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Aliases & Descriptionsfor MINA gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions MYC induced nuclear antigen1 2 NO522 3 MINA531 2 3 5 mdig1 MDIG2 3 5 myc-induced nuclear antigen, 53 kDa2 FLJ143931 2 mineral dust induced gene protein2 Mineral dust-induced gene protein2 3 DKFZp762O19122 Nucleolar protein 522 3 MYC-induced nuclear antigen2
Export aliases for MINA gene to outside databases Previous GC identifers: GC03M098985 GC03M099146 GC03M097660
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Summariesfor MINA gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for MINA : MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 (PubMed 12091391); Zhang et al., 2005 (PubMed 15897898)).(supplied by OMIM) UniProtKB/Swiss-Prot: MINA_HUMAN, Q8IUF8 Function : Involved in cellular proliferation. May play an important role in cell growth and survival. May be involvedin ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles Gene Wiki entry for MINA
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Genomic Viewsfor MINA gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MINA gene promoter: POU3F2 (N-Oct-5b) POU3F2 POU3F2 (N-Oct-5a) Nkx6-1 ATF6 Pbx1a MRF-2 CP1A NF-Y NF-YA Other transcription factors Search SABiosciences Chromatin IP Primers for MINA Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MINA
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3q11.2 Ensembl cytogenetic band: 3q11.2 HGNC cytogenetic band: 3q22.1 MINA Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03M095030: view genomic region
(about GC identifiers )
Start:
95,030,556 bp from pter
End:
95,061,194 bp from pter
Size:
30,639 bases
Orientation:
minus strand
1 alternative location : Chr 3- 97,660,661-97,691,301
RefSeq DNA sequence: NC_000003.11 NT_005612.16
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Proteinsfor MINA gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: MINA_HUMAN, Q8IUF8 (See
protein sequence )Recommended Name: MYC-induced nuclear antigen Size : 465 amino acids; 52800 Da
Subcellular location : Nucleus. Nucleus, nucleolus
Sequence caution : Sequence=CAH10679.1; Type=Erroneous termination; Positions=431; Note=Translated as Trp;
PDB structures from and Proteopedia : 2XDV (3D)
 
Secondary accessions : Q6AHW4 Q6SKS0 Q8IU69 Q8IUF6 Q8IUF7 Q96C17 Q96KB0Alternative splicing : 4 isoforms : Q8IUF8-1 Q8IUF8-2 Q8IUF8-3 Q8IUF8-4 Explore the universe of human proteins at neXtProt for MINA: NX_Q8IUF8 Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (3 alternative transcripts):
NP_001035998.1 NP_116167.3 NP_694822.2 ENSEMBL proteins: ENSP00000327424 ENSP00000424955 ENSP00000421347 ENSP00000377748 ENSP00000328251 ENSP00000402961 ENSP00000423816 ENSP00000424530 ENSP00000353395 Human Recombinant Proteins 3 Gene Ontology (GO) cellular component terms (GO ID links to tree view) :
About this table
MINA for ontologies About GeneDecksing Antibodies for MINA: Assays for MINA:
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Protein
Domains/ Familiesfor MINA gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MINA for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8IUF8 ProtoNet protein and cluster: Q8IUF8
2 Blocks protein families : IPB003347 Transcription factor jumonji IPB013109 Cupin 4 UniProtKB/Swiss-Prot: MINA_HUMAN, Q8IUF8 Similarity : Belongs to the MINA53/NO66 familySimilarity : Contains 1 JmjC domain
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Gene Functionfor MINA gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: MINA_HUMAN, Q8IUF8 Function : Involved in cellular proliferation. May play an important role in cell growth and survival. May be involvedin ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles Induction : Up-regulated in response to MYC, in alveolar macrophages from coal miners and in silica particle-treatedA549 lung cancer cells
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Pathways & Interactionsfor MINA gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section SABiosciences Custom Pathway-Focused PCR Arrays for MINA SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MINA 1 Interacting protein for MINA (Q8IUF8 2 ) via UniProtKB, MINT, and/or STRING About this table 1 Gene Ontology (GO) biological process term (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0042254 ribosome biogenesis
IEA --
About this table
MINA for ontologies About GeneDecksing
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Drugs & Compoundsfor MINA gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for MINA
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Transcriptsfor MINA gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for MINA gene (3 alternative transcripts): NM_001042533.1 NM_032778.4 NM_153182.2
Additional cDNA sequence: AB083189.1 AB083190.1 AB083192.1 AB083193.1 AK027299.1 AK130907.1 AY302110.3 AY390536.1 BC014928.1 CR604605.1 CR626231.1 CR627479.1 DQ453796.1
11 DOTS entries : DT.95356072 DT.101977824 DT.99944672 DT.95268418 DT.100027234 DT.120924275 DT.95148055 DT.40203063
DT.100027233 DT.100027235 DT.97764336 24/135 AceView cDNA sequences (see all 135 ):
Z28710 AI271552 AY302110 BQ002687 BM993108 AY456380 BP344024 AI720443 BI758152 BM826519 AW297807 AA602595 AA464689 BM129584 BQ017091 AB083193 CB131640 BX384540 AI696914 BC014928 CK819575 AW263409 BE463617 CR604605
highest scoring ESTs for MINA :AB083189 AB083190 AB083192 AB083193 AI282933 AK027299 AL550737 AY302110 AY390536 BC014928 Unigene Cluster for MINA:
MYC induced nuclear antigen Hs.607776 [show with all ESTs ] Unigene Representative Sequence: NM_001042533 GeneLoc Exon Structure 5/9 Alternative Splicing Database (ASD) splice patterns (SP) for MINA (see all 9 ) ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b SP1 :                         -   -               -       SP2 :                         -                       SP3 :                         -   -                     SP4 :                                         -       SP5 :   -   -                                          
About this scheme ECgene alternative splicing isoforms for MINA 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000330299 (uc010hpb.1 ) ENST00000514314 (uc010hpa.1 ) ENST00000503097 ENST00000394198 ENST00000333396 ENST00000503517 ENST00000506682 ENST00000442492 (uc003dry.1 uc003drz.1 uc003dsa.1 uc003dsb.1 uc003dsc.1 )ENST00000506099 ENST00000507612 ENST00000360258
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Expression for MINA gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section MINA expression in normal and diseased human tissues 1 / 2 / 3
9 probe-sets matching MINA gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
34662_at2 , 3
U95-A
1
0.88
1.00
0.93
0.80
W27666
0.80
1.00
0.91
1
65108_at2 , 3
U95-C
1
0.56
1.00
0.57
1.23
AI346432
0.40
0.67
0.55
1
213189_at2
U133-A
1
1.00
1.00
--
--
--
--
--
--
--
213188_s_at2 , 3
U133-A
1
0.73
1.00
--
--
AI823896
0.40
0.50
0.45
1
229132_at2 , 3
U133-B
1
0.46
1.00
--
--
AI346432
0.40
0.67
0.55
1
213189_at2
U133Plus2
1
1.00
1.00
--
--
--
--
--
--
--
1554774_at2
U133Plus2
1
0.91
1.00
--
--
--
--
--
--
--
213188_s_at2
U133Plus2
1
0.73
1.00
--
--
--
--
--
--
--
229132_at2
U133Plus2
1
0.46
1.00
--
--
--
--
--
--
--
About this table
MINA for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.607776 Expression variation in blood from EXPOLDB for MINA
UniProtKB/Swiss-Prot: MINA_HUMAN, Q8IUF8 Tissue specificity : Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung orkidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines
SABiosciences Custom PCR Arrays for MINA
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Orthologsfor MINA gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for MINA gene from 5/11 species (see all 11 )
About this table Species with no ortholog for MINA ENSEMBL Gene Tree for MINA (if available)
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Paralogsfor MINA gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section --
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Genomic Variantsfor MINA gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 3 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for MINA (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MINA: --
QIAGEN SeqTarget long-range PCR primers for resequencing MINA
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Disorders & Mutationsfor MINA gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MINA for disorders About GeneDecksing
OMIM: 612049 Export disorders and mutations for MINA gene to outside databases
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Medical Newsfor MINA gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor MINA gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10/21 PubMed articles for MINA gene, integrated from 7 sources (see all 21 ): (articles sorted by number of sources associating them with MINA) A novel myc target gene, mina53, that is involved in cell proliferation. (PubMed id 12091391) 1 , 2 , 3, 7 Tsuneoka M.... Kimura H. (2002) The human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer. (PubMed id 15897898) 1 , 2 Zhang Y.... Chen F. (2005) Protein NO52 -- a constitutive nucleolar component sharing high sequence homologies to protein NO66. (PubMed id 15819408) 1 , 2 Eilbracht J.... Schmidt-Zachmann M.S. (2005) Mina53 as a potential prognostic factor for esophageal squamous cell carcinoma. (PubMed id 15534111) 1 , 2 Tsuneoka M.... Kimura H. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) NO66, a highly conserved dual location protein in the nucleolus and in a special type of synchronously replicating chromatin. (PubMed id 14742713) 1 , 2 Eilbracht J.... Schmidt-Zachmann M.S. (2004) Increased expression of a Myc target gene Mina53 in human colon cancer. (PubMed id 14695334) 1 , 2 Teye K.... Kimura H. (2004) Mina53, a novel c-Myc target gene, is frequently expr essed in lung cancers and exerts oncogenic property in NIH/3T3 cells. (PubMed id 19756735) 1 Komiya K....Sueoka E. (2010) Lung cancer-associated JmjC domain protein mdig suppr esses formation of tri-methyl lysine 9 of histone H3. (PubMed id 19502796) 1 Lu Y....Chen F. (2009) Expression of Mina53 and its significance in gastric carcinoma. (PubMed id 18629780) 1 Zhang Q....Liu N.Z. (2008)
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External Searches for MINA gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MINA gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MINA gene
(According to HUGE )
About This Section --
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Specialized Databases showing MINA gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for MINA gene: Search GeneIP for patents involving MINA GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MINA gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for MINA
ELISAs and CLIAs for MINA
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