Aliases &
Descriptions
for MEIS2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| Meis homeobox 21 2 | | homeobox protein Meis22 | | MRG11 2 3 5 | | TALE homeobox protein Meis22 | | HsT183611 2 | | Meis homolog 22 | | Meis1-related protein 12 3 | | Meis1, myeloid ecotropic viral integration site 1 homolog 22 | | Meis (mouse) homolog 21 | | OTTHUMP000001602092 | | Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse)1 | | MGC28202 | | Meis1-related gene 12 | | |
Export aliases for MEIS2 gene to outside databasesPrevious GC identifers: GC15M032527 GC15M030078 GC15M034762 GC15M034899 GC15M034970 GC15M037183 |
Summaries
for MEIS2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MEIS2:
This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family ofhomeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and severalmembers have been shown to be essential contributors to developmental programs. Multiple transcript variants encodingdistinct isoforms have been described for this gene. (provided by RefSeq)
Gene Wiki entry for MEIS2 |
Genomic Views
for MEIS2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MEIS2 gene promoter:
HNF-1A HOXA9B Meis-1 FOXC1 MZF-1 Nkx2-2 C/EBPalpha Lmo2 TGIF FAC1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MEIS2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MEIS2  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q14 Ensembl cytogenetic band: 15q14 HGNC cytogenetic band: 15q14MEIS2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M014029: view genomic region
(about GC identifiers)
Start:
|
14,029,121 bp from pter |
End:
|
14,239,280 bp from pter |
Size:
|
210,160 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr15- 37,183,222-37,393,500 |
RefSeq DNA sequence:- NC_000015.9 NT_010194.17
|
Proteins
for MEIS2 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: MEIS2_HUMAN, O14770 (See
protein sequence)Recommended Name: Homeobox protein Meis2 Size: 477 amino acids; 51790 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q96KI4 Q96KI5 Q9NRS1 Q9NRS2 Q9NRS3Alternative splicing: 5 isoforms: O14770-1 O14770-2 O14770-3 O14770-4 O14770-5 Explore the universe of human proteins at neXtProt for MEIS2: NX_O14770
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (7 alternative transcripts):
NP_002390.1 NP_733774.1 NP_733775.1 NP_733776.1 NP_733777.1 NP_758526.1 NP_758527.1
ENSEMBL proteins: ENSP00000380745 ENSP00000404185 ENSP00000219869 ENSP00000391887 ENSP00000380749 ENSP00000341400 ENSP00000372216 ENSP00000326296 ENSP00000339549
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
MEIS2 for ontologies About GeneDecksing
Antibodies for MEIS2:
Assays for MEIS2: |
Protein
Domains/
Families
for MEIS2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MEIS2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O14770ProtoNet protein and cluster: O14770 UniProtKB/Swiss-Prot: MEIS2_HUMAN, O14770Similarity: Belongs to the TALE/MEIS homeobox familySimilarity: Contains 1 homeobox DNA-binding domain |
Gene Function
for MEIS2 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
Genatlas biochemistry entry for MEIS2:homeo domain protein,murine Meis1 (myeloid ecotropic viral integration site 1) ortholog,PBX1 related,expressed inhematopoietic tissues and brain,binding DNA cooperatively with the heterodimer E2A/myogenic transcription factors5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
MEIS2 for ontologies About GeneDecksing
|
Pathways & Interactions
for MEIS2 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for MEIS2
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MEIS2
1 Interacting protein for MEIS2 (O147702) via UniProtKB, MINT, and/or STRINGAbout this table
4 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
TAS | 10764806 | | GO:0001654 | eye development |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter |
IEA | -- |
About this table
MEIS2 for ontologies About GeneDecksing
|
Drugs & Compounds
for MEIS2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
MEIS2 for compounds About GeneDecksing
 Browse Tocris compounds for MEIS2
1  Novoseek chemical compound relationship for MEIS2 gene
About this table
|
Transcripts
for MEIS2 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for MEIS2 gene (7 alternative transcripts): NM_002399.2 NM_170674.2 NM_170675.2 NM_170676.2 NM_170677.2 NM_172315.1 NM_172316.1 Additional cDNA sequence: AF017418.1 AF178948.1 AF179896.1 AF179897.1 AF179898.1 AK001298.1 AK055936.1 AK056038.1 AK056216.1 AK056620.1 AK125465.1 AK226072.1 AK294411.1 AK300247.1 AK311546.1 AY349358.1 BC001516.2 BC001844.2 BC007202.1 BC050431.1 24/29 DOTS entries (see all 29): DT.75169805 DT.447935 DT.91693692 DT.95182481 DT.100795878 DT.121049351 DT.91836087 DT.86995473 DT.95182472 DT.100795877 DT.91762585 DT.97780902 DT.216393 DT.100795881 DT.205564 DT.100795879 DT.100017039 DT.100736406 DT.121049185 DT.121049213 DT.121049300 DT.121049480 DT.121049481 DT.91762582 24/184 AceView cDNA sequences (see all 184): BU735702 AK056038 BM717135 CD251460 CA396012 BQ631897 NM_002399 NM_170677 NM_020149 AW771662 AA479234 AA339253 AK125465 BF592815 AI365121 AF179896 BC050431 CA389173 CK822762 CB159976 AW955798 NM_170675 AK055936 NM_172315
 highest scoring ESTs for MEIS2:AF017418 AL134142 AW411224 BQ212278 BU785184 BC001516 BC001844 BC007202 BC050431 AA047138 Unigene Cluster for MEIS2: Meis homeobox 2 Hs.510989 [show with all ESTs]Unigene Representative Sequence: NM_170677
GeneLoc Exon Structure
5/22 Alternative Splicing Database (ASD) splice patterns (SP) for MEIS2 (see all 22)
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ |
|---|
|
| SP1: | | | | | - | | - | | - | | | | - | | | | | | - | | | | | | - | | | | | | | | | | | | - | | - | | - | | - | | | | - | | - | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | | | - | | | | | | - | | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | |
| SP3: | | | | | | | | | - | | | | - | | | | | | - | | | | | | - | | | | | | | | | | | | - | | - | | - | | - | | | | - | | - | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | | | - | | | | | | - | | | | | | | | | | | | - | | - | | - | | - | | | | - | | - | | | | |
| SP5: | | | | | | | | | - | | | | - | | | | | | - | | | | | | - | | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | | |
| ExUns: | 17a | · | 17b | · | 17c | ^ | 18a | · | 18b | · | 18c | · | 18d | · | 18e | · | 18f | · | 18g |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | - | | - | | - | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for MEIS2
9 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000397620(uc001zjm.2) ENST00000424352(uc001zjn.2 uc001zjo.2 uc001zjr.2)
ENST00000219869(uc001zjp.2 uc001zjs.2) ENST00000444725 ENST00000397624(uc001zjl.2 uc010ucj.1)
ENST00000338564(uc001zjt.2) ENST00000382766 ENST00000314177(uc001zjj.2 uc001zjk.2)
ENST00000340545(uc001zju.2)
|
Expression
for MEIS2 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| MEIS2 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching MEIS2 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 41388_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
AF017418 |
0.80 |
1.00 |
0.91 |
1 |
| 207480_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_020149 |
0.60 |
1.00 |
0.82 |
1 |
| 207480_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
MEIS2 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.510989
Expression variation in blood from EXPOLDB for MEIS2 UniProtKB/Swiss-Prot: MEIS2_HUMAN, O14770Tissue specificity: Expressed in various tissues. In hematopoietic tissues, the lymphoid organs express high levels ofMEIS2. Also expressed in some regions of the brain, such as the putamen
SABiosciences Custom PCR Arrays for MEIS2
|
Orthologs
for MEIS2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for MEIS2 gene from 5/7 species (see all 7)
About this table Species with no ortholog for MEIS2
ENSEMBL Gene Tree for MEIS2 (if available) |
Paralogs
for MEIS2 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for MEIS2 gene
- TGIF2LY2 PKNOX12 MEIS32 TGIF22 PKNOX22 TGIF2LX2 TGIF1P12 MEIS12
- TGIF12
MEIS2 for paralogs About GeneDecksing
|
Genomic Variants
for MEIS2 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 15 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for MEIS2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MEIS2
1 CNV: 102080 | | QIAGEN SeqTarget long-range PCR primers for resequencing MEIS2 |
|
Disorders & Mutations
for MEIS2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MEIS2 for disorders About GeneDecksing
OMIM: 601740
Human Gene Mutation Database (HGMD): MEIS2
Human Genome Epidemiology (HuGE) Navigator: MEIS2 (5 documents)
Tumor Gene Database (TGDB): MEIS2
Export disorders and mutations for MEIS2 gene to outside databases
|
Medical News
for MEIS2 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for MEIS2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/39 PubMed articles for MEIS2 gene, integrated from 7 sources (see all 39):
(articles sorted by number of sources associating them with MEIS2)- Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene. (PubMed id 9383298)1, 2, 3 Smith J.E. Jr.... Takeshita K. (1997)
- Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription. (PubMed id 10764806)1, 2, 7 Yang Y.... Mouradian M.M. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin. (PubMed id 10619030)1, 7 Capdevila J....Izpisua Belmonte J.C. (1999)
- An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010 Mar 5)
- MEIS proteins as partners of the TLX1/HOX11 oncoprote in. (PubMed id 19559479)1 Milech N....Watt P.M. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- An autoinhibitory effect of the homothorax domain of Meis2. (PubMed id 20553494)1 Hyman-Walsh C....Wotton D. (2010)
- Genomewide pharmacogenomic study of metabolic side ef fects to antipsychotic drugs. (PubMed id 20195266)1 Adkins D.E....van den Oord E.J. (2010)
- Spatiotemporal distribution of PAX6 and MEIS2 express ion and total cell numbers in the ganglionic eminence in the early developing h uman forebrain. (PubMed id 20523026)1 Larsen K.B....ller M. (2010)
|
External Searches for MEIS2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MEIS2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MEIS2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MEIS2 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MEIS2 gene:
Search GeneIP for patents involving MEIS2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MEIS2 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for MEIS2 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for MEIS2 |
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