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Aliases & Descriptionsfor MOS gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions v-mos Moloney murine sarcoma viral oncogene homolog1 2 MGC1199632 Oocyte maturation factor mos2 3 MSV2 Proto-oncogene c-Mos2 3 c-mos2 MGC1199622 oncogene MOS, Moloney murine sarcoma virus2 proto-oncogene serine/threonine-protein kinase mos2 EC 2.7.11.13
Export aliases for MOS gene to outside databases Previous GC identifers: GC08M056208 GC08M056964 GC08M056748 GC08M057075 GC08M057188 GC08M057025
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Summariesfor MOS gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for MOS : MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 (PubMed 18246541)).(supplied by OMIM) Gene Wiki entry for MOS
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Genomic Viewsfor MOS gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MOS gene promoter: CUTL1 GATA-1 AP-1 STAT5A p53 c-Fos c-Jun ATF Arnt AhR Other transcription factors Search SABiosciences Chromatin IP Primers for MOS Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MOS
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 8q11 Ensembl cytogenetic band: 8q12.1 HGNC cytogenetic band: 8q11 MOS Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure
GeneLoc location for GC08M052492: view genomic region
(about GC identifiers )
Start:
52,492,986 bp from pter
End:
52,494,026 bp from pter
Size:
1,041 bases
Orientation:
minus strand
1 alternative location : Chr 8- 57,025,501-57,026,541
RefSeq DNA sequence: NC_000008.10 NT_008183.19
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Proteinsfor MOS gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: MOS_HUMAN, P00540 (See
protein sequence )Recommended Name: Proto-oncogene serine/threonine-protein kinase mos Size : 346 amino acids; 37820 Da
Secondary accessions : Q3KPG9 Q3KPH0Explore the universe of human proteins at neXtProt for MOS: NX_P00540 Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins: NP_005363.1 ENSEMBL proteins: ENSP00000310722 Human Recombinant Proteins Antibodies for MOS: Assays for MOS:
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Protein
Domains/ Familiesfor MOS gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MOS for domains About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P00540 ProtoNet protein and cluster: P00540
UniProtKB/Swiss-Prot: MOS_HUMAN, P00540 Similarity : Belongs to the protein kinase superfamily. Ser/Thr protein kinase familySimilarity : Contains 1 protein kinase domain
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Gene Functionfor MOS gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: MOS_HUMAN, P00540 Catalytic activity : ATP + a protein = ADP + a phosphoproteinEnzyme Number (IUBMB): EC 2.7.11.1
Genatlas biochemistry entry for MOS :Moloney murine sarcoma viral (v-mos) oncogene homolog (cytostatic factor blocking cells at metaphase) 5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6 ):
About this table
MOS for ontologies About GeneDecksing Animal Models: 3 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Mos) :
MOS for phenotypes About GeneDecksing
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Pathways & Interactionsfor MOS gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section
MOS for pathways About GeneDecksing 1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for MOS 4 Kegg Pathways (Kegg details for MOS) : SABiosciences Pathway-Focused PCR Arrays including MOS : PAHS-061A PAHS-502A Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for MOS SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MOS 5/11 Interacting proteins for MOS (P00540 1 , 2 ENSP00000310722 3 ) via UniProtKB, MINT, and/or STRING (see all 11 )About this table 1 Gene Ontology (GO) biological process term (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006468 protein phosphorylation
IEA --
About this table
MOS for ontologies About GeneDecksing
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Drugs & Compoundsfor MOS gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section
MOS for compounds About GeneDecksing Browse Tocris compounds for MOS 8 Novoseek chemical compound relationships for MOS gene
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
progesterone
53.5
14
9755163 (2), 8007949 (2), 10512866 (2), 14751548 (1) (see all 10 )
threonine
41.5
5
9804168 (1), 9256448 (1), 2150599 (1), 7588633 (1) (see all 5 )
serine
37.9
6
9804168 (1), 9256448 (1), 8404868 (1), 2150599 (1) (see all 6 )
cycloheximide
23.1
3
11408585 (1), 9721872 (1)
actinomycin d
18.7
1
9721872 (1)
atp
0
2
7478569 (1), 8405379 (1)
calcium
0
3
1830371 (1), 9486797 (1), 20015408 (1)
alanine
0
2
16809767 (1), 10838091 (1)
About this table
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Transcriptsfor MOS gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for MOS gene: NM_005372.1
Additional cDNA sequence: BC069569.1 BC069590.1 BC106737.1 BC106738.1
1 DOTS entry : DT.91811430
4 AceView cDNA sequences :
NM_005372 BC069569 BC069590 AY279177
highest scoring ESTs for MOS :BC069569 BC069590 NM_005372 AY279177 BC106737 BC106738 HG1733-HT1748 Unigene Cluster for MOS:
V-mos Moloney murine sarcoma viral oncogene homolog Hs.533432 Unigene Representative Sequence: NM_005372 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000311923 (uc011leb.1 )
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Expression for MOS gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section MOS expression in normal and diseased human tissues 1 / 2 / 3
3 probe-sets matching MOS gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
1174_at2 , 3
U95-A
1
0.38
1.00
1.00
1.00
HG1733-HT1748
0.20
1.00
0.72
1
221367_at2 , 3
U133-A
1
0.64
1.00
--
--
NM_005372
0.60
1.00
0.82
1
221367_at2
U133Plus2
1
0.64
1.00
--
--
--
--
--
--
--
About this table
MOS for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GAGTTCGGTG SOURCE GeneReport for Unigene cluster: Hs.533432 UniProtKB/Swiss-Prot: MOS_HUMAN, P00540 Tissue specificity : Expressed specifically in testis during spermatogenesis
SABiosciences Expression via Pathway-Focused PCR Arrays including MOS : PAHS-061A PAHS-502A
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Orthologsfor MOS gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for MOS gene from 5/10 species (see all 10 )
About this table Species with no ortholog for MOS ENSEMBL Gene Tree for MOS (if available)
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Paralogsfor MOS gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for MOS gene ARAF 2 RAF1 2 BRAF 2 MAP3K7 2
MOS for paralogs About GeneDecksing
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Genomic Variantsfor MOS gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 8 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for MOS (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MOS: --
QIAGEN SeqTarget long-range PCR primers for resequencing MOS
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Disorders & Mutationsfor MOS gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MOS for disorders About GeneDecksing
OMIM: 190060 1 Novoseek disease relationship for MOS gene
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
tumors
0
2
1836123 (1), 8549590 (1)
About this table Human Genome Epidemiology (HuGE) Navigator: MOS (15 documents) Tumor Gene Database (TGDB) : MOS Export disorders and mutations for MOS gene to outside databases
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Medical Newsfor MOS gene (Possibly Related Articles in
Doctor's Guide )
About This Section
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Publicationsfor MOS gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10/94 PubMed articles for MOS gene, integrated from 7 sources (see all 94 ): (articles sorted by number of sources associating them with MOS) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Mos and the cell cycle. (PubMed id 9552420) 1 , 3 Singh B. and Arlinghaus R.B. (1997) Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus. (PubMed id 6287464) 1 , 2 Watson R.... Vande Woude G.F. (1982) Mos 3' UTR regulatory differences underlie species-specific temporal patterns of Mos mRNA cytoplasmic polyadenylation and translational recruitment during oocyte maturation. (PubMed id 18246541) 1 , 7 Prasad C.K....MacNicol A.M. (2008) What does Mos do in oocytes and somatic cells? (PubMed id 9008413) 1 , 7 Sagata N. (1997) Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos. (PubMed id 20186124) 1 , 7 Vitale I....Kroemer G. (2010) Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition. (PubMed id 18550795) 1 , 7 Tang W....Kornbluth S. (2008) The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612) 1 Zhao J....Grant S.F. (2010) Many sequence variants affecting diversity of adult human height. (PubMed id 18391951) 1 Gudbjartsson D.F....Stefansson K. (2008) Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846) 2 Greenman C.... Stratton M.R. (2007)
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External Searches for MOS gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MOS gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MOS gene
(According to HUGE )
About This Section --
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Specialized Databases showing MOS gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for MOS gene: Search GeneIP for patents involving MOS GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MOS gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for MOS
ELISAs and CLIAs for MOS
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Expression for MOS
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