Aliases &
Descriptions
for MPHOSPH8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| M-phase phosphoprotein 81 2 | | M-phase phosphoprotein, mpp2 | | HSMPP81 2 | | FLJ352372 | | mpp81 2 | | M-phase phosphoprotein, mpp82 | | Two hybrid-associated protein 3 with RanBPM2 3 | | MPP83 | | TWA32 5 | | Twa33 |
Export aliases for MPHOSPH8 gene to outside databasesPrevious GC identifers: GC13P019107 GC13P020208 |
Summaries
for MPHOSPH8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for MPHOSPH8 |
Genomic Views
for MPHOSPH8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MPHOSPH8
Other transcription factors
Search SABiosciences Chromatin IP Primers for MPHOSPH8
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MPHOSPH8  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q12.11 Ensembl cytogenetic band: 13q12.11 HGNC cytogenetic band: 13q12.11MPHOSPH8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P001012: view genomic region
(about GC identifiers)
Start:
|
1,012,645 bp from pter |
End:
|
1,052,544 bp from pter |
Size:
|
39,900 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr13+ 20,207,821-20,247,581 |
RefSeq DNA sequence:- NC_000013.10 NT_024524.14
|
Proteins
for MPHOSPH8 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: MPP8_HUMAN, Q99549 (See
protein sequence)Recommended Name: M-phase phosphoprotein 8 Size: 860 amino acids; 97182 Da
Subcellular location: Nucleus
Sequence caution: Sequence=AAH46214.1; Type=Erroneous initiation; Sequence=BAB71284.1; Type=Erroneous initiation;Sequence=CAI46172.1; Type=Frameshift; Positions=248, 255, 731;
PDB structures from  and Proteopedia  :3LWE (3D)
Secondary accessions: B7Z6F9 Q5JPE5 Q5JTQ0 Q86TK3 Q96MK4 Q9BTP1Alternative splicing: 2 isoforms: Q99549-1 Q99549-2 Explore the universe of human proteins at neXtProt for MPHOSPH8: NX_Q99549
Post-translational modifications:
Phosphorylated in M (mitotic) phase1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_059990.2
ENSEMBL proteins: ENSP00000414663 ENSP00000353982 ENSP00000405941 ENSP00000355388
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
MPHOSPH8 for ontologies About GeneDecksing
Antibodies for MPHOSPH8:
Assays for MPHOSPH8: |
Protein
Domains/
Families
for MPHOSPH8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MPHOSPH8 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q99549ProtoNet protein and cluster: Q99549 1 Blocks protein family: IPB000953 Chromo domain
UniProtKB/Swiss-Prot: MPP8_HUMAN, Q99549Similarity: Contains 4 ANK repeatsSimilarity: Contains 1 chromo domain |
Gene Function
for MPHOSPH8 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0003682 | chromatin binding |
IEA | -- |
About this table
MPHOSPH8 for ontologies About GeneDecksing
|
Pathways & Interactions
for MPHOSPH8 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for MPHOSPH8
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MPHOSPH8
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
MPHOSPH8 for ontologies About GeneDecksing
|
Drugs & Compounds
for MPHOSPH8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for MPHOSPH8
|
Transcripts
for MPHOSPH8 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for MPHOSPH8 gene: NM_017520.3 Additional cDNA sequence: AJ293409.1 AK056785.1 AK092556.1 AK300258.1 AL832864.1 BC003542.1 BC017322.2 BC046214.1 CR622896.1 X98259.1 24/26 DOTS entries (see all 26): DT.440607 DT.91837538 DT.95217970 DT.95283184 DT.454778 DT.100791650 DT.91721810 DT.120781551 DT.70102691 DT.86854823 DT.91721813 DT.95107792 DT.95369816 DT.120781572 DT.120781431 DT.120781538 DT.120781556 DT.40190319 DT.91759164 DT.97796598 DT.120781471 DT.120781525 DT.120781558 DT.91867504 24/246 AceView cDNA sequences (see all 246): BE781185 BM459567 AI674362 BM716111 BQ071731 BX105477 BM475270 Z45796 BF591175 T90105 CF619016 BM692745 BU178024 BQ945913 BG258989 CD364865 AI927675 AW207221 AW969331 BG258142 AI091066 AW080118 BU164060 NM_017520 Unigene Cluster for MPHOSPH8: M-phase phosphoprotein 8 Hs.269654 [show with all ESTs]Unigene Representative Sequence: NM_017520
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for MPHOSPH8
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for MPHOSPH8
7 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000467481 ENST00000414242(uc001umg.2) ENST00000360754 ENST00000493437
ENST00000496525 ENST00000449056 ENST00000361479(uc001umf.1 uc001umh.2 uc001umi.2)
|
Expression
for MPHOSPH8 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| MPHOSPH8 expression in normal and diseased human tissues
1 / 2 9 probe-sets matching MPHOSPH8 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 90596_at2
|
U95-E |
1 |
1.00 |
1.00 |
0.66 |
0.64 |
-- |
-- |
-- |
-- |
-- |
| 57834_at2
|
U95-B |
1 |
0.88 |
1.00 |
0.64 |
1.37 |
-- |
-- |
-- |
-- |
-- |
| 35110_at2
|
U95-A |
1 |
0.56 |
1.00 |
0.22 |
0.16 |
-- |
-- |
-- |
-- |
-- |
| 221771_s_at2
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 225041_at2
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 227026_at2
|
U133-B |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 221771_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 225041_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 227026_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
MPHOSPH8 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GGGTGGAACA
SOURCE GeneReport for Unigene cluster: Hs.269654
SABiosciences Custom PCR Arrays for MPHOSPH8
|
Orthologs
for MPHOSPH8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for MPHOSPH8 gene from 5/8 species (see all 8)
About this table Species with no ortholog for MPHOSPH8
ENSEMBL Gene Tree for MPHOSPH8 (if available) |
Paralogs
for MPHOSPH8 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for MPHOSPH8 gene
- CBX32 MIR31982 CBX12
MPHOSPH8 for paralogs About GeneDecksing
|
Genomic Variants
for MPHOSPH8 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 13 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for MPHOSPH8 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MPHOSPH8
1 CNV: 49182 | | QIAGEN SeqTarget long-range PCR primers for resequencing MPHOSPH8 |
|
Disorders & Mutations
for MPHOSPH8 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MPHOSPH8 for disorders About GeneDecksing
OMIM: 611626
Export disorders and mutations for MPHOSPH8 gene to outside databases
|
Medical News
for MPHOSPH8 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for MPHOSPH8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/16 PubMed articles for MPHOSPH8 gene, integrated from 7 sources (see all 16):
(articles sorted by number of sources associating them with MPHOSPH8)- Identification of novel M phase phosphoproteins by expression cloning. (PubMed id 8885239)1, 2, 3 Matsumoto-Taniura N....Westendorf J.M. (1996)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion. (PubMed id 20871592)1 Kokura K....Fang J. (2010 Nov 3)
- Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
|
External Searches for MPHOSPH8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MPHOSPH8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MPHOSPH8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MPHOSPH8 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MPHOSPH8 gene:
Search GeneIP for patents involving MPHOSPH8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MPHOSPH8 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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