Aliases &
Descriptions
for MARK3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| MAP/microtubule affinity-regulating kinase 31 2 | | C-TAK12 3 | | CTAK11 2 3 | | ELKL motif kinase 22 3 | | KP781 2 | | EMK-22 3 | | Ser/Thr protein kinase PAR-12 3 | | PAR1A2 | | Serine/threonine-protein kinase p782 3 | | EMK23 | | Protein kinase STK102 3 | | cTAK13 | | Cdc25C-associated protein kinase 12 3 | | EC 2.7.11.13 |
Export aliases for MARK3 gene to outside databasesPrevious GC identifers: GC14P101243 GC14P097667 GC14P101841 GC14P102921 GC14P103851 |
Summaries
for MARK3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MARK3_HUMAN, P27448Function: Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4.Phosphorylates CDC25C on 'Ser-216'
Gene Wiki entry for MARK3 |
Genomic Views
for MARK3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MARK3 gene promoter:
YY1 GATA-1 JunD AP-1 c-Fos c-Jun Fra-1 JunB POU3F1 CUTL1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MARK3
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MARK3  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.3 Ensembl cytogenetic band: 14q32.32 HGNC cytogenetic band: 14q32.3MARK3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P084029: view genomic region
(about GC identifiers)
Start:
|
84,029,889 bp from pter |
End:
|
84,148,541 bp from pter |
Size:
|
118,653 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr14+ 103,851,701-103,970,164 |
RefSeq DNA sequence:- NC_000014.8 NT_026437.12
|
Proteins
for MARK3 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: MARK3_HUMAN, P27448 (See
protein sequence)Recommended Name: MAP/microtubule affinity-regulating kinase 3 Size: 776 amino acids; 87005 Da
PDB structure from  and Proteopedia  :2QNJ (3D)
3FE3 (3D)
Secondary accessions: O60219 Q8TB41 Q8WX83 Q96RG1 Q9UMY9 Q9UN34Alternative splicing: 7 isoforms: P27448-1 P27448-2 P27448-3 P27448-4 P27448-5 P27448-6 P27448-7 Explore the universe of human proteins at neXtProt for MARK3: NX_P27448
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (5 alternative transcripts):
NP_001122390.1 NP_001122391.1 NP_001122392.1 NP_001122393.1 NP_002367.4
ENSEMBL proteins: ENSP00000408092 ENSP00000216288 ENSP00000335347 ENSP00000395356 ENSP00000402104 ENSP00000411397 ENSP00000303698 ENSP00000412725
Human Recombinant Proteins
Antibodies for MARK3:
Assays for MARK3: |
Protein
Domains/
Families
for MARK3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MARK3 for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry P27448ProtoNet protein and cluster: P27448 2 Blocks protein families: IPB000449 Ubiquitin-associated domain IPB001772 Kinase-associated
UniProtKB/Swiss-Prot: MARK3_HUMAN, P27448Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamilySimilarity: Contains 1 KA1 (kinase-associated) domainSimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 UBA domain |
Gene Function
for MARK3 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: MARK3_HUMAN, P27448Function: Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4.Phosphorylates CDC25C on 'Ser-216'Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Number (IUBMB): EC 2.7.11.1
Genatlas biochemistry entry for MARK3:MAP/microtubule affinity-regulating kinase 3 deleted in pancreas carcinoma5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6): About this table
MARK3 for ontologies About GeneDecksing
Animal Models: 7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Mark3):
MARK3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MARK3 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
MARK3 for pathways About GeneDecksing
1  Millipore Pathway for MARK3
SABiosciences Custom Pathway-Focused PCR Arrays for MARK3
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MARK3
5/22 Interacting proteins for MARK3 (ENSP000003353473 P274481, 2) via UniProtKB, MINT, and/or STRING (see all 22)About this table
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006468 | protein phosphorylation |
IEA | -- |
About this table
MARK3 for ontologies About GeneDecksing
|
Drugs & Compounds
for MARK3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for MARK3
|
Transcripts
for MARK3 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for MARK3 gene (5 alternative transcripts): NM_001128918.1 NM_001128919.1 NM_001128920.1 NM_001128921.1 NM_002376.5 Additional cDNA sequence: AF170723.1 AF387637.1 AF465413.1 AK023963.1 AK055814.1 AK056714.1 AK124459.1 AK124796.1 AK296643.1 AK307448.1 BC024773.1 BX161395.1 BX248250.1 CR598572.1 DQ368336.1 M80359.1 M83780.1 U64205.1 24/37 DOTS entries (see all 37): DT.86855293 DT.95264963 DT.100714279 DT.100698434 DT.100844716 DT.100844722 DT.317922 DT.100844721 DT.100673793 DT.120767212 DT.100029578 DT.100844711 DT.120767219 DT.120767148 DT.120767164 DT.91661899 DT.449218 DT.95124116 DT.95264961 DT.97785685 DT.100844732 DT.100844733 DT.95264965 DT.100844734 24/430 AceView cDNA sequences (see all 430): BE792279 BU685077 F02748 CB240911 BQ955135 BX248250 BX357829 T28619 BU634468 AI065116 AV702573 AU132239 AW138470 AA372558 CA397900 NM_002376 AA642662 CB529992 BM910621 AF170723 BX484862 F04119 CR598572 CF552147
 highest scoring ESTs for MARK3:M80359 AA082201 AA102559 AA160135 AA348895 AA412299 AA470030 AA516359 AA522703 AA642662 Unigene Cluster for MARK3: MAP/microtubule affinity-regulating kinase 3 Hs.35828 [show with all ESTs]Unigene Representative Sequence: NM_001128918
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for MARK3 (see all 14)
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | |
| ExUns: | 18 | ^ | 19a | · | 19b | ^ | 20a | · | 20b | · | 20c | · | 20d | · | 20e | · | 20f | · | 20g |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | |
| SP5: | - | | - | | - | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for MARK3
8 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000416682 ENST00000216288 ENST00000335102(uc001ymz.3 uc001ymy.3 uc010awp.2 uc010tyb.1)
ENST00000454698 ENST00000440884 ENST00000429436 ENST00000303622 ENST00000411530(uc001ymx.3 uc001ymw.3 uc001yna.3 uc010awq.2 uc001ynd.2)
|
Expression
for MARK3 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| MARK3 expression in normal and diseased human tissues
1 / 2 / 3 8 probe-sets matching MARK3 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 40826_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.80 |
1.23 |
M80359 |
1.00 |
0.90 |
0.95 |
1 |
| 49762_at*2, 3
|
U95-B |
1 |
-- |
-- |
0.95 |
0.78 |
T86307 |
0.40 |
1.00 |
0.76 |
1 |
| 202568_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AI745639 |
0.80 |
1.00 |
0.91 |
1 |
| 202569_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_002376 |
0.60 |
1.00 |
0.82 |
1 |
| 232537_x_at*2, 3
|
U133-B |
1 |
0.36 |
1.00 |
-- |
-- |
AU159474 |
0.40 |
1.00 |
0.76 |
1 |
| 202568_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 202569_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 232537_x_at*2
|
U133Plus2 |
1 |
0.36 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
MARK3 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CCTGTGGTTT
SOURCE GeneReport for Unigene cluster: Hs.35828
Expression variation in blood from EXPOLDB for MARK3 UniProtKB/Swiss-Prot: MARK3_HUMAN, P27448Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for MARK3
|
Orthologs
for MARK3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for MARK3 gene from 5/8 species (see all 8)
About this table Species with no ortholog for MARK3
ENSEMBL Gene Tree for MARK3 (if available) |
Paralogs
for MARK3 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for MARK3 gene
- MARK22 MARK12 MARK42
MARK3 for paralogs About GeneDecksing
|
Genomic Variants
for MARK3 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 14 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for MARK3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MARK3
2 CNVs: 5768 5769 | | QIAGEN SeqTarget long-range PCR primers for resequencing MARK3 |
|
Disorders & Mutations
for MARK3 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MARK3 for disorders About GeneDecksing
OMIM: 602678
Human Genome Epidemiology (HuGE) Navigator: MARK3 (3 documents)
Export disorders and mutations for MARK3 gene to outside databases
|
Medical News
for MARK3 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for MARK3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/44 PubMed articles for MARK3 gene, integrated from 7 sources (see all 44):
(articles sorted by number of sources associating them with MARK3)- Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)1, 2 Wissing J.... Daub H. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. (PubMed id 11433294)1, 2 Sun T.-Q....Williams L.T. (2001)
- C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. (PubMed id 9543386)1, 2 Peng C.Y.... Piwnica-Worms H. (1998)
- Assignment of MARK3 alias KP78 to human chromosome band 14q32.3 by in situ hybridization. (PubMed id 9533022)1, 3 Ono T....Okamoto T. (1997)
- Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate. (PubMed id 12941695)1, 7 Muller J....Morrison D.K. (2003)
- New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. (PubMed id 16980613)1, 7 Dequiedt F....Kettmann R. (2006)
- C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. (PubMed id 11741534)1, 7 Muller J....Morrison D.K. (2001)
- C-TAK1 interacts with microphthalmia-associated trans cription factor, Mitf, but not the related family member Tfe3. (PubMed id 20214879)1 Schwarz T....Mansky K.C. (2010)
- OPG and RANK polymorphisms are both associated with c ortical bone mineral density: findings from a metaanalysis of the Avon longitud inal study of parents and children and gothenburg osteoporosis and obesity dete rminants cohorts. (PubMed id 20534768)1 Paternoster L....Tobias J.H. (2010)
|
External Searches for MARK3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MARK3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MARK3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MARK3 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MARK3 gene:
Search GeneIP for patents involving MARK3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MARK3 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
 | Antibodies & Assays for MARK3 |
| | | | Search Tocris compounds for MARK3 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for MARK3 |
| |
|
|
