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MECR Gene

protein-coding GIFtS: 55

GC01M027771

mitochondrial trans-2-enoyl-CoA reductase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
mitochondrial trans-2-enoyl-CoA reductase¹ ²		mitochondrial 2-enoyl thioester reductase²
NRBF1¹ ² ⁵		trans-2-enoyl-CoA reductase, mitochondrial²
CGI-63¹ ²		homolog of yeast 2-enoyl thioester reductase²
FASN2B¹ ²		nuclear receptor binding factor 1²
Nuclear receptor-binding factor 1² ³		NBRF1³
NRBF-1² ³		EC 1.3.1.38³
hsNrbf-1²		HsNrbf-1³

External Ids:	HGNC: 19691¹	Entrez Gene: 51102²	Ensembl: ENSG00000116353⁷	UniProtKB: Q9BV79³

Export aliases for MECR gene to outside databases

Previous GC identifers: GC01M029341 GC01M029391 GC01M029519

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MECR_HUMAN, Q9BV79

Function: Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an

NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial

synthesis of fatty acids

Gene Wiki entry for MECR

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MECR gene promoter:
         NF-1   ATF   ATF-2   CREB   deltaCREB   RFX1   GATA-1   c-Jun   E47   CUTL1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for MECR

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MECR

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.1-p35.1 Ensembl cytogenetic band: 1p35.3 HGNC cytogenetic band: 1pter-p22.3

MECR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MECR gene location

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M027771: view genomic region (about GC identifiers)

Start:	27,771,018 bp from pter
End:	27,808,772 bp from pter
Size:	37,755 bases
Orientation:	minus strand

1 alternative location:

Chr1- 29,519,385-29,557,454

RefSeq DNA sequence:

NC_000001.10 NT_004610.19

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: MECR_HUMAN, Q9BV79 (See protein sequence)

Recommended Name: Trans-2-enoyl-CoA reductase, mitochondrial precursor

Size: 373 amino acids; 40428 Da

Subunit: Homodimer

Subcellular location: Mitochondrion

Sequence caution: Sequence=AAD34058.1; Type=Frameshift; Positions=14, 19; Sequence=CAI14329.1; Type=Erroneous gene

model prediction;

PDB structure from and Proteopedia :

1ZSY (3D)

2VCY (3D)

Secondary accessions: Q5SYU0 Q5SYU1 Q5SYU2 Q6IBU9 Q9Y373

Explore the universe of human proteins at neXtProt for MECR: NX_Q9BV79

REFSEQ proteins (2 alternative transcripts):

NP_001019903.1 NP_057095.2

ENSEMBL proteins:

ENSP00000416960 ENSP00000381801 ENSP00000362897 ENSP00000362896 ENSP00000263702

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: MECR OriGene Protein Over-expression Lysate: MECR
	GenScript Custom Purified and Recombinant Proteins Services for MECR
	Novus Biologicals Proteins for MECR
	Novus Biologicals Lysates for MECR
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for MECR

1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IDA	12654921

About this table

MECR for ontologies About GeneDecksing

Antibodies for MECR:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for MECR
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for MECR
	Novus Biologicals Antibody for MECR
	Browse antibodies at Epitomics

Assays for MECR:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MECR
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MECR

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MECR for domains About GeneDecksing

5 InterPro domains/families:

IPR013149 ADH_C

IPR011032 GroES-like

IPR013154 ADH_GroES-like

IPR002085 ADH_SF_Zn

IPR016040 NAD(P)-bd_dom

Graphical View of Domain Structure for InterPro Entry Q9BV79

ProtoNet protein and cluster: Q9BV79

1 Blocks protein family: IPB013154 Alcohol dehydrogenase GroES-like

UniProtKB/Swiss-Prot: MECR_HUMAN, Q9BV79

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: MECR_HUMAN, Q9BV79

Function: Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an

NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial

synthesis of fatty acids

Catalytic activity: Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH

Biophysicochemical properties: Kinetic parameters: KM=37 uM for trans-2-hexenoyl-CoA; KM=7.1 uM for

trans-2-decenoyl-CoA;

Enzyme Number (IUBMB): EC 1.3.1.38

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for MECR Sigma-Aldrich shRNA for MECR
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): MECR OriGene shRNA RFP (see all 2): MECR OriGene basic RS shRNA (see all 2): MECR OriGene siRNA (see all 2): MECR
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MECR

miRNA:		Sigma-Aldrich microRNA Mimics for MECR Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MECR
		1 SABiosciences Assays for microRNA that regulate MECR:
		hsa-miR-1291

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): MECR OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): MECR OriGene untagged cDNA clones in CMV expression vector (see all 3): MECR OriGene 3'-UTR clone (see all 2): MECR Browse MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): MECR
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for MECR

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	IEA	--
GO:0005488	binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0016491	oxidoreductase activity	IEA	--
GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity	IDA	12654921

About this table

MECR for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

MECR for pathways About GeneDecksing

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for MECR

Fatty Acid Elongation in Mitochondria

2 Kegg Pathways (Kegg details for MECR):

	hsa00062 Fatty acid elongation in mitochondria
	hsa01100 Metabolic pathways

SABiosciences Custom Pathway-Focused PCR Arrays for MECR

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for MECR

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MECR

5/6 Interacting proteins for MECR (ENSP00000263702³) via UniProtKB, MINT, and/or STRING (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ACAA2	ENSP00000285093³	STRING: ENSP00000285093
ECHS1	ENSP00000357535³	STRING: ENSP00000357535
ENSG00000206329	ENSP00000372789³	STRING: ENSP00000372789
HADHA	ENSP00000370023³	STRING: ENSP00000370023
PPT1	ENSP00000361865³	STRING: ENSP00000361865

About this table

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006631	fatty acid metabolic process	IDA	12654921
GO:0006633	fatty acid biosynthetic process	IEA	--
GO:0055114	oxidation-reduction process	IEA	--

About this table

MECR for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

MECR for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MECR
1 Novoseek chemical compound relationship for MECR gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
progesterone	52.5	5	1892850 (2), 8089199 (1), 1815590 (1), 2021645 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for MECR Sigma-Aldrich shRNA for MECR
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): MECR OriGene shRNA RFP (see all 2): MECR OriGene basic RS shRNA (see all 2): MECR OriGene siRNA (see all 2): MECR
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MECR

miRNA:		Sigma-Aldrich microRNA Mimics for MECR Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MECR
		1 SABiosciences Assays for microRNA that regulate MECR:
		hsa-miR-1291

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): MECR OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): MECR OriGene untagged cDNA clones in CMV expression vector (see all 3): MECR OriGene 3'-UTR Clone (see all 2): MECR Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): MECR

Primers:		OriGene genome-wide validated SYBR primer pairs: MECR Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for MECR: PPH13860A

REFSEQ mRNAs for MECR gene (2 alternative transcripts):

NM_001024732.1 NM_016011.2

Additional cDNA sequence:

AF151821.1 AK025830.1 AK095099.1 AK225687.1 AK226084.1 AK300889.1 AK315274.1 BC001419.2

CR456703.1 CR604427.1 CR616740.1 CR624586.1 CR626137.1

18 DOTS entries:

DT.452328 DT.91763770 DT.100798959 DT.91763769 DT.100798953 DT.91763771 DT.100798955 DT.95174118

DT.100798958 DT.431671 DT.91763774 DT.91839251 DT.95174117 DT.100798961 DT.121404917 DT.121404940

DT.99927194 DT.100798960

24/182 AceView cDNA sequences (see all 182):

BI856447 BM673423 CR604427 CR616740 AI609046 BU735019 AA449215 AU099187

AA962664 CR624586 BM665899 AA393872 CR626137 R47992 AA463768 BM762641

BM849428 AW005319 AI354426 BM981418 BM762525 BM696368 BG677456 BM673220

highest scoring ESTs for MECR:

AA150070 AA310756 AA425098 AA449214 AF151821 AK025830 AK095099 AU099187 AV650218 AV650800

Unigene Cluster for MECR:

Mitochondrial trans-2-enoyl-CoA reductase

Hs.183646 [show with all ESTs]

Unigene Representative Sequence: NM_001024732

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for MECR (see all 16)

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2	^	3	^	4	^	5a	·	5b	·	5c	·	5d	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	^	9a	·	9b	^	10	^	11	^	12	^	13	^
SP1:													-		-		-		-		-		-		-		-		-		-		-		-
SP2:													-		-		-		-		-		-		-		-		-		-		-
SP3:													-		-		-		-		-		-		-		-						-		-
SP4:													-		-		-		-						-		-								-
SP5:													-		-		-		-		-		-		-		-		-		-		-		-												-

ExUns:	14	^	15a	·	15b	^	16a	·	16b	·	16c
SP1:			-
SP2:			-
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for MECR
18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):

ENST00000475773 ENST00000463412 ENST00000453185 ENST00000490529 ENST00000464511

ENST00000463052 ENST00000489248 ENST00000475861 ENST00000472630 ENST00000474946

ENST00000464915 ENST00000482610 ENST00000484012 ENST00000493928 ENST00000398820

ENST00000373792(uc001brq.1 uc001brr.1 uc010ofz.1) ENST00000473030

ENST00000373791(uc001brp.1 uc001brs.1 uc001brt.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

MECR expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching MECR gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
49341_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	R77016	0.80	1.00	0.91	1
218664_at²^{, 3}	U133-A	1	0.91	1.00	--	--	NM_016011	0.60	1.00	0.82	1
218664_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

About this table

MECR for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

MECR gene electronic northern expression

About these images

CGAP SAGE TAG: GGAGGGGAGG

SOURCE GeneReport for Unigene cluster: Hs.183646

UniProtKB/Swiss-Prot: MECR_HUMAN, Q9BV79

Tissue specificity: Highly expressed in skeletal and heart muscle. Expressed at lower level in placenta, liver, kidney

and pancreas. Weakly or not expressed in lung

Primers:		OriGene genome-wide validated SYBR primer pairs: MECR Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for MECR: PPH13860A

SABiosciences Custom PCR Arrays for MECR

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MECR gene from 5/19 species (see all 19)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MECR¹	--	mitochondrial trans-2-enoyl-CoA reductase	88.58(n) 87.4(a)	478159 XM_535334.2 XP_535334.2
chimpanzee (Pan troglodytes)	MECR¹	--	mitochondrial trans-2-enoyl-CoA reductase	99.64(n) 99.2(a)	456690 XM_001156115.1 XP_001156115.1
cow (Bos taurus)	MECR¹	--	mitochondrial trans-2-enoyl-CoA reductase	87.04(n) 84.45(a)	353301 NM_181669.1 NP_858055.1
rat (Rattus norvegicus)	Mecr¹	--	mitochondrial trans-2-enoyl-CoA reductase	83.02(n) 81.23(a)	29470 NM_017209.1 NP_058905.1
mouse (Mus musculus)	Mecr^{1 , 5}	4 (64.52 cM)⁵	mitochondrial trans-2-enoyl-CoA reductase^{1, 5}	82.57(n)¹ 81.77(a)¹	26922¹ NM_025297.1¹ NP_079573.1¹ AA241313⁵ AA241805⁵ (see all 21)

About this table Species with no ortholog for MECR

ENSEMBL Gene Tree for MECR (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs903045^1,2	C,F,A,	29528412(-)	`CACATC/GTCCCT`	2	--	int¹		13		MN NS EA NA WA	1150
rs1021461^1,2	C	29528653(-)	`AAAAAG/AAAGCA`	2	--	int¹		4		NS EA	420
rs1062924^1,2	C,F,A,H,	29529699(-)	`CAAGCG/AGTCAT`	4	/A	ref¹ syn¹		19		EA MN NA NS WA	2444
rs1128400^1,2	C,F,A,H,	29542637(-)	`ACGGAC/TTCCTT`	4	L F	mis¹ ref¹		23		EA MN NA NS WA	2942
rs1138114^1,2	--	29519669(-)	`ggtcaA/Gcctag`	2	--	ut3¹		0	--	--	--	--
rs1138115^1,2	--	29519665(-)	`aacctA/Gggtaa`	2	--	ut3¹		0	--	--	--	--
rs1138118^1,2	--	29519595(-)	`cctgtA/Ggtccc`	2	--	ut3¹		0	--	--	--	--
rs1138121^1,2	--	29519559(-)	`ggatcA/Gcctga`	2	--	ut3¹		0	--	--	--	--
rs1466701^1,2	C,A,H,	29554579(-)	`actacC/Ggtatg`	2	--	int¹		9		NA EA WA	222
rs1565715^1,2	C,F,	29539823(-)	`CTGGCG/AGTGAA`	2	--	int¹		6		EA NS NA WA	372

About this table

HapMap Linkage Disequilibrium images for MECR (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MECR: --

QIAGEN SeqTarget long-range PCR primers for resequencing MECR

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MECR for disorders About GeneDecksing

OMIM: 608205

Human Genome Epidemiology (HuGE) Navigator: MECR (1 document)

Export disorders and mutations for MECR gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/17 PubMed articles for MECR gene, integrated from 7 sources (see all 17):
(articles sorted by number of sources associating them with MECR)

Characterization of 2-enoyl thioester reductase from mammals: an ortholog of Ybr026p/Mrf1'p of the yeast mitochondrial fatty acid synthesis type II. (PubMed id 12654921)^{1, 2, 3, 7} Miinalainen I.J.... Hiltunen J.K. (2003)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)^{1, 2} Lai C.H....Lin W. (2000)
Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors. (PubMed id 9795230)^{1, 3} Masuda N....Osumi T. (1998)
Structural enzymological studies of 2-enoyl thioester reductase of the human mitochondrial FAS II pathway: new insights into its substrate recognition properties. (PubMed id 18479707)^{1, 7} Chen Z.J....Haapalainen A.M. (2008)
Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)¹ Suzuki Y.... Sugano S. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 51102	HGNC: 19691	AceView: CGI-63	Ensembl:ENSG00000116353	euGenes: HUgn51102
ECgene: MECR	Kegg: 51102	H-InvDB: MECR

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Intellectual Property for MECR gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for MECR gene:
Search GeneIP for patents involving MECR

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MECR		Antibodies for MECR
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	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
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	Antibodies		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MECR
	SeqTarget long-range PCR primers for resequencing MECR
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MECR
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MECR

	GenScript Custom Purified and Recombinant Proteins Services for MECR		GenScript cDNA clones with any tag delivered in your preferred vector for MECR
	GenScript Custom Assay Services for MECR		GenScript Custom Superior Antibodies Services for MECR
	GenScript Custom overexpressing Cell Line Services for MECR		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in MECR promoter
	Search Chromatin IP Primers for MECR
	RT² qPCR Primer Assay for MECR
	Search GNC Networks for MECR
	Assays for microRNAs that regulate MECR
	SABiosciences Custom PCR Arrays for MECR

Search Tocris compounds for MECR

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for MECR
	Proteins for MECR
	Lysates for MECR

Browse antibodies at Epitomics

Recombinant Protein for MECR

ELISAs and CLIAs for MECR

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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MECR Gene

protein-coding GIFtS: 55

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MECR Gene

protein-coding GIFtS: 55

Aliases & Descriptionsfor MECR gene

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for MECR gene

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for MECR gene

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for MECR gene

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