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MOG Gene

protein-coding   GIFtS: 62

GC06P029431
myelin oligodendrocyte glycoprotein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
myelin oligodendrocyte glycoprotein1 2     MGC261372
OTTHUMP000002148672     OTTHUMP000002148162
OTTHUMP000000291202     OTTHUMP000002148172
MOGIG22     OTTHUMP000002148692
OTTHUMP000002148682     MOG Ig-AluB2
myelin-oligodendrocyte glycoprotein2     

External Ids:    HGNC: 71971   Entrez Gene: 43402   Ensembl: ENSG000002046557   UniProtKB: Q166533   

Export aliases for MOG gene to outside databases

Previous GC identifers: GC06P029682 GC06P029395 GC06P029732 GC06P029624


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MOG:
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface
of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination.
This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication.
Alternatively spliced transcript variants encoding different isoforms have been identified. (provided by RefSeq)

UniProtKB/Swiss-Prot: MOG_HUMAN, Q16653
Function: Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved
in completion and/or maintenance of the myelin sheath and in cell-cell communication


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MOG gene promoter:
         NF-kappaB1   Egr-1   CREB   NF-kappaB   GR-alpha   GR-beta   deltaCREB   FOXC1   ATF6   MEF-2A   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for MOG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22-p21.3

MOG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MOG gene location

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P029431:  view genomic region     (about GC identifiers)

Start:
29,431,836 bp from pter
End:
29,447,189 bp from pter
Size:
15,354 bases
Orientation:
plus strand

6/7 alternative locations (see all 7):
Chr6+,ALT_REF_LOCI_6 29,660,261-29,675,653      Chr6+,ALT_REF_LOCI_5 29,539,370-29,554,754      Chr6+,ALT_REF_LOCI_2 29,660,543-29,675,935     
Chr6+,ALT_REF_LOCI_1 29,624,905-29,648,577      Chr6+,ALT_REF_LOCI_3 29,635,752-29,651,144      Chr6+,ALT_REF_LOCI_4 29,547,377-29,562,765     
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  
NT_167249.1  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: MOG_HUMAN, Q16653 (See protein sequence)
Recommended Name: Myelin-oligodendrocyte glycoprotein precursor  
Size: 247 amino acids; 28179 Da
Subunit: Homodimer (By similarity). May form heterodimers between the different isoforms
Subcellular location: Isoform 1: Cell membrane; Multi-pass membrane protein (Potential)
Subcellular location: Isoform 5: Cell membrane; Multi-pass membrane protein (Potential)
Subcellular location: Isoform 2: Cell membrane; Single-pass type I membrane protein (Potential)
Subcellular location: Isoform 3: Cell membrane; Single-pass type I membrane protein (Potential)
Subcellular location: Isoform 4: Cell membrane; Single-pass type I membrane protein (Potential)
Subcellular location: Isoform 6: Cell membrane; Single-pass type I membrane protein (Potential)
Subcellular location: Isoform 7: Cell membrane; Single-pass type I membrane protein (Potential)
Subcellular location: Isoform 8: Cell membrane; Single-pass type I membrane protein (Potential)
Subcellular location: Isoform 9: Cell membrane; Single-pass type I membrane protein (Potential)
Caution: Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG)
PDB structures from and Proteopedia :
1Q70 (3D)    
Secondary accessions: A6NDR4 B0UZR9 O00713 O00714 O00715 Q13054 Q13055 Q14855 Q5JNY1 Q5JNY4 Q5SSB5
Q5SSB6 Q5STM0 Q5STM5 Q5SUK8 Q92891 Q92892 Q92893 Q92894 Q92895 Q93053 Q96KU9 Q96KV0 Q96KV1 Q99605
Alternative splicing: 9 isoforms:  Q16653-1   Q16653-2   Q16653-3   Q16653-4   Q16653-5   Q16653-6   Q16653-7   Q16653-8   
Q16653-9   (Additional isoforms seem to exist)

Explore the universe of human proteins at neXtProt for MOG: NX_Q16653 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (9 alternative transcripts): 
    NP_001008229.1  NP_001008230.1  NP_001163889.1  NP_002424.3  NP_996532.2  NP_996533.2  NP_996534.2  NP_996535.2  
    NP_996537.3  


    ENSEMBL proteins: 
    ENSP00000366101 ENSP00000410866 ENSP00000366115 ENSP00000418090 ENSP00000366086 ENSP00000420350 
    ENSP00000366095 ENSP00000379932 ENSP00000379929 ENSP00000366085 ENSP00000366103 ENSP00000366088 
    ENSP00000418872 ENSP00000409394 ENSP00000417405 ENSP00000366100 ENSP00000366091 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for MOG
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for MOG 
    Novus Biologicals Proteins for MOG
    Novus Biologicals Lysate for MOG
    Sino Biological Recombinant Protein for MOG
    ProSpec Recombinant Protein for MOG

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    MOG for ontologies           About GeneDecksing



    Antibodies for MOG: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for MOG
    R&D Systems Antibodies for MOG
    OriGene Antibodies (see all 3): MOG
    GenScript Superior Antibodies for MOG 
    Novus Biologicals Antibodies for MOG
    Epitomics antibodies for MOG

    Assays for MOG: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MOG 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MOG 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MOG for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR016663 Myelin-oligodendrocyte_glycop
     IPR003596 Ig_V-set_sub
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like

    Graphical View of Domain Structure for InterPro Entry Q16653

    ProtoNet protein and cluster: Q16653

    1 Blocks protein family: IPB003596 Immunoglobulin V-type

    UniProtKB/Swiss-Prot: MOG_HUMAN, Q16653
    Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: MOG_HUMAN, Q16653
    Function: Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved
    in completion and/or maintenance of the myelin sheath and in cell-cell communication

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for MOG
    Sigma-Aldrich shRNA Panels and shRNA for MOG
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 11): MOG
    OriGene shRNA RFP (see all 11): MOG
    OriGene basic RS shRNA (see all 11): MOG
    OriGene siRNA (see all 11): MOG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MOG 
    miRNA:Sigma-Aldrich microRNA Mimics for MOG
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MOG 
    2 SABiosciences Assays for microRNAs that regulate MOG:
    hsa-miR-653 hsa-miR-599

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 9): MOG
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 11): MOG
    OriGene untagged cDNA clones in CMV expression vector (see all 9): MOG
    OriGene 3'-UTR clone (see all 9): MOG 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for MOG 
    Sino Biological Human cDNA Clone for MOG

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for MOG 

    Genatlas biochemistry entry for MOG:
    myelin oligodendrocyte glycoprotein,26-28kDa,associated with multiple sclerosis susceptibility
    Animal Models: 7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Mog):
    behavior/neurologicalgrowth/sizehematopoietic systemimmune systemmuscle
    nervous systemvision/eye

    MOG for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for MOG 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MOG

    3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155 cell adhesion IEA--
    GO:0007417 central nervous system development TAS1373175
    GO:0034126 positive regulation of MyD88-dependent toll-like receptor signaling pathway ISS--
    About this table

    MOG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    MOG for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MOG available from Tocris Bioscience
    CompoundAction CAS number
    MOG (35-55)Encephalitogenic myelin oligodendrocyte glycoprotein fragment[149635-73-4]
    About this table


    10/15 Novoseek chemical compound relationships for MOG gene (see all 15)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',3'-cyclic nucleotide 71.4 4 10739571 (1), 19473295 (1), 16109311 (1), 15765008 (1)
    glyceryl monooleate 62 10 2155836 (4), 1665456 (3), 11837661 (1)
    glatiramer acetate 42.6 8 8965116 (3), 14512144 (1)
    nitrendipine 22.1 2 1665456 (2)
    oxygen 3.06 1 17640057 (1)
    calcium 2.87 2 1665456 (1), 15634682 (1)
    glucose 1.98 3 2155836 (2)
    oleic acid 0 3 11837661 (1), 2155836 (1)
    phosphoinositide 0 3 2155836 (2)
    nitric oxide 0 1 19301098 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for MOG
    Sigma-Aldrich shRNA Panels and shRNA for MOG
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 11): MOG
    OriGene shRNA RFP (see all 11): MOG
    OriGene basic RS shRNA (see all 11): MOG
    OriGene siRNA (see all 11): MOG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MOG 
    miRNA: Sigma-Aldrich microRNA Mimics for MOG
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MOG 
    2 SABiosciences Assays for microRNAs that regulate MOG:
    hsa-miR-653 hsa-miR-599
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 9): MOG
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 11): MOG
    OriGene untagged cDNA clones in CMV expression vector (see all 9): MOG
    OriGene 3'-UTR Clone (see all 9): MOG 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for MOG 
    Primers:Browse OriGene genome-wide validated SYBR primer pairs
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for MOG: PPH12417A

    REFSEQ mRNAs for MOG gene (9 alternative transcripts): 

    NM_001008228.2  NM_001008229.2  NM_001170418.1  NM_002433.4  NM_206809.3  NM_206810.3  NM_206811.3  NM_206812.3  
    NM_206814.5  

    Additional cDNA sequence: 

    AB209815.1 AK295213.1 AK308949.1 AK312892.1 AY566846.1 AY566847.1 AY566848.1 AY566851.1 
    AY566852.1 AY566853.1 AY566854.1 CR598447.1 CR623648.1 U18798.1 U18799.1 U18800.2 
    U18801.1 U18803.1 U18840.1 U18843.1 U64564.1 U64565.1 U64566.1 U64567.1 
    U64568.1 U64569.1 U64570.1 U64571.1 X74511.1 

    17 DOTS entries:

    DT.100021881  DT.97776718  DT.100758942  DT.86852541  DT.95374215  DT.92423560  DT.451713  DT.101957614 
    DT.92423563  DT.121305358  DT.121305379  DT.95374216  DT.100758944  DT.100038778  DT.100890108  DT.95115608 
    DT.99947945 

    24/29 AceView cDNA sequences (see all 29):

    U64568 U64567 NM_206810 CR598447 U18843 NM_206809 U18840 U18798 
    U64565 U18799 X74511 CR623648 U64571 U18801 U64566 NM_002433 
    BC035938 NM_206812 U64570 U18803 NM_206814 U64569 NM_206811 NM_206813 

    highest scoring ESTs for MOG:

    U64565 AW891562 BC035938 BQ344860 U18801 U18803 U18840 U64564 U64566 U64567 

    Unigene Cluster for MOG:

    Myelin oligodendrocyte glycoprotein
    Hs.141308  [show with all ESTs]
    Unigene Representative Sequence: NM_206809


    GeneLoc Exon Structure

    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000476244 ENST00000376903 ENST00000431798 ENST00000376917(uc011dlt.1 uc003nna.2 uc011dlu.1 uc011dlv.1 uc003nne.2 uc003nnf.2 uc003nng.2 uc003nnh.2 uc003nni.2 uc003nnj.2 uc003nnk.2)
    ENST00000483013 ENST00000376889 ENST00000490427 ENST00000376898 ENST00000485885
    ENST00000396704 ENST00000396701 ENST00000376888 ENST00000376905 ENST00000376891
    ENST00000469353 ENST00000485211 ENST00000469603 ENST00000416766

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    MOG expression in normal and diseased human tissues

    1  / 2  / 3

    9 probe-sets matching MOG gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    37867_at2, 3 U95-A 1 1.00 1.00 0.97 1.10 Z48051 0.20 1.00 0.72 1
    37868_s_at2, 3 U95-A 1 1.00 1.00 0.98 0.91 U64565 1.00 1.00 1.00 1
    214650_x_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --
    211836_s_at2, 3 U133-A 1 1.00 1.00 -- -- U18800 0.60 1.00 0.82 1
    205989_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002433 0.60 1.00 0.82 1
    214650_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    211836_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    205989_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    1555807_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    MOG for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    MOG gene expression
    MOG gene electronic northern expression
    MOG gene sage expression
    About these images

    CGAP SAGE TAG: CCTGCTTTAG

    SOURCE GeneReport for Unigene cluster: Hs.141308

    Expression variation in blood from EXPOLDB for MOG

    UniProtKB/Swiss-Prot: MOG_HUMAN, Q16653
    Tissue specificity: Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte
    cytoplasmic membranes

    Primers:Browse OriGene genome-wide validated SYBR primer pairs
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for MOG: PPH12417A
        SABiosciences Custom PCR Arrays for MOG 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for MOG gene from 5 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    MOG1   -- myelin oligodendrocyte glycoprotein 84.51(n)
    87.14(a)
    488341  XM_545463.2  XP_545463.2 
    chimpanzee
    (Pan troglodytes)
    MOG1   -- myelin oligodendrocyte glycoprotein 99.33(n)
    99.19(a)
    462527  XM_001145644.1  XP_001145644.1 
    cow
    (Bos taurus)
    MOG1   -- myelin oligodendrocyte glycoprotein 88.75(n)
    91.46(a)
    280863  NM_001013584.1  NP_001013602.1 
    rat
    (Rattus norvegicus)
    Mog1   -- myelin oligodendrocyte glycoprotein 82.99(n)
    86.94(a)
    24558  NM_022668.1  NP_073159.1 
    mouse
    (Mus musculus)
    Mog1 , 5 17 (19.16 cM)5
    myelin oligodendrocyte glycoprotein1, 5 83.81(n)1
    86.23(a)1
    174411  NM_010814.21  NP_034944.21 
     AK1350365  AY5668305  (see all 17)
    About this table        Species with no ortholog for MOG

    ENSEMBL Gene Tree for MOG (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for MOG gene
    BTNL82  BTNL22  LOC1001290942  BTNL32  BTNL92  

    MOG for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/328 NCBI SNPs in MOG are shown (see all 328)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs292281,2
    C,F,O,A29623739(-) TTCTGC/TTTTTG 7 -- ng5119Minor allele frequency- T:0.24NS EA NA 1650
    rs292341,2
    C,F,A,H29624112(-) CCTCTT/GGGCTC 7 -- ng519Minor allele frequency- G:0.05NS EA 1004
    rs292351,2
    C,F29624078(-) CCAGCA/GTTGGT 7 -- ng514Minor allele frequency- G:0.06NS EA 420
    rs292541,2
    C,F,H29623594(-) AGTCAA/GGATTG 7 -- ng519Minor allele frequency- G:0.05NS EA NA 830
    rs9268271,2
    C,F29635517(+) TTGGAC/TCGTCT 7 -- int15Minor allele frequency- T:0.09NS EA MN 508
    rs9268281,2
    C,F,A,H29638425(+) GTGGGG/AAAGGT 7 -- int17Minor allele frequency- A:0.06NA EA NS 650
    rs11229471,2
    C,F29638434(+) GTGCTA/GTTCAT 7 -- int117Minor allele frequency- G:0.12NA EA NS WA 2866
    rs13186311,2
    C,F29635508(+) GTCCCG/ATTCTT 7 -- int17Minor allele frequency- A:0.19MN NS EA NA 486
    rs20716521,2
    C,F29635317(+) GGCTGC/TAGAGA 7 -- int16Minor allele frequency- T:0.18EA NS MN 1798
    rs20716531,2
    C,F,A29635928(+) AAAAAC/TGTTAT 7 -- int118Minor allele frequency- T:0.21EA NS NA WA 2924
    About this table

    HapMap Linkage Disequilibrium images for MOG (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MOG
         1 CNV: 3598

    QIAGEN SeqTarget long-range PCR primers for resequencing MOG 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MOG for disorders           About GeneDecksing

    OMIM: 159465

    10/30 Novoseek disease relationships for MOG gene (see all 30)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    multiple sclerosis 88.7 104 12149493 (3), 7593547 (3), 9394837 (2), 10545390 (2) (see all 77)
    encephalomyelitis 86.1 32 11128602 (2), 1991822 (1), 8367453 (1), 12667650 (1) (see all 30)
    demyelination 84.4 50 11536329 (3), 1695240 (2), 15259003 (2), 11128602 (2) (see all 39)
    demyelinating diseases 77.4 14 8220243 (2), 20033986 (1), 12355425 (1), 17294606 (1) (see all 9)
    autoimmune response 66.7 15 9394837 (3), 8965116 (1), 11128602 (1), 11403222 (1) (see all 5)
    multiple sclerosis relapsing-remitting 58.2 1 17628700 (1)
    autoimmune diseases 58 4 11724443 (1), 20033986 (1), 9210466 (1), 11428934 (1)
    neurological disorders 54.2 14 9083925 (2), 8965116 (1), 9394837 (1), 12911279 (1) (see all 10)
    optic neuritis 53.1 2 12732654 (2)
    mimicry 49.3 6 11536329 (2), 14688379 (2), 14597104 (1), 14978022 (1)
    About this table

    Genetic Association Database (GAD): MOG
    Human Genome Epidemiology (HuGE) Navigator: MOG (25 documents)

    Export disorders and mutations for MOG gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/247 PubMed articles for MOG gene, integrated from 7 sources (see all 247):
    (articles sorted by number of sources associating them with MOG)
    1. Genetic study of the myelin oligodendrocyte glycoprotein (MOG) gene in schizophrenia. (PubMed id 15660663)1, 4, 7 Zai G....Kennedy J.L. (2005)
    2. Myelin oligodendrocyte gene polymorphisms and childhood multiple sclerosis. (PubMed id 12149493)1, 4, 7 Ohlenbusch A....Hanefeld F. (2002)
    3. Characterization of cDNA and genomic clones encoding human myelin oligodendrocyte glycoprotein. (PubMed id 7790876)1, 2, 7 Hilton A.A.... Bernard C.C.A. (1995)
    4. Characterization and expression of the cDNA coding for the human myelin/oligodendrocyte glycoprotein. (PubMed id 7964757)1, 2, 7 Pham-Dinh D.... Dautigny A. (1994)
    5. Structure of the human myelin/oligodendrocyte glycoprotein gene and multiple alternative spliced isoforms. (PubMed id 8666381)1, 2, 7 Pham-Dinh D.... Dautigny A. (1995)
    6. The human myelin oligodendrocyte glycoprotein (MOG) gene: complete nucleotide sequence and structural characterization. (PubMed id 8530032)1, 2, 7 Roth M.-P.... Coppin H. (1995)
    7. A conformational study of the human and rat encephalitogenic myelin oligodendrocyte glycoprotein peptides 35-55. (PubMed id 9210466)1, 2, 7 Albouz-Abo S.... von Itzstein M. (1997)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    9. Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B. (PubMed id 11118029)1, 4 Nejentsev S....Ilonen J. (2000)
    10. Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C57BL/6 mice. (PubMed id 12817031)1, 7 Oliver A.R....Ruddle N.H. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4340 HGNC: 7197 AceView: MOG Ensembl:ENSG00000204655 euGenes: HUgn4340
    ECgene: MOG H-InvDB: MOG

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    Wikipedia http://en.wikipedia.org/wiki/Myelin_oligodendrocyte_glycoprotein

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for MOG gene:
    Search GeneIP for patents involving MOG

    GeneCards and IP:
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