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MECR Gene

protein-coding   GIFtS: 55

GC01M027771
mitochondrial trans-2-enoyl-CoA reductase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
mitochondrial trans-2-enoyl-CoA reductase1 2     mitochondrial 2-enoyl thioester reductase2
NRBF11 2 5     trans-2-enoyl-CoA reductase, mitochondrial2
CGI-631 2     homolog of yeast 2-enoyl thioester reductase2
FASN2B1 2     nuclear receptor binding factor 12
Nuclear receptor-binding factor 12 3     NBRF13
NRBF-12 3     EC 1.3.1.383
hsNrbf-12     HsNrbf-13

External Ids:    HGNC: 196911   Entrez Gene: 511022   Ensembl: ENSG000001163537   UniProtKB: Q9BV793   

Export aliases for MECR gene to outside databases

Previous GC identifers: GC01M029341 GC01M029391 GC01M029519


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MECR_HUMAN, Q9BV79
Function: Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an
NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial
synthesis of fatty acids

Gene Wiki entry for MECR

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MECR gene promoter:
         NF-1   ATF   ATF-2   CREB   deltaCREB   RFX1   GATA-1   c-Jun   E47   CUTL1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for MECR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MECR 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.1-p35.1   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1pter-p22.3

MECR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MECR gene location

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M027771:  view genomic region     (about GC identifiers)

Start:
27,771,018 bp from pter
End:
27,808,772 bp from pter
Size:
37,755 bases
Orientation:
minus strand

1 alternative location:
Chr1- 29,519,385-29,557,454     
RefSeq DNA sequence:
NC_000001.10  NT_004610.19  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: MECR_HUMAN, Q9BV79 (See protein sequence)
Recommended Name: Trans-2-enoyl-CoA reductase, mitochondrial precursor  
Size: 373 amino acids; 40428 Da
Subunit: Homodimer
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAD34058.1; Type=Frameshift; Positions=14, 19; Sequence=CAI14329.1; Type=Erroneous gene
model prediction;
PDB structure from and Proteopedia :
1ZSY (3D)    2VCY (3D)    
Secondary accessions: Q5SYU0 Q5SYU1 Q5SYU2 Q6IBU9 Q9Y373

Explore the universe of human proteins at neXtProt for MECR: NX_Q9BV79 

REFSEQ proteins (2 alternative transcripts): 
NP_001019903.1  NP_057095.2  


ENSEMBL proteins: 
ENSP00000416960 ENSP00000381801 ENSP00000362897 ENSP00000362896 ENSP00000263702 


Human Recombinant Proteins 
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein: MECR
OriGene Protein Over-expression Lysate: MECR
GenScript Custom Purified and Recombinant Proteins Services for MECR 
Novus Biologicals Proteins for MECR
Novus Biologicals Lysates for MECR
Browse Sino Biological Recombinant Proteins
ProSpec Recombinant Protein for MECR

1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005739 mitochondrion IDA12654921
About this table

MECR for ontologies           About GeneDecksing



Antibodies for MECR: 
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for MECR
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
GenScript Custom Superior Antibodies Services for MECR 
Novus Biologicals Antibody for MECR
Browse antibodies at Epitomics

Assays for MECR: 
Browse Kits and Assays available from Millipore
Browse ELISAs at Sigma-Aldrich
OriGene Custom Immunoassay Development 
Browse OriGene Fluorogenic Cell Assay Kits 
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for MECR 
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for MECR 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MECR for domains           About GeneDecksing

5 InterPro domains/families:
 IPR013149 ADH_C
 IPR011032 GroES-like
 IPR013154 ADH_GroES-like
 IPR002085 ADH_SF_Zn
 IPR016040 NAD(P)-bd_dom

Graphical View of Domain Structure for InterPro Entry Q9BV79

ProtoNet protein and cluster: Q9BV79

1 Blocks protein family: IPB013154 Alcohol dehydrogenase GroES-like

UniProtKB/Swiss-Prot: MECR_HUMAN, Q9BV79
Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: MECR_HUMAN, Q9BV79
Function: Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an
NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial
synthesis of fatty acids
Catalytic activity: Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH
Biophysicochemical properties: Kinetic parameters: KM=37 uM for trans-2-hexenoyl-CoA; KM=7.1 uM for
trans-2-decenoyl-CoA;
Enzyme Number (IUBMB): EC 1.3.1.38 

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for MECR
Sigma-Aldrich shRNA for MECR
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): MECR
OriGene shRNA RFP (see all 2): MECR
OriGene basic RS shRNA (see all 2): MECR
OriGene siRNA (see all 2): MECR
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MECR 
miRNA:Sigma-Aldrich microRNA Mimics for MECR
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MECR 
1 SABiosciences Assays for microRNA that regulate MECR:
hsa-miR-1291

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): MECR
OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): MECR
OriGene untagged cDNA clones in CMV expression vector (see all 3): MECR
OriGene 3'-UTR clone (see all 2): MECR 
Browse MicroRNA Expression Plasmids 
GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): MECR 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for MECR 

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005102 receptor binding IEA--
GO:0005488 binding IEA--
GO:0008270 zinc ion binding IEA--
GO:0016491 oxidoreductase activity IEA--
GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity IDA12654921
About this table

MECR for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


MECR for pathways           About GeneDecksing

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  MECR
    Fatty Acid Elongation in Mitochondria

2 Kegg Pathways  (Kegg details for MECR):
    hsa00062 Fatty acid elongation in mitochondria
hsa01100 Metabolic pathways

    SABiosciences Custom Pathway-Focused PCR Arrays for MECR 

    Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for MECR
    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MECR

5/6 Interacting proteins for MECR (ENSP000002637023) via UniProtKB, MINT, and/or STRING (see all 6)
InteractantInteraction Details
GeneCardExternal ID(s)
ACAA2ENSP000002850933STRING: ENSP00000285093
ECHS1ENSP000003575353STRING: ENSP00000357535
ENSG00000206329ENSP000003727893STRING: ENSP00000372789
HADHAENSP000003700233STRING: ENSP00000370023
PPT1ENSP000003618653STRING: ENSP00000361865
About this table

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006631 fatty acid metabolic process IDA12654921
GO:0006633 fatty acid biosynthetic process IEA--
GO:0055114 oxidation-reduction process IEA--
About this table

MECR for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

MECR for compounds           About GeneDecksing

Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MECR
1 Novoseek chemical compound relationship for MECR gene
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
progesterone 52.5 5 1892850 (2), 8089199 (1), 1815590 (1), 2021645 (1)
About this table



(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for MECR
Sigma-Aldrich shRNA for MECR
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): MECR
OriGene shRNA RFP (see all 2): MECR
OriGene basic RS shRNA (see all 2): MECR
OriGene siRNA (see all 2): MECR
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MECR 
miRNA: Sigma-Aldrich microRNA Mimics for MECR
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MECR 
1 SABiosciences Assays for microRNA that regulate MECR:
hsa-miR-1291
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): MECR
OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): MECR
OriGene untagged cDNA clones in CMV expression vector (see all 3): MECR
OriGene 3'-UTR Clone (see all 2): MECR 
Browse OriGene MicroRNA Expression Plasmids 
GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): MECR 
Primers: OriGene genome-wide validated SYBR primer pairs: MECR
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for MECR: PPH13860A

REFSEQ mRNAs for MECR gene (2 alternative transcripts): 

NM_001024732.1  NM_016011.2  

Additional cDNA sequence: 

AF151821.1 AK025830.1 AK095099.1 AK225687.1 AK226084.1 AK300889.1 AK315274.1 BC001419.2 
CR456703.1 CR604427.1 CR616740.1 CR624586.1 CR626137.1 

18 DOTS entries:

DT.452328  DT.91763770  DT.100798959  DT.91763769  DT.100798953  DT.91763771  DT.100798955  DT.95174118 
DT.100798958  DT.431671  DT.91763774  DT.91839251  DT.95174117  DT.100798961  DT.121404917  DT.121404940 
DT.99927194  DT.100798960 

24/182 AceView cDNA sequences (see all 182):

BI856447 BM673423 CR604427 CR616740 AI609046 BU735019 AA449215 AU099187 
AA962664 CR624586 BM665899 AA393872 CR626137 R47992 AA463768 BM762641 
BM849428 AW005319 AI354426 BM981418 BM762525 BM696368 BG677456 BM673220 

highest scoring ESTs for MECR:

AA150070 AA310756 AA425098 AA449214 AF151821 AK025830 AK095099 AU099187 AV650218 AV650800 

Unigene Cluster for MECR:

Mitochondrial trans-2-enoyl-CoA reductase
Hs.183646  [show with all ESTs]
Unigene Representative Sequence: NM_001024732


GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for MECR (see all 16)

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^
SP1:                                      -     -     -     -     -     -     -     -     -     -     -     -                                                   
SP2:                                      -     -     -     -     -     -     -     -     -     -     -                                                         
SP3:                                      -     -     -     -     -     -     -     -                 -     -                                                   
SP4:                                      -     -     -     -                 -     -                       -                                                   
SP5:                                      -     -     -     -     -     -     -     -     -     -     -     -                                   -               

ExUns: 14 ^ 15a · 15b ^ 16a · 16b · 16c
SP1:        -                           
SP2:        -                           
SP3:                                    
SP4:                                    
SP5:                                    

About this scheme

ECgene alternative splicing isoforms for MECR
18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
ENST00000475773 ENST00000463412 ENST00000453185 ENST00000490529 ENST00000464511
ENST00000463052 ENST00000489248 ENST00000475861 ENST00000472630 ENST00000474946
ENST00000464915 ENST00000482610 ENST00000484012 ENST00000493928 ENST00000398820
ENST00000373792(uc001brq.1 uc001brr.1 uc010ofz.1) ENST00000473030
ENST00000373791(uc001brp.1 uc001brs.1 uc001brt.1)

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

MECR expression in normal and diseased human tissues

1  / 2  / 3

3 probe-sets matching MECR gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
49341_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 R77016 0.80 1.00 0.91 1
218664_at2, 3 U133-A 1 0.91 1.00 -- -- NM_016011 0.60 1.00 0.82 1
218664_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
About this table

MECR for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
MECR gene expression
MECR gene electronic northern expression
MECR gene sage expression
About these images

CGAP SAGE TAG: GGAGGGGAGG

SOURCE GeneReport for Unigene cluster: Hs.183646

UniProtKB/Swiss-Prot: MECR_HUMAN, Q9BV79
Tissue specificity: Highly expressed in skeletal and heart muscle. Expressed at lower level in placenta, liver, kidney
and pancreas. Weakly or not expressed in lung

Primers: OriGene genome-wide validated SYBR primer pairs: MECR
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for MECR: PPH13860A
    SABiosciences Custom PCR Arrays for MECR 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MECR gene from 5/19 species (see all 19)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
MECR1   -- mitochondrial trans-2-enoyl-CoA reductase 88.58(n)
87.4(a)
478159  XM_535334.2  XP_535334.2 
chimpanzee
(Pan troglodytes)
MECR1   -- mitochondrial trans-2-enoyl-CoA reductase 99.64(n)
99.2(a)
456690  XM_001156115.1  XP_001156115.1 
cow
(Bos taurus)
MECR1   -- mitochondrial trans-2-enoyl-CoA reductase 87.04(n)
84.45(a)
353301  NM_181669.1  NP_858055.1 
rat
(Rattus norvegicus)
Mecr1   -- mitochondrial trans-2-enoyl-CoA reductase 83.02(n)
81.23(a)
29470  NM_017209.1  NP_058905.1 
mouse
(Mus musculus)
Mecr1 , 5 4 (64.52 cM)5
mitochondrial trans-2-enoyl-CoA reductase1, 5 82.57(n)1
81.77(a)1
269221  NM_025297.11  NP_079573.11 
 AA2413135  AA2418055  (see all 21)
About this table        Species with no ortholog for MECR

ENSEMBL Gene Tree for MECR (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
  --

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/375 NCBI SNPs in MECR are shown (see all 375)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs9030451,2
C,F,A,29528412(-) CACATC/GTCCCT 2 -- int113Minor allele frequency- G:0.09MN NS EA NA WA 1150
rs10214611,2
C29528653(-) AAAAAG/AAAGCA 2 -- int14Minor allele frequency- A:0.00NS EA 420
rs10629241,2
C,F,A,H,29529699(-) CAAGCG/AGTCAT 4 /A ref1 syn119Minor allele frequency- A:0.38EA MN NA NS WA 2444
rs11284001,2
C,F,A,H,29542637(-) ACGGAC/TTCCTT 4 L F mis1 ref123Minor allele frequency- T:0.39EA MN NA NS WA 2942
rs11381141,2
--29519669(-) ggtcaA/Gcctag 2 -- ut310--------
rs11381151,2
--29519665(-) aacctA/Gggtaa 2 -- ut310--------
rs11381181,2
--29519595(-) cctgtA/Ggtccc 2 -- ut310--------
rs11381211,2
--29519559(-) ggatcA/Gcctga 2 -- ut310--------
rs14667011,2
C,A,H,29554579(-) actacC/Ggtatg 2 -- int19Minor allele frequency- G:0.45NA EA WA 222
rs15657151,2
C,F,29539823(-) CTGGCG/AGTGAA 2 -- int16Minor allele frequency- A:0.03EA NS NA WA 372
About this table

HapMap Linkage Disequilibrium images for MECR (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for MECR: --

QIAGEN SeqTarget long-range PCR primers for resequencing MECR 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MECR for disorders           About GeneDecksing

OMIM: 608205

Human Genome Epidemiology (HuGE) Navigator: MECR (1 document)

Export disorders and mutations for MECR gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

10/17 PubMed articles for MECR gene, integrated from 7 sources (see all 17):
(articles sorted by number of sources associating them with MECR)
  1. Characterization of 2-enoyl thioester reductase from mammals: an ortholog of Ybr026p/Mrf1'p of the yeast mitochondrial fatty acid synthesis type II. (PubMed id 12654921)1, 2, 3, 7 Miinalainen I.J.... Hiltunen J.K. (2003)
  2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
  5. Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors. (PubMed id 9795230)1, 3 Masuda N....Osumi T. (1998)
  6. Structural enzymological studies of 2-enoyl thioester reductase of the human mitochondrial FAS II pathway: new insights into its substrate recognition properties. (PubMed id 18479707)1, 7 Chen Z.J....Haapalainen A.M. (2008)
  7. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
  8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  10. Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)1 Suzuki Y.... Sugano S. (1997)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51102 HGNC: 19691 AceView: CGI-63 Ensembl:ENSG00000116353 euGenes: HUgn51102
ECgene: MECR Kegg: 51102 H-InvDB: MECR

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
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Patent Information for MECR gene:
Search GeneIP for patents involving MECR

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
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