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MARK3 Gene

protein-coding   GIFtS: 60

GC14P084029
MAP/microtubule affinity-regulating kinase 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
MAP/microtubule affinity-regulating kinase 31 2     C-TAK12 3
CTAK11 2 3     ELKL motif kinase 22 3
KP781 2     EMK-22 3
Ser/Thr protein kinase PAR-12 3     PAR1A2
Serine/threonine-protein kinase p782 3     EMK23
Protein kinase STK102 3     cTAK13
Cdc25C-associated protein kinase 12 3     EC 2.7.11.13

External Ids:    HGNC: 68971   Entrez Gene: 41402   Ensembl: ENSG000000754137   UniProtKB: P274483   

Export aliases for MARK3 gene to outside databases

Previous GC identifers: GC14P101243 GC14P097667 GC14P101841 GC14P102921 GC14P103851


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MARK3_HUMAN, P27448
Function: Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4.
Phosphorylates CDC25C on 'Ser-216'

Gene Wiki entry for MARK3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MARK3 gene promoter:
         YY1   GATA-1   JunD   AP-1   c-Fos   c-Jun   Fra-1   JunB   POU3F1   CUTL1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for MARK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MARK3 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.3   Ensembl cytogenetic band:  14q32.32   HGNC cytogenetic band: 14q32.3

MARK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MARK3 gene location

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P084029:  view genomic region     (about GC identifiers)

Start:
84,029,889 bp from pter
End:
84,148,541 bp from pter
Size:
118,653 bases
Orientation:
plus strand

1 alternative location:
Chr14+ 103,851,701-103,970,164     
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: MARK3_HUMAN, P27448 (See protein sequence)
Recommended Name: MAP/microtubule affinity-regulating kinase 3  
Size: 776 amino acids; 87005 Da
PDB structure from and Proteopedia :
2QNJ (3D)    3FE3 (3D)    
Secondary accessions: O60219 Q8TB41 Q8WX83 Q96RG1 Q9UMY9 Q9UN34
Alternative splicing: 7 isoforms:  P27448-1   P27448-2   P27448-3   P27448-4   P27448-5   P27448-6   P27448-7   

Explore the universe of human proteins at neXtProt for MARK3: NX_P27448 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (5 alternative transcripts): 
    NP_001122390.1  NP_001122391.1  NP_001122392.1  NP_001122393.1  NP_002367.4  


    ENSEMBL proteins: 
    ENSP00000408092 ENSP00000216288 ENSP00000335347 ENSP00000395356 ENSP00000402104 ENSP00000411397 
    ENSP00000303698 ENSP00000412725 


    Human Recombinant Proteins 
    Millipore Purified and/or Recombinant MARK3 Protein
    Sigma-Aldrich Proteins for MARK3
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MARK3
    OriGene Protein Over-expression Lysate: MARK3
    GenScript Custom Purified and Recombinant Proteins Services for MARK3 
    Novus Biologicals Proteins for MARK3
    Novus Biologicals Lysates for MARK3
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins


    Antibodies for MARK3: 
    Millipore Mono- and Polyclonal Antibodies for the study of MARK3
    Sigma-Aldrich Antibodies for MARK3
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for MARK3 
    OriGene Antibodies: MARK3
    GenScript Custom Superior Antibodies Services for MARK3 
    Novus Biologicals Antibodies for MARK3
    Epitomics antibodies for MARK3

    Assays for MARK3: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MARK3 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MARK3 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MARK3 for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR017441 Protein_kinase_ATP_BS
     IPR001772 Kinase-assoc_KA1
     IPR002290 Ser/Thr_prot_kinase_dom
     IPR020669 MAP/microtub-affinity-reg_kin3
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry P27448

    ProtoNet protein and cluster: P27448

    2 Blocks protein families:
    IPB000449 Ubiquitin-associated domain
    IPB001772 Kinase-associated


    UniProtKB/Swiss-Prot: MARK3_HUMAN, P27448
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily
    Similarity: Contains 1 KA1 (kinase-associated) domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UBA domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: MARK3_HUMAN, P27448
    Function: Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4.
    Phosphorylates CDC25C on 'Ser-216'
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme Number (IUBMB): EC 2.7.11.1 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for MARK3
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for MARK3
    Sigma-Aldrich shRNA Panels and shRNA for MARK3
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): MARK3
    OriGene shRNA RFP (see all 5): MARK3
    OriGene basic RS shRNA (see all 5): MARK3
    OriGene siRNA (see all 5): MARK3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MARK3 
    miRNA:Sigma-Aldrich microRNA Mimics for MARK3
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MARK3 
    3 SABiosciences Assays for microRNAs that regulate MARK3:
    hsa-miR-433 hsa-miR-557 hsa-miR-1284

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: MARK3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): MARK3
    OriGene untagged cDNA clones in CMV expression vector (see all 8): MARK3
    OriGene 3'-UTR clone (see all 5): MARK3 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for MARK3 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for MARK3 

    Genatlas biochemistry entry for MARK3:
    MAP/microtubule affinity-regulating kinase 3 deleted in pancreas carcinoma

    5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004672 protein kinase activity ----
    GO:0004674 protein serine/threonine kinase activity IEA--
    GO:0005515 protein binding IPI16169070
    GO:0005524 ATP binding IEA--
    About this table

    MARK3 for ontologies           About GeneDecksing

    Animal Models: 7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mark3):

    adipose tissuegrowth/sizehomeostasis/metabolismlethality-postnatallethality-prenatal/perinatal
    liver/biliary systemno phenotypic analysis

    MARK3 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    MARK3 for pathways           About GeneDecksing

    1 Millipore Pathway for MARK3
        Cytoplasmic microtubules

        SABiosciences Custom Pathway-Focused PCR Arrays for MARK3 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MARK3

    5/22 Interacting proteins for MARK3 (ENSP000003353473 P274481, 2) via UniProtKB, MINT, and/or STRING (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASB13Q8WXK31, 2EBI-707595,EBI-707573 MINT-63623
    YWHABP319461, 2EBI-707595,EBI-359815 MINT-50984
    YWHAGP619811, 2EBI-707595,EBI-359832 MINT-50822
    PRKCQQ047592STRING: ENSP00000263125 MINT-4787821
    TCEA2Q155601EBI-707595,EBI-710310
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468 protein phosphorylation IEA--
    About this table

    MARK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MARK3


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for MARK3
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for MARK3
    Sigma-Aldrich shRNA Panels and shRNA for MARK3
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): MARK3
    OriGene shRNA RFP (see all 5): MARK3
    OriGene basic RS shRNA (see all 5): MARK3
    OriGene siRNA (see all 5): MARK3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MARK3 
    miRNA: Sigma-Aldrich microRNA Mimics for MARK3
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MARK3 
    3 SABiosciences Assays for microRNAs that regulate MARK3:
    hsa-miR-433 hsa-miR-557 hsa-miR-1284
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: MARK3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): MARK3
    OriGene untagged cDNA clones in CMV expression vector (see all 8): MARK3
    OriGene 3'-UTR Clone (see all 5): MARK3 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for MARK3 
    Primers: OriGene genome-wide validated SYBR primer pairs: MARK3
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for MARK3: PPH20732A

    REFSEQ mRNAs for MARK3 gene (5 alternative transcripts): 

    NM_001128918.1  NM_001128919.1  NM_001128920.1  NM_001128921.1  NM_002376.5  

    Additional cDNA sequence: 

    AF170723.1 AF387637.1 AF465413.1 AK023963.1 AK055814.1 AK056714.1 AK124459.1 AK124796.1 
    AK296643.1 AK307448.1 BC024773.1 BX161395.1 BX248250.1 CR598572.1 DQ368336.1 M80359.1 
    M83780.1 U64205.1 

    24/37 DOTS entries (see all 37):

    DT.86855293  DT.95264963  DT.100714279  DT.100698434  DT.100844716  DT.100844722  DT.317922  DT.100844721 
    DT.100673793  DT.120767212  DT.100029578  DT.100844711  DT.120767219  DT.120767148  DT.120767164  DT.91661899 
    DT.449218  DT.95124116  DT.95264961  DT.97785685  DT.100844732  DT.100844733  DT.95264965  DT.100844734 

    24/430 AceView cDNA sequences (see all 430):

    BE792279 BU685077 F02748 CB240911 BQ955135 BX248250 BX357829 T28619 
    BU634468 AI065116 AV702573 AU132239 AW138470 AA372558 CA397900 NM_002376 
    AA642662 CB529992 BM910621 AF170723 BX484862 F04119 CR598572 CF552147 

    highest scoring ESTs for MARK3:

    M80359 AA082201 AA102559 AA160135 AA348895 AA412299 AA470030 AA516359 AA522703 AA642662 

    Unigene Cluster for MARK3:

    MAP/microtubule affinity-regulating kinase 3
    Hs.35828  [show with all ESTs]
    Unigene Representative Sequence: NM_001128918


    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for MARK3 (see all 14)

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
    SP1:                                                                                                              -     -                             -         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                              -                                   -         
    SP5:                                                        -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -         

    ExUns: 18 ^ 19a · 19b ^ 20a · 20b · 20c · 20d · 20e · 20f · 20g
    SP1:        -                                                   
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:  -     -     -                                             

    About this scheme

    ECgene alternative splicing isoforms for MARK3
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000416682 ENST00000216288 ENST00000335102(uc001ymz.3 uc001ymy.3 uc010awp.2 uc010tyb.1)
    ENST00000454698 ENST00000440884 ENST00000429436 ENST00000303622 ENST00000411530(uc001ymx.3 uc001ymw.3 uc001yna.3 uc010awq.2 uc001ynd.2)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    MARK3 expression in normal and diseased human tissues

    1  / 2  / 3

    8 probe-sets matching MARK3 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    40826_at2, 3 U95-A 1 1.00 1.00 0.80 1.23 M80359 1.00 0.90 0.95 1
    49762_at*2, 3 U95-B 1 -- -- 0.95 0.78 T86307 0.40 1.00 0.76 1
    202568_s_at2, 3 U133-A 1 1.00 1.00 -- -- AI745639 0.80 1.00 0.91 1
    202569_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002376 0.60 1.00 0.82 1
    232537_x_at*2, 3 U133-B 1 0.36 1.00 -- -- AU159474 0.40 1.00 0.76 1
    202568_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    202569_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    232537_x_at*2 U133Plus2 1 0.36 1.00 -- -- -- -- -- -- --
    About this table

    MARK3 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    MARK3 gene expression
    MARK3 gene electronic northern expression
    MARK3 gene sage expression
    About these images

    CGAP SAGE TAG: CCTGTGGTTT

    SOURCE GeneReport for Unigene cluster: Hs.35828

    Expression variation in blood from EXPOLDB for MARK3

    UniProtKB/Swiss-Prot: MARK3_HUMAN, P27448
    Tissue specificity: Ubiquitous

    Primers: OriGene genome-wide validated SYBR primer pairs: MARK3
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for MARK3: PPH20732A
        SABiosciences Custom PCR Arrays for MARK3 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for MARK3 gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    MARK31   -- MAP/microtubule affinity-regulating kinase 3 93(n)
    98.49(a)
    611285  XM_863554.1  XP_868647.1 
    chimpanzee
    (Pan troglodytes)
    MARK31   -- MAP/microtubule affinity-regulating kinase 3 99.54(n)
    99.73(a)
    453184  XM_001137919.1  XP_001137919.1 
    mouse
    (Mus musculus)
    Mark35 12 (61.05 cM) MAP/microtubule affinity-regulating kinase 3   -- X57244 
    chicken
    (Gallus gallus)
    MARK31   -- MAP/microtubule affinity-regulating kinase 3 83.95(n)
    96.3(a)
    423480  XM_421385.2  XP_421385.2 
    zebrafish
    (Danio rerio)
    BC047179.12   --   -- 73.64(n) 334300  BC047179.1 
    About this table        Species with no ortholog for MARK3

    ENSEMBL Gene Tree for MARK3 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for MARK3 gene
    MARK22  MARK12  MARK42  

    MARK3 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/1347 NCBI SNPs in MARK3 are shown (see all 1347)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 14 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs139871,2
    C,F,O,103969909(+) TCATTA/GCTAGT 5 -- ut31 ese321Minor allele frequency- G:0.31MN EA NA NS 2616
    rs9115561,2
    C,F,A,H,103955495(-) ATCTCC/TATGAA 5 -- int113Minor allele frequency- T:0.03NA NS EA WA 578
    rs9115571,2
    H103947905(-) ACAGAA/CCAAAT 5 -- int18Minor allele frequency- C:0.00EA NA NS 562
    rs9115581,2
    H103947887(-) CTCATA/GTCAAC 5 -- int16Minor allele frequency- G:0.00NA NS EA 580
    rs9622301,2
    C,F,H,103857537(-) TCCTAT/CGTACT 5 -- int119Minor allele frequency- C:0.03NS EA NA WA 732
    rs9758911,2
    --103883685(-) TCTAGA/TACTCT 5 -- int10--------
    rs9758921,2
    C,F,103883349(-) tctatT/Aacatt 5 -- int116Minor allele frequency- A:0.39NS EA NA WA 1128
    rs10136501,2
    C,F,A,H,103909203(-) TGACTC/TCTTAC 5 -- int121Minor allele frequency- T:0.29NA EA NS WA 1013
    rs10286131,2
    C,F,A,H,103888324(-) ggagaC/Taagga 5 -- int18Minor allele frequency- T:0.19NS EA NA 512
    rs10585451,2
    H103941432(+) ATCAAG/CTGGCA 10 /T /S mis1 ref15Minor allele frequency- C:0.00MN NS EA 562
    About this table

    HapMap Linkage Disequilibrium images for MARK3 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for MARK3
         2 CNVs: 5768 5769

    QIAGEN SeqTarget long-range PCR primers for resequencing MARK3 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MARK3 for disorders           About GeneDecksing

    OMIM: 602678

    Human Genome Epidemiology (HuGE) Navigator: MARK3 (3 documents)

    Export disorders and mutations for MARK3 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
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    10/44 PubMed articles for MARK3 gene, integrated from 7 sources (see all 44):
    (articles sorted by number of sources associating them with MARK3)
    1. Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)1, 2 Wissing J.... Daub H. (2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. (PubMed id 11433294)1, 2 Sun T.-Q....Williams L.T. (2001)
    4. C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. (PubMed id 9543386)1, 2 Peng C.Y.... Piwnica-Worms H. (1998)
    5. Assignment of MARK3 alias KP78 to human chromosome band 14q32.3 by in situ hybridization. (PubMed id 9533022)1, 3 Ono T....Okamoto T. (1997)
    6. Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate. (PubMed id 12941695)1, 7 Muller J....Morrison D.K. (2003)
    7. New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. (PubMed id 16980613)1, 7 Dequiedt F....Kettmann R. (2006)
    8. C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. (PubMed id 11741534)1, 7 Muller J....Morrison D.K. (2001)
    9. C-TAK1 interacts with microphthalmia-associated trans cription factor, Mitf, but not the related family member Tfe3. (PubMed id 20214879)1 Schwarz T....Mansky K.C. (2010)
    10. OPG and RANK polymorphisms are both associated with c ortical bone mineral density: findings from a metaanalysis of the Avon longitud inal study of parents and children and gothenburg osteoporosis and obesity dete rminants cohorts. (PubMed id 20534768)1 Paternoster L....Tobias J.H. (2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4140 HGNC: 6897 AceView: MARK3 Ensembl:ENSG00000075413 euGenes: HUgn4140
    ECgene: MARK3 H-InvDB: MARK3

    (According to HUGE)
    About This Section
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for MARK3 gene:
    Search GeneIP for patents involving MARK3

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