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Aliases & Descriptionsfor MFF gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions mitochondrial fission factor1 2 MGC1109132 GL0041 2 OTTHUMP000002039892 C2orf332 3 OTTHUMP000001642352 chromosome 2 open reading frame 331 DKFZp666J1682
Export aliases for MFF gene to outside databases Previous GC identifers: GC02P227899 GC02P228189
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Summariesfor MFF gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: MFF_HUMAN, Q9GZY8 Function : Plays a role in mitochondrial and peroxisomal fission
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Genomic Viewsfor MFF gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for MFF Other transcription factors Search SABiosciences Chromatin IP Primers for MFF Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MFF
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2q36.3 Ensembl cytogenetic band: 2q36.3 HGNC cytogenetic band: 2q36 MFF Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02P220036: view genomic region
(about GC identifiers )
Start:
220,035,637 bp from pter
End:
220,065,947 bp from pter
Size:
30,311 bases
Orientation:
plus strand
1 alternative location : Chr 2+ 228,189,867-228,222,550
RefSeq DNA sequence: NC_000002.11 NT_005403.17
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Proteinsfor MFF gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: MFF_HUMAN, Q9GZY8 (See
protein sequence )Recommended Name: Mitochondrial fission factor Size : 342 amino acids; 38465 Da
Subcellular location : Mitochondrion outer membrane; Single-pass type IV membrane protein
Secondary accessions : Q567U1 Q658R6 Q9BVZ1 Q9H690 Q9NRG8Alternative splicing : 5 isoforms : Q9GZY8-1 Q9GZY8-2 Q9GZY8-3 Q9GZY8-4 Q9GZY8-5 Explore the universe of human proteins at neXtProt for MFF: NX_Q9GZY8 Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins: NP_064579.3 ENSEMBL proteins: ENSP00000390165 ENSP00000304898 ENSP00000302037 ENSP00000386964 ENSP00000415996 ENSP00000386641 ENSP00000338412 ENSP00000411386 ENSP00000391829 ENSP00000407547 ENSP00000398298 ENSP00000415313 ENSP00000375912 ENSP00000375911 ENSP00000304134 ENSP00000346498 Human Recombinant Proteins 5 Gene Ontology (GO) cellular component terms (GO ID links to tree view) :
About this table
MFF for ontologies About GeneDecksing Antibodies for MFF: Assays for MFF:
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Protein
Domains/ Familiesfor MFF gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MFF for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q9GZY8 ProtoNet protein and cluster: Q9GZY8
UniProtKB/Swiss-Prot: MFF_HUMAN, Q9GZY8 Similarity : Belongs to the tango11 family
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Gene Functionfor MFF gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: MFF_HUMAN, Q9GZY8 Function : Plays a role in mitochondrial and peroxisomal fission
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Pathways & Interactionsfor MFF gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section SABiosciences Custom Pathway-Focused PCR Arrays for MFF Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MFF
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Drugs & Compoundsfor MFF gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for MFF
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Transcriptsfor MFF gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for MFF gene: NM_020194.4
Additional cDNA sequence: AF226049.1 AF246239.1 AF258660.1 AK026137.1 AL833032.1 BC000797.1 BC093024.1 CR593325.1 CR604101.1 CR605975.1 CR610466.1 CR619534.1 CR625753.1
24/46 DOTS entries (see all 46 ): DT.100039364 DT.95095294 DT.91862879 DT.419092 DT.100039362 DT.100889797 DT.92017025 DT.100039363
DT.91776269 DT.100889748 DT.100889791 DT.95342457 DT.91776249 DT.121013360 DT.121013432 DT.121013429 DT.95342420 DT.99994693 DT.100889784 DT.100889790 DT.91735333 DT.100889785 DT.40211143 DT.437069 24/466 AceView cDNA sequences (see all 466 ):
BM769021 BM718271 CA421494 CA418251 BQ014605 BM856464 W74362 CA432994 NM_020194 AA548624 AI241535 AW131824 CA312651 AA767495 BU626027 CR619534 AF226049 N22129 AI792644 CR610466 AI005034 BU683953 BM855494 AI359755 Unigene Cluster for MFF:
Mitochondrial fission factor Hs.471528 [show with all ESTs ] Unigene Representative Sequence: NM_020194 GeneLoc Exon Structure 5/16 Alternative Splicing Database (ASD) splice patterns (SP) for MFF (see all 16 ) ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ SP1 :               -       -   -   -   -               -   -   -   -   -   -   SP2 :               -       -   -   -   -               -   -   -   -       SP3 :               -       -   -   -   -               -   -   -   -   -   -   SP4 :                     -   -   -   -                   -   -       SP5 :                                               -      
ExUns: 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c · 14d · 14e · 14f SP1 : -                     SP2 :                     SP3 : -   -                   SP4 :                     SP5 :                    
About this scheme ECgene alternative splicing isoforms for MFF 18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24 ): ENST00000423098 ENST00000304593 (uc002vot.2 uc002vov.2 uc002vox.2 uc002voz.2 )ENST00000476924 ENST00000489696 ENST00000353339 (uc002vos.2 uc002vou.2 uc002vow.2 )ENST00000409565 ENST00000452930 ENST00000409616 ENST00000460756 ENST00000337110 ENST00000470090 ENST00000485697 ENST00000436237 ENST00000443428 ENST00000418961 ENST00000436791 ENST00000456345 ENST00000490857 (uc002vpa.2 )
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Expression for MFF gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section MFF expression in normal and diseased human tissues 1 / 2
11 probe-sets matching MFF gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
65925_at2
U95-C
2
1.00
0.97
0.91
1.09
--
--
--
--
--
65926_at2
U95-C
3
1.00
0.92
0.64
1.06
--
--
--
--
--
61046_i_at*2
U95-C
1
--
--
-0.24
0.85
--
--
--
--
--
219137_s_at2
U133-A
1
1.00
1.00
--
--
--
--
--
--
--
222832_s_at2
U133-B
2
1.00
0.95
--
--
--
--
--
--
--
223354_x_at2
U133-B
3
1.00
0.91
--
--
--
--
--
--
--
223091_x_at2
U133-B
3
1.00
0.91
--
--
--
--
--
--
--
219137_s_at2
U133Plus2
1
1.00
1.00
--
--
--
--
--
--
--
222832_s_at2
U133Plus2
2
1.00
0.95
--
--
--
--
--
--
--
223354_x_at2
U133Plus2
3
1.00
0.91
--
--
--
--
--
--
--
223091_x_at2
U133Plus2
3
1.00
0.91
--
--
--
--
--
--
--
About this table
MFF for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CGTGAACAAT SOURCE GeneReport for Unigene cluster: Hs.471528 UniProtKB/Swiss-Prot: MFF_HUMAN, Q9GZY8 Tissue specificity : Highly expressed in heart, kidney, liver, brain, muscle, and stomach
SABiosciences Custom PCR Arrays for MFF
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Orthologsfor MFF gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for MFF gene from 5/6 species (see all 6 )
About this table Species with no ortholog for MFF ENSEMBL Gene Tree for MFF (if available)
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Paralogsfor MFF gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section --
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Genomic Variantsfor MFF gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 2 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for MFF (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MFF: --
QIAGEN SeqTarget long-range PCR primers for resequencing MFF
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Disorders & Mutationsfor MFF gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
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Medical Newsfor MFF gene (Possibly Related Articles in
Doctor's Guide )
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Publicationsfor MFF gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10/11 PubMed articles for MFF gene, integrated from 7 sources (see all 11 ): (articles sorted by number of sources associating them with MFF) The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. (PubMed id 18353969) 1 , 2 , 3 Gandre-Babbe S. and van der Bliek A.M. (2008) Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336) 2 Cantin G.T....Yates J.R. III (2008) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 2 Dephoure N.... Gygi S.P. (2008) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 2 Olsen J.V....Mann M. (2006) The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974) 2 Sjoeblom T.... Velculescu V.E. (2006) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621) 2 Hillier L.W....Wilson R.K. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004)
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External Searches for MFF gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MFF gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MFF gene
(According to HUGE )
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Specialized Databases showing MFF gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for MFF gene: Search GeneIP for patents involving MFF GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MFF gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for MFF
ELISAs and CLIAs for MFF
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