMAL DOMINANT
Pathological Processes
Early Onset Alzheimer Disease
Motor Neuron Disease
Late Onset Alzheimer Disease
Demyelinating Diseases
immunodeficiency
Tauopathies
Tumors
Mental Retardation
Postencephalitic Parkinsonism
Autoimmunity
Necrosis
molecular pathology
progressive disease
Neurofibrillary Tangles
Senile Plaques
Parkinsonism
Huntington Disease
Cerebral Amyloid Angiopathy
Neurodegenerative Diseases
PERSONALITY CHANGE
Neurological Disorders
Parkinson Disease
Amyloid deposition
Glioma
Frontotemporal Dementia with Parkinsonism-17
Familial Dementia
paired helical filament
Hydrocephalus Normal Pressure
Gliosis
Neuropil Threads
Alzheimers Disease
Pathology Brain
Prion Diseases
neurodegeneration
Multiple System Atrophy
Alcoholism
CMV INFECTION
cognitive deficit
Calcification
Amyotrophic Lateral Sclerosis
Autosomal Dominant Parkinsonism
Dementia Vascular
Picks Disease
Movement Disorders
Atrophy
STROKE
neuron loss
Lewy Body Disease
Primary Lateral Sclerosis
Subacute Sclerosing Panencephalitis
Brain Diseases
Myositis
brain atrophy
Myotonic Dystrophy
Binswanger Disease
genetic disorder
Neuropathology
CNS Diseases
Postmortem Changes

Advanced Search

Export list of displayed genes

MAPT Gene

protein-coding GIFtS: 74

Aliases & Descriptionsfor MAPT gene

Summariesfor MAPT gene

Genomic Viewsfor MAPT gene

Proteinsfor MAPT gene

Protein Domains/Familiesfor MAPT gene

Gene Functionfor MAPT gene

Pathways & Interactionsfor MAPT gene

Drugs & Compoundsfor MAPT gene

Transcriptsfor MAPT gene

Expression for MAPT gene

Orthologsfor MAPT gene

Paralogsfor MAPT gene

Genomic Variantsfor MAPT gene

Disorders & Mutationsfor MAPT gene

Medical Newsfor MAPT gene

Publicationsfor MAPT gene

External Searches for MAPT gene

Genome Databases showing MAPT gene

Other Databases showing MAPT gene

Specialized Databases showing MAPT gene

Intellectual Propertyfor MAPT gene

Productsfor MAPT gene

View Random Gene

Aliases &
Descriptions
for MAPT gene

Summaries
for MAPT gene

Genomic Views
for MAPT gene

Proteins
for MAPT gene

Protein Domains/
Families
for MAPT gene

Gene Function
for MAPT gene

Pathways & Interactions
for MAPT gene

Drugs & Compounds
for MAPT gene

Transcripts
for MAPT gene

Expression
for MAPT gene

Orthologs
for MAPT gene

Paralogs
for MAPT gene

Genomic Variants
for MAPT gene

Disorders & Mutations
for MAPT gene

Medical News
for MAPT gene

Publications
for MAPT gene

Intellectual Property
for MAPT gene

Products
for MAPT gene