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Aliases & Descriptionsfor MRPL36 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions mitochondrial ribosomal protein L361 2 39S ribosomal protein L36, mitochondrial2 BRIP11 2 3 MGC1042452 MRP-L361 2 3 OTTHUMP000002206572 L36mt1 2 3 OTTHUMP000002206582 RPMJ1 2 putative BRCA1-interacting protein2 PRPL361 2 OTTHUMP000002206562 BRCA1-interacting protein 12 3 OTTHUMP000002206592
Export aliases for MRPL36 gene to outside databases Previous GC identifers: GC05M001939 GC05M001831
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Summariesfor MRPL36 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for MRPL36 : Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 2p. (provided by RefSeq) UniProtKB/Swiss-Prot: RM36_HUMAN, Q9P0J6 Function : Component of the large subunit of the mitochondrial ribosome (Potential)
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Genomic Viewsfor MRPL36 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MRPL36 gene promoter: CUTL1 CREB deltaCREB AhR Arnt Egr-1 Sox9 HNF-4alpha2 PPAR-gamma1 PPAR-gamma2 Other transcription factors Search SABiosciences Chromatin IP Primers for MRPL36 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MRPL36
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 5p15.3 Ensembl cytogenetic band: 5p15.33 HGNC cytogenetic band: 5p15.3 MRPL36 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure
GeneLoc location for GC05M001851: view genomic region
(about GC identifiers )
Start:
1,780,117 bp from pter
End:
1,781,591 bp from pter
Size:
1,475 bases
Orientation:
minus strand
1 alternative location : Chr 5- 1,798,500-1,801,480
RefSeq DNA sequence: NC_000005.9 NT_006576.16
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Proteinsfor MRPL36 gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: RM36_HUMAN, Q9P0J6 (See
protein sequence )Recommended Name: 39S ribosomal protein L36, mitochondrial precursor Size : 103 amino acids; 11784 Da
Subcellular location : Mitochondrion
Sequence caution : Sequence=AAF04788.1; Type=Erroneous initiation;
Secondary accessions : A4UCS0 B2R4Z2 Q3SWV6 Q9UKL7Explore the universe of human proteins at neXtProt for MRPL36: NX_Q9P0J6
REFSEQ proteins: NP_115868.1 ENSEMBL proteins: ENSP00000427152 ENSP00000372093 ENSP00000423152 ENSP00000423399 ENSP00000424366 Human Recombinant Proteins 4 Gene Ontology (GO) cellular component terms (GO ID links to tree view) :
About this table
MRPL36 for ontologies About GeneDecksing Antibodies for MRPL36: Assays for MRPL36:
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Protein
Domains/ Familiesfor MRPL36 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MRPL36 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q9P0J6 ProtoNet protein and cluster: Q9P0J6
1 Blocks protein family : IPB000473 Ribosomal protein L36 UniProtKB/Swiss-Prot: RM36_HUMAN, Q9P0J6 Similarity : Belongs to the ribosomal protein L36P family
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Gene Functionfor MRPL36 gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: RM36_HUMAN, Q9P0J6 Function : Component of the large subunit of the mitochondrial ribosome (Potential)
1 Gene Ontology (GO) molecular function term (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0003735 structural constituent of ribosome
IEA --
About this table
MRPL36 for ontologies About GeneDecksing
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Pathways & Interactionsfor MRPL36 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section SABiosciences Custom Pathway-Focused PCR Arrays for MRPL36 Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL36 1 Gene Ontology (GO) biological process term (GO ID links to tree view) :
About this table
MRPL36 for ontologies About GeneDecksing
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Drugs & Compoundsfor MRPL36 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for MRPL36
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Transcriptsfor MRPL36 gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for MRPL36 gene: NM_032479.3
Additional cDNA sequence: AB049654.1 AF151109.1 AF155653.1 AK312001.1 BC020642.1 BC104652.1 EF036487.1
6 DOTS entries : DT.75192658 DT.95369944 DT.91752418 DT.91752435 DT.99971246 DT.95186808
24/166 AceView cDNA sequences (see all 166 ):
AA443024 AA478610 AI598208 NM_032479 H79084 AA954613 H77596 H77420 AI571297 AA904619 CF529649 AA977298 BQ012845 AI089399 AA454963 BQ007463 AA737421 AA262336 H93719 AA830635 CF529678 BQ671162 BG027687 BQ012351
highest scoring ESTs for MRPL36 :AB049654 AF151109 AF155653 AV701007 AV701094 AV701291 AV701300 AV701305 AV701347 AV701465 Unigene Cluster for MRPL36:
Mitochondrial ribosomal protein L36 Hs.719465 [show with all ESTs ] Unigene Representative Sequence: BG250351 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for MRPL36 ExUns: 1a · 1b · 1c ^ 2a · 2b SP1 :           SP2 :     -      
About this scheme ECgene alternative splicing isoforms for MRPL36 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000505818 ENST00000382647 ENST00000505059 ENST00000508987 (uc003jcx.3 )ENST00000510999
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Expression for MRPL36 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section MRPL36 expression in normal and diseased human tissues 1 / 2 / 3
3 probe-sets matching MRPL36 gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
65855_at2 , 3
U95-C
1
0.88
1.00
1.00
1.00
W45609
0.60
1.00
0.82
1
224331_s_at2 , 3
U133-B
2
0.82
0.94
--
--
AB049654
0.80
1.00
0.91
1
224331_s_at2
U133Plus2
2
0.82
0.94
--
--
--
--
--
--
--
About this table
MRPL36 for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GCAAATCTTT SOURCE GeneReport for Unigene cluster: Hs.719465 SABiosciences Custom PCR Arrays for MRPL36
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Orthologsfor MRPL36 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for MRPL36 gene from 5/6 species (see all 6 )
About this table Species with no ortholog for MRPL36 ENSEMBL Gene Tree for MRPL36 (if available)
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Paralogsfor MRPL36 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section --
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Genomic Variantsfor MRPL36 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 5 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for MRPL36 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MRPL36: --
QIAGEN SeqTarget long-range PCR primers for resequencing MRPL36
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Disorders & Mutationsfor MRPL36 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MRPL36 for disorders About GeneDecksing
OMIM: 611842 Human Genome Epidemiology (HuGE) Navigator: MRPL36 (1 document)Export disorders and mutations for MRPL36 gene to outside databases
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Medical Newsfor MRPL36 gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor MRPL36 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10/11 PubMed articles for MRPL36 gene, integrated from 7 sources (see all 11 ): (articles sorted by number of sources associating them with MRPL36) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PubMed id 11279069) 1 , 2 Suzuki T....Watanabe K. (2001) The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634) 1 , 3 Kenmochi N....Tanaka T. (2001) Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946) 1 , 2 Hu R.-M.... Chen J.-L. (2000) Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624) 1 Hendrickson S.L....O'Brien S.J. (2010) Association of LETM1 and MRPL36 contributes to the regulation of mitochondrial ATP production and necrotic cell death. (PubMed id 19318571) 1 Piao L....Park J. (2009) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. (PubMed id 12706105) 1 Zhang Z. and Gerstein M. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for MRPL36 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MRPL36 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MRPL36 gene
(According to HUGE )
About This Section --
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Specialized Databases showing MRPL36 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for MRPL36 gene: Search GeneIP for patents involving MRPL36 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MRPL36 gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for MRPL36
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