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MEIS2 Gene

protein-coding   GIFtS: 60

GC15M014029
Meis homeobox 2
(Previous names: Meis (mouse) homolog 2, Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
Meis homeobox 21 2     homeobox protein Meis22
MRG11 2 3 5     TALE homeobox protein Meis22
HsT183611 2     Meis homolog 22
Meis1-related protein 12 3     Meis1, myeloid ecotropic viral integration site 1 homolog 22
Meis (mouse) homolog 21     OTTHUMP000001602092
Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse)1     MGC28202
Meis1-related gene 12     

External Ids:    HGNC: 70011   Entrez Gene: 42122   Ensembl: ENSG000001341387   UniProtKB: O147703   

Export aliases for MEIS2 gene to outside databases

Previous GC identifers: GC15M032527 GC15M030078 GC15M034762 GC15M034899 GC15M034970 GC15M037183


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MEIS2:
This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of
homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several
members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding
distinct isoforms have been described for this gene. (provided by RefSeq)

Gene Wiki entry for MEIS2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MEIS2 gene promoter:
         HNF-1A   HOXA9B   Meis-1   FOXC1   MZF-1   Nkx2-2   C/EBPalpha   Lmo2   TGIF   FAC1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for MEIS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MEIS2 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q14   Ensembl cytogenetic band:  15q14   HGNC cytogenetic band: 15q14

MEIS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MEIS2 gene location

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M014029:  view genomic region     (about GC identifiers)

Start:
14,029,121 bp from pter
End:
14,239,280 bp from pter
Size:
210,160 bases
Orientation:
minus strand

1 alternative location:
Chr15- 37,183,222-37,393,500     
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: MEIS2_HUMAN, O14770 (See protein sequence)
Recommended Name: Homeobox protein Meis2  
Size: 477 amino acids; 51790 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q96KI4 Q96KI5 Q9NRS1 Q9NRS2 Q9NRS3
Alternative splicing: 5 isoforms:  O14770-1   O14770-2   O14770-3   O14770-4   O14770-5   

Explore the universe of human proteins at neXtProt for MEIS2: NX_O14770 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (7 alternative transcripts): 
    NP_002390.1  NP_733774.1  NP_733775.1  NP_733776.1  NP_733777.1  NP_758526.1  NP_758527.1  


    ENSEMBL proteins: 
    ENSP00000380745 ENSP00000404185 ENSP00000219869 ENSP00000391887 ENSP00000380749 ENSP00000341400 
    ENSP00000372216 ENSP00000326296 ENSP00000339549 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): MEIS2
    OriGene Protein Over-expression Lysate (see all 3): MEIS2
    GenScript Custom Purified and Recombinant Proteins Services for MEIS2 
    Novus Biologicals Protein for MEIS2
    Novus Biologicals Lysates for MEIS2
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm ----
    About this table

    MEIS2 for ontologies           About GeneDecksing



    Antibodies for MEIS2: 
    Millipore Mono- and Polyclonal Antibodies for the study of MEIS2
    Sigma-Aldrich Antibodies for MEIS2
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for MEIS2 
    Novus Biologicals Antibodies for MEIS2
    Browse antibodies at Epitomics

    Assays for MEIS2: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MEIS2 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MEIS2 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MEIS2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR012287 Homeodomain-rel
     IPR001356 Homeobox
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry O14770

    ProtoNet protein and cluster: O14770

    UniProtKB/Swiss-Prot: MEIS2_HUMAN, O14770
    Similarity: Belongs to the TALE/MEIS homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for MEIS2
    Sigma-Aldrich shRNA for MEIS2
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 8): MEIS2
    OriGene shRNA RFP (see all 8): MEIS2
    OriGene basic RS shRNA (see all 8): MEIS2
    OriGene siRNA (see all 8): MEIS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MEIS2 
    miRNA:Sigma-Aldrich microRNA Mimics for MEIS2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MEIS2 
    8/31 SABiosciences Assays for microRNAs that regulate MEIS2 (see all 31):
    hsa-miR-623 hsa-let-7d hsa-miR-199b-3p hsa-miR-202 hsa-miR-199a-3p hsa-miR-139-5p hsa-let-7c hsa-miR-570

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 7): MEIS2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 7): MEIS2
    OriGene untagged cDNA clones in CMV expression vector (see all 9): MEIS2
    OriGene 3'-UTR clone (see all 7): MEIS2 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 7): MEIS2 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for MEIS2 

    Genatlas biochemistry entry for MEIS2:
    homeo domain protein,murine Meis1 (myeloid ecotropic viral integration site 1) ortholog,PBX1 related,expressed in
    hematopoietic tissues and brain,binding DNA cooperatively with the heterodimer E2A/myogenic transcription factors

    5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding ----
    GO:0003700 sequence-specific DNA binding transcription factor activity IEA--
    GO:0003704 specific RNA polymerase II transcription factor activity TAS10764806
    GO:0003714 transcription corepressor activity TAS10764806
    GO:0043565 sequence-specific DNA binding IEA--
    About this table

    MEIS2 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for MEIS2 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MEIS2

    1 Interacting protein for MEIS2 (O147702) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PBX1P404242MINT-7718083 MINT-7718330 MINT-7718353 MINT-7718110 MINT-7718300 MINT-7718256 MINT-7718172
    About this table

    4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS10764806
    GO:0001654 eye development IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA--
    About this table

    MEIS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    MEIS2 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MEIS2
    1 Novoseek chemical compound relationship for MEIS2 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 37.2 4 15069081 (1), 10952894 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for MEIS2
    Sigma-Aldrich shRNA for MEIS2
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 8): MEIS2
    OriGene shRNA RFP (see all 8): MEIS2
    OriGene basic RS shRNA (see all 8): MEIS2
    OriGene siRNA (see all 8): MEIS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MEIS2 
    miRNA: Sigma-Aldrich microRNA Mimics for MEIS2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MEIS2 
    8/31 SABiosciences Assays for microRNAs that regulate MEIS2 (see all 31):
    hsa-miR-623 hsa-let-7d hsa-miR-199b-3p hsa-miR-202 hsa-miR-199a-3p hsa-miR-139-5p hsa-let-7c hsa-miR-570
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 7): MEIS2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 7): MEIS2
    OriGene untagged cDNA clones in CMV expression vector (see all 9): MEIS2
    OriGene 3'-UTR Clone (see all 7): MEIS2 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 7): MEIS2 
    Primers: OriGene genome-wide validated SYBR primer pairs: MEIS2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for MEIS2: PPH17891A

    REFSEQ mRNAs for MEIS2 gene (7 alternative transcripts): 

    NM_002399.2  NM_170674.2  NM_170675.2  NM_170676.2  NM_170677.2  NM_172315.1  NM_172316.1  

    Additional cDNA sequence: 

    AF017418.1 AF178948.1 AF179896.1 AF179897.1 AF179898.1 AK001298.1 AK055936.1 AK056038.1 
    AK056216.1 AK056620.1 AK125465.1 AK226072.1 AK294411.1 AK300247.1 AK311546.1 AY349358.1 
    BC001516.2 BC001844.2 BC007202.1 BC050431.1 

    24/29 DOTS entries (see all 29):

    DT.75169805  DT.447935  DT.91693692  DT.95182481  DT.100795878  DT.121049351  DT.91836087  DT.86995473 
    DT.95182472  DT.100795877  DT.91762585  DT.97780902  DT.216393  DT.100795881  DT.205564  DT.100795879 
    DT.100017039  DT.100736406  DT.121049185  DT.121049213  DT.121049300  DT.121049480  DT.121049481  DT.91762582 

    24/184 AceView cDNA sequences (see all 184):

    BU735702 AK056038 BM717135 CD251460 CA396012 BQ631897 NM_002399 NM_170677 
    NM_020149 AW771662 AA479234 AA339253 AK125465 BF592815 AI365121 AF179896 
    BC050431 CA389173 CK822762 CB159976 AW955798 NM_170675 AK055936 NM_172315 

    highest scoring ESTs for MEIS2:

    AF017418 AL134142 AW411224 BQ212278 BU785184 BC001516 BC001844 BC007202 BC050431 AA047138 

    Unigene Cluster for MEIS2:

    Meis homeobox 2
    Hs.510989  [show with all ESTs]
    Unigene Representative Sequence: NM_170677


    GeneLoc Exon Structure

    5/22 Alternative Splicing Database (ASD) splice patterns (SP) for MEIS2 (see all 22)

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c ^
    SP1:              -     -     -           -                 -                 -                                   -     -     -     -           -     -         
    SP2:                          -           -                 -                 -                                   -     -     -     -           -               
    SP3:                          -           -                 -                 -                                   -     -     -     -           -     -         
    SP4:                                      -     -           -                 -                                   -     -     -     -           -     -         
    SP5:                          -           -                 -                 -                                   -     -     -     -           -               

    ExUns: 17a · 17b · 17c ^ 18a · 18b · 18c · 18d · 18e · 18f · 18g
    SP1:              -                                             
    SP2:              -                                             
    SP3:              -                                             
    SP4:              -                                             
    SP5:  -     -     -                                             

    About this scheme

    ECgene alternative splicing isoforms for MEIS2
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397620(uc001zjm.2) ENST00000424352(uc001zjn.2 uc001zjo.2 uc001zjr.2)
    ENST00000219869(uc001zjp.2 uc001zjs.2) ENST00000444725 ENST00000397624(uc001zjl.2 uc010ucj.1)
    ENST00000338564(uc001zjt.2) ENST00000382766 ENST00000314177(uc001zjj.2 uc001zjk.2)
    ENST00000340545(uc001zju.2)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    MEIS2 expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching MEIS2 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    41388_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AF017418 0.80 1.00 0.91 1
    207480_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_020149 0.60 1.00 0.82 1
    207480_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    MEIS2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    MEIS2 gene expression
    MEIS2 gene electronic northern expression
    MEIS2 gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.510989

    Expression variation in blood from EXPOLDB for MEIS2

    UniProtKB/Swiss-Prot: MEIS2_HUMAN, O14770
    Tissue specificity: Expressed in various tissues. In hematopoietic tissues, the lymphoid organs express high levels of
    MEIS2. Also expressed in some regions of the brain, such as the putamen

    Primers: OriGene genome-wide validated SYBR primer pairs: MEIS2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for MEIS2: PPH17891A
        SABiosciences Custom PCR Arrays for MEIS2 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for MEIS2 gene from 5/7 species (see all 7)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    MEIS21   -- Meis homeobox 2 97.52(n)
    99.57(a)
    612759  XM_843724.1  XP_848817.1 
    chimpanzee
    (Pan troglodytes)
    MEIS21   -- Meis homeobox 2 100(n)
    100(a)
    453312  XM_510290.2  XP_510290.2 
    rat
    (Rattus norvegicus)
    Meis21   -- Meis1, myeloid ecotropic viral integration site 1 homolog more 92.37(n)
    97.43(a)
    311311  XM_230449.4  XP_230449.4 
    mouse
    (Mus musculus)
    Meis21 , 5 2 (58.28 cM)5
    Meis homeobox 21, 5 95.32(n)1
    99.57(a)1
    175361  NM_010825.21  NP_034955.11 
     AA0492235  AJ0005045  (see all 24)
    chicken
    (Gallus gallus)
    MEIS21   -- Meis homeobox 2 89.12(n)
    96.92(a)
    395588  NM_204803.1  NP_990134.1 
    About this table        Species with no ortholog for MEIS2

    ENSEMBL Gene Tree for MEIS2 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for MEIS2 gene
    TGIF2LY2  PKNOX12  MEIS32  TGIF22  PKNOX22  TGIF2LX2  TGIF1P12  MEIS12  
    TGIF12  

    MEIS2 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/1831 NCBI SNPs in MEIS2 are shown (see all 1831)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 15 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs36841,2
    C,F,O,37186672(+) CACAGT/CAAATA 6 -- int18Minor allele frequency- C:0.01MN NA NS EA 742
    rs6984551,2
    C,F,O,A,37229316(+) GAGGTT/GGGATA 6 -- int112Minor allele frequency- G:0.25EA NS NA WA 506
    rs6984561,2
    C,F,O,A,37229236(+) CAAGCA/CACCCA 6 -- int16Minor allele frequency- C:0.32NA EA WA 216
    rs7162181,2
    C,F,37191961(+) AAAAGA/GTTCCA 6 -- int123Minor allele frequency- T:0.02NA EA NS WA 1620
    rs8371271,2
    C,F,A,H,37244186(+) ATGAGG/TCTGCT 6 -- int110Minor allele frequency- T:0.26NS EA NA WA 518
    rs8371281,2
    C,F,O,A,H,37244216(+) CCTGGC/TCATCA 6 -- int111Minor allele frequency- T:0.15NA NS EA WA 520
    rs8371291,2
    C,F,37244629(+) AGGATG/ACATCA 6 -- int111Minor allele frequency- A:0.35NS EA NA WA 636
    rs8371301,2
    C,A,H37244810(+) TCTCTC/GTGTGT 6 -- int12Minor allele frequency- G:0.25NA 4
    rs8371311,2
    C,F37228558(+) cgcccG/Agctaa 6 -- int13Minor allele frequency- A:0.33NA 6
    rs8371321,2
    C,F,O,37229391(+) ACTTGT/CAGATT 6 -- int112Minor allele frequency- C:0.26EA NS NA WA 512
    About this table

    HapMap Linkage Disequilibrium images for MEIS2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MEIS2
         1 CNV: 102080

    QIAGEN SeqTarget long-range PCR primers for resequencing MEIS2 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MEIS2 for disorders           About GeneDecksing

    OMIM: 601740

    Human Gene Mutation Database (HGMD): MEIS2
    Human Genome Epidemiology (HuGE) Navigator: MEIS2 (5 documents)
    Tumor Gene Database (TGDB): MEIS2

    Export disorders and mutations for MEIS2 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/39 PubMed articles for MEIS2 gene, integrated from 7 sources (see all 39):
    (articles sorted by number of sources associating them with MEIS2)
    1. Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene. (PubMed id 9383298)1, 2, 3 Smith J.E. Jr.... Takeshita K. (1997)
    2. Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription. (PubMed id 10764806)1, 2, 7 Yang Y.... Mouradian M.M. (2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin. (PubMed id 10619030)1, 7 Capdevila J....Izpisua Belmonte J.C. (1999)
    5. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010 Mar 5)
    6. MEIS proteins as partners of the TLX1/HOX11 oncoprote in. (PubMed id 19559479)1 Milech N....Watt P.M. (2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. An autoinhibitory effect of the homothorax domain of Meis2. (PubMed id 20553494)1 Hyman-Walsh C....Wotton D. (2010)
    9. Genomewide pharmacogenomic study of metabolic side ef fects to antipsychotic drugs. (PubMed id 20195266)1 Adkins D.E....van den Oord E.J. (2010)
    10. Spatiotemporal distribution of PAX6 and MEIS2 express ion and total cell numbers in the ganglionic eminence in the early developing h uman forebrain. (PubMed id 20523026)1 Larsen K.B....ller M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4212 HGNC: 7001 AceView: MEIS2 Ensembl:ENSG00000134138 euGenes: HUgn4212
    ECgene: MEIS2 H-InvDB: MEIS2

    (According to HUGE)
    About This Section
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    ATLAS Chromosomes in Cancer entry for MEIS2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for MEIS2 gene:
    Search GeneIP for patents involving MEIS2

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