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MPZL1 Gene

protein-coding GIFtS: 56

GC01P138937

myelin protein zero-like 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
myelin protein zero-like 1¹ ²		PZRb²
PZR¹ ² ³		immunoglobulin family transmembrane protein²
FLJ21047¹ ²		protein zero related²
Protein zero-related² ³		MPZL1b²
PZRa²		myelin protein zero-like protein 1²
OTTHUMP00000032521²		PZR1b²

External Ids:	HGNC: 7226¹	Entrez Gene: 9019²	Ensembl: ENSG00000197965⁷	UniProtKB: O95297³

Export aliases for MPZL1 gene to outside databases

Previous GC identifers: GC01P165326 GC01P163342 GC01P164387 GC01P164878 GC01P164422 GC01P165957 GC01P167690

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MPZL1_HUMAN, O95297

Function: Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell

membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in

cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to

have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform

2 and isoform 3, may be involved in regulation of integrin-mediated cell motility

Gene Wiki entry for MPZL1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MPZL1 gene promoter:
         Nkx2-2   Cdc5   Cart-1   GR-alpha   Nkx3-1 v2   Nkx3-1 v4   Nkx3-1   Nkx3-1 v1   Egr-3   Nkx3-1 v3
         Other transcription factors

Search SABiosciences Chromatin IP Primers for MPZL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MPZL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.2 Ensembl cytogenetic band: 1q24.2 HGNC cytogenetic band: 1q24.2

MPZL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MPZL1 gene location

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P138937: view genomic region (about GC identifiers)

Start:	138,937,273 bp from pter
End:	139,007,435 bp from pter
Size:	70,163 bases
Orientation:	plus strand

1 alternative location:

Chr1+ 167,690,429-167,761,156

RefSeq DNA sequence:

NC_000001.10 NT_004487.19

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: MPZL1_HUMAN, O95297 (See protein sequence)

Recommended Name: Myelin protein zero-like protein 1 precursor

Size: 269 amino acids; 29082 Da

Subunit: Interacts with phosphorylated PTPN11/SHP-2

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Sequence caution: Sequence=CAI20144.2; Type=Erroneous gene model prediction;

Secondary accessions: B2REB9 Q5R332 Q8IX11 Q9BWZ3 Q9NYK4 Q9UL20

Alternative splicing: 4 isoforms: O95297-1 O95297-2 O95297-3 O95297-4

Explore the universe of human proteins at neXtProt for MPZL1: NX_O95297

Post-translational modifications:

Phosphorylated on tyrosine residues upon stimulation with pervanadate and concanavalin-A (ConA). Phosphorylation at

Tyr-241 and Tyr-263 is required for interaction with PTPN11/SHP-2. Dephosphorylated by PTPN11/SHP-2 (in vitro)¹

N-glycosylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001139663.1 NP_003944.1 NP_078845.3

ENSEMBL proteins:

ENSP00000352513 ENSP00000399490 ENSP00000375968 ENSP00000420455 ENSP00000356827

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: MPZL1 OriGene Protein Over-expression Lysate: MPZL1
	GenScript Custom Purified and Recombinant Proteins Services for MPZL1
	Novus Biologicals Protein for MPZL1
	Novus Biologicals Lysates for MPZL1
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	TAS	9792637
GO:0016020	membrane	IEA	--

About this table

MPZL1 for ontologies About GeneDecksing

Antibodies for MPZL1:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for MPZL1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for MPZL1 (PZR)
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for MPZL1
	Novus Biologicals Antibodies for MPZL1
	Browse antibodies at Epitomics

Assays for MPZL1:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MPZL1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MPZL1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MPZL1 for domains About GeneDecksing

5 InterPro domains/families:

IPR003596 Ig_V-set_sub

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

IPR007110 Ig-like

IPR000920 Myelin_P0

Graphical View of Domain Structure for InterPro Entry O95297

ProtoNet protein and cluster: O95297

3 Blocks protein families:

IPB000920 Myelin P0 protein

IPB003596 Immunoglobulin V-type

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: MPZL1_HUMAN, O95297

Domain: Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor

motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the

SH2 domain of several SH2-containing phosphatases

Similarity: Belongs to the myelin P0 protein family

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: MPZL1_HUMAN, O95297

Function: Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell

membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in

cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to

have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform

2 and isoform 3, may be involved in regulation of integrin-mediated cell motility

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for MPZL1 Sigma-Aldrich shRNA for MPZL1
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): MPZL1 OriGene shRNA RFP (see all 3): MPZL1 OriGene basic RS shRNA (see all 3): MPZL1 OriGene siRNA (see all 3): MPZL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MPZL1

miRNA:		Sigma-Aldrich microRNA Mimics for MPZL1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MPZL1
		5 SABiosciences Assays for microRNAs that regulate MPZL1:
		hsa-miR-136 hsa-miR-544 hsa-miR-501-5p hsa-miR-938 hsa-miR-129-3p

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): MPZL1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): MPZL1 OriGene untagged cDNA clones in CMV expression vector (see all 3): MPZL1 OriGene 3'-UTR clone (see all 3): MPZL1 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for MPZL1
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for MPZL1

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	TAS	9792637
GO:0005515	protein binding	IPI	9792637

About this table

MPZL1 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

MPZL1 for pathways About GeneDecksing

1 Kegg Pathway (Kegg details for MPZL1):

hsa04514 Cell adhesion molecules (CAMs)

SABiosciences Custom Pathway-Focused PCR Arrays for MPZL1

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MPZL1

3 Interacting proteins for MPZL1 (ENSP00000352513³ O95297^{1, 2}) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPN11	Q06124¹^,²	STRING: ENSP00000340944 EBI-963338,EBI-297779 MINT-8030561 MINT-8032236
SRC	ENSP00000362659³	STRING: ENSP00000362659
--	ENSP00000356955³	STRING: ENSP00000356955

About this table

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	TAS	10681522
GO:0007267	cell-cell signaling	TAS	9792637

About this table

MPZL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MPZL1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for MPZL1 Sigma-Aldrich shRNA for MPZL1
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): MPZL1 OriGene shRNA RFP (see all 3): MPZL1 OriGene basic RS shRNA (see all 3): MPZL1 OriGene siRNA (see all 3): MPZL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MPZL1

miRNA:		Sigma-Aldrich microRNA Mimics for MPZL1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MPZL1
		5 SABiosciences Assays for microRNAs that regulate MPZL1:
		hsa-miR-136 hsa-miR-544 hsa-miR-501-5p hsa-miR-938 hsa-miR-129-3p

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): MPZL1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): MPZL1 OriGene untagged cDNA clones in CMV expression vector (see all 3): MPZL1 OriGene 3'-UTR Clone (see all 3): MPZL1 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for MPZL1

Primers:		OriGene genome-wide validated SYBR primer pairs: MPZL1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for MPZL1: PPH08008A

REFSEQ mRNAs for MPZL1 gene (3 alternative transcripts):

NM_001146191.1 NM_003953.5 NM_024569.4

Additional cDNA sequence:

AF087020.1 AF092425.1 AF095726.1 AF095727.1 AF181660.1 AF239756.1 AF478447.1 AK024700.1

AK075334.1 AK291249.1 AK297112.1 AK307250.1 AK315546.1 AL035302.1 AL035308.1 AY359019.1

BC007881.2 BC019890.1 BC050613.1 BT019542.1 CR542160.1 CR604001.1

23 DOTS entries:

DT.75169571 DT.121383759 DT.440141 DT.100846337 DT.40218461 DT.121383767 DT.100846336 DT.100846335

DT.121383782 DT.40108538 DT.92445700 DT.95160660 DT.99983664 DT.121383740 DT.121383758 DT.121383768

DT.40268087 DT.91912072 DT.95299267 DT.80100410 DT.91703378 DT.91828626 DT.95277364

24/445 AceView cDNA sequences (see all 445):

D82555 CB243656 BU158295 AI279501 AW468701 BC050613 AI342326 BU628080

BX282719 AF092424 AI222740 CA449221 AA587712 AI085676 BU182686 AA337279

BU633448 BC007881 AA936648 AW675446 AI097437 BM802099 AI753237 AA425593

highest scoring ESTs for MPZL1:

AF087020 W63710 AA004925 AA004926 AA005425 AA005426 AA025880 AA035526 AA071326 AA071368

Unigene Cluster for MPZL1:

Myelin protein zero-like 1

Hs.493919 [show with all ESTs]

Unigene Representative Sequence: NM_003953

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MPZL1 (see all 7)

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	·	6d	^	7	^	8
SP1:			-				-						-
SP2:			-				-						-		-
SP3:							-						-
SP4:			-				-
SP5:			-				-		-		-		-		-

About this scheme

ECgene alternative splicing isoforms for MPZL1
11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000487858 ENST00000359523(uc001geo.2 uc001gep.2 uc001geq.2 uc009wvh.2)

ENST00000464954 ENST00000448405 ENST00000392121 ENST00000465787(uc001gen.3)

ENST00000474859 ENST00000474729 ENST00000367853 ENST00000403379 ENST00000498279

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

MPZL1 expression in normal and diseased human tissues

¹ / ² / ³

16 probe-sets matching MPZL1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
57035_at²^{, 3}	U95-B	1	1.00	1.00	0.33	1.44	W63710	1.00	1.00	1.00	1
33769_at²^{, 3}	U95-A	1	0.94	1.00	0.47	0.60	AF087020	1.00	1.00	1.00	1
82311_at²^{, 3}	U95-E	1	0.81	1.00	0.56	0.87	AI939506	0.20	1.00	0.72	1
83683_at²^{, 3}	U95-E	1	0.56	1.00	-0.26	1.10	AI342326	0.80	1.00	0.91	1
210594_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF239756	0.80	1.00	0.91	1
201874_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF978611	0.80	1.00	0.91	1
201875_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_024569	0.60	1.00	0.82	1
210087_s_at²^{, 3}	U133-A	2	1.00	0.91	--	--	AF095727	0.80	1.00	0.91	1
231621_at²^{, 3}	U133-B	1	0.64	1.00	--	--	BF941526	0.20	1.00	0.72	1
210210_at²^{, 3}	U133-A	1	0.46	1.00	--	--	AF181660	0.60	1.00	0.82	1
210594_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201874_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201875_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210087_s_at²	U133Plus2	2	1.00	0.91	--	--	--	--	--	--	--
231621_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--
210210_at²	U133Plus2	1	0.46	1.00	--	--	--	--	--	--	--

About this table

MPZL1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

MPZL1 gene electronic northern expression

About these images

CGAP SAGE TAG: TCTTCGTCCT

SOURCE GeneReport for Unigene cluster: Hs.493919

Expression variation in blood from EXPOLDB for MPZL1

UniProtKB/Swiss-Prot: MPZL1_HUMAN, O95297

Tissue specificity: Widely expressed with highest levels in heart, placenta, kidney and pancreas. Isoform 3 is

relatively abundant in hematopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB

monocytes and pre-B cell progenitors. Isoform 3 appears to be the major isoform in CD34- promyelocytic and

promonocytic cells. During differentiation in monocytic cells, the expression level of isoform 3 decreases and that of

isoform 1 increases. Isoform 1 is prominent in stromal cells and, to a lesser extent, in umbelical vein endothelial

cells and erythroid progenitors. Isoform 2 is expressed in a erythroid progenitor cell line

Primers:		OriGene genome-wide validated SYBR primer pairs: MPZL1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for MPZL1: PPH08008A

SABiosciences Custom PCR Arrays for MPZL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MPZL1 gene from 5/7 species (see all 7)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MPZL1¹	--	myelin protein zero-like 1	90.58(n) 92.19(a)	480088 XM_537211.2 XP_537211.2
chimpanzee (Pan troglodytes)	MPZL1¹	--	myelin protein zero-like 1	99.63(n) 99.63(a)	469569 XM_524952.2 XP_524952.2
cow (Bos taurus)	MPZL1¹	--	myelin protein zero-like 1	90.71(n) 91.45(a)	539387 NM_001076158.1 NP_001069626.1
rat (Rattus norvegicus)	Mpzl1¹	--	myelin protein zero-like 1	84.63(n) 82.53(a)	360871 NM_001007728.1 NP_001007729.1
mouse (Mus musculus)	Mpzl1^{1 , 5}	1 (72.94 cM)⁵	myelin protein zero-like 1^{1, 5}	84.88(n)¹ 83.27(a)¹	68481¹ NM_001083897.1¹ NP_001077366.1¹ AA009137⁵ AK003513⁵ (see all 37)

About this table Species with no ortholog for MPZL1

ENSEMBL Gene Tree for MPZL1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MPZL1 gene

MPZL2² SCN2B² MPZL3² MPZ² SCN4B²

MPZL1 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs7605^1,2	C,F,A,	167759281(+)	`CACATC/TGTAGA`	5	--	ut3¹ ese³		20	MN NA NS EA WA	1564
rs8623^1,2	C,F,A,	167759838(+)	`CTGCCC/TTCTCC`	5	--	ut3¹ ese³		10	MN NS EA NA	1096
rs8917^1,2	C,F,	167759751(-)	`AAAAGG/AGCTGC`	5	--	ut3¹ ese³		7	MN NS EA NA	760
rs10125^1,2	C,F,A,H,	167758651(+)	`TCTCCC/TTGTAG`	5	--	ut3¹ trp³		16	EA MN NS NA WA	2880
rs12316^1,2	--	167759902(-)	`GAGTGC/TTCCCA`	5	--	ut3¹		1	MN	184
rs14212^1,2	C,F,O,A,H,	167759573(-)	`AGGGCA/GCTGAC`	5	--	ut3¹ ese³		26	MN EA NS NA WA	4688
rs720612^1,2	C,F,O,A,H,	167758262(-)	`ATAAAG/AAAGGT`	5	--	ut3¹		10	MN NA NS EA WA	810
rs763283^1,2	C,F,O,A,H,	167734793(+)	`ACTTTC/TAACTA`	3	--	int¹ ese³		10	MN NS EA NA WA	866
rs768666^1,2	C,F,A,	167704731(-)	`ACACaT/Cgcaca`	3	--	int¹		6	NA EA WA	216
rs929137^1,2	C,F,A,H,	167751269(+)	`tctaaG/Atctct`	3	--	int¹		10	NS EA NA WA	636

About this table

HapMap Linkage Disequilibrium images for MPZL1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MPZL1: --

QIAGEN SeqTarget long-range PCR primers for resequencing MPZL1

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MPZL1 for disorders About GeneDecksing

OMIM: 604376

1 PharmGKB disease relationship for MPZL1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12730115

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Human Genome Epidemiology (HuGE) Navigator: MPZL1 (4 documents)

Export disorders and mutations for MPZL1 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
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10/31 PubMed articles for MPZL1 gene, integrated from 7 sources (see all 31):
(articles sorted by number of sources associating them with MPZL1)

Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2. (PubMed id 9792637)^{1, 2, 3} Zhao Z.J. and Zhao R. (1998)
Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: identification, molecular cloning and effects on cell migration. (PubMed id 12410637)^{1, 2, 7} Zannettino A.C.W.... Watt S.M. (2003)
Identification of a variant form of PZR lacking immunoreceptor tyrosine-based inhibitory motifs. (PubMed id 12684038)^{1, 2, 7} Zhao R. and Zhao Z.J. (2003)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Cell surface glycoprotein PZR is a major mediator of concanavalin A- induced cell signaling. (PubMed id 11751924)^{1, 2} Zhao R.... Zhao Z.J. (2002)
Cloning of human myelin protein zero-like genes by bioinformatics strategy. (PubMed id 12075424)^{1, 2} Tang D.S.... Xia J.H. (2000)
Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs. (PubMed id 10681522)^{1, 2} Zhao R. and Zhao Z.J. (2000)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9019	HGNC: 7226	AceView: MPZL1	Ensembl:ENSG00000197965	euGenes: HUgn9019
ECgene: MPZL1	Kegg: 9019	H-InvDB: MPZL1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Intellectual Property for MPZL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for MPZL1 gene:
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